JP2014509515A - エリブリンに対する応答を予測するための方法及び組成物 - Google Patents

エリブリンに対する応答を予測するための方法及び組成物 Download PDF

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JP2014509515A
JP2014509515A JP2013558214A JP2013558214A JP2014509515A JP 2014509515 A JP2014509515 A JP 2014509515A JP 2013558214 A JP2013558214 A JP 2013558214A JP 2013558214 A JP2013558214 A JP 2013558214A JP 2014509515 A JP2014509515 A JP 2014509515A
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biomarker
eribulin
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expression level
breast cancer
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JP2014509515A5 (https=
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アゴウルニク，セルゲイ・アイ
バーン，マイケル・チヤツプマン
リトルフイールド，ブルース・エイ
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biotechnology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
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JP2013558214A 2011-03-18 2012-03-16 エリブリンに対する応答を予測するための方法及び組成物 Pending JP2014509515A (ja)

Applications Claiming Priority (3)

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US201161454426P 2011-03-18 2011-03-18
US61/454,426 2011-03-18
PCT/US2012/029479 WO2012129100A1 (en) 2011-03-18 2012-03-16 Methods and compositions for predicting response to eribulin

Related Child Applications (1)

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JP2017046070A Division JP6612280B2 (ja) 2011-03-18 2017-03-10 エリブリンに対する応答を予測するための方法及び組成物

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JP2014509515A true JP2014509515A (ja) 2014-04-21
JP2014509515A5 JP2014509515A5 (https=) 2015-04-23

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JP2013558214A Pending JP2014509515A (ja) 2011-03-18 2012-03-16 エリブリンに対する応答を予測するための方法及び組成物
JP2017046070A Expired - Fee Related JP6612280B2 (ja) 2011-03-18 2017-03-10 エリブリンに対する応答を予測するための方法及び組成物
JP2019069638A Pending JP2019150027A (ja) 2011-03-18 2019-04-01 エリブリンに対する応答を予測するための方法及び組成物

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JP2017046070A Expired - Fee Related JP6612280B2 (ja) 2011-03-18 2017-03-10 エリブリンに対する応答を予測するための方法及び組成物
JP2019069638A Pending JP2019150027A (ja) 2011-03-18 2019-04-01 エリブリンに対する応答を予測するための方法及び組成物

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US (1) US9637795B2 (https=)
EP (1) EP2686441B1 (https=)
JP (3) JP2014509515A (https=)
CN (1) CN103562406B (https=)
CA (1) CA2828959A1 (https=)
ES (1) ES2731653T3 (https=)
SG (2) SG193489A1 (https=)
WO (1) WO2012129100A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501213A (ja) * 2012-12-04 2016-01-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 乳がんの処置におけるエリブリンの使用
WO2016178374A1 (ja) * 2015-05-01 2016-11-10 国立研究開発法人科学技術振興機構 腫瘍細胞の悪性化抑制剤及び抗腫瘍剤
WO2020179712A1 (en) * 2019-03-01 2020-09-10 Eisai R&D Management Co., Ltd. Methods for predicting tumor response to eribulin

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102369008B (zh) 2009-03-30 2014-10-29 卫材R&D管理有限公司 脂质体组合物
BR112015029386B1 (pt) * 2013-06-26 2023-11-14 Eisai R&D Management Co., Ltd. Uso de eribulina e lenvatinibe como terapia de combinação e kit
US20170100367A1 (en) * 2014-05-28 2017-04-13 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of cancer
WO2015184145A1 (en) * 2014-05-28 2015-12-03 Eisai R&D Management Co., Ltd. Use of eribulin and poly (adp ribose) polymerase (parp) inhibitors as combination therapy for the treatment of cancer
AU2016226157B2 (en) * 2015-03-04 2022-01-27 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and eribulin for treating cancer
PE20231050A1 (es) 2016-03-02 2023-07-11 Eisai Randd Man Co Ltd Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso
WO2017188350A1 (ja) 2016-04-28 2017-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍の成長を抑制する方法
WO2019097073A1 (en) 2017-11-20 2019-05-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN113174427B (zh) * 2021-04-29 2023-02-28 遵义医科大学 基于DNA分子检测ERGIC3 mRNA的方法
CN113512733B (zh) * 2021-05-13 2022-07-26 浙江工业大学 一种电化学nhk反应合成艾日布林中间体的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032347A2 (en) * 2003-10-01 2005-04-14 The Ohio State University Research Foundation Determining the chemosensitivity of cells to cytotoxic agents
JP2008522623A (ja) * 2004-12-09 2008-07-03 エーザイ株式会社 ハリコンドリンｂアナログを使用した癌治療でのチューブリンアイソタイプのスクリーニング

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5075216A (en) 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
DE69433811T2 (de) 1993-01-07 2005-06-23 Sequenom, Inc., San Diego Dns - sequenzierung durch massenspektronomie
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
DE69829402T2 (de) 1997-10-31 2006-04-13 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Expressionsprofile in adulten und fötalen organen
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
JP4454151B2 (ja) 1998-06-17 2010-04-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 大環状類似体及びそれらの使用並びに調製方法
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
TW201132813A (en) * 2010-03-03 2011-10-01 Koo Foundation Sun Yat Sen Cancer Ct Methods for classifying and treating breast cancers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032347A2 (en) * 2003-10-01 2005-04-14 The Ohio State University Research Foundation Determining the chemosensitivity of cells to cytotoxic agents
JP2008522623A (ja) * 2004-12-09 2008-07-03 エーザイ株式会社 ハリコンドリンｂアナログを使用した癌治療でのチューブリンアイソタイプのスクリーニング

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6016004230; Ｔｈｅ　Ｌａｎｃｅｔ Ｖｏｌ．３７７, 20110312, ｐ．９１４-９２３ *
JPN6016004232; Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ Ｖｏｌ．６１, 2001, ｐ．１０１３-１０２１ *
JPN6016004234; Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｏｎｃｏｌｏｇｙ Ｖｏｌ．２８，　Ｎｏ．２５, 2010, ｐ．３９２２-３９２８ *
JPN6016004236; Ｎａｔｕｒｅ Ｖｏｌ．４４６, 2007, ｐ．８１５-８１９ *
JPN6016004238; Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ Ｖｏｌ．１３８, 2010, ｐ．９４９-９５７ *
JPN6016004240; Ｅｘｐｅｒｔ　Ｏｐｉｎｉｏｎ　ｏｎ　Ｐｈａｒｍａｃｏｔｈｅｒａｐｙ Ｖｏｌ．１１，　Ｎｏ．９, 2010, ｐ．１５８７-１５９３ *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501213A (ja) * 2012-12-04 2016-01-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 乳がんの処置におけるエリブリンの使用
WO2016178374A1 (ja) * 2015-05-01 2016-11-10 国立研究開発法人科学技術振興機構 腫瘍細胞の悪性化抑制剤及び抗腫瘍剤
US10669545B2 (en) 2015-05-01 2020-06-02 Japan Science And Technology Agency Tumor cell malignant transformation suppressor and anti-tumor agent
WO2020179712A1 (en) * 2019-03-01 2020-09-10 Eisai R&D Management Co., Ltd. Methods for predicting tumor response to eribulin

Also Published As

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US20140235707A1 (en) 2014-08-21
CN103562406A (zh) 2014-02-05
ES2731653T3 (es) 2019-11-18
US9637795B2 (en) 2017-05-02
JP2019150027A (ja) 2019-09-12
WO2012129100A1 (en) 2012-09-27
SG193489A1 (en) 2013-10-30
EP2686441B1 (en) 2019-05-08
JP2017148049A (ja) 2017-08-31
JP6612280B2 (ja) 2019-11-27
CA2828959A1 (en) 2012-09-27
EP2686441A1 (en) 2014-01-22
SG10201602147YA (en) 2016-05-30
CN103562406B (zh) 2018-03-27

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