JP2019196405A5 - - Google Patents
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- Publication number
- JP2019196405A5 JP2019196405A5 JP2019150807A JP2019150807A JP2019196405A5 JP 2019196405 A5 JP2019196405 A5 JP 2019196405A5 JP 2019150807 A JP2019150807 A JP 2019150807A JP 2019150807 A JP2019150807 A JP 2019150807A JP 2019196405 A5 JP2019196405 A5 JP 2019196405A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethylamino
- methyl
- phenol
- propyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012601 diabetes mellitus Diseases 0.000 claims description 17
- 239000003814 drug Substances 0.000 claims description 13
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 claims description 13
- 208000004296 neuralgia Diseases 0.000 claims description 10
- 208000021722 neuropathic pain Diseases 0.000 claims description 10
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 8
- 201000001119 neuropathy Diseases 0.000 claims description 6
- 230000007823 neuropathy Effects 0.000 claims description 6
- 230000002093 peripheral effect Effects 0.000 claims description 6
- -1 phenol compound Chemical class 0.000 claims description 5
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- 150000002989 phenols Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 229920006395 saturated elastomer Polymers 0.000 description 6
- KWTWDQCKEHXFFR-UHFFFAOYSA-N 3-[1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)CC(C)C(CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-UHFFFAOYSA-N 0.000 description 5
- KWTWDQCKEHXFFR-RISCZKNCSA-N 3-[(2s,3s)-1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)C[C@@H](C)[C@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-RISCZKNCSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- PZNRRUTVGXCKFC-IUODEOHRSA-N (2r,3r)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol Chemical compound CN(C)C[C@@H](C)[C@](O)(CC)C1=CC=CC(OC)=C1 PZNRRUTVGXCKFC-IUODEOHRSA-N 0.000 description 2
- PZNRRUTVGXCKFC-WFASDCNBSA-N (2s,3s)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol Chemical compound CN(C)C[C@H](C)[C@@](O)(CC)C1=CC=CC(OC)=C1 PZNRRUTVGXCKFC-WFASDCNBSA-N 0.000 description 2
- UMTBGMDYYBKESP-ZWNOBZJWSA-N 3-[(2r,3r)-4-(dimethylamino)-2-hydroxy-3-methylbutan-2-yl]phenol Chemical compound CN(C)C[C@@H](C)[C@@](C)(O)C1=CC=CC(O)=C1 UMTBGMDYYBKESP-ZWNOBZJWSA-N 0.000 description 2
- UMTBGMDYYBKESP-GWCFXTLKSA-N 3-[(2s,3s)-4-(dimethylamino)-2-hydroxy-3-methylbutan-2-yl]phenol Chemical compound CN(C)C[C@H](C)[C@](C)(O)C1=CC=CC(O)=C1 UMTBGMDYYBKESP-GWCFXTLKSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- YBYOJLGHTBBSOM-BXUZGUMPSA-N (2r,3r)-4-(dimethylamino)-2-(3-methoxyphenyl)-3-methylbutan-2-ol Chemical compound COC1=CC=CC([C@](C)(O)[C@H](C)CN(C)C)=C1 YBYOJLGHTBBSOM-BXUZGUMPSA-N 0.000 description 1
- DSYYVFJOQLAICR-UHFFFAOYSA-N 1-(dimethylamino)-2-methyl-3-(3-methylsulfanylphenyl)pentan-3-ol Chemical compound CN(C)CC(C)C(O)(CC)C1=CC=CC(SC)=C1 DSYYVFJOQLAICR-UHFFFAOYSA-N 0.000 description 1
- PZNRRUTVGXCKFC-UHFFFAOYSA-N 1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol Chemical compound CN(C)CC(C)C(O)(CC)C1=CC=CC(OC)=C1 PZNRRUTVGXCKFC-UHFFFAOYSA-N 0.000 description 1
- QSHYRDQULOQBSQ-UHFFFAOYSA-N 1-(dimethylamino)-3-(3-methoxyphenyl)-4,4-dimethylpentan-3-ol Chemical compound COC1=CC=CC(C(O)(CCN(C)C)C(C)(C)C)=C1 QSHYRDQULOQBSQ-UHFFFAOYSA-N 0.000 description 1
- CJHTXPLNTROVHR-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-1-(dimethylamino)-2-methylpentan-3-ol Chemical compound CN(C)CC(C)C(O)(CC)C1=CC=C(Cl)C(Cl)=C1 CJHTXPLNTROVHR-UHFFFAOYSA-N 0.000 description 1
- GYDHGSUDUMBHNZ-UHFFFAOYSA-N 3-(4-chlorophenyl)-1-(dimethylamino)-2-methylpentan-3-ol Chemical compound CN(C)CC(C)C(O)(CC)C1=CC=C(Cl)C=C1 GYDHGSUDUMBHNZ-UHFFFAOYSA-N 0.000 description 1
- VIBKCCHMNVUCEA-UHFFFAOYSA-N 3-[3-(difluoromethyl)phenyl]-1-(dimethylamino)-2-methylpentan-3-ol Chemical compound CN(C)CC(C)C(O)(CC)C1=CC=CC(C(F)F)=C1 VIBKCCHMNVUCEA-UHFFFAOYSA-N 0.000 description 1
- UMTBGMDYYBKESP-UHFFFAOYSA-N 3-[4-(dimethylamino)-2-hydroxy-3-methylbutan-2-yl]phenol Chemical compound CN(C)CC(C)C(C)(O)C1=CC=CC(O)=C1 UMTBGMDYYBKESP-UHFFFAOYSA-N 0.000 description 1
- YBYOJLGHTBBSOM-UHFFFAOYSA-N 4-(dimethylamino)-2-(3-methoxyphenyl)-3-methylbutan-2-ol Chemical compound COC1=CC=CC(C(C)(O)C(C)CN(C)C)=C1 YBYOJLGHTBBSOM-UHFFFAOYSA-N 0.000 description 1
- CBFGWFWDTULPPI-CXAGYDPISA-N [(2r,3r)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-yl] acetate Chemical compound CN(C)C[C@@H](C)[C@](OC(C)=O)(CC)C1=CC=CC(OC)=C1 CBFGWFWDTULPPI-CXAGYDPISA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- NMXXDRKTOJAAQS-UHFFFAOYSA-N n,n-dimethyl-3-phenylpropan-1-amine Chemical class CN(C)CCCC1=CC=CC=C1 NMXXDRKTOJAAQS-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007012165A DE102007012165A1 (de) | 2007-03-12 | 2007-03-12 | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
| DE102007012165.4 | 2007-03-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017230230A Division JP2018030886A (ja) | 2007-03-12 | 2017-11-30 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019196405A JP2019196405A (ja) | 2019-11-14 |
| JP2019196405A5 true JP2019196405A5 (https=) | 2020-01-23 |
| JP6745959B2 JP6745959B2 (ja) | 2020-08-26 |
Family
ID=39345501
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553058A Pending JP2010520907A (ja) | 2007-03-12 | 2008-03-10 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
| JP2013206992A Expired - Fee Related JP6081337B2 (ja) | 2007-03-12 | 2013-10-02 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
| JP2016001448A Pending JP2016056188A (ja) | 2007-03-12 | 2016-01-07 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
| JP2017230230A Pending JP2018030886A (ja) | 2007-03-12 | 2017-11-30 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
| JP2019150807A Expired - Fee Related JP6745959B2 (ja) | 2007-03-12 | 2019-08-21 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553058A Pending JP2010520907A (ja) | 2007-03-12 | 2008-03-10 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
| JP2013206992A Expired - Fee Related JP6081337B2 (ja) | 2007-03-12 | 2013-10-02 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
| JP2016001448A Pending JP2016056188A (ja) | 2007-03-12 | 2016-01-07 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
| JP2017230230A Pending JP2018030886A (ja) | 2007-03-12 | 2017-11-30 | ニューロパシー痛の治療のための１−フェニル−３−ジメチルアミノ−プロパン化合物の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20080269326A1 (https=) |
| EP (1) | EP2117525B1 (https=) |
| JP (5) | JP2010520907A (https=) |
| CA (1) | CA2680771C (https=) |
| CY (1) | CY1115455T1 (https=) |
| DE (1) | DE102007012165A1 (https=) |
| DK (1) | DK2117525T3 (https=) |
| ES (1) | ES2452830T3 (https=) |
| HR (1) | HRP20140280T1 (https=) |
| PL (1) | PL2117525T3 (https=) |
| PT (1) | PT2117525E (https=) |
| SI (1) | SI2117525T1 (https=) |
| WO (1) | WO2008110323A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2582366T1 (sl) * | 2010-06-15 | 2016-02-29 | Gruenenthal Gmbh | Farmacevtska kombinacija za zdravljenje bolečine |
| EP3597628A1 (en) * | 2010-07-23 | 2020-01-22 | Grünenthal GmbH | Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
| WO2012051246A1 (en) | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
| JP2019142972A (ja) * | 2011-03-04 | 2019-08-29 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールの非経口的投与 |
| RS56692B1 (sr) * | 2011-03-04 | 2018-03-30 | Gruenenthal Gmbh | Polučvrsta vodena farmaceutska kompozicija koja sadrži tapentadol |
| CA2828635C (en) * | 2011-03-04 | 2020-01-14 | Grunenthal Gmbh | Parenteral administration of tapentadol |
| KR101946790B1 (ko) | 2011-03-04 | 2019-02-13 | 그뤼넨탈 게엠베하 | 경구 투여를 위한 타펜타돌의 수성 약제학적 제형 |
| US20120309840A1 (en) | 2011-04-05 | 2012-12-06 | Gruenenthal Gmbh | Treatment of Pain Associated with Trigeminal Neuralgia |
| RS58064B1 (sr) | 2011-04-05 | 2019-02-28 | Gruenenthal Gmbh | Tapentadol za sprečavanje hronifikacije bola |
| LT3272343T (lt) | 2011-04-29 | 2020-05-11 | Grünenthal GmbH | Tapentadolis, skirtas depresijos ir nerimo prevencijai ir gydymui |
| EP2736501B1 (en) * | 2011-07-29 | 2017-12-20 | Grünenthal GmbH | Intrathecal or epidural administration of 3-[(1s,2s)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol |
| US8853393B2 (en) | 2011-07-29 | 2014-10-07 | Anhui New Star Pharmaceutical Development Co., Ltd. | Intermediate for preparing tapentadol or analogues thereof |
| CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
| EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
| EP3273953B1 (en) | 2015-03-27 | 2019-01-02 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| CN109996533A (zh) | 2016-09-23 | 2019-07-09 | 格吕伦塔尔有限公司 | 用于肠胃外施用他喷他多的稳定制剂 |
| WO2018153947A1 (en) | 2017-02-23 | 2018-08-30 | Grünenthal GmbH | Tapentadol as local anesthetic |
| CN114788814B (zh) * | 2021-01-26 | 2023-10-13 | 浙江创新生物有限公司 | 一种高稳定性的注射用达托霉素组合物及其制备方法和其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| PT1562567T (pt) * | 2002-11-22 | 2017-08-24 | Gruenenthal Gmbh | Combinação de analgésicos selecionados e inibidores da cox-ii |
| RU2442576C2 (ru) * | 2006-04-28 | 2012-02-20 | Грюненталь Гмбх | Фармацевтическая комбинация, содержащая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и парацетамол |
-
2007
- 2007-03-12 DE DE102007012165A patent/DE102007012165A1/de not_active Withdrawn
-
2008
- 2008-03-10 SI SI200831144T patent/SI2117525T1/sl unknown
- 2008-03-10 EP EP08716394.5A patent/EP2117525B1/de active Active
- 2008-03-10 ES ES08716394.5T patent/ES2452830T3/es active Active
- 2008-03-10 JP JP2009553058A patent/JP2010520907A/ja active Pending
- 2008-03-10 HR HRP20140280AT patent/HRP20140280T1/hr unknown
- 2008-03-10 WO PCT/EP2008/001884 patent/WO2008110323A1/de not_active Ceased
- 2008-03-10 PT PT87163945T patent/PT2117525E/pt unknown
- 2008-03-10 DK DK08716394.5T patent/DK2117525T3/da active
- 2008-03-10 CA CA2680771A patent/CA2680771C/en active Active
- 2008-03-10 PL PL08716394T patent/PL2117525T3/pl unknown
- 2008-03-11 US US12/045,830 patent/US20080269326A1/en not_active Abandoned
-
2010
- 2010-08-04 US US12/850,208 patent/US8536130B2/en active Active
-
2013
- 2013-10-02 JP JP2013206992A patent/JP6081337B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-28 CY CY20141100171T patent/CY1115455T1/el unknown
-
2016
- 2016-01-07 JP JP2016001448A patent/JP2016056188A/ja active Pending
-
2017
- 2017-11-30 JP JP2017230230A patent/JP2018030886A/ja active Pending
-
2019
- 2019-08-21 JP JP2019150807A patent/JP6745959B2/ja not_active Expired - Fee Related
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