JP2013504590A5 - - Google Patents
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- Publication number
- JP2013504590A5 JP2013504590A5 JP2012528915A JP2012528915A JP2013504590A5 JP 2013504590 A5 JP2013504590 A5 JP 2013504590A5 JP 2012528915 A JP2012528915 A JP 2012528915A JP 2012528915 A JP2012528915 A JP 2012528915A JP 2013504590 A5 JP2013504590 A5 JP 2013504590A5
- Authority
- JP
- Japan
- Prior art keywords
- radioactive
- compound
- iodine
- group
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002285 radioactive effect Effects 0.000 claims 32
- -1 phospholipid compound Chemical class 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052740 iodine Inorganic materials 0.000 claims 11
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 10
- 239000011630 iodine Substances 0.000 claims 10
- 239000008177 pharmaceutical agent Substances 0.000 claims 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 4
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- ZOAIEFWMQLYMTF-UHFFFAOYSA-N 18-(4-iodophenyl)octadecyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OCCCCCCCCCCCCCCCCCCC1=CC=C(I)C=C1 ZOAIEFWMQLYMTF-UHFFFAOYSA-N 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- 125000006306 4-iodophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1I 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- SUHOQUVVVLNYQR-MRVPVSSYSA-O glycerylphosphorylcholine Chemical compound C[N+](C)(C)CCO[P@](O)(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-O 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24175909P | 2009-09-11 | 2009-09-11 | |
| US24176209P | 2009-09-11 | 2009-09-11 | |
| US61/241,759 | 2009-09-11 | ||
| US61/241,762 | 2009-09-11 | ||
| US30921310P | 2010-03-01 | 2010-03-01 | |
| US30918710P | 2010-03-01 | 2010-03-01 | |
| US61/309,187 | 2010-03-01 | ||
| US61/309,213 | 2010-03-01 | ||
| PCT/US2010/048351 WO2011031919A2 (en) | 2009-09-11 | 2010-09-10 | Non-radioactive phospholipid compounds, compositions, and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013504590A JP2013504590A (ja) | 2013-02-07 |
| JP2013504590A5 true JP2013504590A5 (https=) | 2013-10-24 |
Family
ID=43730778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528915A Pending JP2013504590A (ja) | 2009-09-11 | 2010-09-10 | 非放射性リン脂質化合物、組成物、及び使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110064661A1 (https=) |
| EP (1) | EP2475400A2 (https=) |
| JP (1) | JP2013504590A (https=) |
| RU (1) | RU2012114146A (https=) |
| WO (1) | WO2011031919A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070015518A (ko) * | 2004-03-02 | 2007-02-05 | 셀렉타, 엘엘씨 | 암의 진단 및 치료를 위한 포스포리피드 유사체 |
| US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| SI3708192T1 (sl) | 2009-06-12 | 2023-12-29 | Cellectar, Inc. | Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic |
| EP2475400A2 (en) * | 2009-09-11 | 2012-07-18 | Cellectar, Inc. | Non-radioactive phospholipid compounds, compositions, and methods of use |
| CN107708702A (zh) | 2014-11-17 | 2018-02-16 | 塞勒克塔生物科学有限公司 | 磷脂醚类似物作为靶向癌症的药物载体 |
| KR102821508B1 (ko) | 2018-04-10 | 2025-06-16 | 셀렉타 바이오사이언시스, 인코퍼레이티드 | 인지질-플라베글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법 |
| CA3150991A1 (en) * | 2019-09-12 | 2021-03-18 | Cellectar Biosciences, Inc. | Phospholipid ether conjugates as cancer-targeting drug vehicles |
| CA3154192A1 (en) | 2019-10-10 | 2021-04-15 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925649A (en) * | 1987-06-12 | 1990-05-15 | The University Of Michigan | Radioiodinated diacylglycerol analogues and methods of use |
| US5347030A (en) * | 1987-10-23 | 1994-09-13 | The Board Of Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogues and methods of using same |
| US4965391A (en) * | 1987-10-23 | 1990-10-23 | The University Of Michigan | Radioiodinated phospholipid ether analogues |
| US5087721A (en) * | 1987-10-23 | 1992-02-11 | The University Of Michigan | Radioiodinated phosphate esters |
| US5369097A (en) * | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5626654A (en) * | 1995-12-05 | 1997-05-06 | Xerox Corporation | Ink compositions containing liposomes |
| CA2276284C (en) * | 1996-12-04 | 2006-10-10 | The Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US6255519B1 (en) * | 1996-12-04 | 2001-07-03 | Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US6503478B2 (en) * | 1999-01-13 | 2003-01-07 | Lightouch Medical, Inc. | Chemically specific imaging of tissue |
| US7220539B1 (en) * | 2002-06-12 | 2007-05-22 | The Salk Institute For Biological Studies | Protein kinase B/Akt modulators and methods for the use thereof |
| US7632644B2 (en) * | 2004-03-02 | 2009-12-15 | Cellectar, Inc. | Imaging and selective retention of phospholipid ether analogs |
| US7700075B2 (en) * | 2004-07-08 | 2010-04-20 | Cellectar, Llc | Virtual colonoscopy with radiolabeled phospholipid ether analogs |
| US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| KR20070015518A (ko) * | 2004-03-02 | 2007-02-05 | 셀렉타, 엘엘씨 | 암의 진단 및 치료를 위한 포스포리피드 유사체 |
| CA2560956A1 (en) * | 2004-03-29 | 2005-10-20 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Amphipathic glycopeptides |
| US20060115426A1 (en) * | 2004-08-11 | 2006-06-01 | Weichert Jamey P | Methods of detecting breast cancer, brain cancer, and pancreatic cancer |
| US7041859B1 (en) * | 2004-09-09 | 2006-05-09 | University Of Tennessee Research Foundation | Method for halogenating or radiohalogenating a chemical compound |
| KR20080005178A (ko) * | 2004-12-20 | 2008-01-10 | 셀렉타, 엘엘씨 | 암 검출 및 치료용 인지질 에테르 동족체 |
| AU2007355882A1 (en) * | 2006-08-15 | 2009-01-08 | Cellectar, Inc. | Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications |
| US7893286B2 (en) * | 2007-06-01 | 2011-02-22 | Cellectar, Inc. | Method for the synthesis of phospholipid ethers |
| SI3708192T1 (sl) * | 2009-06-12 | 2023-12-29 | Cellectar, Inc. | Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic |
| EP2475400A2 (en) * | 2009-09-11 | 2012-07-18 | Cellectar, Inc. | Non-radioactive phospholipid compounds, compositions, and methods of use |
| US20110064660A1 (en) * | 2009-09-11 | 2011-03-17 | Pinchuk Anatoly | Deuterated alkyl phospholipid compounds, compositions, and methods of use |
-
2010
- 2010-09-10 EP EP10816122A patent/EP2475400A2/en not_active Withdrawn
- 2010-09-10 US US12/879,167 patent/US20110064661A1/en not_active Abandoned
- 2010-09-10 JP JP2012528915A patent/JP2013504590A/ja active Pending
- 2010-09-10 WO PCT/US2010/048351 patent/WO2011031919A2/en not_active Ceased
- 2010-09-10 RU RU2012114146/15A patent/RU2012114146A/ru unknown
-
2012
- 2012-02-23 US US13/403,445 patent/US20120156133A1/en not_active Abandoned
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