|
US2803586A
(en)
|
1953-06-29 |
1957-08-20 |
Abbott Lab |
ph control in production of fumagillin
|
|
GB8500209D0
(en)
|
1985-01-04 |
1985-02-13 |
Ceskoslovenska Akademie Ved |
Synthetic polymeric drugs
|
|
SE8702550D0
(sv)
|
1987-06-18 |
1987-06-18 |
Anders Grubb |
Cysteinproteashemmare
|
|
US5166172A
(en)
|
1988-09-01 |
1992-11-24 |
Takeda Chemical Industries, Ltd. |
Fumagillol derivatives and pharmaceutical compositions thereof
|
|
US4997878A
(en)
|
1988-12-29 |
1991-03-05 |
Exxon Research And Engineering Company |
Hydrophobically associating polymers containing dimethyl acrylamide functionality
|
|
US5258453A
(en)
|
1992-01-21 |
1993-11-02 |
University Of Utah |
Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
|
|
GB9320781D0
(en)
|
1993-10-08 |
1993-12-01 |
Erba Carlo Spa |
Polymer-bound camptothecin derivatives
|
|
US20030220233A1
(en)
|
1994-01-24 |
2003-11-27 |
Neorx Corporation |
Radiolabeled annexins
|
|
TW527183B
(en)
|
1996-06-06 |
2003-04-11 |
Daiichi Seiyaku Co |
Drug complex
|
|
TW409058B
(en)
|
1996-06-06 |
2000-10-21 |
Daiichi Seiyaku Co |
Method for preparation of a drug complex
|
|
US6759509B1
(en)
|
1996-11-05 |
2004-07-06 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
WO1999011272A1
(en)
|
1997-09-02 |
1999-03-11 |
Johns Hopkins University School Of Medicine |
Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
|
|
AU3352799A
(en)
|
1997-10-31 |
1999-08-23 |
Children's Medical Center Corporation |
Method for regulating size and growth of vascularized normal tissue
|
|
BR9910092A
(pt)
|
1998-05-01 |
2002-01-22 |
Abbott Lab |
Inibidores de beta-aminoácido substituìdo de metionina aminopeptidase-2
|
|
CO5021134A1
(es)
*
|
1998-05-01 |
2001-03-27 |
Abbott Lab |
Inhibidores beta-aminoacidos substituidos de aminopeptida- sa-2 metionina
|
|
US6242494B1
(en)
|
1998-05-01 |
2001-06-05 |
Abbott Laboratories |
Substituted β-amino acid inhibitors of methionine aminopeptidase-2
|
|
KR100357542B1
(ko)
|
1998-05-15 |
2002-10-18 |
주식회사종근당 |
푸마질롤 유도체 및 그 제조방법
|
|
HK1040052B
(zh)
|
1998-05-22 |
2006-09-15 |
第一制药株式会社 |
药物复合物
|
|
US6464850B1
(en)
|
1998-07-31 |
2002-10-15 |
Biowhittaker Molecular Applications, Inc. |
Method for producing hydrophilic monomers and uses thereof
|
|
EP1619210A1
(en)
|
1998-10-30 |
2006-01-25 |
Daiichi Pharmaceutical Co., Ltd. |
DDS compounds and method for assaying the same
|
|
US6803438B1
(en)
|
1999-09-08 |
2004-10-12 |
Polytherics Limited |
Uniform molecular weight polymers
|
|
US6811788B2
(en)
|
2000-01-19 |
2004-11-02 |
Baofa Yu |
Combinations and methods for treating neoplasms
|
|
US20020002152A1
(en)
|
2000-04-14 |
2002-01-03 |
Craig Richard A. |
Hydrazide and alkoxyamide angiogenesis inhibitors
|
|
US20070161570A1
(en)
|
2000-11-01 |
2007-07-12 |
Praecis Pharmaceuticals, Inc. |
Methionine aminopeptidase-2 inhibitors and methods of use thereof
|
|
US6548477B1
(en)
|
2000-11-01 |
2003-04-15 |
Praecis Pharmaceuticals Inc. |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
EP1436286B1
(en)
|
2001-09-27 |
2009-08-19 |
Equispharm Co., Ltd. |
Fumagillol derivatives and preparing method thereof
|
|
EP1483579A4
(en)
|
2002-02-15 |
2006-07-12 |
Merckle Gmbh |
CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, PROCESS FOR THEIR MANUFACTURE AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF
|
|
EP1494662B1
(en)
|
2002-04-11 |
2012-11-28 |
Children's Medical Center Corporation |
Tnp-470-hpma-methacrylic acid copolymer conjugates and use thereof
|
|
US20040001801A1
(en)
|
2002-05-23 |
2004-01-01 |
Corvas International, Inc. |
Conjugates activated by cell surface proteases and therapeutic uses thereof
|
|
US7030262B2
(en)
|
2002-08-06 |
2006-04-18 |
Abbott Laboratories |
3-Amino-2-hydroxyalkanoic acids and their prodrugs
|
|
US20040116348A1
(en)
|
2002-09-23 |
2004-06-17 |
Ying Chau |
Polymer-linker-drug conjugates for targeted drug delivery
|
|
US7491718B2
(en)
|
2002-10-08 |
2009-02-17 |
Abbott Laboratories |
Sulfonamides having antiangiogenic and anticancer activity
|
|
US20040228831A1
(en)
|
2003-05-15 |
2004-11-18 |
Belinka Benjamin A. |
Polymeric conjugates for tissue activated drug delivery
|
|
US7700280B2
(en)
*
|
2003-12-31 |
2010-04-20 |
The Penn State Research Foundation |
Methods for assessing cisplatin resistance, disease progression, and treatment efficacy in ovarian cancer
|
|
US20070287680A1
(en)
|
2004-05-10 |
2007-12-13 |
University Of Utah Research Foundation |
Combined Active and Passive Targeting of Biologically Active Agents
|
|
US7214664B2
(en)
|
2004-12-03 |
2007-05-08 |
The Curators Of The University Of Missouri |
Peptidyl prodrugs that resist P-glycoprotein mediated drug efflux
|
|
US20080248030A1
(en)
|
2005-02-02 |
2008-10-09 |
Children's Medical Center Corporation |
Method of Treating Angiogenic Diseases
|
|
US7629315B2
(en)
|
2005-03-09 |
2009-12-08 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Compositions for blocking the inhibitory effect of human CRP on human leptin
|
|
WO2006124711A1
(en)
|
2005-05-16 |
2006-11-23 |
The Board Of Trustees Of The University Of Illinois |
Composition and method for providing localized delivery of a therapeutic agent
|
|
WO2009003110A2
(en)
|
2007-06-26 |
2008-12-31 |
Children's Medical Center Corporation |
Metap-2 inhibitor polymersomes for therapeutic administration
|
|
WO2009036108A1
(en)
|
2007-09-13 |
2009-03-19 |
Children's Medical Center Corporation |
Methods and compositions for inhibiting vascular leakage
|
|
US20090104210A1
(en)
|
2007-10-17 |
2009-04-23 |
Tota Michael R |
Peptide compounds for treating obesity and insulin resistance
|
|
CA2705417A1
(en)
*
|
2007-11-12 |
2009-05-22 |
Bipar Sciences, Inc. |
Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents
|
|
JP2011503111A
(ja)
*
|
2007-11-12 |
2011-01-27 |
バイパー サイエンシズ，インコーポレイティド |
Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療
|
|
CN101990441A
(zh)
|
2007-11-28 |
2011-03-23 |
默萨那治疗学股份有限公司 |
生物相容的生物可降解的烟曲霉素类似物轭合物
|
|
CN101896177A
(zh)
*
|
2007-12-13 |
2010-11-24 |
诺瓦提斯公司 |
用于治疗癌症的治疗剂的组合
|
|
CN102105156B
(zh)
|
2008-05-22 |
2016-05-25 |
特拉维夫大学拉莫特有限公司 |
连接有治疗活性剂和血管生成靶向部分的聚合物的新型缀合物及其在治疗血管生成相关疾病中的用途
|
|
DE102008027574A1
(de)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
|
|
WO2010065877A2
(en)
|
2008-12-04 |
2010-06-10 |
Zafgen Corporation |
Methods of treating an overweight or obese subject
|
|
WO2010065883A2
(en)
|
2008-12-04 |
2010-06-10 |
Zafgen Corporation |
Method of treating an overweight or obese subject
|
|
TWI373345B
(en)
|
2009-02-19 |
2012-10-01 |
Academia Sinica |
Breast cancer-targeting peptides and use thereof
|
|
EP2493497A4
(en)
|
2009-11-01 |
2013-07-24 |
Brigham & Womens Hospital |
NOTCH INHIBITION IN THE TREATMENT AND PROPHYLAXIS OF ADIPOSITAS AND METABOLISM SYNDROME
|
|
AU2011204267B2
(en)
*
|
2010-01-08 |
2015-12-03 |
Zafgen Corporation |
Fumagillol type compounds and methods of making and using same
|
|
WO2011127304A2
(en)
|
2010-04-07 |
2011-10-13 |
Zafgen Corporation |
Methods of treating an overweight subject
|
|
US9895449B2
(en)
|
2010-05-25 |
2018-02-20 |
Syndevrx, Inc. |
Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
|
|
US20130137831A1
(en)
|
2010-05-25 |
2013-05-30 |
John S. Petersen |
Optimized drug conjugates
|
|
ES2853204T3
(es)
|
2010-05-25 |
2021-09-15 |
Syndevrx Inc |
Inhibidores de MetAP2 conjugado con polímero, y métodos terapéuticos de uso de los mismos
|
|
PH12013500934A1
(en)
*
|
2010-11-09 |
2022-10-24 |
Zafgen Inc |
Crystalline solids of a metap-2 inhibitor and methods of making and using same
|
|
DK2786753T3
(en)
*
|
2010-11-12 |
2019-04-15 |
Pharma Mar Sa |
Combination therapy with an antitumor antibiotic
|
|
CN103534244B
(zh)
|
2011-03-08 |
2016-10-12 |
扎夫根股份有限公司 |
氧杂螺[2.5]辛烷衍生物及类似物
|
|
MX386958B
(es)
*
|
2013-04-10 |
2025-03-19 |
Syndevrx Inc |
Inhibidores de metionina aminopeptidasa-2 y métodos de tratamiento de la obesidad.
|
|
SI3033086T1
(sl)
*
|
2013-08-14 |
2022-01-31 |
Novartis Ag |
Kombinirana terapija za zdravljenje raka
|
|
AU2016366306B2
(en)
|
2015-12-10 |
2021-02-25 |
Syndevrx, Inc. |
Fumagillol derivatives and polymorphs thereof
|
|
WO2017123603A1
(en)
|
2016-01-11 |
2017-07-20 |
Syndevrx, Inc. |
Treatment for tumors driven by metabolic dysfunction
|
|
WO2018027084A2
(en)
|
2016-08-03 |
2018-02-08 |
Remd Biotherapeutics, Inc. |
Combination of glucagon receptor antagonists and pi3k pathway inhibitors for the treatment of cancer
|
|
CN113453721B
(zh)
|
2018-10-26 |
2025-09-16 |
辛德弗雷克斯公司 |
Metap2抑制剂的生物标志物及其应用
|