JP2018534932A5 - - Google Patents
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- Publication number
- JP2018534932A5 JP2018534932A5 JP2018522662A JP2018522662A JP2018534932A5 JP 2018534932 A5 JP2018534932 A5 JP 2018534932A5 JP 2018522662 A JP2018522662 A JP 2018522662A JP 2018522662 A JP2018522662 A JP 2018522662A JP 2018534932 A5 JP2018534932 A5 JP 2018534932A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- activity
- ion
- small molecule
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 53
- 229920001184 polypeptide Polymers 0.000 claims 52
- 102000004196 processed proteins & peptides Human genes 0.000 claims 52
- 150000002500 ions Chemical class 0.000 claims 20
- 150000003384 small molecules Chemical class 0.000 claims 20
- 230000000694 effects Effects 0.000 claims 19
- 238000000034 method Methods 0.000 claims 14
- 238000003556 assay Methods 0.000 claims 10
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 4
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 4
- 229910000037 hydrogen sulfide Inorganic materials 0.000 claims 4
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 claims 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 230000027455 binding Effects 0.000 claims 2
- 229960001340 histamine Drugs 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 229910052979 sodium sulfide Inorganic materials 0.000 claims 2
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022068158A JP7390748B2 (ja) | 2015-11-02 | 2022-04-18 | 条件的活性型ポリペプチド |
| JP2023193435A JP2024020382A (ja) | 2015-11-02 | 2023-11-14 | 条件的活性型ポリペプチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562249907P | 2015-11-02 | 2015-11-02 | |
| US62/249,907 | 2015-11-02 | ||
| PCT/US2016/019242 WO2016138071A1 (en) | 2015-02-24 | 2016-02-24 | Conditionally active biological proteins |
| USPCT/US2016/019242 | 2016-02-24 | ||
| PCT/US2016/049715 WO2017078839A1 (en) | 2015-11-02 | 2016-08-31 | Conditionally active polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022068158A Division JP7390748B2 (ja) | 2015-11-02 | 2022-04-18 | 条件的活性型ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534932A JP2018534932A (ja) | 2018-11-29 |
| JP2018534932A5 true JP2018534932A5 (OSRAM) | 2019-10-10 |
| JP7064769B2 JP7064769B2 (ja) | 2022-05-11 |
Family
ID=58662272
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522662A Active JP7064769B2 (ja) | 2015-11-02 | 2016-08-31 | 条件的活性型ポリペプチド |
| JP2022068158A Active JP7390748B2 (ja) | 2015-11-02 | 2022-04-18 | 条件的活性型ポリペプチド |
| JP2023193435A Pending JP2024020382A (ja) | 2015-11-02 | 2023-11-14 | 条件的活性型ポリペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022068158A Active JP7390748B2 (ja) | 2015-11-02 | 2022-04-18 | 条件的活性型ポリペプチド |
| JP2023193435A Pending JP2024020382A (ja) | 2015-11-02 | 2023-11-14 | 条件的活性型ポリペプチド |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11472876B2 (OSRAM) |
| EP (1) | EP3371349A1 (OSRAM) |
| JP (3) | JP7064769B2 (OSRAM) |
| KR (2) | KR102714709B1 (OSRAM) |
| CN (2) | CN115521374B (OSRAM) |
| AU (2) | AU2016350613B2 (OSRAM) |
| CA (1) | CA3003399A1 (OSRAM) |
| MX (2) | MX2018005063A (OSRAM) |
| RU (1) | RU2735023C9 (OSRAM) |
| WO (1) | WO2017078839A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2913205T3 (es) * | 2014-05-13 | 2022-06-01 | Bioatla Inc | Proteínas biológicas activas condicionalmente |
| RU2735023C9 (ru) * | 2015-11-02 | 2021-06-18 | Биоатла, Ллс | Условно активные полипептиды |
| US10697972B2 (en) | 2016-01-12 | 2020-06-30 | Bioatla, Llc | Diagnostics using conditionally active antibodies |
| WO2017123537A1 (en) * | 2016-01-12 | 2017-07-20 | Bioatla, Llc | Diagnostics using conditionally active antibodies |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| KR102585956B1 (ko) * | 2016-08-31 | 2023-10-05 | 바이오아트라, 인코퍼레이티드 | 조건부 활성 폴리펩티드 및 이를 제조하는 방법 |
| EP3568159A4 (en) | 2017-01-11 | 2020-08-05 | Bristol-Myers Squibb Company | PSGL-1 ANTAGONISTS AND THEIR USES |
| IL267902B1 (en) | 2017-01-18 | 2025-09-01 | F1 Oncology Inc | Chimeric antigen receptors against axl or ror2 and methods of use thereof |
| PE20191708A1 (es) | 2017-03-14 | 2019-11-28 | Five Prime Therapeutics Inc | ANTICUERPOS DE UNION A VISTA A pH ACIDO |
| KR20250154550A (ko) | 2018-03-21 | 2025-10-28 | 파이브 프라임 테라퓨틱스, 인크. | 산성 pH에서 VISTA에 결합하는 항체 |
| WO2019241216A1 (en) * | 2018-06-14 | 2019-12-19 | Bioatla, Llc | Multi-specific antibody constructs |
| JP7700036B2 (ja) | 2018-07-11 | 2025-06-30 | ファイヴ プライム セラピューティクス インク | 酸性ｐＨでＶＩＳＴＡと結合する抗体 |
| AU2019326407A1 (en) * | 2018-08-21 | 2021-02-18 | Bioatla, Inc. | Conditionally active proteins with pH selectivity |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN113924118A (zh) | 2019-04-18 | 2022-01-11 | 百时美施贵宝公司 | 在低ph下具有增强的结合特异性的伊匹单抗变体 |
| US12391745B2 (en) * | 2020-06-15 | 2025-08-19 | Sarepta Therapeutics, Inc. | Adeno-associated virus antibodies and fragments thereof |
| US20230235054A1 (en) * | 2020-06-18 | 2023-07-27 | Bioatla, Inc. | Conditionally active anti-nectin-4 antibodies |
| CA3182384A1 (en) * | 2020-06-18 | 2021-12-23 | Jay M. Short | Conditionally active anti-cd46 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| EP4651894A2 (en) * | 2023-01-18 | 2025-11-26 | Harpoon Therapeutics, Inc. | Her2 targeting trispecific protein for treatment of cancer |
| WO2024182645A1 (en) * | 2023-03-02 | 2024-09-06 | Bioatla, Inc. | Conditionally active anti-epcam antibodies, antibody fragments and constructs incorporating same |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| JPH02500329A (ja) | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| KR900005995A (ko) | 1988-10-31 | 1990-05-07 | 우메모또 요시마사 | 변형 인터류킨-2 및 그의 제조방법 |
| EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
| US5112946A (en) | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
| WO1991006570A1 (en) | 1989-10-25 | 1991-05-16 | The University Of Melbourne | HYBRID Fc RECEPTOR MOLECULES |
| US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
| DE69123241T2 (de) | 1990-12-14 | 1997-04-17 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| DK0573551T3 (da) | 1991-02-27 | 2003-08-04 | Micromet Ag | Serinrige peptidlinkere |
| US5844095A (en) | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| GB9320668D0 (en) | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| MX9700764A (es) | 1994-07-29 | 1997-05-31 | Smithkline Beecham Plc | Compuestos novedosos. |
| GB9415379D0 (en) | 1994-07-29 | 1994-09-21 | Smithkline Beecham Plc | Novel compounds |
| DK1323346T3 (da) | 1995-01-17 | 2006-10-30 | Brigham & Womens Hospital | Receptorspecifik transport af immunogener gennem epitelet |
| US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| AU6330896A (en) | 1995-06-07 | 1996-12-30 | Governors Of The University Of Alberta, The | A method for eliciting a th1-specific immune response |
| US6764835B2 (en) | 1995-12-07 | 2004-07-20 | Diversa Corporation | Saturation mutageneis in directed evolution |
| US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| AU753196B2 (en) | 1998-02-09 | 2002-10-10 | Bracco Research S.A. | Targeted delivery of biologically active media |
| JP4169478B2 (ja) | 1998-04-21 | 2008-10-22 | マイクロメット アーゲー | Ｃｄ１９×ｃｄ３特異的ポリペプチドおよびその使用 |
| US20020006404A1 (en) | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| US20020028178A1 (en) | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| MXPA02010011A (es) | 2000-04-11 | 2003-04-25 | Genentech Inc | Anticuerpos multivalentes y usos para los mismos. |
| AU6461201A (en) | 2000-07-12 | 2002-01-21 | Idec Pharma Corp | Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications |
| JP2004508420A (ja) | 2000-09-18 | 2004-03-18 | アイデック ファーマスーティカルズ コーポレイション | Ｂ細胞枯渇抗体／免疫調節性抗体の組合せを用いて自己免疫疾患を治療するための併用療法 |
| JP2004527528A (ja) | 2001-04-09 | 2004-09-09 | プロジェニクス・ファーマスーティカルズ・インコーポレイテッド | 抗ｃｄ１９免疫毒素 |
| US20030138405A1 (en) | 2001-04-17 | 2003-07-24 | Juan Fueyo | Conditionally replicative adenovirus to target the Rb and Rb-related pathways |
| DK1381402T3 (da) | 2001-04-27 | 2010-03-08 | Vivoxid Oy | Fremgangsmåde til forbedring af blødvævsmodtagelse og implantater der gør brug af denne fremgangsmåde |
| WO2003033205A1 (de) | 2001-10-17 | 2003-04-24 | Schneider Gmbh & Co. Kg | Vorrichtung und verfahren zur komplettbearbeitung von zweiseitig optisch aktiven linsen |
| US20060141456A1 (en) | 2002-06-12 | 2006-06-29 | Cynthia Edwards | Methods and compositions for milieu-dependent binding of a targeted agent to a target |
| US20040064050A1 (en) | 2002-09-20 | 2004-04-01 | Jun Liu | System and method for screening tissue |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| WO2005086922A2 (en) | 2004-03-10 | 2005-09-22 | Board Of Regents, University Of Texas System | Oncolytic adenovirus armed with therapeutic genes |
| US20050260711A1 (en) * | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
| US20060067930A1 (en) | 2004-08-19 | 2006-03-30 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US8961877B2 (en) | 2007-08-09 | 2015-02-24 | Massachusetts Institute Of Technology | High-throughput, whole-animal screening system |
| JP2010068746A (ja) * | 2008-09-18 | 2010-04-02 | Chiba Univ | 抗腫瘍効果を有する化合物の同定方法 |
| CN102482347B (zh) | 2009-01-12 | 2017-04-26 | 希托马克斯医疗有限责任公司 | 修饰抗体组合物及其制备和使用方法 |
| KR20110136825A (ko) * | 2009-03-09 | 2011-12-21 | 바이오아트라, 엘엘씨 | 미락 단백질 |
| DK3636759T3 (da) | 2009-07-17 | 2023-10-23 | Bioatla Inc | Samtidig, integreret udvælgelse og udvikling af antistof/protein-ydelse og ekspression hos produktionsværter |
| US20110143960A1 (en) | 2009-12-10 | 2011-06-16 | Labarbera Daniel V | 3d-models for high-throughput screening drug discovery and development |
| WO2011091078A2 (en) | 2010-01-19 | 2011-07-28 | Xencor, Inc. | Antibody fc variants with enhanced complement activity |
| KR20130096731A (ko) * | 2010-09-08 | 2013-08-30 | 할로자임, 아이엔씨 | 조건부 활성 치료적 단백질을 평가，확인 또는 진화시키는 방법 |
| WO2013040445A1 (en) | 2011-09-15 | 2013-03-21 | Whitehead Institute For Biomedical Research | Arrays for cell-based screening and uses thereof |
| KR102528622B1 (ko) | 2011-09-30 | 2023-05-04 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존성 결합 분자 라이브러리 |
| CN104379602B (zh) | 2012-03-08 | 2017-05-03 | 哈洛齐梅公司 | 具有条件活性的抗表皮生长因子受体抗体及其使用方法 |
| US20140206596A1 (en) * | 2013-01-18 | 2014-07-24 | University Of Southern California | Design of pH-Sensitive Oligopeptide Complexes For Drug Release Under Mildly Acidic Conditions |
| ES2913205T3 (es) | 2014-05-13 | 2022-06-01 | Bioatla Inc | Proteínas biológicas activas condicionalmente |
| RU2735023C9 (ru) | 2015-11-02 | 2021-06-18 | Биоатла, Ллс | Условно активные полипептиды |
| KR102585956B1 (ko) * | 2016-08-31 | 2023-10-05 | 바이오아트라, 인코퍼레이티드 | 조건부 활성 폴리펩티드 및 이를 제조하는 방법 |
-
2016
- 2016-08-31 RU RU2018115781A patent/RU2735023C9/ru active
- 2016-08-31 MX MX2018005063A patent/MX2018005063A/es unknown
- 2016-08-31 CA CA3003399A patent/CA3003399A1/en active Pending
- 2016-08-31 AU AU2016350613A patent/AU2016350613B2/en active Active
- 2016-08-31 KR KR1020187014104A patent/KR102714709B1/ko active Active
- 2016-08-31 WO PCT/US2016/049715 patent/WO2017078839A1/en not_active Ceased
- 2016-08-31 CN CN202211275600.XA patent/CN115521374B/zh active Active
- 2016-08-31 CN CN201680077540.7A patent/CN108473555B/zh active Active
- 2016-08-31 EP EP16862643.0A patent/EP3371349A1/en active Pending
- 2016-08-31 JP JP2018522662A patent/JP7064769B2/ja active Active
- 2016-08-31 KR KR1020247032903A patent/KR20240150525A/ko active Pending
- 2016-08-31 US US15/773,122 patent/US11472876B2/en active Active
-
2018
- 2018-04-24 MX MX2023001319A patent/MX2023001319A/es unknown
-
2022
- 2022-04-18 JP JP2022068158A patent/JP7390748B2/ja active Active
- 2022-08-19 US US17/820,913 patent/US20220403024A1/en active Pending
-
2023
- 2023-11-14 JP JP2023193435A patent/JP2024020382A/ja active Pending
- 2023-12-21 AU AU2023285915A patent/AU2023285915A1/en active Pending
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