JP2019150027A5 - - Google Patents
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- JP2019150027A5 JP2019150027A5 JP2019069638A JP2019069638A JP2019150027A5 JP 2019150027 A5 JP2019150027 A5 JP 2019150027A5 JP 2019069638 A JP2019069638 A JP 2019069638A JP 2019069638 A JP2019069638 A JP 2019069638A JP 2019150027 A5 JP2019150027 A5 JP 2019150027A5
- Authority
- JP
- Japan
- Prior art keywords
- klhl17
- biomarker
- breast cancer
- expression level
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 101001049220 Homo sapiens Kelch-like protein 17 Proteins 0.000 claims 66
- 102100023684 Kelch-like protein 17 Human genes 0.000 claims 66
- 239000000090 biomarker Substances 0.000 claims 50
- 238000000034 method Methods 0.000 claims 47
- 206010006187 Breast cancer Diseases 0.000 claims 35
- 208000026310 Breast neoplasm Diseases 0.000 claims 35
- UFNVPOGXISZXJD-JBQZKEIOSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-JBQZKEIOSA-N 0.000 claims 24
- 229960003649 eribulin Drugs 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 17
- 239000000523 sample Substances 0.000 claims 9
- 210000001519 tissue Anatomy 0.000 claims 9
- 102000015694 estrogen receptors Human genes 0.000 claims 8
- 108010038795 estrogen receptors Proteins 0.000 claims 8
- 102000003998 progesterone receptors Human genes 0.000 claims 8
- 108090000468 progesterone receptors Proteins 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 102100028220 ABI gene family member 3 Human genes 0.000 claims 6
- 102100036438 Amyloid beta precursor protein binding family B member 2 Human genes 0.000 claims 6
- 102100022987 Angiogenin Human genes 0.000 claims 6
- 102100021935 C-C motif chemokine 26 Human genes 0.000 claims 6
- 108700020472 CDC20 Proteins 0.000 claims 6
- 101150023302 Cdc20 gene Proteins 0.000 claims 6
- 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 claims 6
- 102100023309 Centrosomal protein of 152 kDa Human genes 0.000 claims 6
- 101710181192 Centrosomal protein of 152 kDa Proteins 0.000 claims 6
- 102000004360 Cofilin 1 Human genes 0.000 claims 6
- 108090000996 Cofilin 1 Proteins 0.000 claims 6
- 102100024335 Collagen alpha-1(VII) chain Human genes 0.000 claims 6
- 102100024901 Cytochrome P450 4F3 Human genes 0.000 claims 6
- 102100032881 DNA-binding protein SATB1 Human genes 0.000 claims 6
- 102100032248 Dysferlin Human genes 0.000 claims 6
- 102100032449 EGF-like repeat and discoidin I-like domain-containing protein 3 Human genes 0.000 claims 6
- 102100029988 Endoplasmic reticulum-Golgi intermediate compartment protein 3 Human genes 0.000 claims 6
- 102100038392 GRAM domain-containing protein 4 Human genes 0.000 claims 6
- 102100028260 Gamma-secretase subunit PEN-2 Human genes 0.000 claims 6
- 102100039261 Guanine nucleotide-binding protein G(t) subunit alpha-1 Human genes 0.000 claims 6
- 101000724234 Homo sapiens ABI gene family member 3 Proteins 0.000 claims 6
- 101000928680 Homo sapiens Amyloid beta precursor protein binding family B member 2 Proteins 0.000 claims 6
- 101000757236 Homo sapiens Angiogenin Proteins 0.000 claims 6
- 101000897493 Homo sapiens C-C motif chemokine 26 Proteins 0.000 claims 6
- 101000888518 Homo sapiens Chemokine-like factor Proteins 0.000 claims 6
- 101000909498 Homo sapiens Collagen alpha-1(VII) chain Proteins 0.000 claims 6
- 101000909121 Homo sapiens Cytochrome P450 4F3 Proteins 0.000 claims 6
- 101000655234 Homo sapiens DNA-binding protein SATB1 Proteins 0.000 claims 6
- 101001016184 Homo sapiens Dysferlin Proteins 0.000 claims 6
- 101001016381 Homo sapiens EGF-like repeat and discoidin I-like domain-containing protein 3 Proteins 0.000 claims 6
- 101001010804 Homo sapiens Endoplasmic reticulum-Golgi intermediate compartment protein 3 Proteins 0.000 claims 6
- 101001033004 Homo sapiens GRAM domain-containing protein 4 Proteins 0.000 claims 6
- 101000579663 Homo sapiens Gamma-secretase subunit PEN-2 Proteins 0.000 claims 6
- 101000888178 Homo sapiens Guanine nucleotide-binding protein G(t) subunit alpha-1 Proteins 0.000 claims 6
- 101000962526 Homo sapiens Hyaluronidase-2 Proteins 0.000 claims 6
- 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 claims 6
- 101000969581 Homo sapiens MOB kinase activator 1A Proteins 0.000 claims 6
- 101001091425 Homo sapiens Papilin Proteins 0.000 claims 6
- 101001062776 Homo sapiens Protein FAM234A Proteins 0.000 claims 6
- 101000601855 Homo sapiens Protocadherin-1 Proteins 0.000 claims 6
- 101001071164 Homo sapiens Pyridoxal phosphate phosphatase PHOSPHO2 Proteins 0.000 claims 6
- 101000633142 Homo sapiens Sorting nexin-11 Proteins 0.000 claims 6
- 101000881267 Homo sapiens Spectrin alpha chain, erythrocytic 1 Proteins 0.000 claims 6
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 6
- 101000764622 Homo sapiens Transmembrane and immunoglobulin domain-containing protein 2 Proteins 0.000 claims 6
- 101000648679 Homo sapiens Transmembrane protein 79 Proteins 0.000 claims 6
- 101000652472 Homo sapiens Tubulin beta-6 chain Proteins 0.000 claims 6
- 101000744742 Homo sapiens YTH domain-containing family protein 1 Proteins 0.000 claims 6
- 101000976649 Homo sapiens Zinc finger protein ZIC 5 Proteins 0.000 claims 6
- 102100039285 Hyaluronidase-2 Human genes 0.000 claims 6
- 108090000174 Interleukin-10 Proteins 0.000 claims 6
- 102000003814 Interleukin-10 Human genes 0.000 claims 6
- 102100020680 Krueppel-like factor 5 Human genes 0.000 claims 6
- 102100021437 MOB kinase activator 1A Human genes 0.000 claims 6
- 108010029782 Nuclear Cap-Binding Protein Complex Proteins 0.000 claims 6
- 102000001745 Nuclear Cap-Binding Protein Complex Human genes 0.000 claims 6
- 102100034934 Papilin Human genes 0.000 claims 6
- 102100040990 Platelet-derived growth factor subunit B Human genes 0.000 claims 6
- 102100030560 Protein FAM234A Human genes 0.000 claims 6
- 108010019674 Proto-Oncogene Proteins c-sis Proteins 0.000 claims 6
- 102100037551 Protocadherin-1 Human genes 0.000 claims 6
- 102100036843 Pyridoxal phosphate phosphatase PHOSPHO2 Human genes 0.000 claims 6
- 101100010298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pol2 gene Proteins 0.000 claims 6
- 102100029609 Sorting nexin-11 Human genes 0.000 claims 6
- 102100037608 Spectrin alpha chain, erythrocytic 1 Human genes 0.000 claims 6
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 6
- 102100026224 Transmembrane and immunoglobulin domain-containing protein 2 Human genes 0.000 claims 6
- 102100028839 Transmembrane protein 79 Human genes 0.000 claims 6
- 102100030303 Tubulin beta-6 chain Human genes 0.000 claims 6
- 102100039647 YTH domain-containing family protein 1 Human genes 0.000 claims 6
- 102100023494 Zinc finger protein ZIC 5 Human genes 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 210000000481 breast Anatomy 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 238000003018 immunoassay Methods 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 5
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 4
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 238000001574 biopsy Methods 0.000 claims 3
- 210000001124 body fluid Anatomy 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000011984 electrochemiluminescence immunoassay Methods 0.000 claims 2
- 229960000439 eribulin mesylate Drugs 0.000 claims 2
- 125000003106 haloaryl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000006720 (C1-C6) alkyl (C6-C10) aryl group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 238000000636 Northern blotting Methods 0.000 claims 1
- 238000012341 Quantitative reverse-transcriptase PCR Methods 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 238000002875 fluorescence polarization Methods 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 125000005027 hydroxyaryl group Chemical group 0.000 claims 1
- 230000000951 immunodiffusion Effects 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 238000001114 immunoprecipitation Methods 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000000019 nipple aspirate fluid Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 238000012340 reverse transcriptase PCR Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161454426P | 2011-03-18 | 2011-03-18 | |
| US61/454,426 | 2011-03-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017046070A Division JP6612280B2 (ja) | 2011-03-18 | 2017-03-10 | エリブリンに対する応答を予測するための方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019150027A JP2019150027A (ja) | 2019-09-12 |
| JP2019150027A5 true JP2019150027A5 (https=) | 2019-12-26 |
Family
ID=45879070
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558214A Pending JP2014509515A (ja) | 2011-03-18 | 2012-03-16 | エリブリンに対する応答を予測するための方法及び組成物 |
| JP2017046070A Expired - Fee Related JP6612280B2 (ja) | 2011-03-18 | 2017-03-10 | エリブリンに対する応答を予測するための方法及び組成物 |
| JP2019069638A Pending JP2019150027A (ja) | 2011-03-18 | 2019-04-01 | エリブリンに対する応答を予測するための方法及び組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558214A Pending JP2014509515A (ja) | 2011-03-18 | 2012-03-16 | エリブリンに対する応答を予測するための方法及び組成物 |
| JP2017046070A Expired - Fee Related JP6612280B2 (ja) | 2011-03-18 | 2017-03-10 | エリブリンに対する応答を予測するための方法及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9637795B2 (https=) |
| EP (1) | EP2686441B1 (https=) |
| JP (3) | JP2014509515A (https=) |
| CN (1) | CN103562406B (https=) |
| CA (1) | CA2828959A1 (https=) |
| ES (1) | ES2731653T3 (https=) |
| SG (2) | SG193489A1 (https=) |
| WO (1) | WO2012129100A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2593027T3 (es) | 2009-03-30 | 2016-12-05 | Eisai R&D Management Co., Ltd. | Composición liposomal |
| MX2015007185A (es) * | 2012-12-04 | 2017-09-05 | Eisai R&D Man Co Ltd | Uso de eribulina en el tratamiento de cancer de pecho. |
| KR102265952B1 (ko) * | 2013-06-26 | 2021-06-16 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 암 치료 병용요법으로서 에리불린 및 렌바티닙의 용도 |
| US10238630B2 (en) | 2014-05-28 | 2019-03-26 | Eisai R&D Management Co., Ltd. | Use of eribulin and poly (ADP ribose) polymerase (PARP) inhibitors as combination therapy for the treatment of cancer |
| RU2699545C2 (ru) * | 2014-05-28 | 2019-09-06 | ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД | Применение эрибулина в лечении рака |
| CA2978311A1 (en) | 2015-03-04 | 2016-09-09 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and eribulin for treating cancer |
| US10669545B2 (en) | 2015-05-01 | 2020-06-02 | Japan Science And Technology Agency | Tumor cell malignant transformation suppressor and anti-tumor agent |
| EP3423105B1 (en) | 2016-03-02 | 2021-05-05 | Eisai R&D Management Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
| US12029724B2 (en) | 2016-04-28 | 2024-07-09 | Eisai R&D Management Co., Ltd. | Method for inhibiting tumor growth |
| US11419856B2 (en) | 2017-11-20 | 2022-08-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| WO2020179712A1 (en) * | 2019-03-01 | 2020-09-10 | Eisai R&D Management Co., Ltd. | Methods for predicting tumor response to eribulin |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US11083705B2 (en) | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| CN113174427B (zh) * | 2021-04-29 | 2023-02-28 | 遵义医科大学 | 基于DNA分子检测ERGIC3 mRNA的方法 |
| CN113512733B (zh) * | 2021-05-13 | 2022-07-26 | 浙江工业大学 | 一种电化学nhk反应合成艾日布林中间体的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5075216A (en) | 1988-09-23 | 1991-12-24 | Cetus Corporation | Methods for dna sequencing with thermus aquaticus dna polymerase |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| DE69233501T2 (de) | 1991-11-22 | 2006-02-23 | Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara | Kombinatorische Strategien für die Polymersynthese |
| CA2153387A1 (en) | 1993-01-07 | 1994-07-21 | Hubert Koester | Dna sequencing by mass spectrometry |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| EP1027456B1 (en) | 1997-10-31 | 2005-03-16 | Affymetrix, Inc. (a Delaware Corporation) | Expression profiles in adult and fetal organs |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6214865B1 (en) | 1998-06-17 | 2001-04-10 | Eisai Co., Ltd. | Macrocyclic analogs and methods of their use and preparation |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| WO2005032347A2 (en) * | 2003-10-01 | 2005-04-14 | The Ohio State University Research Foundation | Determining the chemosensitivity of cells to cytotoxic agents |
| EP1831697A4 (en) * | 2004-12-09 | 2011-01-26 | Eisai R&D Man Co Ltd | SEARCH FOR TUBULINISOTYPES IN CANCER THERAPY USING HALICHONDRIN B ANALOG |
| WO2011109637A1 (en) * | 2010-03-03 | 2011-09-09 | Koo Foundation Sun Yat-Sen Cancer Center | Methods for classifying and treating breast cancers |
-
2012
- 2012-03-16 EP EP12710643.3A patent/EP2686441B1/en active Active
- 2012-03-16 ES ES12710643T patent/ES2731653T3/es active Active
- 2012-03-16 CA CA2828959A patent/CA2828959A1/en not_active Abandoned
- 2012-03-16 JP JP2013558214A patent/JP2014509515A/ja active Pending
- 2012-03-16 US US14/001,737 patent/US9637795B2/en not_active Expired - Fee Related
- 2012-03-16 SG SG2013069646A patent/SG193489A1/en unknown
- 2012-03-16 CN CN201280013701.8A patent/CN103562406B/zh not_active Expired - Fee Related
- 2012-03-16 SG SG10201602147YA patent/SG10201602147YA/en unknown
- 2012-03-16 WO PCT/US2012/029479 patent/WO2012129100A1/en not_active Ceased
-
2017
- 2017-03-10 JP JP2017046070A patent/JP6612280B2/ja not_active Expired - Fee Related
-
2019
- 2019-04-01 JP JP2019069638A patent/JP2019150027A/ja active Pending
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