JP2018538307A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018538307A5 JP2018538307A5 JP2018532035A JP2018532035A JP2018538307A5 JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5 JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018532035 A JP2018532035 A JP 2018532035A JP 2018538307 A5 JP2018538307 A5 JP 2018538307A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- lymphoma
- fibrosis
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O Chemical compound *c(cccc1)c1C(NCc(cc1)ccc1-c1n[n](C(CCC2)CC2O)c(N)c1C(N)=O)=O 0.000 description 13
- ZJBPMQFCMFACQD-UHFFFAOYSA-O CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O Chemical compound CC(C(CN(C)C1COC1)(F)F)[NH2+]C(N)=C(C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)c(F)c1)=N)C(N)=O ZJBPMQFCMFACQD-UHFFFAOYSA-O 0.000 description 1
- FUZMNSBMAWGICZ-UHFFFAOYSA-N CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F Chemical compound CC(C)NCCC(C(C)[n](c(NC)c1C(N)=O)nc1-c1ccc(CNC(c2cc(F)ccc2OC)=O)c(F)c1)(F)F FUZMNSBMAWGICZ-UHFFFAOYSA-N 0.000 description 1
- YXKMZZLFDQINKP-CSKWCJJFSA-N CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O Chemical compound CC/C(/NC(CN(CC1)C2COC2)C1F)=C(/C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)\C(N)=O YXKMZZLFDQINKP-CSKWCJJFSA-N 0.000 description 1
- RGSRIRHSVLYJIG-YYOOZPTRSA-N CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O Chemical compound CCN/C(/N)=C(\C(c1ccc(CNC(c(cc(cc2)F)c2OC)=O)cc1)=N)/C(NC)=O RGSRIRHSVLYJIG-YYOOZPTRSA-N 0.000 description 1
- VPMRBWJJRDQKLC-UHFFFAOYSA-N COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F Chemical compound COc(c(C(NCc(c(F)c1)ccc1-c1n[n](C(CNCC2)C2(F)F)c(N)c1C(N)=O)=O)c1)ccc1F VPMRBWJJRDQKLC-UHFFFAOYSA-N 0.000 description 1
- BZTXIQSFUSNIMJ-UHFFFAOYSA-N COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O Chemical compound COc(cccc1)c1C(NCC1C=CC(c(c(C(N)=O)c2N)n[n]2-c2ccccn2)=CC1)=O BZTXIQSFUSNIMJ-UHFFFAOYSA-N 0.000 description 1
- COSCVQYQAHCLMI-UHFFFAOYSA-N COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O Chemical compound COc1ccccc1C(NCc(cc1)ccc1-c(c(C(N)=O)c1N)n[n]1-c1ccc(CO)cc1)=O COSCVQYQAHCLMI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1522245.8 | 2015-12-16 | ||
| GBGB1522245.8A GB201522245D0 (en) | 2015-12-16 | 2015-12-16 | Compounds useful as kinase inhibitors |
| GB1613945.3 | 2016-08-15 | ||
| GBGB1613945.3A GB201613945D0 (en) | 2016-08-15 | 2016-08-15 | Compounds useful as kinase inhibitors |
| PCT/GB2016/053968 WO2017103611A1 (en) | 2015-12-16 | 2016-12-16 | Compounds useful as kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Division JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018538307A JP2018538307A (ja) | 2018-12-27 |
| JP2018538307A5 true JP2018538307A5 (cg-RX-API-DMAC7.html) | 2020-06-18 |
| JP6731483B2 JP6731483B2 (ja) | 2020-07-29 |
Family
ID=57590725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532035A Active JP6731483B2 (ja) | 2015-12-16 | 2016-12-16 | キナーゼ阻害剤として有用な化合物 |
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020116636A Active JP7086140B2 (ja) | 2015-12-16 | 2020-07-06 | キナーゼ阻害剤として有用な化合物 |
| JP2022092275A Active JP7419437B2 (ja) | 2015-12-16 | 2022-06-07 | キナーゼ阻害剤として有用な化合物 |
Country Status (37)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| KR20180109842A (ko) | 2015-09-16 | 2018-10-08 | 록쏘 온콜로지, 인코포레이티드 | 화합물 |
| CN114605327B (zh) | 2015-12-16 | 2025-03-11 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| GB201801226D0 (en) | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| RU2020136310A (ru) * | 2018-04-06 | 2022-05-06 | ПРАКСИС БАЙОТЕК ЭлЭлСи | Ингибиторы atf6 и их применение |
| JP6995195B2 (ja) | 2018-05-18 | 2022-02-04 | 富士フイルム株式会社 | ３－ジフルオロメチルピラゾール化合物の製造方法及び３－ジフルオロメチルピラゾール－４－カルボン酸化合物の製造方法、並びに、ピラゾリジン化合物 |
| KR102653681B1 (ko) * | 2018-07-31 | 2024-04-03 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제 |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2021053234A1 (en) * | 2019-09-19 | 2021-03-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Compounds and compositions for treating kidney disease |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| MX2022006631A (es) * | 2019-12-06 | 2022-09-07 | Loxo Oncology Inc | Dosificacion de un inhibidor de la tirosina cinasa de bruton. |
| CA3163365A1 (en) | 2020-01-02 | 2021-07-08 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Btk inhibitors |
| US20230145305A1 (en) * | 2020-03-12 | 2023-05-11 | Fochon Biosciences, Ltd. | Compounds useful as kinase inhibitors |
| TWI809489B (zh) * | 2020-09-10 | 2023-07-21 | 美商絡速藥業公司 | 用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體 |
| CN112386597B (zh) * | 2020-10-15 | 2022-03-15 | 天津济坤医药科技有限公司 | 泽布替尼在制备治疗肺纤维化疾病药物中的应用 |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| CN116348453B (zh) * | 2021-04-25 | 2025-07-04 | 烨辉医药科技(上海)有限公司 | 杂芳族甲酰胺化合物及其用途 |
| CA3217452A1 (en) * | 2021-05-14 | 2022-11-17 | David Andrew Coates | Cocrystalline forms of a bruton's tyrosine kinase inhibitor |
| CA3223769A1 (en) * | 2021-07-01 | 2023-01-05 | Xinglu ZHOU | Bruton's tyrosine kinase and mutant degrader, composition and application thereof |
| CN115611810B (zh) * | 2021-07-16 | 2025-03-04 | 深圳市塔吉瑞生物医药有限公司 | 取代的吡唑类化合物及包含该化合物的组合物及其用途 |
| KR20240157639A (ko) | 2021-12-14 | 2024-11-01 | 크로스파이어 온콜로지 홀딩 비.브이. | 거대고리 btk 억제제 |
| WO2023143355A1 (en) * | 2022-01-28 | 2023-08-03 | Hansoh Bio Llc | Azacycle amide derivative, preparation methods and medicinal uses thereof |
| EP4474377A4 (en) * | 2022-03-03 | 2025-07-30 | Shenzhen Targetrx Inc | Cycloalkyl or heterocyclyl substituted heteroaryl compound, and composition and use thereof |
| CN119053592A (zh) * | 2022-03-18 | 2024-11-29 | 英矽智能科技知识产权有限公司 | 吡唑膜相关的酪氨酸和苏氨酸特异性cdc2抑制激酶(pkmyt1)抑制剂及其用途 |
| CN115894376B (zh) * | 2022-12-15 | 2025-05-16 | 南京雷正医药科技有限公司 | 一种芳香族酰胺类化合物、药物组合物及其用途 |
| EP4669430A1 (en) | 2023-02-22 | 2025-12-31 | Assia Chemical Industries Ltd. | SOLID FORM OF PIRTOBRUTINIB |
| WO2024246287A1 (en) | 2023-06-02 | 2024-12-05 | Crossfire Oncology Holding B.V. | Medical use of a macrocyclic reversible btk inhibitor |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024256568A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Salt and crystal forms of a macrocyclic btk inhibitor |
| WO2024256574A1 (en) | 2023-06-13 | 2024-12-19 | Crossfire Oncology Holding B.V. | Process for preparing macrocyclic btk inhibitors |
| KR20250046558A (ko) | 2023-09-27 | 2025-04-03 | 임창섭 | 5g 사물인터넷 기반 하드월렛 간의 디지털자산 안심이체 시스템 |
| WO2025124496A1 (zh) * | 2023-12-13 | 2025-06-19 | 正大天晴药业集团股份有限公司 | 含有吡唑环和双环杂芳基的化合物、其药物组合物及用途 |
| WO2025137329A1 (en) * | 2023-12-22 | 2025-06-26 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
| CN119059974B (zh) * | 2024-08-12 | 2025-10-28 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的制备方法 |
| CN119059973A (zh) * | 2024-08-12 | 2024-12-03 | 武汉九州钰民医药科技有限公司 | 一种吡托布鲁替尼的合成工艺 |
| CN120504661B (zh) * | 2025-07-14 | 2025-11-07 | 复旦大学 | Alkbh8小分子抑制剂及其制备方法和用途 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003509428A (ja) | 1999-09-17 | 2003-03-11 | アボツト・ゲー・エム・ベー・ハー・ウント・コンパニー・カーゲー | 治療薬としてのピラゾロピリミジン |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| US6291504B1 (en) * | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| US20030225098A1 (en) | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| ES2616789T3 (es) | 2006-09-22 | 2017-06-14 | Pharmacyclics, Inc. | Inhibidores de tirosina cinasa de Bruton |
| CA2665214A1 (en) * | 2006-10-06 | 2008-05-29 | Abbott Laboratories | Novel imidazothiazoles and imidazoxazoles |
| EP2089391B1 (en) | 2006-11-03 | 2013-01-16 | Pharmacyclics, Inc. | Bruton's tyrosine kinase activity probe and method of using |
| ES2562215T3 (es) | 2007-03-28 | 2016-03-03 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton |
| CA2986640C (en) | 2008-06-27 | 2019-03-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| CN102159214A (zh) | 2008-07-16 | 2011-08-17 | 药品循环公司 | 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂 |
| HRP20120577T1 (hr) | 2008-07-24 | 2012-08-31 | Nerviano Medical Sciences S.R.L. | 3,4-diarilpirazoli kao inhibitori proteinskih kinaza |
| US8426428B2 (en) | 2008-12-05 | 2013-04-23 | Principia Biopharma, Inc. | EGFR kinase knockdown via electrophilically enhanced inhibitors |
| US7741330B1 (en) * | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
| MX342405B (es) | 2010-06-03 | 2016-09-28 | Pharmacyclics Inc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| DK2588465T3 (en) | 2010-06-30 | 2017-05-01 | Ironwood Pharmaceuticals Inc | SGC stimulators |
| CN103534258B (zh) | 2011-05-17 | 2016-09-14 | 普林斯匹亚生物制药公司 | 酪氨酸激酶抑制剂 |
| BR112013029508B1 (pt) | 2011-05-17 | 2022-05-03 | Principia Biopharma, Inc. | Composto, composição farmacêutica, e, uso do referido composto |
| CN103857396A (zh) | 2011-07-13 | 2014-06-11 | 药品循环公司 | 布鲁顿酪氨酸激酶抑制剂 |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| WO2013191965A1 (en) | 2012-06-18 | 2013-12-27 | Principia Biopharma Inc. | Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases |
| WO2014022569A1 (en) | 2012-08-03 | 2014-02-06 | Principia Biopharma Inc. | Treatment of dry eye |
| US20140045813A1 (en) * | 2012-08-10 | 2014-02-13 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| GB201214750D0 (en) * | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| WO2014068527A1 (en) * | 2012-11-02 | 2014-05-08 | Pfizer Inc. | Bruton's tyrosine kinase inhibitors |
| CN103848810A (zh) | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| GB201309085D0 (en) | 2013-05-20 | 2013-07-03 | Redx Pharma Ltd | Compounds |
| WO2015048662A2 (en) * | 2013-09-30 | 2015-04-02 | X-Rx Discovery, Inc. | Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease |
| WO2015075051A1 (en) * | 2013-11-19 | 2015-05-28 | Universitaet Des Saarlandes | Allosteric inhibitors of atypical protein kinases c |
| WO2015095099A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| KR20220027271A (ko) | 2014-02-21 | 2022-03-07 | 프린시피아 바이오파마, 인코퍼레이티드 | Btk 억제제의 염 및 고체 형태 |
| GB201404987D0 (en) * | 2014-03-20 | 2014-05-07 | Redx Pharma Ltd | Compounds |
| CN105085474B (zh) * | 2014-05-07 | 2018-05-18 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| GB201410430D0 (en) | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
| JP6704398B2 (ja) | 2015-01-28 | 2020-06-03 | バイエル ファーマ アクチエンゲゼルシャフト | ４Ｈ−ピロロ［３，２−ｃ］ピリジン−４−オン誘導体 |
| GB2548542A (en) * | 2015-06-16 | 2017-09-27 | Redx Pharma Plc | Compounds |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| KR20180109842A (ko) | 2015-09-16 | 2018-10-08 | 록쏘 온콜로지, 인코포레이티드 | 화합물 |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3005268C (en) | 2015-12-16 | 2024-04-30 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| WO2017106623A1 (en) | 2015-12-16 | 2017-06-22 | Ecolab Usa Inc. | Peroxyformic acid compositions for membrane filtration cleaning |
| CN114605327B (zh) | 2015-12-16 | 2025-03-11 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| BR112018012112A2 (pt) | 2015-12-16 | 2018-12-04 | Bristol-Myers Squibb Company | heteroaril-hidroxipirimidinonas como agonistas do receptor apj |
| ES2986022T3 (es) | 2015-12-16 | 2024-11-08 | Loveland Products Inc | Dendrímero y sus formulaciones |
-
2016
- 2016-12-16 CN CN202210312064.XA patent/CN114605327B/zh active Active
- 2016-12-16 CN CN202210312050.8A patent/CN114591242B/zh active Active
- 2016-12-16 TN TNP/2018/000213A patent/TN2018000213A1/en unknown
- 2016-12-16 IL IL285976A patent/IL285976B2/en unknown
- 2016-12-16 UA UAA202003795A patent/UA127863C2/uk unknown
- 2016-12-16 CN CN202111022488.4A patent/CN113603645B/zh active Active
- 2016-12-16 CN CN201680073031.7A patent/CN108473481B/zh active Active
- 2016-12-16 US US16/063,542 patent/US10695323B2/en active Active
- 2016-12-16 PE PE2018001143A patent/PE20181449A1/es unknown
- 2016-12-16 HR HRP20201835TT patent/HRP20201835T1/hr unknown
- 2016-12-16 UA UAA201807294A patent/UA122258C2/uk unknown
- 2016-12-16 CO CONC2018/0006164A patent/CO2018006164A2/es unknown
- 2016-12-16 SI SI201630920T patent/SI3390395T1/sl unknown
- 2016-12-16 PE PE2021001581A patent/PE20220507A1/es unknown
- 2016-12-16 MD MDE20181001T patent/MD3390395T2/ro unknown
- 2016-12-16 ES ES20194724T patent/ES3041897T3/es active Active
- 2016-12-16 HU HUE16816363A patent/HUE051921T2/hu unknown
- 2016-12-16 ES ES16816363T patent/ES2828431T3/es active Active
- 2016-12-16 CA CA3008488A patent/CA3008488C/en active Active
- 2016-12-16 EA EA201891268A patent/EA035132B1/ru not_active IP Right Cessation
- 2016-12-16 MY MYPI2022003989A patent/MY202026A/en unknown
- 2016-12-16 MY MYPI2022003990A patent/MY200590A/en unknown
- 2016-12-16 SG SG11201805044WA patent/SG11201805044WA/en unknown
- 2016-12-16 WO PCT/GB2016/053968 patent/WO2017103611A1/en not_active Ceased
- 2016-12-16 CN CN202210311995.8A patent/CN114634447B/zh active Active
- 2016-12-16 CN CN202210310724.0A patent/CN114716381B/zh active Active
- 2016-12-16 NZ NZ743553A patent/NZ743553A/en unknown
- 2016-12-16 RS RS20201291A patent/RS60982B9/sr unknown
- 2016-12-16 MX MX2021003478A patent/MX394193B/es unknown
- 2016-12-16 JP JP2018532035A patent/JP6731483B2/ja active Active
- 2016-12-16 MA MA49809A patent/MA49809A1/fr unknown
- 2016-12-16 PT PT168163632T patent/PT3390395T/pt unknown
- 2016-12-16 MA MA055064A patent/MA55064A/fr unknown
- 2016-12-16 CN CN202210312076.2A patent/CN114621146A/zh active Pending
- 2016-12-16 CN CN202111022492.0A patent/CN113636978B/zh active Active
- 2016-12-16 EP EP16816363.2A patent/EP3390395B1/en active Active
- 2016-12-16 MX MX2018007267A patent/MX380907B/es unknown
- 2016-12-16 KR KR1020217003683A patent/KR20210018530A/ko not_active Withdrawn
- 2016-12-16 KR KR1020187020225A patent/KR102215792B1/ko active Active
- 2016-12-16 EP EP20194724.9A patent/EP3782994B1/en active Active
- 2016-12-16 LT LTEP16816363.2T patent/LT3390395T/lt unknown
- 2016-12-16 CN CN202210311970.8A patent/CN114573510B/zh active Active
- 2016-12-16 CR CR20180367A patent/CR20180367A/es unknown
- 2016-12-16 SG SG10202012498TA patent/SG10202012498TA/en unknown
- 2016-12-16 AU AU2016373530A patent/AU2016373530B2/en active Active
- 2016-12-16 PE PE2021001592A patent/PE20220502A1/es unknown
- 2016-12-16 DK DK16816363.2T patent/DK3390395T3/da active
-
2018
- 2018-06-10 IL IL259923A patent/IL259923B/en active IP Right Grant
- 2018-06-13 PH PH12018501268A patent/PH12018501268A1/en unknown
- 2018-06-14 CL CL2018001591A patent/CL2018001591A1/es unknown
- 2018-06-20 ZA ZA2018/04137A patent/ZA201804137B/en unknown
- 2018-08-22 US US16/109,162 patent/US10342780B2/en active Active
- 2018-08-27 US US16/113,661 patent/US10464905B2/en active Active
-
2020
- 2020-05-13 US US15/930,657 patent/US10918622B2/en active Active
- 2020-07-06 JP JP2020116636A patent/JP7086140B2/ja active Active
- 2020-07-26 IL IL276283A patent/IL276283B/en active IP Right Grant
- 2020-11-16 CY CY20201101090T patent/CY1123561T1/el unknown
- 2020-12-15 US US17/122,103 patent/US11471441B2/en active Active
-
2021
- 2021-01-26 ZA ZA2021/00544A patent/ZA202100544B/en unknown
- 2021-02-24 IL IL281067A patent/IL281067B/en unknown
- 2021-03-23 AU AU2021201811A patent/AU2021201811B2/en active Active
- 2021-08-31 AU AU2021225161A patent/AU2021225161B2/en active Active
- 2021-08-31 AU AU2021225162A patent/AU2021225162B2/en active Active
- 2021-10-05 ZA ZA2021/07472A patent/ZA202107472B/en unknown
- 2021-10-05 ZA ZA2021/07471A patent/ZA202107471B/en unknown
- 2021-11-12 US US17/525,350 patent/US11826351B2/en active Active
-
2022
- 2022-06-07 JP JP2022092275A patent/JP7419437B2/ja active Active
-
2023
- 2023-07-31 US US18/362,249 patent/US12220401B2/en active Active
-
2024
- 2024-02-27 HU HUS2400003C patent/HUS2400003I1/hu unknown
- 2024-02-29 NO NO2024008C patent/NO2024008I1/no unknown
- 2024-03-01 FI FIC20240004C patent/FIC20240004I1/fi unknown
- 2024-03-04 FR FR24C1009C patent/FR24C1009I2/fr active Active
- 2024-03-04 CY CY2024003C patent/CY2024003I2/el unknown
- 2024-03-06 NL NL301262C patent/NL301262I2/nl unknown
- 2024-03-06 LT LTPA2024506C patent/LTPA2024506I1/lt unknown
- 2024-11-21 US US18/955,844 patent/US20250090500A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018538307A5 (cg-RX-API-DMAC7.html) | ||
| HRP20201835T1 (hr) | Spojevi korisni kao inhibitori kinaze | |
| JP2020172535A5 (cg-RX-API-DMAC7.html) | ||
| WO2021249057A1 (zh) | 杂环化合物及其用途 | |
| EP3013337B1 (en) | Primary carboxamides as btk inhibitors | |
| US10800792B2 (en) | Inhibitors of Bruton's tyrosine kinase and method of their use | |
| ES2655971T9 (es) | Compuestos de aminopirimidinilo como inhibidores de JAK | |
| SI2892900T1 (en) | Pyrazolopyrimidine compounds as kinase inhibitors | |
| WO2010131146A1 (en) | Cyclobutenedione derivatives | |
| JP2016534146A5 (cg-RX-API-DMAC7.html) | ||
| CN106459045A (zh) | 杂环激酶抑制剂 | |
| JP2018534326A5 (cg-RX-API-DMAC7.html) | ||
| RU2014131707A (ru) | Соединения пиридазинамида и их применение в качестве ингибиторов тирозинкиназы селезенки (syk) | |
| CA3045371C (en) | Inhibitors of influenza virus replication and uses thereof | |
| JP2018515531A5 (cg-RX-API-DMAC7.html) | ||
| JP2018536686A (ja) | ブルトン型チロシンキナーゼの阻害剤としての多環式化合物 | |
| JP2024508794A (ja) | Ｔｙｋ２阻害剤およびその使用 | |
| US20150361100A1 (en) | Indolizine derivatives as phoshoinositide 3-kinases inhibitors | |
| US20230416205A1 (en) | Compounds, compositions, and methods | |
| TW201247657A (en) | Isoxazolines as therapeutic agents | |
| HRP20250644T1 (hr) | Magl inhibitor | |
| CN104098553A (zh) | 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法 | |
| JP2012509931A5 (cg-RX-API-DMAC7.html) | ||
| AU2012269133A1 (en) | Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives | |
| ES2970180T3 (es) | Inhibidores de la dihidroorotato deshidrogenasa bi-arilo |