JP2019500043A5 - - Google Patents
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- JP2019500043A5 JP2019500043A5 JP2018534141A JP2018534141A JP2019500043A5 JP 2019500043 A5 JP2019500043 A5 JP 2019500043A5 JP 2018534141 A JP2018534141 A JP 2018534141A JP 2018534141 A JP2018534141 A JP 2018534141A JP 2019500043 A5 JP2019500043 A5 JP 2019500043A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021096653A JP2021166514A (ja) | 2015-12-28 | 2021-06-09 | 異常ヘモグロビン症の治療用組成物および方法 |
| JP2023128086A JP2023159185A (ja) | 2015-12-28 | 2023-08-04 | 異常ヘモグロビン症の治療用組成物および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562271968P | 2015-12-28 | 2015-12-28 | |
| US62/271,968 | 2015-12-28 | ||
| US201662347484P | 2016-06-08 | 2016-06-08 | |
| US62/347,484 | 2016-06-08 | ||
| PCT/IB2016/058007 WO2017115268A1 (en) | 2015-12-28 | 2016-12-26 | Compositions and methods for the treatment of hemoglobinopathies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096653A Division JP2021166514A (ja) | 2015-12-28 | 2021-06-09 | 異常ヘモグロビン症の治療用組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019500043A JP2019500043A (ja) | 2019-01-10 |
| JP2019500043A5 true JP2019500043A5 (enExample) | 2020-02-13 |
Family
ID=57822008
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534141A Pending JP2019500043A (ja) | 2015-12-28 | 2016-12-26 | 異常ヘモグロビン症の治療用組成物および方法 |
| JP2021096653A Pending JP2021166514A (ja) | 2015-12-28 | 2021-06-09 | 異常ヘモグロビン症の治療用組成物および方法 |
| JP2023128086A Pending JP2023159185A (ja) | 2015-12-28 | 2023-08-04 | 異常ヘモグロビン症の治療用組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096653A Pending JP2021166514A (ja) | 2015-12-28 | 2021-06-09 | 異常ヘモグロビン症の治療用組成物および方法 |
| JP2023128086A Pending JP2023159185A (ja) | 2015-12-28 | 2023-08-04 | 異常ヘモグロビン症の治療用組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20190010495A1 (enExample) |
| EP (2) | EP4053277A1 (enExample) |
| JP (3) | JP2019500043A (enExample) |
| KR (2) | KR20250141840A (enExample) |
| CN (1) | CN108779462A (enExample) |
| AU (4) | AU2016381313B2 (enExample) |
| CA (1) | CA3009727A1 (enExample) |
| EA (1) | EA201891532A1 (enExample) |
| HK (1) | HK1258205A1 (enExample) |
| IL (2) | IL308706A (enExample) |
| MX (2) | MX2018007987A (enExample) |
| MY (1) | MY192848A (enExample) |
| NZ (4) | NZ783532A (enExample) |
| PH (1) | PH12018501378A1 (enExample) |
| SG (1) | SG11201805217XA (enExample) |
| WO (1) | WO2017115268A1 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US12129471B2 (en) | 2015-02-23 | 2024-10-29 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
| US20180030438A1 (en) | 2015-02-23 | 2018-02-01 | Crispr Therapeutics Ag | Materials and methods for treatment of hemoglobinopathies |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| WO2016182917A1 (en) * | 2015-05-08 | 2016-11-17 | Children's Medical Center Corporation | Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction |
| EP3294896A1 (en) | 2015-05-11 | 2018-03-21 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| MX382223B (es) | 2015-05-12 | 2025-03-13 | Sangamo Therapeutics Inc | Regulacion de expresion genica mediada por nucleasa. |
| JP7396783B2 (ja) | 2015-06-09 | 2023-12-12 | エディタス・メディシン、インコーポレイテッド | 移植を改善するためのｃｒｉｓｐｒ／ｃａｓ関連方法および組成物 |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| ES2942309T3 (es) | 2015-11-04 | 2023-05-31 | Vertex Pharma | Materiales y métodos para el tratamiento de hemoglobinopatías |
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| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN109844126A (zh) | 2016-09-28 | 2019-06-04 | 诺华股份有限公司 | 基于多孔膜的大分子递送系统 |
| GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
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| US20210380937A1 (en) | 2017-04-04 | 2021-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Preparation , expansion, and uses of adult pluripotent stem cells |
| EP3615664A4 (en) * | 2017-04-24 | 2021-01-27 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | HOMOLOGY-DIRECTED REPAIR COMPOSITIONS FOR THE TREATMENT OF HEMOGLOBINOPATHIES |
| EP3622070A2 (en) * | 2017-05-10 | 2020-03-18 | Editas Medicine, Inc. | Crispr/rna-guided nuclease systems and methods |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2018218135A1 (en) * | 2017-05-25 | 2018-11-29 | The Children's Medical Center Corporation | Bcl11a guide delivery |
| US20200140896A1 (en) | 2017-06-30 | 2020-05-07 | Novartis Ag | Methods for the treatment of disease with gene editing systems |
| WO2019014564A1 (en) | 2017-07-14 | 2019-01-17 | Editas Medicine, Inc. | SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物 |
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| KR102832035B1 (ko) * | 2017-09-29 | 2025-07-09 | 인텔리아 테라퓨틱스, 인크. | 지질 나노파티클을 이용한 mRNA 전달의 체외 방법 |
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| CN109722415B (zh) * | 2017-10-27 | 2021-01-26 | 博雅辑因（北京）生物科技有限公司 | 一种造血干细胞的培养组合物、培养基以及造血干细胞的培养方法 |
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| JP2021503284A (ja) * | 2017-11-16 | 2021-02-12 | モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ | 形質転換ヒト細胞およびその使用 |
| WO2019106522A1 (en) * | 2017-11-28 | 2019-06-06 | Novartis Ag | Pooled crispr/cas9 screening in primary cells using guide swap technology |
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| US11268077B2 (en) * | 2018-02-05 | 2022-03-08 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies |
| EP3749767A1 (en) | 2018-02-05 | 2020-12-16 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies |
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