CN109071452A - 治疗癌症的方法 - Google Patents

治疗癌症的方法 Download PDF

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Publication number
CN109071452A
CN109071452A CN201780026925.5A CN201780026925A CN109071452A CN 109071452 A CN109071452 A CN 109071452A CN 201780026925 A CN201780026925 A CN 201780026925A CN 109071452 A CN109071452 A CN 109071452A
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CN
China
Prior art keywords
cancer
compound
hepatocellular carcinoma
fxr agonist
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780026925.5A
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English (en)
Chinese (zh)
Inventor
安东尼奥·莫斯奇塔
耶稣·玛丽亚·巴尼亚莱斯·阿苏儿美蒂
路易斯·布罕达·费尔南德斯·德·佩罗拉
玛丽亚·耶稣·佩鲁戈里亚·蒙提尔
欧亨·埃里切·阿斯帕伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ntercept Pharmaceuticals Inc
Original Assignee
Ntercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ntercept Pharmaceuticals Inc filed Critical Ntercept Pharmaceuticals Inc
Publication of CN109071452A publication Critical patent/CN109071452A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780026925.5A 2016-04-13 2017-04-11 治疗癌症的方法 Pending CN109071452A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662321816P 2016-04-13 2016-04-13
US62/321,816 2016-04-13
US201762468259P 2017-03-07 2017-03-07
US62/468,259 2017-03-07
PCT/US2017/026931 WO2017180577A1 (en) 2016-04-13 2017-04-11 Methods of treating cancer

Publications (1)

Publication Number Publication Date
CN109071452A true CN109071452A (zh) 2018-12-21

Family

ID=60039308

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780026925.5A Pending CN109071452A (zh) 2016-04-13 2017-04-11 治疗癌症的方法

Country Status (10)

Country Link
US (2) US10369160B2 (enExample)
EP (1) EP3442946A4 (enExample)
JP (1) JP6968821B2 (enExample)
KR (1) KR102377338B1 (enExample)
CN (1) CN109071452A (enExample)
AU (1) AU2017249226B2 (enExample)
CA (1) CA3020698A1 (enExample)
IL (1) IL262342B (enExample)
TW (1) TW201737919A (enExample)
WO (1) WO2017180577A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114306349A (zh) * 2022-01-07 2022-04-12 北京蕴汇医药科技有限公司 鹅去氧胆酸或其衍生物制备协同预防或治疗与egfr相关疾病药物的用途
WO2022171040A1 (zh) * 2021-02-10 2022-08-18 北京蕴汇医药科技有限公司 鹅去氧胆酸或其衍生物在制备egfr和/或stat3的抑制剂中的用途

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201832768A (zh) * 2017-03-07 2018-09-16 英特賽普醫藥品公司 治療癌症的方法
US20210000966A1 (en) * 2017-12-14 2021-01-07 Tarveda Therapeutics, Inc. Hsp90-targeting conjugates and formulations thereof
CN108680696B (zh) * 2018-05-15 2020-06-30 南京正大天晴制药有限公司 一种奥贝胆酸起始物料的检测方法
US20230146782A1 (en) * 2019-08-06 2023-05-11 Du Jessica Xinyun Deoxycholic acid compounds, pharmaceutical compositions and uses thereof
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
EP4153589A4 (en) 2020-05-19 2024-06-12 Kallyope, Inc. AMPK ACTIVATORS
WO2021263039A1 (en) 2020-06-26 2021-12-30 Kallyope, Inc. Ampk activators

Citations (9)

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US20050107475A1 (en) * 2002-03-21 2005-05-19 Jones Stacey A. Methods of using farnesoid x receptor (frx) agonists
WO2013037482A1 (en) * 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
US20140186438A1 (en) * 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Compositions comprising epa and obeticholic acid and methods of use thereof
US20140371190A1 (en) * 2013-05-14 2014-12-18 TES Pharma SrI. Farnesoid X receptor modulators
CN104853758A (zh) * 2012-11-28 2015-08-19 英特赛普特医药品公司 肺部疾病的治疗
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
US20150359805A1 (en) * 2006-06-27 2015-12-17 Intercept Pharmaceuticals, Inc. Bile Acid Derivatives as FXR Ligands for the Prevention or Treatment of FXR-Mediated Diseases or Conditions
CN107531742A (zh) * 2015-04-27 2018-01-02 英特塞普特医药品公司 奥贝胆酸的组合物和使用方法
CN108348543A (zh) * 2015-09-21 2018-07-31 英特塞普特医药品公司 促进肝再生的方法

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
DE60205891T2 (de) 2001-03-12 2006-06-22 Intercept Pharmaceuticals, Inc. Steroide als agonisten für fxr
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
US8338628B2 (en) 2007-08-28 2012-12-25 City Of Hope Method of synthesizing alkylated bile acid derivatives
PL2698375T3 (pl) 2008-11-19 2018-08-31 Intercept Pharmaceuticals, Inc. Modulatory TGR5 i sposób ich zastosowania
CN108250264A (zh) 2012-10-26 2018-07-06 英特塞普特医药品公司 制备胆汁酸衍生物的方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107475A1 (en) * 2002-03-21 2005-05-19 Jones Stacey A. Methods of using farnesoid x receptor (frx) agonists
US20150359805A1 (en) * 2006-06-27 2015-12-17 Intercept Pharmaceuticals, Inc. Bile Acid Derivatives as FXR Ligands for the Prevention or Treatment of FXR-Mediated Diseases or Conditions
WO2013037482A1 (en) * 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
CN104853758A (zh) * 2012-11-28 2015-08-19 英特赛普特医药品公司 肺部疾病的治疗
US20140186438A1 (en) * 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Compositions comprising epa and obeticholic acid and methods of use thereof
US20140371190A1 (en) * 2013-05-14 2014-12-18 TES Pharma SrI. Farnesoid X receptor modulators
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
CN107531742A (zh) * 2015-04-27 2018-01-02 英特塞普特医药品公司 奥贝胆酸的组合物和使用方法
CN108348543A (zh) * 2015-09-21 2018-07-31 英特塞普特医药品公司 促进肝再生的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUI LIU ET AL.: "Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice", 《WORLD J GASTROENTEROL》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022171040A1 (zh) * 2021-02-10 2022-08-18 北京蕴汇医药科技有限公司 鹅去氧胆酸或其衍生物在制备egfr和/或stat3的抑制剂中的用途
CN114306349A (zh) * 2022-01-07 2022-04-12 北京蕴汇医药科技有限公司 鹅去氧胆酸或其衍生物制备协同预防或治疗与egfr相关疾病药物的用途

Also Published As

Publication number Publication date
JP6968821B2 (ja) 2021-11-17
US20190298742A1 (en) 2019-10-03
WO2017180577A1 (en) 2017-10-19
EP3442946A1 (en) 2019-02-20
JP2019511550A (ja) 2019-04-25
US20170296556A1 (en) 2017-10-19
US10369160B2 (en) 2019-08-06
IL262342B (en) 2022-08-01
AU2017249226B2 (en) 2021-07-15
CA3020698A1 (en) 2017-10-19
IL262342A (en) 2018-11-29
AU2017249226A1 (en) 2019-08-22
KR20180129925A (ko) 2018-12-05
EP3442946A4 (en) 2019-12-04
KR102377338B1 (ko) 2022-03-21
TW201737919A (zh) 2017-11-01

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