JP2009537526A5 - - Google Patents

Info

Publication number

JP2009537526A5

JP2009537526A5 JP2009510991A JP2009510991A JP2009537526A5 JP 2009537526 A5 JP2009537526 A5 JP 2009537526A5 JP 2009510991 A JP2009510991 A JP 2009510991A JP 2009510991 A JP2009510991 A JP 2009510991A JP 2009537526 A5 JP2009537526 A5 JP 2009537526A5

Authority

JP

Japan

Prior art keywords

cationic

antibody

complex

immunoliposome

small molecule

Prior art date

2007-05-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 125000002091 cationic group Chemical group 0.000 claims 43
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 18
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 18
• 239000002502 liposome Substances 0.000 claims 17
• 150000003384 small molecules Chemical class 0.000 claims 15
• 238000000034 method Methods 0.000 claims 11
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 5
• 235000012000 cholesterol Nutrition 0.000 claims 4
• MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 claims 4
• 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 3
• -1 cationic lipid Chemical class 0.000 claims 3
• 229940127089 cytotoxic agent Drugs 0.000 claims 3
• 229960005073 erlotinib hydrochloride Drugs 0.000 claims 3
• GTTBEUCJPZQMDZ-UHFFFAOYSA-N erlotinib hydrochloride Chemical compound [H+].[Cl-].C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 GTTBEUCJPZQMDZ-UHFFFAOYSA-N 0.000 claims 3
• 229960002584 gefitinib Drugs 0.000 claims 3
• XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 3
• 229960003685 imatinib mesylate Drugs 0.000 claims 3
• YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 claims 3
• LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 claims 3
• 229960002812 sunitinib malate Drugs 0.000 claims 3
• HPGLFJZJIHFMIT-UHFFFAOYSA-N 2-[4-(2-methylphenyl)phenyl]-6-nitro-2,3-dihydro-1h-quinazolin-4-one Chemical compound CC1=CC=CC=C1C1=CC=C(C2NC3=CC=C(C=C3C(=O)N2)[N+]([O-])=O)C=C1 HPGLFJZJIHFMIT-UHFFFAOYSA-N 0.000 claims 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 229910019142 PO4 Inorganic materials 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 claims 2
• 150000002632 lipids Chemical class 0.000 claims 2
• 230000007935 neutral effect Effects 0.000 claims 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
• 239000010452 phosphate Substances 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 239000012581 transferrin Substances 0.000 claims 2
• 241000255925 Diptera Species 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 241001061127 Thione Species 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 230000001093 anti-cancer Effects 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
• 230000002601 intratumoral effect Effects 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229960001156 mitoxantrone Drugs 0.000 claims 1
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 239000002356 single layer Substances 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 229940063683 taxotere Drugs 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1