CY1115455T1 - Χρησιμοποιηση ενωσεων 1-φαινυλο-3-διμεθυλαμινο-προπανιου για τη θεραπεια του πονου νευροπαθειας - Google Patents
Χρησιμοποιηση ενωσεων 1-φαινυλο-3-διμεθυλαμινο-προπανιου για τη θεραπεια του πονου νευροπαθειαςInfo
- Publication number
- CY1115455T1 CY1115455T1 CY20141100171T CY141100171T CY1115455T1 CY 1115455 T1 CY1115455 T1 CY 1115455T1 CY 20141100171 T CY20141100171 T CY 20141100171T CY 141100171 T CY141100171 T CY 141100171T CY 1115455 T1 CY1115455 T1 CY 1115455T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dimethylamino
- treatment
- compounds
- fenylo
- propanium
- Prior art date
Links
- 208000033808 peripheral neuropathy Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 201000001119 neuropathy Diseases 0.000 title 1
- 230000007823 neuropathy Effects 0.000 title 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- NMXXDRKTOJAAQS-UHFFFAOYSA-N n,n-dimethyl-3-phenylpropan-1-amine Chemical class CN(C)CCCC1=CC=CC=C1 NMXXDRKTOJAAQS-UHFFFAOYSA-N 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η εφεύρεση αφορά στην χρησιμοποίηση ενώσεων 1-φαινυλο-3-διμεθυλαμινο-προπανίου για την παρασκευή φαρμάκων για την θεραπεία, νευροπαθητικού, κατά προτίμηση πολυνευροπαθητικού, ακόμη κατά προτίμηση διαβητικού νευροπαθητικού πόνου, κατά προτίμηση διαβητικού περιφερικού νευροπαθητικού πόνου, ακόμη κατά προτίμηση για τη θεραπεία διαβητικής περιφερικής νευροπάθειας.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007012165A DE102007012165A1 (de) | 2007-03-12 | 2007-03-12 | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
EP08716394.5A EP2117525B1 (de) | 2007-03-12 | 2008-03-10 | Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie des neuropathieschmerzes |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115455T1 true CY1115455T1 (el) | 2017-01-04 |
Family
ID=39345501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100171T CY1115455T1 (el) | 2007-03-12 | 2014-02-28 | Χρησιμοποιηση ενωσεων 1-φαινυλο-3-διμεθυλαμινο-προπανιου για τη θεραπεια του πονου νευροπαθειας |
Country Status (13)
Country | Link |
---|---|
US (2) | US20080269326A1 (el) |
EP (1) | EP2117525B1 (el) |
JP (5) | JP2010520907A (el) |
CA (1) | CA2680771C (el) |
CY (1) | CY1115455T1 (el) |
DE (1) | DE102007012165A1 (el) |
DK (1) | DK2117525T3 (el) |
ES (1) | ES2452830T3 (el) |
HR (1) | HRP20140280T1 (el) |
PL (1) | PL2117525T3 (el) |
PT (1) | PT2117525E (el) |
SI (1) | SI2117525T1 (el) |
WO (1) | WO2008110323A1 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR081931A1 (es) | 2010-06-15 | 2012-10-31 | Gruenenthal Gmbh | Combinacion farmaceutica |
WO2012010316A1 (en) * | 2010-07-23 | 2012-01-26 | Grünenthal GmbH | Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
WO2012051246A1 (en) | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
JP2019142972A (ja) * | 2011-03-04 | 2019-08-29 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールの非経口的投与 |
PT2680834T (pt) | 2011-03-04 | 2018-01-25 | Gruenenthal Gmbh | Composição farmacêutica aquosa semissólida contendo tapentadol |
DK2680833T3 (en) * | 2011-03-04 | 2016-05-23 | Gruenenthal Gmbh | PARENTERAL SUBMISSION OF TAPENTADOL |
SI2680832T1 (sl) | 2011-03-04 | 2019-11-29 | Gruenenthal Gmbh | Vodna farmacevtska formulacija tapentadola za peroralno dovajanje |
PT2694050T (pt) * | 2011-04-05 | 2019-11-22 | Gruenenthal Gmbh | Tapentadol para uso no tratamento da dor associada à neuralgia trigeminal |
WO2012136349A1 (en) | 2011-04-05 | 2012-10-11 | Grünenthal GmbH | Tapentadol for preventing chronification of pain |
RS60152B1 (sr) | 2011-04-29 | 2020-05-29 | Gruenenthal Gmbh | Tapentadol za sprečavanje i lečenje depresije i anksioznosti |
EP2617706B1 (en) | 2011-07-29 | 2017-09-06 | Anhui New Star Pharmaceutical Development Co., Ltd | Novel intermediate used for preparing tapentadol or analogues thereof |
SI2736501T1 (en) * | 2011-07-29 | 2018-03-30 | Gruenenthal Gmbh | Intrathecal or epidural administration of 3 - ((1S, 2S) -3- (dimethylamino) -1-ethyl-2-methylpropyl) phenol |
CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
CN107847471A (zh) | 2015-03-27 | 2018-03-27 | 格吕伦塔尔有限公司 | 他喷他多肠胃外给药的稳定制剂 |
EP3515412A1 (en) | 2016-09-23 | 2019-07-31 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
EP3585370A1 (en) | 2017-02-23 | 2020-01-01 | Grünenthal GmbH | Tapentadol as local anesthetic |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
SI1685829T1 (sl) * | 2002-11-22 | 2008-08-31 | Gruenenthal Gmbh | Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine |
BRPI0710682B8 (pt) * | 2006-04-28 | 2021-05-25 | Gruenenthal Gmbh | combinação farmacêutica compreendendo 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol e paracetamol |
-
2007
- 2007-03-12 DE DE102007012165A patent/DE102007012165A1/de not_active Withdrawn
-
2008
- 2008-03-10 DK DK08716394.5T patent/DK2117525T3/da active
- 2008-03-10 CA CA2680771A patent/CA2680771C/en active Active
- 2008-03-10 EP EP08716394.5A patent/EP2117525B1/de active Active
- 2008-03-10 ES ES08716394.5T patent/ES2452830T3/es active Active
- 2008-03-10 PT PT87163945T patent/PT2117525E/pt unknown
- 2008-03-10 SI SI200831144T patent/SI2117525T1/sl unknown
- 2008-03-10 PL PL08716394T patent/PL2117525T3/pl unknown
- 2008-03-10 WO PCT/EP2008/001884 patent/WO2008110323A1/de active Application Filing
- 2008-03-10 JP JP2009553058A patent/JP2010520907A/ja active Pending
- 2008-03-11 US US12/045,830 patent/US20080269326A1/en not_active Abandoned
-
2010
- 2010-08-04 US US12/850,208 patent/US8536130B2/en active Active
-
2013
- 2013-10-02 JP JP2013206992A patent/JP6081337B2/ja active Active
-
2014
- 2014-02-28 CY CY20141100171T patent/CY1115455T1/el unknown
- 2014-03-24 HR HRP20140280AT patent/HRP20140280T1/hr unknown
-
2016
- 2016-01-07 JP JP2016001448A patent/JP2016056188A/ja active Pending
-
2017
- 2017-11-30 JP JP2017230230A patent/JP2018030886A/ja active Pending
-
2019
- 2019-08-21 JP JP2019150807A patent/JP6745959B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
EP2117525A1 (de) | 2009-11-18 |
PT2117525E (pt) | 2014-02-14 |
SI2117525T1 (sl) | 2014-03-31 |
ES2452830T3 (es) | 2014-04-02 |
CA2680771A1 (en) | 2008-09-18 |
JP6745959B2 (ja) | 2020-08-26 |
JP2013256540A (ja) | 2013-12-26 |
DE102007012165A1 (de) | 2008-09-18 |
PL2117525T3 (pl) | 2014-05-30 |
EP2117525B1 (de) | 2013-12-25 |
JP2016056188A (ja) | 2016-04-21 |
CA2680771C (en) | 2015-11-17 |
JP2018030886A (ja) | 2018-03-01 |
JP2019196405A (ja) | 2019-11-14 |
DK2117525T3 (da) | 2014-02-03 |
US8536130B2 (en) | 2013-09-17 |
US20080269326A1 (en) | 2008-10-30 |
JP6081337B2 (ja) | 2017-02-15 |
HRP20140280T1 (hr) | 2014-04-25 |
US20100311842A1 (en) | 2010-12-09 |
JP2010520907A (ja) | 2010-06-17 |
WO2008110323A1 (de) | 2008-09-18 |
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