|
EA035817B1
(ru)
|
2015-03-10 |
2020-08-14 |
Адуро Байотек, Инк. |
Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона"
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
KR102222186B1
(ko)
|
2015-08-13 |
2021-03-03 |
머크 샤프 앤드 돔 코포레이션 |
Sting 효능제로서 시클릭 디-뉴클레오티드 화합물
|
|
KR102789862B1
(ko)
*
|
2016-01-11 |
2025-04-03 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드
|
|
NZ746112A
(en)
|
2016-03-18 |
2023-01-27 |
Immune Sensor Llc |
Cyclic di-nucleotide compounds and methods of use
|
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
IL264049B2
(en)
|
2016-07-06 |
2023-11-01 |
Sperovie Biosciences Inc |
Compounds, preparations and methods for treating the disease
|
|
AU2017321609C1
(en)
|
2016-08-30 |
2023-11-09 |
Dana-Farber Cancer Institute, Inc. |
Drug delivery compositions and uses thereof
|
|
PT3523287T
(pt)
|
2016-10-04 |
2021-10-06 |
Merck Sharp & Dohme |
Compostos de benzo[b]tiofeno como agonistas de sting
|
|
PE20210255A1
(es)
|
2016-12-01 |
2021-02-10 |
Takeda Pharmaceuticals Co |
Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon)
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
KR102702926B1
(ko)
|
2017-04-13 |
2024-09-06 |
사이로파 비.브이. |
항-sirp 알파 항체
|
|
US11466047B2
(en)
|
2017-05-12 |
2022-10-11 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
US11259980B2
(en)
|
2017-07-31 |
2022-03-01 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Soft inflatable exosuit for knee rehabilitation
|
|
JP2020530838A
(ja)
|
2017-08-04 |
2020-10-29 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト
|
|
RU2020109328A
(ru)
|
2017-08-04 |
2021-09-06 |
Мерк Шарп И Доум Корп. |
Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака
|
|
MX2020002303A
(es)
|
2017-08-30 |
2020-09-10 |
Beijing Xuanyi Pharmasciences Co Ltd |
Dinucleotidos ciclicos como moduladores del estimulador de genes de interferon.
|
|
WO2019046511A1
(en)
|
2017-08-31 |
2019-03-07 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
|
|
KR102812783B1
(ko)
*
|
2017-08-31 |
2025-05-26 |
브리스톨-마이어스 스큅 컴퍼니 |
항암제로서의 시클릭 디뉴클레오티드
|
|
US11584774B2
(en)
|
2017-09-11 |
2023-02-21 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US11707531B2
(en)
|
2017-09-11 |
2023-07-25 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
CN111465610A
(zh)
*
|
2017-09-14 |
2020-07-28 |
詹森生物制药有限公司 |
经修饰核苷亚磷酰胺
|
|
US11660311B2
(en)
*
|
2017-10-10 |
2023-05-30 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
WO2019084060A1
(en)
|
2017-10-24 |
2019-05-02 |
Silverback Therapeutics, Inc. |
CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
|
|
KR20200098511A
(ko)
|
2017-11-10 |
2020-08-20 |
다케다 야쿠힌 고교 가부시키가이샤 |
Sting 조절제 화합물, 및 제조 및 사용 방법
|
|
EP3728283B1
(en)
|
2017-12-20 |
2023-11-22 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
EP3727401A4
(en)
|
2017-12-20 |
2022-04-06 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
|
WO2019123339A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
EP3505527A1
(en)
*
|
2017-12-29 |
2019-07-03 |
Invivogen |
Cyclic dinucleotides for cytokine induction
|
|
US10519187B2
(en)
|
2018-02-13 |
2019-12-31 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
ES2980374T3
(es)
*
|
2018-03-08 |
2024-10-01 |
Bristol Myers Squibb Co |
Dinucleótidos cíclicos como agentes anticancerosos
|
|
WO2019180683A1
(en)
|
2018-03-23 |
2019-09-26 |
Takeda Pharmaceutical Company Limited |
Sting modulator compounds with sulfamate linkages, and methods of making and using
|
|
EP3774765A4
(en)
|
2018-04-03 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
|
JP7326319B2
(ja)
|
2018-04-03 |
2023-08-15 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
JP7570235B2
(ja)
|
2018-05-25 |
2024-10-21 |
インサイト・コーポレイション |
Sting活性化剤としての三環式複素環式化合物
|
|
WO2020014127A1
(en)
|
2018-07-10 |
2020-01-16 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
TW202030199A
(zh)
*
|
2018-07-17 |
2020-08-16 |
美商健生生物科技公司 |
作為sting促效劑之環狀二核苷酸
|
|
US11008344B2
(en)
|
2018-07-31 |
2021-05-18 |
Incyte Corporation |
Tricyclic heteroaryl compounds as STING activators
|
|
WO2020028566A1
(en)
|
2018-07-31 |
2020-02-06 |
Incyte Corporation |
Heteroaryl amide compounds as sting activators
|
|
US11691990B2
(en)
|
2018-08-16 |
2023-07-04 |
Eisai R&D Management Co., Ltd |
Salts of compounds and crystals thereof
|
|
EP3848054B1
(en)
|
2018-09-06 |
2025-01-29 |
Daiichi Sankyo Company, Limited |
Antibody-drug conjugates of cyclic dinucleotide derivatives
|
|
MX2021002764A
(es)
|
2018-09-12 |
2021-05-12 |
Silverback Therapeutics Inc |
Composiciones para el tratamiento de enfermedades con conjugados inmunoestimuladores.
|
|
CN110938104B
(zh)
|
2018-09-21 |
2024-07-12 |
上海迪诺医药科技有限公司 |
环状二核苷酸类似物、其药物组合物及应用
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
WO2020092127A1
(en)
|
2018-10-29 |
2020-05-07 |
Venenum Biodesign, LLC |
Novel sting agonists
|
|
WO2020089815A1
(en)
|
2018-10-31 |
2020-05-07 |
Novartis Ag |
Antibody conjugates comprising sting agonist
|
|
US11596692B1
(en)
|
2018-11-21 |
2023-03-07 |
Incyte Corporation |
PD-L1/STING conjugates and methods of use
|
|
US12269840B2
(en)
*
|
2018-12-04 |
2025-04-08 |
Bristol-Myers Squibb Company |
Process for the preparation of a cyclic dinucleotide
|
|
WO2020146237A1
(en)
|
2019-01-07 |
2020-07-16 |
Incyte Corporation |
Heteroaryl amide compounds as sting activators
|
|
CN113423713A
(zh)
*
|
2019-02-05 |
2021-09-21 |
百时美施贵宝公司 |
1,2,5-三-o-苯甲酰基-3-二苄基氨基-3-脱氧核糖作为生产3′-氨基-3′-脱氧腺苷和3′-氨基-3′-脱氧鸟苷的中间体及其受保护的衍生物的合成
|
|
IL287938B2
(en)
|
2019-05-10 |
2025-07-01 |
Takeda Pharmaceuticals Co |
Antibody-drug conjugates
|
|
WO2021007160A1
(en)
|
2019-07-05 |
2021-01-14 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
US12435104B2
(en)
*
|
2019-07-25 |
2025-10-07 |
Beigene, Ltd. |
Cyclic dinucleotides as sting agonists
|
|
CA3151322A1
(en)
|
2019-10-01 |
2021-04-08 |
Silverback Therapeutics, Inc. |
Combination therapy with immune stimulatory conjugates
|
|
EP4082579A4
(en)
|
2019-12-26 |
2024-06-26 |
National University Corporation Tokai National Higher Education and Research System |
POLYNUCLEOTIDE AND MEDICINAL COMPOSITION
|
|
JP7735291B2
(ja)
|
2020-02-21 |
2025-09-08 |
エーアールエス ファーマシューティカルズ、インコーポレイテッド |
ネクチン-4抗体コンジュゲートおよびその使用
|
|
IL296124A
(en)
|
2020-03-06 |
2022-11-01 |
Daiichi Sankyo Co Ltd |
Antibody-drug conjugate including novel cyclic dinucleotide derivative
|
|
TW202200136A
(zh)
|
2020-04-10 |
2022-01-01 |
日商小野藥品工業股份有限公司 |
癌治療方法
|
|
US20230158057A1
(en)
*
|
2020-04-21 |
2023-05-25 |
Duke University |
Compositions and methods for the treatment of pain
|
|
AU2021270347A1
(en)
|
2020-05-11 |
2022-12-15 |
Erytech Pharma |
Red cell extracellular vesicles (RCEVs) containing cargoes and methods of use and production thereof
|
|
JP2023532304A
(ja)
|
2020-07-01 |
2023-07-27 |
エーアールエス ファーマシューティカルズ オペレーションズ,インク. |
抗asgr1抗体コンジュゲートおよびその使用
|
|
CN116056765A
(zh)
|
2020-08-07 |
2023-05-02 |
坦伯公司 |
反式环辛烯生物正交剂及在癌症和免疫疗法中的用途
|
|
WO2022050300A1
(ja)
|
2020-09-02 |
2022-03-10 |
第一三共株式会社 |
新規エンド-β-N-アセチルグルコサミニダーゼ
|
|
JP2023545466A
(ja)
*
|
2020-10-15 |
2023-10-30 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
免疫応答を調節することができる、金属イオンと会合したstingアゴニストの結晶多形体
|
|
KR102466750B1
(ko)
|
2020-10-23 |
2022-11-15 |
아주대학교산학협력단 |
인돌리진 유도체를 유효성분으로 포함하는 인터페론 유전자 자극제 조성물
|
|
JP2023548310A
(ja)
|
2020-10-30 |
2023-11-16 |
アバクタ・ライフ・サイエンシーズ・リミテッド |
Fap活性化血清半減期延長型治療用コンジュゲート
|
|
IL302390A
(en)
|
2020-11-09 |
2023-06-01 |
Takeda Pharmaceuticals Co |
Drug antibody conjugates
|
|
AU2022302611A1
(en)
|
2021-06-30 |
2024-02-15 |
Kyowa Kirin Co., Ltd. |
Polynucleotide and medicinal composition
|
|
CN118804983A
(zh)
|
2022-03-02 |
2024-10-18 |
第一三共株式会社 |
含Fc分子的制造方法
|
|
KR20250054799A
(ko)
|
2022-08-29 |
2025-04-23 |
다이이찌 산쿄 가부시키가이샤 |
변이 Fc 영역을 포함하는 항체 약물 콘쥬게이트
|
|
WO2026027944A1
(en)
|
2024-07-30 |
2026-02-05 |
Sairopa B.V. |
Anti-sirp alpha antibody formulations and uses thereof
|