JP6845267B2 - 抗菌組成物を含む創傷被覆材 - Google Patents
抗菌組成物を含む創傷被覆材 Download PDFInfo
- Publication number
- JP6845267B2 JP6845267B2 JP2019017869A JP2019017869A JP6845267B2 JP 6845267 B2 JP6845267 B2 JP 6845267B2 JP 2019017869 A JP2019017869 A JP 2019017869A JP 2019017869 A JP2019017869 A JP 2019017869A JP 6845267 B2 JP6845267 B2 JP 6845267B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- wound dressing
- dressing
- antibacterial
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 38
- 239000000203 mixture Substances 0.000 title claims description 36
- 239000000835 fiber Substances 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 18
- 229910021645 metal ion Inorganic materials 0.000 claims description 16
- 239000003093 cationic surfactant Substances 0.000 claims description 15
- 239000011248 coating agent Substances 0.000 claims description 15
- 238000000576 coating method Methods 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 13
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 10
- 229910052709 silver Inorganic materials 0.000 claims description 9
- 239000004332 silver Substances 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 229920002678 cellulose Polymers 0.000 claims description 7
- 239000001913 cellulose Substances 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 229960001950 benzethonium chloride Drugs 0.000 claims description 5
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 3
- 239000004611 light stabiliser Substances 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 description 43
- 208000027418 Wounds and injury Diseases 0.000 description 43
- 238000000034 method Methods 0.000 description 12
- 239000003242 anti bacterial agent Substances 0.000 description 11
- 229920003043 Cellulose fiber Polymers 0.000 description 8
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 8
- 239000003960 organic solvent Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000007613 environmental effect Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- -1 alkyl sulfonic acid Chemical compound 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 230000001143 conditioned effect Effects 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 230000004580 weight loss Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 206010048038 Wound infection Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009960 carding Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical class C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 208000035874 Excoriation Diseases 0.000 description 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000005227 alkyl sulfonate group Chemical group 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- 229960003872 benzethonium Drugs 0.000 description 1
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 229940006460 bromide ion Drugs 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 229940106681 chloroacetic acid Drugs 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 231100000749 chronicity Toxicity 0.000 description 1
- 229940069078 citric acid / sodium citrate Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 229910052733 gallium Inorganic materials 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000001937 non-anti-biotic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000012785 packaging film Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000176 photostabilization Effects 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940023144 sodium glycolate Drugs 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
本願は、出典明示によりその全体が本明細書に取り込まれる2013年5月15日出願のGB1308770.5の優先権の利益を請求するものである。
第四級陽イオン界面活性剤を製剤中に含むことによって抗菌性金属イオンの有効性を高めることが知られている。WO2012/136968は、抗菌性金属イオンおよび第四級陽イオン界面活性剤の供給源を含む、皮膚および創傷における使用に適する抗菌組成物を開示している。
本発明による銀を含有する創傷被覆材の抗張力における含水率の効果。
包装された環境で前処理することなく試験した;
0湿度:シリカゲル乾燥剤の上に3つの穴の開いたパースペクスシェルフの備わった四角形デシケーター中で保存し、最低5日間条件付けし;
続いて、湿度制御室(Source Bioscience Ltd.)中で最低6日間保存した:
25+2℃/60+5%RH
30+2℃/65%+5RH
40+2℃/75%+5RH。
試料のLODは、Ohaus水分計MB23を用いて取扱説明書に従って操作して測定した。1グラム以上の試料質量を用いた。試料を計量パン内に合わせて切断し、発熱体からの適当な間隔を確保した。標準化された方法を110℃の最大温度限界で用いた。終点は、試料質量が減少しなくなり、安定した場合に機械的に決定した。これらの条件下で繊維は焦げなかった。典型的に、試料を10分間隔でかけた。
試料は、Hampden Soft Materials Thickness Gauge,Model FMTml−4D,S/N 14082を用いて試験した。繊維の厚さ(ロフトとも呼ばれることがある)を1つのバッチにつき6つの被覆材について測定した。
2.5cmx7.5cmの長方形短冊片は、リボン切断ダイスおよびプレスを用いて長さ(機械方向)に沿って横幅(横断方向)に切断した。試料を表に記載されるような条件とした。50mmの試験の長さを1分あたり100mmの一定の分離速度で広げた場合、ピーク力およびその力が起こす伸展を記録した。
本発明による銀を含有する創傷被覆材の実施例のなじみ性における含水率の効果
材料:
試験被覆材:
AQUACEL Ag(市販品),吸収性ゲル化繊維状フェルト被覆材(1.2w/w% イオン化銀を含有)
Lot 1G 00157 5cmx5cm
Lot 1H 03025 10cmx10cm
Lot 1E 02908 15cmx15cm
Lot 1H 01291B 5cmx5cm
Lot 1H 01302B+C 10cmx10cm
Lot 1H 01303D 15cmx15cm
Lot 1H 01251C+D 20cmx30cm
本発明によるAQUACEL Agの試料(EDTA二ナトリウムおよび塩化ベンゼトニウムを含む抗菌組成物で処理)は、実施例1の方法で調製した。
Lot 1H 01291B 5cmx5cm LOD 12%
Lot 1H 01302B+C 10cmx10cm LOD 11%
Lot 1H 01303D 15cmx15cm LOD 11%
Lot 1H 01251C+D 20cmx30cm LOD 11%
(A)比較対照よりはるかに良好
(B)比較対照より良好
(C)比較対照と同一
(D)比較対照より悪い
(E)比較対照よりはるかに悪い
Claims (10)
- 抗菌組成物を含有する修飾セルロース系繊維を含む、包装された創傷被覆材であって、前記抗菌組成物が、抗菌性金属イオン、金属キレート剤、ポリソルベート 20、および前記ポリソルベート 20に加えて0.1重量%〜2重量%の塩化ベンゼトニウムを含む第四級陽イオン界面活性剤の供給源を含み、前記抗菌性金属イオンが、0.01重量%〜10重量%のレベルの銀であり、前記創傷被覆材が、10重量%〜20重量%の含水率を有するものであり、前記被覆材の含水率を使用時まで10重量%〜20重量%の範囲に保持するように包装されたものである、創傷被覆材。
- 前記包装が、前記抗菌組成物を含有し、かつ10重量%未満の含水率を有する修飾セルロース系繊維を含む創傷被覆材と比較して、改善した抗張力を有する、請求項1に記載の創傷被覆材。
- 光安定化剤をさらに含む、請求項1または2に記載の創傷被覆材。
- 前記抗菌性金属イオンが、0.5重量%〜1.5重量%のレベルで前記被覆材中に存在するものである、請求項1〜3のいずれか1項に記載の創傷被覆材。
- 前記第四級陽イオン界面活性剤が、第四級アンモニウム界面活性剤を含む、請求項1〜4のいずれか1項に記載の創傷被覆材。
- 前記金属キレート剤が、二、三または四塩基性塩として存在するEDTAである、請求項1〜5のいずれか1項に記載の創傷被覆材。
- 前記金属キレート剤が、0.1重量%〜4重量%、2重量%以下、または0.2〜1重量%のレベルで前記被覆材中に存在するものである、請求項1〜6のいずれか1項に記載の創傷被覆材。
- 前記含水率が、11重量%〜18重量%である、請求項1〜7のいずれか1項に記載の創傷被覆材。
- 前記含水率が、11.5重量%〜15重量%である、請求項1〜8のいずれか1項に記載の創傷被覆材。
- 前記含水率が、11.5重量%〜13重量%である、請求項1〜9のいずれか1項に記載の創傷被覆材。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1308770.5A GB201308770D0 (en) | 2013-05-15 | 2013-05-15 | Wound Dressing Comprising an Antimicrobial Composition |
GB1308770.5 | 2013-05-15 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016514095A Division JP6738727B2 (ja) | 2013-05-15 | 2014-05-15 | 抗菌組成物を含む創傷被覆材 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019076785A JP2019076785A (ja) | 2019-05-23 |
JP6845267B2 true JP6845267B2 (ja) | 2021-03-17 |
Family
ID=48700854
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016514095A Active JP6738727B2 (ja) | 2013-05-15 | 2014-05-15 | 抗菌組成物を含む創傷被覆材 |
JP2019017869A Active JP6845267B2 (ja) | 2013-05-15 | 2019-02-04 | 抗菌組成物を含む創傷被覆材 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016514095A Active JP6738727B2 (ja) | 2013-05-15 | 2014-05-15 | 抗菌組成物を含む創傷被覆材 |
Country Status (19)
Country | Link |
---|---|
US (2) | US20160101207A1 (ja) |
EP (1) | EP2996730B1 (ja) |
JP (2) | JP6738727B2 (ja) |
KR (1) | KR20160010546A (ja) |
CN (2) | CN105407930A (ja) |
AR (1) | AR096313A1 (ja) |
AU (2) | AU2014265336B2 (ja) |
BR (1) | BR112015028703A2 (ja) |
CA (1) | CA2910285C (ja) |
CL (1) | CL2015003274A1 (ja) |
DK (1) | DK2996730T3 (ja) |
ES (1) | ES2897373T3 (ja) |
GB (1) | GB201308770D0 (ja) |
MX (1) | MX2015015197A (ja) |
PL (1) | PL2996730T3 (ja) |
RU (1) | RU2015153446A (ja) |
TW (1) | TWI653059B (ja) |
WO (1) | WO2014186590A1 (ja) |
ZA (1) | ZA201508002B (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0525504D0 (en) | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
EP2935688A2 (en) | 2012-12-20 | 2015-10-28 | ConvaTec Technologies Inc. | Processing of chemically modified cellulosic fibres |
GB2533975A (en) * | 2014-12-30 | 2016-07-13 | Trio Healthcare Ltd | Antibiofilm compositions |
FR3037788B1 (fr) * | 2015-06-29 | 2022-01-21 | Urgo Lab | Nouveau pansement absorbant antimicrobien |
GB201607814D0 (en) * | 2016-05-04 | 2016-06-15 | 5D Health Prot Group Ltd | Anti-microbial compositions |
KR20240025050A (ko) | 2016-07-29 | 2024-02-26 | 임베드 바이오사이언시스 아이엔씨. | 상처 치유를 위한 방법 및 조성물 |
KR102090576B1 (ko) | 2018-02-26 | 2020-03-18 | 주식회사 엔도비전 | 상처치료용 다층 드레싱재 |
US20210046163A1 (en) * | 2019-08-12 | 2021-02-18 | Bioregentech, Inc. | Therapeutic systems, devices, and compositions with wound healing and tissue regenerative properties, uses thereof, and corresponding methods |
CN111450304A (zh) * | 2020-03-17 | 2020-07-28 | 青岛博益特生物材料股份有限公司 | 一种带正电荷生物纤维止血抑菌材料及其制备方法和应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9126193D0 (en) * | 1991-12-10 | 1992-02-12 | Courtaulds Plc | Cellulosic fibres |
US5762620A (en) * | 1992-04-02 | 1998-06-09 | Ndm Acquisition Corp. | Wound dressing containing a partially dehydrated hydrogel |
GB9301258D0 (en) * | 1993-01-22 | 1993-03-17 | Courtaulds Plc | Use of absorbent fibre |
WO1994016746A1 (en) * | 1993-01-22 | 1994-08-04 | Courtaulds Plc | Wound dressings |
ATE184474T1 (de) * | 1993-11-01 | 1999-10-15 | Hartmann Paul Ag | Wundverband und seine verpackung |
DE19909214A1 (de) * | 1999-03-03 | 2000-09-07 | Basf Ag | Wasserabsorbierende, schaumförmige, vernetzte Polymerisate mit verbesserter Verteilungswirkung, Verfahren zu ihrer Herstellung und ihre Verwendung |
GB2370226A (en) * | 2000-09-21 | 2002-06-26 | Acordis Speciality Fibres Ltd | Wound dressing |
GB2382527A (en) * | 2001-12-03 | 2003-06-04 | Acordis Speciality Fibres Ltd | Wound dressings |
US20060115440A1 (en) * | 2004-09-07 | 2006-06-01 | Arata Andrew B | Silver dihydrogen citrate compositions |
US9826770B2 (en) * | 2005-03-10 | 2017-11-28 | 3M Innovative Properties Company | Antimicrobial compositions comprising esters of hydroxycarboxylic acids |
GB0513552D0 (en) * | 2005-07-01 | 2005-08-10 | Bristol Myers Squibb Co | Bandage |
GB0525504D0 (en) * | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
WO2007120608A2 (en) * | 2006-04-11 | 2007-10-25 | Tyco Healthcare Group Lp | Wound dressings with anti-microbial and chelating agents |
JP4826382B2 (ja) * | 2006-08-08 | 2011-11-30 | アルケア株式会社 | 抗菌性セルロース繊維及び皮膚接触用繊維製品 |
EP1925719B1 (en) * | 2006-09-21 | 2011-11-09 | Alcare Co., Ltd. | Antibacterial fiber, method for production of the fiber, antibacterial fiber product comprising the antibacterial fiber, method for production of the product, and method for regeneration of the product |
GB0710846D0 (en) * | 2007-06-06 | 2007-07-18 | Bristol Myers Squibb Co | A wound dressing |
GB0805162D0 (en) * | 2008-03-19 | 2008-04-23 | Bristol Myers Squibb Co | Antibacterial wound dressing |
US20110237994A1 (en) * | 2010-03-25 | 2011-09-29 | Combat Medical Systems, Llc | Void-filling wound dressing |
GB201105829D0 (en) * | 2011-04-06 | 2011-05-18 | Convatec Technologies Inc | Antimicrobial compositions |
EP2976095B1 (en) * | 2013-03-15 | 2020-12-23 | 3M Innovative Properties Company | Wound healing compositions |
-
2013
- 2013-05-15 GB GBGB1308770.5A patent/GB201308770D0/en not_active Ceased
-
2014
- 2014-05-15 ES ES14797983T patent/ES2897373T3/es active Active
- 2014-05-15 KR KR1020157035527A patent/KR20160010546A/ko not_active Application Discontinuation
- 2014-05-15 CA CA2910285A patent/CA2910285C/en active Active
- 2014-05-15 EP EP14797983.5A patent/EP2996730B1/en active Active
- 2014-05-15 US US14/889,818 patent/US20160101207A1/en not_active Abandoned
- 2014-05-15 JP JP2016514095A patent/JP6738727B2/ja active Active
- 2014-05-15 DK DK14797983.5T patent/DK2996730T3/da active
- 2014-05-15 TW TW103117207A patent/TWI653059B/zh not_active IP Right Cessation
- 2014-05-15 MX MX2015015197A patent/MX2015015197A/es unknown
- 2014-05-15 CN CN201480028155.4A patent/CN105407930A/zh active Pending
- 2014-05-15 AU AU2014265336A patent/AU2014265336B2/en active Active
- 2014-05-15 RU RU2015153446A patent/RU2015153446A/ru not_active Application Discontinuation
- 2014-05-15 WO PCT/US2014/038224 patent/WO2014186590A1/en active Application Filing
- 2014-05-15 BR BR112015028703A patent/BR112015028703A2/pt not_active Application Discontinuation
- 2014-05-15 CN CN202110186761.0A patent/CN112957513A/zh active Pending
- 2014-05-15 AR ARP140101954A patent/AR096313A1/es unknown
- 2014-05-15 PL PL14797983T patent/PL2996730T3/pl unknown
-
2015
- 2015-10-28 ZA ZA2015/08002A patent/ZA201508002B/en unknown
- 2015-11-09 CL CL2015003274A patent/CL2015003274A1/es unknown
-
2018
- 2018-07-11 AU AU2018205129A patent/AU2018205129A1/en not_active Abandoned
-
2019
- 2019-02-04 JP JP2019017869A patent/JP6845267B2/ja active Active
-
2022
- 2022-04-18 US US17/722,986 patent/US20220233741A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN105407930A (zh) | 2016-03-16 |
US20220233741A1 (en) | 2022-07-28 |
EP2996730B1 (en) | 2021-02-24 |
TWI653059B (zh) | 2019-03-11 |
CA2910285A1 (en) | 2014-11-20 |
JP6738727B2 (ja) | 2020-08-12 |
US20160101207A1 (en) | 2016-04-14 |
AU2014265336B2 (en) | 2018-04-12 |
DK2996730T3 (da) | 2021-05-25 |
ES2897373T3 (es) | 2022-02-28 |
AR096313A1 (es) | 2015-12-23 |
BR112015028703A2 (pt) | 2017-07-25 |
TW201521797A (zh) | 2015-06-16 |
JP2019076785A (ja) | 2019-05-23 |
MX2015015197A (es) | 2016-03-04 |
WO2014186590A1 (en) | 2014-11-20 |
RU2015153446A (ru) | 2017-06-20 |
KR20160010546A (ko) | 2016-01-27 |
JP2016519966A (ja) | 2016-07-11 |
AU2018205129A1 (en) | 2018-07-26 |
GB201308770D0 (en) | 2013-06-26 |
EP2996730A4 (en) | 2017-01-11 |
AU2014265336A1 (en) | 2015-11-12 |
CA2910285C (en) | 2022-03-01 |
CN112957513A (zh) | 2021-06-15 |
EP2996730A1 (en) | 2016-03-23 |
ZA201508002B (en) | 2019-06-26 |
PL2996730T3 (pl) | 2021-08-02 |
CL2015003274A1 (es) | 2016-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6845267B2 (ja) | 抗菌組成物を含む創傷被覆材 | |
EP1925719B1 (en) | Antibacterial fiber, method for production of the fiber, antibacterial fiber product comprising the antibacterial fiber, method for production of the product, and method for regeneration of the product | |
JP4984266B2 (ja) | 銀結合抗菌性湿潤創傷被覆材を製造する方法及び該方法により製造された湿潤創傷被覆材 | |
US11129847B2 (en) | Antibacterial wound dressing, method for preparing the same, and use thereof | |
US8900610B2 (en) | Biocidal fibrous and film materials comprising silver and chlorite ions | |
TW200532069A (en) | Antiviral fiber, process for producing the fiber, and textile product comprising the fiber | |
JP2013527327A (ja) | 過酸化物を有する抗菌性織物 | |
JPH04146218A (ja) | 創傷被覆材及びその製造方法 | |
CN101450222A (zh) | 一种具有抗菌作用的含银海藻酸纤维及制备方法 | |
KR100724780B1 (ko) | 항균,탈취조성물이 도포된 위생마스크 | |
JP4826382B2 (ja) | 抗菌性セルロース繊維及び皮膚接触用繊維製品 | |
US20160106879A1 (en) | Antiseptic wound dressing | |
CN110644234A (zh) | 一种可吸收氧化再生纤维素材料及其制备方法与应用 | |
DK2170081T3 (en) | Antimicrobial preparations | |
KR20210000009A (ko) | 항균성과 가교특성을 동시에 부여하는 수용성 하이드로화이버 부직포 제조방법, 이로부터 제조된 수용성 하이드로화이버 부직포를 이용한 운드드레싱 | |
US20030118631A1 (en) | Anti-microbial soluble hemostatic gauze and method of making same | |
CN104474584B (zh) | 一种纳米复合抗菌敷料的制备方法 | |
JP7515160B2 (ja) | 抗菌性組成物 | |
CN109758602B (zh) | 高吸型、强抑菌敷料及其制备方法 | |
CN106521942B (zh) | 尿囊素应用方法及原位合成纳米银抗菌整理纺织品的方法 | |
CN108914305A (zh) | 一种抗菌纱线 | |
Kucharska et al. | Bioactive Composite Materials In | |
PL219078B1 (pl) | Niecytotoksyczny materiał opatrunkowy na trudno gojące się rany oraz sposób wytwarzania tego materiału |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190305 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190305 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191126 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200804 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201102 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210216 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210225 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6845267 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |