JP2007530584A5 - - Google Patents
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- Publication number
- JP2007530584A5 JP2007530584A5 JP2007505204A JP2007505204A JP2007530584A5 JP 2007530584 A5 JP2007530584 A5 JP 2007530584A5 JP 2007505204 A JP2007505204 A JP 2007505204A JP 2007505204 A JP2007505204 A JP 2007505204A JP 2007530584 A5 JP2007530584 A5 JP 2007530584A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- cancer
- integrin
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55642204P | 2004-03-24 | 2004-03-24 | |
| US55642104P | 2004-03-24 | 2004-03-24 | |
| US60/556,421 | 2004-03-24 | ||
| US60/556,422 | 2004-03-24 | ||
| US62504904P | 2004-11-03 | 2004-11-03 | |
| US60/625,049 | 2004-11-03 | ||
| US65109805P | 2005-02-07 | 2005-02-07 | |
| US60/651,098 | 2005-02-07 | ||
| US65751405P | 2005-02-28 | 2005-02-28 | |
| US60/657,514 | 2005-02-28 | ||
| PCT/US2005/009939 WO2005092073A2 (en) | 2004-03-24 | 2005-03-24 | Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007530584A JP2007530584A (ja) | 2007-11-01 |
| JP2007530584A5 true JP2007530584A5 (enExample) | 2008-05-08 |
| JP4857259B2 JP4857259B2 (ja) | 2012-01-18 |
Family
ID=35056776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505204A Expired - Fee Related JP4857259B2 (ja) | 2004-03-24 | 2005-03-24 | 癌細胞増殖を阻害するための抗α5β1抗体の使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7662384B2 (enExample) |
| EP (1) | EP1755659B1 (enExample) |
| JP (1) | JP4857259B2 (enExample) |
| KR (1) | KR20070009637A (enExample) |
| AT (1) | ATE531388T1 (enExample) |
| AU (1) | AU2005226736B2 (enExample) |
| BR (1) | BRPI0509177A (enExample) |
| CA (1) | CA2560508A1 (enExample) |
| DK (1) | DK1755659T3 (enExample) |
| ES (1) | ES2376556T3 (enExample) |
| IL (1) | IL178042A (enExample) |
| NO (1) | NO20064794L (enExample) |
| NZ (1) | NZ549893A (enExample) |
| WO (1) | WO2005092073A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007106585A1 (en) | 2006-03-15 | 2007-09-20 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
| EP1989231B1 (en) * | 2006-03-21 | 2015-05-20 | Genentech, Inc. | Combinatorial therapy involving alpha5beta1 antagonists |
| WO2007114851A1 (en) * | 2006-04-04 | 2007-10-11 | The Board Of Trustees Of The University Of Illinois | Methods and compositions to induce cell death of invasive tumors |
| EP2032605A2 (en) * | 2006-05-24 | 2009-03-11 | Bayer Schering Pharma Aktiengesellschaft | HIGH AFFINITY HUMAN AND HUMANIZED ANTI-alpha5ß1 INTEGRIN FUNCTION BLOCKING ANTIBODIES WITH REDUCED IMMUNOGENICITY |
| US20100150931A1 (en) * | 2006-11-22 | 2010-06-17 | Centre Hospitalier De L'universite De Montreal | Novel receptor for cd40l and uses thereof |
| US20090041767A1 (en) * | 2007-07-27 | 2009-02-12 | Vanitha Ramakrishnan | Pharmaceutical combinations |
| PE20091029A1 (es) | 2007-09-26 | 2009-08-19 | Genentech Inc | Anticuerpos anti-alfa 5 beta 1 |
| CA2714071A1 (en) * | 2008-02-05 | 2009-08-13 | Bristol-Myers Squibb Company | Alpha 5 - beta 1 antibodies and their uses |
| AU2009331528A1 (en) | 2008-12-23 | 2011-08-11 | Astrazeneca Ab | Targeted binding agents directed to alpha5beta1 and uses thereof |
| NZ594343A (en) | 2009-03-25 | 2013-10-25 | Genentech Inc | Novel anti-alpha5beta1 antibodies and uses thereof |
| US20110319335A1 (en) | 2010-06-23 | 2011-12-29 | Xiaodong Feng | Combined administration of integrin receptor antagonists for anti-angiogenic therapy |
| HK1198689A1 (en) | 2011-10-25 | 2015-05-29 | Prothena Biosciences Limited | Antibody formulations and methods |
| US8946159B2 (en) | 2011-12-22 | 2015-02-03 | California Northstate College Of Pharmacy, Llc | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
| NO2760138T3 (enExample) | 2012-10-01 | 2018-08-04 | ||
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| KR20210089215A (ko) | 2018-11-07 | 2021-07-15 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항-pd-1 항체의 공동-제제 |
| WO2025106724A2 (en) * | 2023-11-15 | 2025-05-22 | Morphic Therapeutic, Inc. | USE OF ANTI-α5β1 ANTIBODIES IN THE TREATMENT OF PULMONARY HYPERTENSION AND HEART FAILURE |
| WO2025106725A2 (en) * | 2023-11-15 | 2025-05-22 | Morphic Therapeutic, Inc. | HUMAN ANTI-α5β1 ANTIBODIES AND USES THEREOF |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704366A (en) | 1984-06-22 | 1987-11-03 | Bio-Rad Laboratories, Inc. | Process for binding IgG to protein A |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4801687A (en) | 1986-10-27 | 1989-01-31 | Bioprobe International, Inc. | Monoclonal antibody purification process using protein A |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CZ282603B6 (cs) | 1991-03-06 | 1997-08-13 | Merck Patent Gesellschaft Mit Beschränkter Haftun G | Humanizované a chimerické monoklonální protilátky |
| CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| GB9125979D0 (en) | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
| US5863537A (en) | 1992-02-19 | 1999-01-26 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| AU673865B2 (en) | 1992-10-29 | 1996-11-28 | Australian National University, The | Angiogenesis inhibitory antibodies |
| US5536814A (en) | 1993-09-27 | 1996-07-16 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| EP0745134A1 (en) | 1994-02-22 | 1996-12-04 | Danafarber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
| DE69516351T2 (de) * | 1994-09-21 | 2000-12-07 | Matsushita Electric Industrial Co., Ltd. | Sekundäre Lithium Feststoffbatterie |
| US5705154A (en) | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| EP0888344A1 (en) | 1996-03-15 | 1999-01-07 | The Du Pont Merck Pharmaceutical Company | Spirocycle integrin inhibitors |
| US5922676A (en) | 1996-09-20 | 1999-07-13 | The Burnham Institute | Methods of inhibiting cancer by using superfibronectin |
| US5846536A (en) | 1996-10-04 | 1998-12-08 | The Regents Of The University Of California | Restoration of normal phenotype in cancer cells |
| CA2250291A1 (en) | 1997-01-29 | 1998-07-30 | Toray Industries Inc. | Chimeric proteins, their heterodimer complexes, and platelet substitutes |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| WO1999037329A1 (en) * | 1998-01-22 | 1999-07-29 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
| CA2330277A1 (en) | 1998-04-27 | 1999-11-04 | Sidney Kimmel Cancer Center | Reduced complexity nucleic acid targets and methods of using same |
| US6852318B1 (en) | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
| EP1075277B2 (en) * | 1998-05-08 | 2012-10-31 | The Regents of the University of California | Methods for detecting and inhibiting angiogenesis |
| EP1204764A2 (en) | 1999-08-11 | 2002-05-15 | EOS Biotechnology, Inc. | Methods of screening for angiogenesis modulators |
| CA2397194C (en) | 2000-01-20 | 2011-05-17 | Mark E. Duggan | Alpha v integrin receptor antagonists |
| CA2397665A1 (en) | 2000-01-24 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
| US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
| US20040259152A1 (en) | 2000-02-22 | 2004-12-23 | Richard Murray | Novel methods of diagnosing and screening for modulators of tissue remodeling and treating related diseases |
| WO2002079492A2 (en) | 2001-02-14 | 2002-10-10 | Protein Design Labs, Inc. | Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
| NZ540562A (en) | 2002-11-26 | 2008-04-30 | Pdl Biopharma Inc | Therapeutic chimeric and humanized antibodies directed against alpha5beta1 integrin, methods for purification of these antibodies, and their use in treating conditions comprising undesirable tissue angiogenesis |
| US7276589B2 (en) * | 2002-11-26 | 2007-10-02 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
| EP1625165A2 (en) * | 2003-04-03 | 2006-02-15 | Protein Design Labs, Inc. | Inhibitors of integrin alpha5beta1 and their use for the control of tissue granulation |
| MX342007B (es) | 2003-05-14 | 2016-09-09 | Immunogen Inc | Composicion de farmaco conjugado. |
-
2005
- 2005-03-24 WO PCT/US2005/009939 patent/WO2005092073A2/en not_active Ceased
- 2005-03-24 KR KR1020067021955A patent/KR20070009637A/ko not_active Ceased
- 2005-03-24 JP JP2007505204A patent/JP4857259B2/ja not_active Expired - Fee Related
- 2005-03-24 US US11/090,331 patent/US7662384B2/en not_active Expired - Fee Related
- 2005-03-24 AT AT05744016T patent/ATE531388T1/de active
- 2005-03-24 NZ NZ549893A patent/NZ549893A/en not_active IP Right Cessation
- 2005-03-24 BR BRPI0509177-2A patent/BRPI0509177A/pt not_active IP Right Cessation
- 2005-03-24 ES ES05744016T patent/ES2376556T3/es not_active Expired - Lifetime
- 2005-03-24 AU AU2005226736A patent/AU2005226736B2/en not_active Ceased
- 2005-03-24 CA CA002560508A patent/CA2560508A1/en not_active Abandoned
- 2005-03-24 DK DK05744016.6T patent/DK1755659T3/da active
- 2005-03-24 EP EP05744016A patent/EP1755659B1/en not_active Expired - Lifetime
-
2006
- 2006-09-12 IL IL178042A patent/IL178042A/en not_active IP Right Cessation
- 2006-10-23 NO NO20064794A patent/NO20064794L/no not_active Application Discontinuation
-
2009
- 2009-12-18 US US12/642,687 patent/US20100291111A1/en not_active Abandoned
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