AU2017206718B2 - Treatment for tumors driven by metabolic dysfunction - Google Patents

Treatment for tumors driven by metabolic dysfunction Download PDF

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Publication number
AU2017206718B2
AU2017206718B2 AU2017206718A AU2017206718A AU2017206718B2 AU 2017206718 B2 AU2017206718 B2 AU 2017206718B2 AU 2017206718 A AU2017206718 A AU 2017206718A AU 2017206718 A AU2017206718 A AU 2017206718A AU 2017206718 B2 AU2017206718 B2 AU 2017206718B2
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AU
Australia
Prior art keywords
cancer
compound
tumor
present disclosure
certain aspects
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AU2017206718A
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AU2017206718A1 (en
Inventor
Peter Cornelius
James Shanahan
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SynDevRX Inc
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SynDevRX Inc
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Publication of AU2017206718A1 publication Critical patent/AU2017206718A1/en
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Publication of AU2017206718B2 publication Critical patent/AU2017206718B2/en
Priority to AU2021286420A priority Critical patent/AU2021286420B2/en
Priority to AU2024204027A priority patent/AU2024204027A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2017206718A 2016-01-11 2017-01-11 Treatment for tumors driven by metabolic dysfunction Active AU2017206718B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021286420A AU2021286420B2 (en) 2016-01-11 2021-12-17 Treatment for tumors driven by metabolic dysfunction
AU2024204027A AU2024204027A1 (en) 2016-01-11 2024-06-13 Treatment for tumors driven by metabolic dysfunction

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662277293P 2016-01-11 2016-01-11
US62/277,293 2016-01-11
US201662393929P 2016-09-13 2016-09-13
US62/393,929 2016-09-13
US201662395446P 2016-09-16 2016-09-16
US62/395,446 2016-09-16
PCT/US2017/012968 WO2017123603A1 (en) 2016-01-11 2017-01-11 Treatment for tumors driven by metabolic dysfunction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021286420A Division AU2021286420B2 (en) 2016-01-11 2021-12-17 Treatment for tumors driven by metabolic dysfunction

Publications (2)

Publication Number Publication Date
AU2017206718A1 AU2017206718A1 (en) 2018-07-05
AU2017206718B2 true AU2017206718B2 (en) 2021-09-30

Family

ID=57882196

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2017206718A Active AU2017206718B2 (en) 2016-01-11 2017-01-11 Treatment for tumors driven by metabolic dysfunction
AU2021286420A Active AU2021286420B2 (en) 2016-01-11 2021-12-17 Treatment for tumors driven by metabolic dysfunction
AU2024204027A Pending AU2024204027A1 (en) 2016-01-11 2024-06-13 Treatment for tumors driven by metabolic dysfunction

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2021286420A Active AU2021286420B2 (en) 2016-01-11 2021-12-17 Treatment for tumors driven by metabolic dysfunction
AU2024204027A Pending AU2024204027A1 (en) 2016-01-11 2024-06-13 Treatment for tumors driven by metabolic dysfunction

Country Status (9)

Country Link
US (3) US10646463B2 (enExample)
EP (1) EP3402529A1 (enExample)
JP (3) JP7022066B2 (enExample)
KR (1) KR20180100663A (enExample)
CN (2) CN114225045B (enExample)
AU (3) AU2017206718B2 (enExample)
CA (2) CA3239447A1 (enExample)
MX (2) MX2018008321A (enExample)
WO (1) WO2017123603A1 (enExample)

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WO2011150022A2 (en) 2010-05-25 2011-12-01 Syndevrx, Inc. Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof
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EA033912B1 (ru) 2013-04-10 2019-12-09 Синдевркс, Инк. ИНГИБИТОРЫ MetAP2 И СПОСОБЫ ЛЕЧЕНИЯ ОЖИРЕНИЯ
KR20250127347A (ko) 2015-12-10 2025-08-26 신데브알엑스, 인크. 푸마길롤 유도체 및 그의 다형체
JP7022066B2 (ja) * 2016-01-11 2022-02-17 シンデブルックス，インコーポレイティド 代謝機能不全によって引き起こされる腫瘍の治療
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドＭ３ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 化合物
CN107670048B (zh) 2017-08-30 2019-04-26 南京明臻医药科技有限公司 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用
US11612577B2 (en) 2018-10-26 2023-03-28 Syndevrx, Inc. Biomarkers of METAP2 inhibitors and applications thereof
CN112915210B (zh) * 2019-12-06 2024-08-20 重庆阿普格雷生物科技有限公司 一种聚乙二醇偶联药物、其制备方法及应用
WO2022103834A1 (en) * 2020-11-11 2022-05-19 Syndevrx, Inc. Combinations of metap2 inhibitors and cdk4/6 inhibitors for the treatment of cancer
CN116887836A (zh) * 2020-11-11 2023-10-13 辛德弗雷克斯公司 用于治疗癌症的metap2抑制剂和cdk4/6抑制剂的组合
JP2025526665A (ja) * 2022-08-10 2025-08-15 シンデブルックス，インコーポレイティド 肺線維症の治療のためのｍｅｔａｐ２阻害剤
JP2025538421A (ja) * 2022-11-16 2025-11-28 シンデブルックス，インコーポレイティド 前立腺がん治療のためのｍｅｔａｐ２阻害剤
CN119932197B (zh) * 2025-04-09 2025-06-13 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 磷酸二酯酶6d作为前列腺癌用药指导标志物的应用

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Also Published As

Publication number Publication date
CN114225045B (zh) 2025-09-26
US10646463B2 (en) 2020-05-12
EP3402529A1 (en) 2018-11-21
KR20180100663A (ko) 2018-09-11
MX2018008321A (es) 2018-09-21
JP2022048388A (ja) 2022-03-25
JP2025071236A (ja) 2025-05-02
WO2017123603A1 (en) 2017-07-20
AU2021286420A1 (en) 2022-01-20
CN108697807A (zh) 2018-10-23
JP7022066B2 (ja) 2022-02-17
AU2021286420B2 (en) 2024-03-14
CN114225045A (zh) 2022-03-25
AU2024204027A1 (en) 2024-07-04
US20170196830A1 (en) 2017-07-13
CN108697807B (zh) 2021-11-26
JP7640481B2 (ja) 2025-03-05
US20210077452A1 (en) 2021-03-18
JP2019501206A (ja) 2019-01-17
CA3008960C (en) 2024-07-02
CA3239447A1 (en) 2017-07-20
US20220280470A1 (en) 2022-09-08
CA3008960A1 (en) 2017-07-20
MX2023002076A (es) 2023-03-17
AU2017206718A1 (en) 2018-07-05
US11273142B2 (en) 2022-03-15

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