JP2006265245A5 - - Google Patents

Info

Publication number

JP2006265245A5

JP2006265245A5 JP2006068066A JP2006068066A JP2006265245A5 JP 2006265245 A5 JP2006265245 A5 JP 2006265245A5 JP 2006068066 A JP2006068066 A JP 2006068066A JP 2006068066 A JP2006068066 A JP 2006068066A JP 2006265245 A5 JP2006265245 A5 JP 2006265245A5

Authority

JP

Japan

Prior art keywords

seq

antibody

acid sequence

amino acid

pharmaceutical composition

Prior art date

2006-03-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims 27
• 239000008194 pharmaceutical composition Substances 0.000 claims 22
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
• BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical group CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 claims 7
• 239000000427 antigen Substances 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 claims 6
• 229960005386 ipilimumab Drugs 0.000 claims 6
• 150000007523 nucleic acids Chemical group 0.000 claims 6
• 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 5
• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 3
• AKWIAIDKXNKXDI-UHFFFAOYSA-N 1h-pyrrole-3-carboxamide Chemical compound NC(=O)C=1C=CNC=1 AKWIAIDKXNKXDI-UHFFFAOYSA-N 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• CPECNDIGIFHFKM-UHFFFAOYSA-N 1,2-dimethylpyrrole-3-carboxamide Chemical compound CC1=C(C(N)=O)C=CN1C CPECNDIGIFHFKM-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• CTNPALGJUAXMMC-PMFHANACSA-N 5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-n-[(2s)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide Chemical compound C([C@@H](O)CNC(=O)C=1C(C)=C(\C=C/2C3=CC(F)=CC=C3NC\2=O)NC=1C)N1CCOCC1 CTNPALGJUAXMMC-PMFHANACSA-N 0.000 claims 1
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
• 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
• 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 1
• 101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
• 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims 1
• 238000009098 adjuvant therapy Methods 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 1
• 238000009093 first-line therapy Methods 0.000 claims 1
• -1 fluoro-2-oxo-1,2-dihydro-3H-indole-3-ylidene Chemical group 0.000 claims 1
• 102000054751 human RUNX1T1 Human genes 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 238000009099 neoadjuvant therapy Methods 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 238000009094 second-line therapy Methods 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1