JP2012158602A5 - - Google Patents
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- Publication number
- JP2012158602A5 JP2012158602A5 JP2012104769A JP2012104769A JP2012158602A5 JP 2012158602 A5 JP2012158602 A5 JP 2012158602A5 JP 2012104769 A JP2012104769 A JP 2012104769A JP 2012104769 A JP2012104769 A JP 2012104769A JP 2012158602 A5 JP2012158602 A5 JP 2012158602A5
- Authority
- JP
- Japan
- Prior art keywords
- mol
- cholesterol
- sphingomyelin
- liposome
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 42
- 235000012000 cholesterol Nutrition 0.000 claims 21
- 229960004528 vincristine Drugs 0.000 claims 21
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 21
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 239000002502 liposome Substances 0.000 claims 11
- 239000000243 solution Substances 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- 239000007979 citrate buffer Substances 0.000 claims 4
- AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical group OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 claims 4
- 229960002110 vincristine sulfate Drugs 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008363 phosphate buffer Substances 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 2
- 229960004618 prednisone Drugs 0.000 claims 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001794 hormone therapy Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 231100000189 neurotoxic Toxicity 0.000 claims 1
- 230000002887 neurotoxic effect Effects 0.000 claims 1
- 239000008055 phosphate buffer solution Substances 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12744499P | 1999-04-01 | 1999-04-01 | |
| US13719499P | 1999-06-02 | 1999-06-02 | |
| US60/137,194 | 1999-06-02 | ||
| US60/127,444 | 1999-06-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609037A Division JP2002541088A (ja) | 1999-04-01 | 2000-03-31 | リンパ腫の治療のための組成物および方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246221A Division JP2015071631A (ja) | 1999-04-01 | 2014-12-04 | リンパ腫の治療のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012158602A JP2012158602A (ja) | 2012-08-23 |
| JP2012158602A5 true JP2012158602A5 (https=) | 2013-05-30 |
| JP5981214B2 JP5981214B2 (ja) | 2016-08-31 |
Family
ID=26825635
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609037A Pending JP2002541088A (ja) | 1999-04-01 | 2000-03-31 | リンパ腫の治療のための組成物および方法 |
| JP2012104769A Expired - Lifetime JP5981214B2 (ja) | 1999-04-01 | 2012-05-01 | リンパ腫の治療のための組成物および方法 |
| JP2014246221A Pending JP2015071631A (ja) | 1999-04-01 | 2014-12-04 | リンパ腫の治療のための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609037A Pending JP2002541088A (ja) | 1999-04-01 | 2000-03-31 | リンパ腫の治療のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246221A Pending JP2015071631A (ja) | 1999-04-01 | 2014-12-04 | リンパ腫の治療のための組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (3) | EP1985285A3 (https=) |
| JP (3) | JP2002541088A (https=) |
| AT (1) | ATE442839T1 (https=) |
| AU (1) | AU777572B2 (https=) |
| BR (1) | BRPI0009448B8 (https=) |
| CA (1) | CA2366787C (https=) |
| CY (1) | CY1109641T1 (https=) |
| DE (1) | DE60042968D1 (https=) |
| DK (2) | DK2266537T3 (https=) |
| ES (2) | ES2333400T3 (https=) |
| IL (4) | IL145720A0 (https=) |
| PT (1) | PT1169021E (https=) |
| WO (1) | WO2000059473A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1985285A3 (en) * | 1999-04-01 | 2009-08-12 | Hana Biosciences, Inc. | Compositions and methods for treating lymphoma |
| US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| PT1389089E (pt) * | 2001-03-27 | 2009-11-30 | Phares Pharm Res Nv | Processo e composição para solubilizar um composto biologicamente activo com uma baixa solubilidade em água |
| CN102342938B (zh) * | 2002-05-17 | 2014-08-20 | 细胞基因公司 | 用于治疗和控制实体瘤的方法及组合物 |
| FR2840203B1 (fr) * | 2002-05-31 | 2004-08-27 | Scherer Technologies Inc R P | Composition pharmaceutique orale pour capsules molles contenant vinorelbine et methode de traitement |
| US6890558B2 (en) | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| RU2252764C2 (ru) * | 2003-03-04 | 2005-05-27 | Российский научный центр рентгенорадиологии МЗ РФ | Способ комплексного лечения лимфогранулематоза |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| WO2005011698A1 (en) * | 2003-07-28 | 2005-02-10 | Inex Pharmaceuticals Corporation | Combination comprising a liposome-encapsulated vinca alkaloid and a topoisomerase ii inhibitor and the use thereof for treating neoplasia |
| WO2006005477A1 (en) * | 2004-07-09 | 2006-01-19 | Schering Ag | Combination therapywith radiolabeled anti-cd20 antibody in the treatment of b-cell lymphoma |
| ATE545408T1 (de) * | 2004-08-10 | 2012-03-15 | Talon Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von leukämie |
| EP3050566B1 (en) * | 2007-09-10 | 2018-11-28 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
| NZ602675A (en) | 2008-03-18 | 2014-03-28 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| JP2012506428A (ja) * | 2008-10-24 | 2012-03-15 | グルオウセステル プハルマセウトイカルス | ガンの療法 |
| US9801874B2 (en) | 2012-11-20 | 2017-10-31 | Spectrum Pharmaceuticals | Method for the preparation of liposome encapsulated vincristine for therapeutic use |
| EP2948132B1 (en) * | 2013-01-24 | 2020-08-19 | Memorial Sloan Kettering Cancer Center | Method for diagnosing or treating tumors using sphingomyelin containing liposomes |
| EP2983790A2 (en) | 2013-04-09 | 2016-02-17 | Boston Biomedical, Inc. | Methods for treating cancer |
| TWI678213B (zh) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| JP7106563B2 (ja) | 2016-11-29 | 2022-07-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | ナフトフラン誘導体、その調製、および使用方法 |
| CA3062656A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| SI26542A (sl) | 2023-09-12 | 2025-03-31 | Univerza V Ljubljani | Nove liposomske formulacije in postopek za njihovo pripravo |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4603044A (en) | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5059421A (en) | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
| US4885172A (en) | 1985-06-26 | 1989-12-05 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
| US5171578A (en) | 1985-06-26 | 1992-12-15 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4952408A (en) * | 1988-05-23 | 1990-08-28 | Georgetown University | Liposome-encapsulated vinca alkaloids and their use in combatting tumors |
| US4957773A (en) | 1989-02-13 | 1990-09-18 | Syracuse University | Deposition of boron-containing films from decaborane |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5165922A (en) * | 1990-05-22 | 1992-11-24 | Bristol-Myers Squibb Company | Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy |
| GB9304745D0 (en) * | 1993-03-09 | 1993-04-28 | Oncholab Ab | Use of pharmaceutical formulations |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5741516A (en) * | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5543152A (en) * | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5714163A (en) * | 1994-06-27 | 1998-02-03 | Nexstar Pharmaceuticals, Inc. | Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5837282A (en) | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| EP1985285A3 (en) * | 1999-04-01 | 2009-08-12 | Hana Biosciences, Inc. | Compositions and methods for treating lymphoma |
-
2000
- 2000-03-31 EP EP08003804A patent/EP1985285A3/en not_active Withdrawn
- 2000-03-31 DE DE60042968T patent/DE60042968D1/de not_active Expired - Lifetime
- 2000-03-31 WO PCT/US2000/008669 patent/WO2000059473A1/en not_active Ceased
- 2000-03-31 ES ES00920004T patent/ES2333400T3/es not_active Expired - Lifetime
- 2000-03-31 DK DK10011105.3T patent/DK2266537T3/en active
- 2000-03-31 IL IL14572000A patent/IL145720A0/xx unknown
- 2000-03-31 AU AU40606/00A patent/AU777572B2/en not_active Expired
- 2000-03-31 AT AT00920004T patent/ATE442839T1/de active
- 2000-03-31 PT PT00920004T patent/PT1169021E/pt unknown
- 2000-03-31 ES ES10011105.3T patent/ES2524141T3/es not_active Expired - Lifetime
- 2000-03-31 JP JP2000609037A patent/JP2002541088A/ja active Pending
- 2000-03-31 EP EP00920004A patent/EP1169021B1/en not_active Expired - Lifetime
- 2000-03-31 BR BRPI0009448A patent/BRPI0009448B8/pt not_active IP Right Cessation
- 2000-03-31 CA CA2366787A patent/CA2366787C/en not_active Expired - Lifetime
- 2000-03-31 DK DK00920004T patent/DK1169021T3/da active
- 2000-03-31 EP EP10011105.3A patent/EP2266537B1/en not_active Expired - Lifetime
-
2001
- 2001-09-30 IL IL145720A patent/IL145720A/en not_active IP Right Cessation
-
2009
- 2009-11-17 CY CY20091101201T patent/CY1109641T1/el unknown
-
2011
- 2011-04-14 IL IL212390A patent/IL212390A/en not_active IP Right Cessation
- 2011-04-14 IL IL212389A patent/IL212389A/en not_active IP Right Cessation
-
2012
- 2012-05-01 JP JP2012104769A patent/JP5981214B2/ja not_active Expired - Lifetime
-
2014
- 2014-12-04 JP JP2014246221A patent/JP2015071631A/ja active Pending
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