JP2013504590A - 非放射性リン脂質化合物、組成物、及び使用方法 - Google Patents

非放射性リン脂質化合物、組成物、及び使用方法 Download PDF

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JP2013504590A
JP2013504590A JP2012528915A JP2012528915A JP2013504590A JP 2013504590 A JP2013504590 A JP 2013504590A JP 2012528915 A JP2012528915 A JP 2012528915A JP 2012528915 A JP2012528915 A JP 2012528915A JP 2013504590 A JP2013504590 A JP 2013504590A
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radioactive
cancer
group
iodine
compound
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JP2013504590A5 (https=
Inventor
ピンチュク アナトリー
ロンギーノ マーク
ピー．ウェイチャート ジェイミー
アール．クラーク ウィリアム
エム．バッカロ アブラム
カンデラ イラワティ
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セレクター，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0408—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012528915A 2009-09-11 2010-09-10 非放射性リン脂質化合物、組成物、及び使用方法 Pending JP2013504590A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US24175909P 2009-09-11 2009-09-11
US24176209P 2009-09-11 2009-09-11
US61/241,759 2009-09-11
US61/241,762 2009-09-11
US30918710P 2010-03-01 2010-03-01
US30921310P 2010-03-01 2010-03-01
US61/309,187 2010-03-01
US61/309,213 2010-03-01
PCT/US2010/048351 WO2011031919A2 (en) 2009-09-11 2010-09-10 Non-radioactive phospholipid compounds, compositions, and methods of use

Publications (2)

Publication Number Publication Date
JP2013504590A true JP2013504590A (ja) 2013-02-07
JP2013504590A5 JP2013504590A5 (https=) 2013-10-24

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JP2012528915A Pending JP2013504590A (ja) 2009-09-11 2010-09-10 非放射性リン脂質化合物、組成物、及び使用方法

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US (2) US20110064661A1 (https=)
EP (1) EP2475400A2 (https=)
JP (1) JP2013504590A (https=)
RU (1) RU2012114146A (https=)
WO (1) WO2011031919A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017535608A (ja) * 2014-11-17 2017-11-30 セレクター・バイオサイエンシズ・インコーポレイテッド 癌標的化薬物ビヒクルとしてのリン脂質エーテル類似体
US12496346B2 (en) 2019-10-10 2025-12-16 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy
US12503479B2 (en) 2018-04-10 2025-12-23 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE437657T1 (de) * 2004-03-02 2009-08-15 Cellectar Inc Phospholipid-analoga für die behandlung von krebs
US8540968B2 (en) 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
JP6092624B2 (ja) * 2009-06-12 2017-03-08 セレクター，インコーポレイティド 癌の治療並びに癌幹細胞の造影および検出のためのエーテルおよびアルキルリン脂質化合物
WO2011031919A2 (en) * 2009-09-11 2011-03-17 Cellectar, Inc. Non-radioactive phospholipid compounds, compositions, and methods of use
NZ786360A (en) * 2019-09-12 2025-12-19 Cellectar Biosciences Inc Phospholipid ether conjugates as cancer-targeting drug vehicles

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024480A1 (en) * 1996-12-04 1998-06-11 The Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US20050196339A1 (en) * 2004-03-02 2005-09-08 Cellectar, Llc Phospholipid analogs as diapeutic* agents and methods thereof
JP2008545614A (ja) * 2004-12-20 2008-12-18 セレクター、リミテッド ライアビリティ カンパニー 癌の検出および治療のためのリン脂質エーテル類似体
WO2009005509A1 (en) * 2006-08-15 2009-01-08 Cellectar, Inc. Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications

Family Cites Families (20)

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US4925649A (en) * 1987-06-12 1990-05-15 The University Of Michigan Radioiodinated diacylglycerol analogues and methods of use
US5347030A (en) * 1987-10-23 1994-09-13 The Board Of Regents Of The University Of Michigan Radioiodinated phospholipid ether analogues and methods of using same
US5087721A (en) * 1987-10-23 1992-02-11 The University Of Michigan Radioiodinated phosphate esters
US4965391A (en) * 1987-10-23 1990-10-23 The University Of Michigan Radioiodinated phospholipid ether analogues
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5626654A (en) * 1995-12-05 1997-05-06 Xerox Corporation Ink compositions containing liposomes
US6255519B1 (en) * 1996-12-04 2001-07-03 Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US6503478B2 (en) * 1999-01-13 2003-01-07 Lightouch Medical, Inc. Chemically specific imaging of tissue
US7220539B1 (en) * 2002-06-12 2007-05-22 The Salk Institute For Biological Studies Protein kinase B/Akt modulators and methods for the use thereof
US8540968B2 (en) * 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
US7632644B2 (en) * 2004-03-02 2009-12-15 Cellectar, Inc. Imaging and selective retention of phospholipid ether analogs
WO2005097158A1 (en) * 2004-03-29 2005-10-20 The Arizona Board Of Regents On Behalf Of The University Of Arizona Amphipathic glycopeptides
EP1773408A2 (en) * 2004-07-08 2007-04-18 Cellectar, Llc Virtual colonoscopy with radiolabeled phospholipid ether analogs
US20060115426A1 (en) * 2004-08-11 2006-06-01 Weichert Jamey P Methods of detecting breast cancer, brain cancer, and pancreatic cancer
US7041859B1 (en) * 2004-09-09 2006-05-09 University Of Tennessee Research Foundation Method for halogenating or radiohalogenating a chemical compound
US7893286B2 (en) * 2007-06-01 2011-02-22 Cellectar, Inc. Method for the synthesis of phospholipid ethers
JP6092624B2 (ja) * 2009-06-12 2017-03-08 セレクター，インコーポレイティド 癌の治療並びに癌幹細胞の造影および検出のためのエーテルおよびアルキルリン脂質化合物
WO2011031919A2 (en) * 2009-09-11 2011-03-17 Cellectar, Inc. Non-radioactive phospholipid compounds, compositions, and methods of use
WO2011031911A1 (en) * 2009-09-11 2011-03-17 Cellectar, Inc. Deuterated alkyl phospholipid compounds, compositions, and methods of use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024480A1 (en) * 1996-12-04 1998-06-11 The Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US20050196339A1 (en) * 2004-03-02 2005-09-08 Cellectar, Llc Phospholipid analogs as diapeutic* agents and methods thereof
JP2008545614A (ja) * 2004-12-20 2008-12-18 セレクター、リミテッド ライアビリティ カンパニー 癌の検出および治療のためのリン脂質エーテル類似体
WO2009005509A1 (en) * 2006-08-15 2009-01-08 Cellectar, Inc. Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017535608A (ja) * 2014-11-17 2017-11-30 セレクター・バイオサイエンシズ・インコーポレイテッド 癌標的化薬物ビヒクルとしてのリン脂質エーテル類似体
US11439709B2 (en) 2014-11-17 2022-09-13 Cellectar Biosciences, Inc. Phospholipid ether analogs as cancer-targeting drug vehicles
US12503479B2 (en) 2018-04-10 2025-12-23 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy
US12496346B2 (en) 2019-10-10 2025-12-16 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy

Also Published As

Publication number Publication date
US20110064661A1 (en) 2011-03-17
US20120156133A1 (en) 2012-06-21
RU2012114146A (ru) 2013-10-20
WO2011031919A2 (en) 2011-03-17
WO2011031919A3 (en) 2014-03-27
EP2475400A2 (en) 2012-07-18

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