JP2009537526A - 治療もしくは診断剤の全身投与のための抗体もしくは抗体断片標的化免疫リポソームの製造およびその使用 - Google Patents

治療もしくは診断剤の全身投与のための抗体もしくは抗体断片標的化免疫リポソームの製造およびその使用 Download PDF

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JP2009537526A
JP2009537526A JP2009510991A JP2009510991A JP2009537526A JP 2009537526 A JP2009537526 A JP 2009537526A JP 2009510991 A JP2009510991 A JP 2009510991A JP 2009510991 A JP2009510991 A JP 2009510991A JP 2009537526 A JP2009537526 A JP 2009537526A
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エスター・エイチ・チャン
キャスリーン・エフ・ピロロ
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Georgetown University
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JP2009510991A 2006-05-15 2007-05-11 治療もしくは診断剤の全身投与のための抗体もしくは抗体断片標的化免疫リポソームの製造およびその使用 Pending JP2009537526A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80016306P 2006-05-15 2006-05-15
US84435206P 2006-09-14 2006-09-14
PCT/US2007/011407 WO2007142781A1 (en) 2006-05-15 2007-05-11 Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof

Publications (2)

Publication Number Publication Date
JP2009537526A true JP2009537526A (ja) 2009-10-29
JP2009537526A5 JP2009537526A5 (https=) 2010-07-01

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JP2009510991A Pending JP2009537526A (ja) 2006-05-15 2007-05-11 治療もしくは診断剤の全身投与のための抗体もしくは抗体断片標的化免疫リポソームの製造およびその使用

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US (2) US9034330B2 (https=)
EP (1) EP2023897A4 (https=)
JP (1) JP2009537526A (https=)
KR (2) KR20140135267A (https=)
AU (1) AU2007257357B2 (https=)
CA (1) CA2652222A1 (https=)
IL (1) IL195216A (https=)
MX (1) MX2008014362A (https=)
WO (1) WO2007142781A1 (https=)
ZA (1) ZA200809725B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034330B2 (en) * 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
EP2711000B1 (en) 2012-09-19 2019-04-03 Georgetown University Targeted Liposomes
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
CA2901616A1 (en) 2013-03-14 2014-10-02 Georgetown University Treatment for exposure to nerve agent
WO2017082213A1 (ja) * 2015-11-09 2017-05-18 国立大学法人京都工芸繊維大学 ヒト血清由来ＩｇＧポリクローナル抗体の分離剤、及び、それを用いたヒト血清由来ＩｇＧポリクローナル抗体を分離する方法
US12274784B2 (en) * 2018-10-12 2025-04-15 Synergene Therapeutics, Inc. Methods for reducing side effects of immunotherapy
WO2022040435A1 (en) * 2020-08-19 2022-02-24 The Board Of Regents Of The University Of Texas System Nanodrugs for targeted drug delivery and use thereof
WO2022226513A1 (en) * 2021-04-21 2022-10-27 University Of Florida Research Foundation, Inc. Enzymatically-cleavable glycidyl methacrylate hyaluronic acid

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044407A1 (en) * 1999-02-22 2003-03-06 Chang Esther H. Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome or polyplex for systemic administration of a therapeutic or diagnostic agent
CN1448183A (zh) * 2002-04-04 2003-10-15 深圳市生尔易实业发展有限责任公司 一种肿瘤特异性靶向给药系统及其在制备治疗肿瘤药物中的应用
WO2005000271A1 (en) * 2003-06-04 2005-01-06 Georgetown University Method for improving stability and shelf-life of liposome complexes
JP2005306865A (ja) * 2004-03-25 2005-11-04 Japan Science & Technology Agency ホウ酸基含有シス−スチルベン化合物及びその製造方法、並びに、ホウ酸基含有トランス−スチルベン化合物及びその製造方法
WO2005117876A1 (en) * 2004-06-01 2005-12-15 University Of Virginia Patent Foundation Dual small molecule inhibitors of cancer and angiogenesis

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429008B1 (en) 1981-12-10 1995-05-16 Univ California Thiol reactive liposomes
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5688488A (en) * 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
AU642980B2 (en) 1990-03-21 1993-11-04 Quest International B.V. Ultilization of enzymes
US6099842A (en) * 1990-12-03 2000-08-08 The United States Of America As Represented By The Department Of Health And Human Services Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin
US5705655A (en) 1992-12-17 1998-01-06 Megabios Corporation Amphiphilic nitrogen containing imidazolinium derivative compounds and uses
CA2194221C (en) 1994-06-22 2001-01-02 Megabios Corporation Cationic amphiphiles
US5786214A (en) * 1994-12-15 1998-07-28 Spinal Cord Society pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US5977322A (en) * 1995-06-14 1999-11-02 The Regents Of The University Of California High affinity human antibodies to tumor antigens
JPH09110722A (ja) * 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
AU2112697A (en) 1996-02-09 1997-08-28 Pi-Wan Cheng Receptor ligand-facilitated delivery of biologically active molecules
US6210707B1 (en) * 1996-11-12 2001-04-03 The Regents Of The University Of California Methods of forming protein-linked lipidic microparticles, and compositions thereof
ES2392246T3 (es) 1996-11-12 2012-12-07 The Regents Of The University Of California Preparación de formulaciones estables de complejos de lípido-ácido nucleico para el suministro eficaz in vivo
JP2001522871A (ja) 1997-11-19 2001-11-20 ジョージタウン・ユニバーシティ 標的化リポゾーム遺伝子送達
US6794128B2 (en) * 1998-04-24 2004-09-21 The Regents Of The University Of California Methods of selecting internalizing antibodies
WO1999059643A2 (en) 1998-05-20 1999-11-25 Sdg, Inc. Liposomal delivery complex
US20030022854A1 (en) * 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
US6693086B1 (en) * 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
JP4680385B2 (ja) 1998-09-11 2011-05-11 トーマス・ジェファーソン・ユニバーシティ ＲＢ２／ｐ１３０を発現するベクターによる平滑筋細胞増殖の抑制および再狭窄の防止方法
US9034330B2 (en) * 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
JP4799736B2 (ja) 1999-02-22 2011-10-26 ジョージタウン・ユニバーシティ 全身性遺伝子送達のための抗体フラグメント標的化イムノリポソーム
JP4593961B2 (ja) 2004-04-20 2010-12-08 Ｔｈｋ株式会社 直動案内用広速度域グリース組成物及びこれを用いた直動案内装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044407A1 (en) * 1999-02-22 2003-03-06 Chang Esther H. Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome or polyplex for systemic administration of a therapeutic or diagnostic agent
CN1448183A (zh) * 2002-04-04 2003-10-15 深圳市生尔易实业发展有限责任公司 一种肿瘤特异性靶向给药系统及其在制备治疗肿瘤药物中的应用
WO2005000271A1 (en) * 2003-06-04 2005-01-06 Georgetown University Method for improving stability and shelf-life of liposome complexes
JP2005306865A (ja) * 2004-03-25 2005-11-04 Japan Science & Technology Agency ホウ酸基含有シス−スチルベン化合物及びその製造方法、並びに、ホウ酸基含有トランス−スチルベン化合物及びその製造方法
WO2005117876A1 (en) * 2004-06-01 2005-12-15 University Of Virginia Patent Foundation Dual small molecule inhibitors of cancer and angiogenesis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6012033432; Ｒｏｄｒｉｇｕｅｚ　Ｍ，　ｅｔ　ａｌ．: 'Ｄｅｖｅｌｏｐｍｅｎｔ　ａｎｄ　Ｅｆｆｅｃｔｓ　ｏｆ　Ｉｍｍｕｎｏｌｉｐｏｓｏｍｅｓ　Ｃａｒｒｙｉｎｇ　ａｎ　Ａｎｔｉｓｅｎｓｅ　Ｏｌｉｇｏｎｕｃｌｅｏｔｉｄｅ　Ａｇａｉｎｓｔ　ＤＨＦＲ　ＲＮＡ　ａｎ' Ａｎｔｉｓｅｎｓｅ　ａｎｄ　Ｎｕｃｌｅｉｃ　Ａｃｉｄ　Ｄｒｕｇ　Ｄｅｖｅｌｏｐｍｅｎｔ Ｖｏｌ．　１２，　Ｎｏ．　５, 20020708, ｐ．　３１１-３２５ *
JPN6012033433; 塩津行正: '新規分子標的癌治療薬のスクリーニングとその概況' 癌と化学療法 Ｖｏｌ．　３０，　Ｎｏ．　１２, 200311, ｐ．　１８６３-１８７２ *
JPN6012033434; Ｈａｒａｔａ　Ｍ，　ｅｔ　ａｌ．: 'ＣＤ１９-ｔａｒｇｅｔｉｎｇ　ｌｉｐｏｓｏｍｅｓ　ｃｏｎｔａｉｎｉｎｇ　ｉｍａｔｉｎｉｂ　ｅｆｆｉｃｉｅｎｔｌｙ　ｋｉｌｌ　Ｐｈｉｌａｄｅｌｐｈｉａ　ｃｈｒｏｍｏｓｏｍｅ--ｐｏｓｉｔｉｖｅ　ａｃｕｔ' Ｂｌｏｏｄ Ｖｏｌ．　１０４，　Ｎｏ．　５, 20040901, ｐ．　１４４２-１４４９ *

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