JP2019076785A - 抗菌組成物を含む創傷被覆材 - Google Patents
抗菌組成物を含む創傷被覆材 Download PDFInfo
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- JP2019076785A JP2019076785A JP2019017869A JP2019017869A JP2019076785A JP 2019076785 A JP2019076785 A JP 2019076785A JP 2019017869 A JP2019017869 A JP 2019017869A JP 2019017869 A JP2019017869 A JP 2019017869A JP 2019076785 A JP2019076785 A JP 2019076785A
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- Prior art keywords
- wound dressing
- weight
- antimicrobial
- dressing according
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 37
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- 239000004599 antimicrobial Substances 0.000 claims abstract description 23
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 18
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
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- 238000000034 method Methods 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- -1 dimethyldialkynium Chemical compound 0.000 claims description 12
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- 239000004332 silver Substances 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 9
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
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- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 4
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- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 claims description 3
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims description 2
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- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims description 2
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- 239000011651 chromium Substances 0.000 claims description 2
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
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- 239000011701 zinc Substances 0.000 claims description 2
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- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
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- 229920003043 Cellulose fiber Polymers 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 6
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- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 4
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- 230000003111 delayed effect Effects 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
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- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
Description
本願は、出典明示によりその全体が本明細書に取り込まれる2013年5月15日出願のGB1308770.5の優先権の利益を請求するものである。
第四級陽イオン界面活性剤を製剤中に含むことによって抗菌性金属イオンの有効性を高めることが知られている。WO2012/136968は、抗菌性金属イオンおよび第四級陽イオン界面活性剤の供給源を含む、皮膚および創傷における使用に適する抗菌組成物を開示している。
本発明による銀を含有する創傷被覆材の抗張力における含水率の効果。
包装された環境で前処理することなく試験した;
0湿度:シリカゲル乾燥剤の上に3つの穴の開いたパースペクスシェルフの備わった四角形デシケーター中で保存し、最低5日間条件付けし;
続いて、湿度制御室(Source Bioscience Ltd.)中で最低6日間保存した:
25+2℃/60+5%RH
30+2℃/65%+5RH
40+2℃/75%+5RH。
試料のLODは、Ohaus水分計MB23を用いて取扱説明書に従って操作して測定した。1グラム以上の試料質量を用いた。試料を計量パン内に合わせて切断し、発熱体からの適当な間隔を確保した。標準化された方法を110℃の最大温度限界で用いた。終点は、試料質量が減少しなくなり、安定した場合に機械的に決定した。これらの条件下で繊維は焦げなかった。典型的に、試料を10分間隔でかけた。
試料は、Hampden Soft Materials Thickness Gauge,Model FMTml−4D,S/N 14082を用いて試験した。繊維の厚さ(ロフトとも呼ばれることがある)を1つのバッチにつき6つの被覆材について測定した。
2.5cmx7.5cmの長方形短冊片は、リボン切断ダイスおよびプレスを用いて長さ(機械方向)に沿って横幅(横断方向)に切断した。試料を表に記載されるような条件とした。50mmの試験の長さを1分あたり100mmの一定の分離速度で広げた場合、ピーク力およびその力が起こす伸展を記録した。
本発明による銀を含有する創傷被覆材の実施例のなじみ性における含水率の効果
材料:
試験被覆材:
AQUACEL Ag(市販品),吸収性ゲル化繊維状フェルト被覆材(1.2w/w% イオン化銀を含有)
Lot 1G 00157 5cmx5cm
Lot 1H 03025 10cmx10cm
Lot 1E 02908 15cmx15cm
Lot 1H 01291B 5cmx5cm
Lot 1H 01302B+C 10cmx10cm
Lot 1H 01303D 15cmx15cm
Lot 1H 01251C+D 20cmx30cm
本発明によるAQUACEL Agの試料(EDTA二ナトリウムおよび塩化ベンゼトニウムを含む抗菌組成物で処理)は、実施例1の方法で調製した。
Lot 1H 01291B 5cmx5cm LOD 12%
Lot 1H 01302B+C 10cmx10cm LOD 11%
Lot 1H 01303D 15cmx15cm LOD 11%
Lot 1H 01251C+D 20cmx30cm LOD 11%
(A)比較対照よりはるかに良好
(B)比較対照より良好
(C)比較対照と同一
(D)比較対照より悪い
(E)比較対照よりはるかに悪い
Claims (14)
- 抗菌性金属イオンおよび第四級陽イオン界面活性剤の供給源を含む抗菌組成物で処理した修飾セルロース系繊維を含む、包装された創傷被覆材であって、10重量%〜20重量%の含水率を有する創傷被覆材。
- 前記包装が、前記被覆材の含水率を使用時まで10%〜20%の範囲に保持するものである、請求項1に記載の創傷被覆材。
- 前記抗菌性金属イオンが、遷移金属、特に、銀、鉄、ニッケル、銅、クロム、マンガン、金、ガリウム、水銀、鉛、アルミニウム、鉛、亜鉛、ビスマス、スズ、およびパラジウムの群またはこれらの組み合わせから選択されるものである、請求項1または請求項2に記載の創傷被覆材。
- 前記金属イオンが、銀イオンである、請求項1〜3のいずれか1項に記載の創傷被覆材。
- 前記金属イオンが、0.01重量%〜10重量%、より好ましくは、0.1重量%〜5重量%、さらにより好ましくは、0.5重量%〜1.5重量%のレベルで被覆材中に含まれるものである、請求項1〜4のいずれか1項に記載の創傷被覆材。
- 前記第四級陽イオン界面活性剤が、第四級アンモニウム界面活性剤である、請求項1〜5のいずれか1項に記載の創傷被覆材。
- 前記陽イオン界面活性剤が、ベンゼトニウム、ベンザルコニウム、ジメチルジアルキロニウム、アルキルピリジニウムまたはアルキルトリメチルアンモニウムである陽イオンの塩の群から選択されるものである、請求項1〜6のいずれか1項に記載の創傷被覆材。
- 二、三または四塩基性塩として存在するEDTAのようなキレート剤をさらに含むものである、請求項1〜7のいずれか1項に記載の創傷被覆材。
- 前記金属キレート剤が、0.1重量%〜4重量%、より好ましくは、2重量%以下、より好ましくは、0.2〜1重量%のレベルで被覆材中に存在するものである、請求項8に記載の創傷被覆材。
- 前記含水率が、11重量%〜18重量%である、請求項1〜9のいずれか1項に記載の創傷被覆材。
- 前記含水率が、11.5重量%〜15重量%である、請求項1〜10のいずれか1項に記載の創傷被覆材。
- 前記含水率が、11.5重量%〜13重量%である、請求項1〜11のいずれか1項に記載の創傷被覆材。
- 請求項1〜12のいずれか1項に記載の創傷被覆材の製造方法。
- 請求項1〜12のいずれか1項に記載の創傷被覆材を供することを含む、創傷被覆材のなじみ性を保持するための方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1308770.5A GB201308770D0 (en) | 2013-05-15 | 2013-05-15 | Wound Dressing Comprising an Antimicrobial Composition |
GB1308770.5 | 2013-05-15 |
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CL (1) | CL2015003274A1 (ja) |
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GB (1) | GB201308770D0 (ja) |
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GB2533975A (en) * | 2014-12-30 | 2016-07-13 | Trio Healthcare Ltd | Antibiofilm compositions |
FR3037788B1 (fr) | 2015-06-29 | 2022-01-21 | Urgo Lab | Nouveau pansement absorbant antimicrobien |
GB201607814D0 (en) * | 2016-05-04 | 2016-06-15 | 5D Health Prot Group Ltd | Anti-microbial compositions |
WO2018023021A1 (en) | 2016-07-29 | 2018-02-01 | Imbed Biosciences Inc. | Methods and compositions for wound healing |
KR102090576B1 (ko) | 2018-02-26 | 2020-03-18 | 주식회사 엔도비전 | 상처치료용 다층 드레싱재 |
US20210046163A1 (en) * | 2019-08-12 | 2021-02-18 | Bioregentech, Inc. | Therapeutic systems, devices, and compositions with wound healing and tissue regenerative properties, uses thereof, and corresponding methods |
CN111450304A (zh) * | 2020-03-17 | 2020-07-28 | 青岛博益特生物材料股份有限公司 | 一种带正电荷生物纤维止血抑菌材料及其制备方法和应用 |
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Also Published As
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RU2015153446A (ru) | 2017-06-20 |
ZA201508002B (en) | 2019-06-26 |
KR20160010546A (ko) | 2016-01-27 |
CA2910285A1 (en) | 2014-11-20 |
CN112957513A (zh) | 2021-06-15 |
CN105407930A (zh) | 2016-03-16 |
PL2996730T3 (pl) | 2021-08-02 |
CA2910285C (en) | 2022-03-01 |
EP2996730A1 (en) | 2016-03-23 |
TWI653059B (zh) | 2019-03-11 |
DK2996730T3 (da) | 2021-05-25 |
EP2996730A4 (en) | 2017-01-11 |
JP6845267B2 (ja) | 2021-03-17 |
WO2014186590A1 (en) | 2014-11-20 |
CL2015003274A1 (es) | 2016-09-02 |
ES2897373T3 (es) | 2022-02-28 |
EP2996730B1 (en) | 2021-02-24 |
TW201521797A (zh) | 2015-06-16 |
GB201308770D0 (en) | 2013-06-26 |
JP2016519966A (ja) | 2016-07-11 |
US20160101207A1 (en) | 2016-04-14 |
AU2014265336B2 (en) | 2018-04-12 |
AR096313A1 (es) | 2015-12-23 |
AU2018205129A1 (en) | 2018-07-26 |
MX2015015197A (es) | 2016-03-04 |
AU2014265336A1 (en) | 2015-11-12 |
BR112015028703A2 (pt) | 2017-07-25 |
JP6738727B2 (ja) | 2020-08-12 |
US20220233741A1 (en) | 2022-07-28 |
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