JP2019511550A5 - - Google Patents

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Publication number
JP2019511550A5
JP2019511550A5 JP2018554089A JP2018554089A JP2019511550A5 JP 2019511550 A5 JP2019511550 A5 JP 2019511550A5 JP 2018554089 A JP2018554089 A JP 2018554089A JP 2018554089 A JP2018554089 A JP 2018554089A JP 2019511550 A5 JP2019511550 A5 JP 2019511550A5
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JP
Japan
Prior art keywords
hepatocellular carcinoma
compound
fxr agonist
pharmaceutically acceptable
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2018554089A
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English (en)
Japanese (ja)
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JP6968821B2 (ja
JP2019511550A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/026931 external-priority patent/WO2017180577A1/en
Publication of JP2019511550A publication Critical patent/JP2019511550A/ja
Publication of JP2019511550A5 publication Critical patent/JP2019511550A5/ja
Application granted granted Critical
Publication of JP6968821B2 publication Critical patent/JP6968821B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2018554089A 2016-04-13 2017-04-11 癌を治療する方法 Active JP6968821B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662321816P 2016-04-13 2016-04-13
US62/321,816 2016-04-13
US201762468259P 2017-03-07 2017-03-07
US62/468,259 2017-03-07
PCT/US2017/026931 WO2017180577A1 (en) 2016-04-13 2017-04-11 Methods of treating cancer

Publications (3)

Publication Number Publication Date
JP2019511550A JP2019511550A (ja) 2019-04-25
JP2019511550A5 true JP2019511550A5 (enExample) 2020-03-05
JP6968821B2 JP6968821B2 (ja) 2021-11-17

Family

ID=60039308

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018554089A Active JP6968821B2 (ja) 2016-04-13 2017-04-11 癌を治療する方法

Country Status (10)

Country Link
US (2) US10369160B2 (enExample)
EP (1) EP3442946A4 (enExample)
JP (1) JP6968821B2 (enExample)
KR (1) KR102377338B1 (enExample)
CN (1) CN109071452A (enExample)
AU (1) AU2017249226B2 (enExample)
CA (1) CA3020698A1 (enExample)
IL (1) IL262342B (enExample)
TW (1) TW201737919A (enExample)
WO (1) WO2017180577A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201832768A (zh) * 2017-03-07 2018-09-16 英特賽普醫藥品公司 治療癌症的方法
US20210000966A1 (en) * 2017-12-14 2021-01-07 Tarveda Therapeutics, Inc. Hsp90-targeting conjugates and formulations thereof
CN108680696B (zh) * 2018-05-15 2020-06-30 南京正大天晴制药有限公司 一种奥贝胆酸起始物料的检测方法
US20230146782A1 (en) * 2019-08-06 2023-05-11 Du Jessica Xinyun Deoxycholic acid compounds, pharmaceutical compositions and uses thereof
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
EP4153589A4 (en) 2020-05-19 2024-06-12 Kallyope, Inc. AMPK ACTIVATORS
WO2021263039A1 (en) 2020-06-26 2021-12-30 Kallyope, Inc. Ampk activators
CN113143936B (zh) * 2021-02-10 2022-03-25 北京蕴汇医药科技有限公司 鹅去氧胆酸或其衍生物在制备egfr和/或stat3的抑制剂中的用途
CN114306349A (zh) * 2022-01-07 2022-04-12 北京蕴汇医药科技有限公司 鹅去氧胆酸或其衍生物制备协同预防或治疗与egfr相关疾病药物的用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60205891T2 (de) 2001-03-12 2006-06-22 Intercept Pharmaceuticals, Inc. Steroide als agonisten für fxr
WO2003080803A2 (en) * 2002-03-21 2003-10-02 Smithkline Beecham Corporation Methods of using farnesoid x receptor (fxr) agonists
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
PL2040713T3 (pl) * 2006-06-27 2014-11-28 Intercept Pharmaceuticals Inc Pochodne kwasów żółciowych jako ligandy FXR do zapobiegania lub leczenia chorób lub stanów, w których pośredniczy FXR
US8338628B2 (en) 2007-08-28 2012-12-25 City Of Hope Method of synthesizing alkylated bile acid derivatives
PL2698375T3 (pl) 2008-11-19 2018-08-31 Intercept Pharmaceuticals, Inc. Modulatory TGR5 i sposób ich zastosowania
WO2013037482A1 (en) * 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
CN108250264A (zh) 2012-10-26 2018-07-06 英特塞普特医药品公司 制备胆汁酸衍生物的方法
NZ708501A (en) * 2012-11-28 2019-03-29 Intercept Pharmaceuticals Inc Treatment of pulmonary disease
US9814733B2 (en) * 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
EA030152B1 (ru) * 2013-05-14 2018-06-29 Интерсепт Фармасьютикалз, Инк 11-гидроксилпроизводные желчных кислот и их аминокислотные конъюгаты в качестве модуляторов фарнезоидных х-рецепторов
US10166246B2 (en) * 2014-05-27 2019-01-01 City Of Hope TGR5 agonist complexes for treating diabetes and cancer
PE20180690A1 (es) * 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
CA2998876A1 (en) * 2015-09-21 2017-03-30 Intercept Pharmaceuticals, Inc. Methods of promoting hepatic regeneration

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