JP2018533954A5 - - Google Patents
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- JP2018533954A5 JP2018533954A5 JP2018524194A JP2018524194A JP2018533954A5 JP 2018533954 A5 JP2018533954 A5 JP 2018533954A5 JP 2018524194 A JP2018524194 A JP 2018524194A JP 2018524194 A JP2018524194 A JP 2018524194A JP 2018533954 A5 JP2018533954 A5 JP 2018533954A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15194367.7 | 2015-11-12 | ||
| EP15194367 | 2015-11-12 | ||
| EP16189502.4 | 2016-09-19 | ||
| EP16189502 | 2016-09-19 | ||
| PCT/EP2016/077383 WO2017081223A1 (en) | 2015-11-12 | 2016-11-11 | Oligonucleotides for inducing paternal ube3a expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020136397A Division JP7279000B2 (ja) | 2015-11-12 | 2020-08-12 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533954A JP2018533954A (ja) | 2018-11-22 |
| JP2018533954A5 true JP2018533954A5 (cg-RX-API-DMAC7.html) | 2020-04-09 |
| JP6751142B2 JP6751142B2 (ja) | 2020-09-02 |
Family
ID=57345910
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521350A Pending JP2018533362A (ja) | 2015-11-12 | 2016-11-11 | 薬物候補の有効性プロファイルを決定するための方法 |
| JP2018524194A Active JP6751142B2 (ja) | 2015-11-12 | 2016-11-11 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
| JP2018521433A Active JP7066609B2 (ja) | 2015-11-12 | 2016-11-11 | 霊長類種に由来する標準化された神経細胞アッセイ |
| JP2020136397A Active JP7279000B2 (ja) | 2015-11-12 | 2020-08-12 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
| JP2021113496A Pending JP2021191262A (ja) | 2015-11-12 | 2021-07-08 | 薬物候補の有効性プロファイルを決定するための方法 |
| JP2023009553A Pending JP2023052630A (ja) | 2015-11-12 | 2023-01-25 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
| JP2024196762A Pending JP2025024060A (ja) | 2015-11-12 | 2024-11-11 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521350A Pending JP2018533362A (ja) | 2015-11-12 | 2016-11-11 | 薬物候補の有効性プロファイルを決定するための方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521433A Active JP7066609B2 (ja) | 2015-11-12 | 2016-11-11 | 霊長類種に由来する標準化された神経細胞アッセイ |
| JP2020136397A Active JP7279000B2 (ja) | 2015-11-12 | 2020-08-12 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
| JP2021113496A Pending JP2021191262A (ja) | 2015-11-12 | 2021-07-08 | 薬物候補の有効性プロファイルを決定するための方法 |
| JP2023009553A Pending JP2023052630A (ja) | 2015-11-12 | 2023-01-25 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
| JP2024196762A Pending JP2025024060A (ja) | 2015-11-12 | 2024-11-11 | 父方ube3aの発現を誘導するオリゴヌクレオチド |
Country Status (30)
Families Citing this family (30)
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| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| PL3461895T3 (pl) | 2012-06-25 | 2021-01-11 | Ionis Pharmaceuticals, Inc. | Modulacja ekspresji ube3a-ats |
| SG10201912895PA (en) | 2012-07-13 | 2020-02-27 | Wave Life Sciences Ltd | Chiral control |
| JP6268157B2 (ja) | 2012-07-13 | 2018-01-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| PT3094728T (pt) | 2014-01-16 | 2022-05-19 | Wave Life Sciences Ltd | Desenho quiral |
| WO2016086104A1 (en) | 2014-11-25 | 2016-06-02 | Ionis Pharmaceuticals, Inc. | Modulation of ube3a-ats expression |
| CN108350431A (zh) | 2015-11-12 | 2018-07-31 | 豪夫迈·罗氏有限公司 | 用于确定候选药物的功效特征的方法 |
| RU2020121752A (ru) * | 2017-12-01 | 2021-12-30 | ТЕХАССКАЯ УНИВЕРСИТЕТСКАЯ СИСТЕМА А энд М | Средство для лечения синдрома ангельмана на основе антисмысловой нуклеиновой кислоты |
| WO2019157531A1 (en) | 2018-02-12 | 2019-08-15 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
| CN108795935B (zh) * | 2018-05-23 | 2022-06-21 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 日本血吸虫SjELAV-like 1基因的siRNA及其应用 |
| US12221609B2 (en) | 2018-09-21 | 2025-02-11 | University Of Connecticut | Compositions and methods to restore paternal UBE3A gene expression in human Angelman syndrome |
| EP3911957A1 (en) | 2019-01-17 | 2021-11-24 | F. Hoffmann-La Roche AG | E3 ubiquitin ligase (ube3a) protein targets |
| MX2021009950A (es) * | 2019-02-20 | 2021-09-21 | Roche Innovation Ct Copenhagen As | Oligonucleotidos gapmeros de fosfonoacetato. |
| UA128437C2 (uk) * | 2019-03-29 | 2024-07-10 | Айоніс Фармасьютикалз, Інк. | Сполуки і способи модулювання ube3a-ats |
| MX2021014248A (es) | 2019-05-22 | 2022-01-06 | Univ North Carolina Chapel Hill | Genes ube3a y casetes de expresion y su uso. |
| JP7701879B2 (ja) | 2019-05-28 | 2025-07-02 | エフ. ホフマン-ラ ロシュ アーゲー | 単球前駆細胞を生成するための方法 |
| TW202204607A (zh) * | 2020-04-16 | 2022-02-01 | 英商羅斯林科技有限公司 | 誘導性多功能幹細胞(iPSC)之誘導 |
| CN115702243A (zh) * | 2020-06-09 | 2023-02-14 | 罗氏创新中心哥本哈根有限公司 | 用于治疗性多核苷酸的鸟苷类似物 |
| JPWO2022158487A1 (cg-RX-API-DMAC7.html) | 2021-01-21 | 2022-07-28 | ||
| JP2025516554A (ja) | 2022-05-10 | 2025-05-30 | エフ. ホフマン-ラ ロシュ アーゲー | Cfp-elk1遺伝子間領域を標的とするアンチセンスオリゴヌクレオチド |
| WO2024227765A2 (en) | 2023-05-04 | 2024-11-07 | F. Hoffmann-La Roche Ag | Oligonucleotides capable of upregulating glucocerebrosidase expression |
| KR20250068540A (ko) * | 2023-11-08 | 2025-05-16 | 한국과학기술원 | Ube3a를 표적으로 하여 발현증강을 유도하는 안티센스 올리고뉴클레오티드 및 이의 용도 |
| WO2025125542A1 (en) | 2023-12-15 | 2025-06-19 | F. Hoffmann-La Roche Ag | Intrathecal dosage method |
| WO2025217466A1 (en) * | 2024-04-11 | 2025-10-16 | Ultragenyx Pharmaceutical Inc. | Dosing regimens for antisense treatment of angelman syndrome |
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| UA128437C2 (uk) | 2019-03-29 | 2024-07-10 | Айоніс Фармасьютикалз, Інк. | Сполуки і способи модулювання ube3a-ats |
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2016
- 2016-11-11 CN CN201680065987.2A patent/CN108350431A/zh active Pending
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- 2016-11-11 JP JP2018521350A patent/JP2018533362A/ja active Pending
- 2016-11-11 WO PCT/EP2016/077435 patent/WO2017081254A1/en not_active Ceased
- 2016-11-11 HR HRP20210227TT patent/HRP20210227T1/hr unknown
- 2016-11-11 AU AU2016352836A patent/AU2016352836B2/en active Active
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- 2016-11-11 ES ES23152543T patent/ES2991800T3/es active Active
- 2016-11-11 IL IL281211A patent/IL281211B2/en unknown
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- 2016-11-11 DK DK23152543.7T patent/DK4220360T3/da active
- 2016-11-11 RS RS20210241A patent/RS61529B9/sr unknown
- 2016-11-11 WO PCT/EP2016/077383 patent/WO2017081223A1/en not_active Ceased
- 2016-11-11 WO PCT/EP2016/077429 patent/WO2017081250A1/en not_active Ceased
- 2016-11-11 EP EP16797824.6A patent/EP3374498A1/en not_active Withdrawn
- 2016-11-11 EP EP16798672.8A patent/EP3374499A1/en not_active Withdrawn
- 2016-11-11 MA MA67580A patent/MA67580B1/fr unknown
- 2016-11-11 CA CA3004799A patent/CA3004799C/en active Active
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- 2016-11-11 KR KR1020257024980A patent/KR20250121139A/ko active Pending
- 2016-11-11 SI SI201631093T patent/SI3374509T1/sl unknown
- 2016-11-11 RS RS20241003A patent/RS66036B1/sr unknown
- 2016-11-11 PL PL16798440T patent/PL3374509T3/pl unknown
- 2016-11-11 PE PE2020000810A patent/PE20210451A1/es unknown
- 2016-11-11 CN CN202211275978.XA patent/CN116064540A/zh active Pending
- 2016-11-11 KR KR1020207033999A patent/KR102482440B1/ko active Active
- 2016-11-11 HR HRP20241138TT patent/HRP20241138T1/hr unknown
- 2016-11-11 EP EP16798440.0A patent/EP3374509B1/en active Active
- 2016-11-11 UA UAA201806476A patent/UA125963C2/uk unknown
- 2016-11-11 HK HK19100676.0A patent/HK1258309A1/zh unknown
- 2016-11-11 RU RU2018119315A patent/RU2742007C2/ru active
- 2016-11-11 HK HK19100670.6A patent/HK1258434A1/zh unknown
- 2016-11-11 CN CN202211275954.4A patent/CN116064539A/zh active Pending
- 2016-11-11 SG SG11201803951QA patent/SG11201803951QA/en unknown
- 2016-11-11 EP EP20204481.4A patent/EP3798307A1/en active Pending
- 2016-11-11 LT LTEP16798440.0T patent/LT3374509T/lt unknown
- 2016-11-11 CR CR20220077A patent/CR20220077A/es unknown
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- 2016-11-11 EP EP23152543.7A patent/EP4220360B9/en active Active
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- 2016-11-11 CN CN201680066253.6A patent/CN108291226B/zh active Active
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- 2016-11-11 FI FIEP23152543.7T patent/FI4220360T3/fi active
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