EP1670901A4 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells - Google Patents
Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cellsInfo
- Publication number
- EP1670901A4 EP1670901A4 EP04782339A EP04782339A EP1670901A4 EP 1670901 A4 EP1670901 A4 EP 1670901A4 EP 04782339 A EP04782339 A EP 04782339A EP 04782339 A EP04782339 A EP 04782339A EP 1670901 A4 EP1670901 A4 EP 1670901A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- stem cells
- neurons
- vitro differentiation
- primate embryonic
- embryonic stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/46—Amines, e.g. putrescine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49883103P | 2003-08-29 | 2003-08-29 | |
US49957003P | 2003-09-02 | 2003-09-02 | |
PCT/US2004/027841 WO2005021720A2 (en) | 2003-08-29 | 2004-08-27 | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1670901A2 EP1670901A2 (en) | 2006-06-21 |
EP1670901A4 true EP1670901A4 (en) | 2007-09-05 |
Family
ID=34278616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04782339A Withdrawn EP1670901A4 (en) | 2003-08-29 | 2004-08-27 | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1670901A4 (en) |
JP (2) | JP2007503811A (en) |
KR (2) | KR20060115351A (en) |
AU (1) | AU2004269361B2 (en) |
CA (1) | CA2536588C (en) |
GB (1) | GB2421029B (en) |
IL (2) | IL173832A (en) |
WO (1) | WO2005021720A2 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7588937B2 (en) | 2001-10-03 | 2009-09-15 | Wisconsin Alumni Research Foundation | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells |
US8153424B2 (en) | 2001-10-03 | 2012-04-10 | Wisconsin Alumni Research Foundation | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells |
US7632679B2 (en) * | 2002-07-16 | 2009-12-15 | The Trustees Of Columbia University In The City Of New York | Systems and methods for screening for modulators of neural differentiation |
JP4792290B2 (en) * | 2005-12-27 | 2011-10-12 | 財団法人 東京都医学総合研究所 | Method for producing neural stem cells |
CA2644922C (en) | 2006-03-07 | 2019-07-23 | Geeta Shroff | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation |
KR100838013B1 (en) * | 2006-06-07 | 2008-06-12 | 제일약품주식회사 | Efficient Generation of Neural Progenitors, Neurons and Dopaminergic Neurons from Human Embryonic Stem Cells |
WO2009132156A1 (en) | 2008-04-22 | 2009-10-29 | Regenerative Research Foundation | Retinal pigment epithelial stem cells |
KR101168053B1 (en) * | 2009-11-06 | 2012-07-24 | 연세대학교 산학협력단 | Efficient and Universal Method for Neural Differentiation of Pluripotent Stem Cells |
US20130149287A1 (en) | 2010-07-30 | 2013-06-13 | Cambridge Enterprise Limited | Corticogenesis of Human Pluripotent Cells |
US9487752B2 (en) | 2011-03-30 | 2016-11-08 | Cellular Dynamics International, Inc. | Priming of pluripotent stem cells for neural differentiation |
JP6015112B2 (en) * | 2012-05-11 | 2016-10-26 | 株式会社ニコン | Cell evaluation apparatus, cell evaluation method and program |
PE20210451A1 (en) * | 2015-11-12 | 2021-03-08 | Hoffmann La Roche | OLIGONUCLEOTIDES TO INDUCE PATERNAL EXPRESSION OF UBE3A |
US11473061B2 (en) | 2016-02-01 | 2022-10-18 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
JPWO2017209290A1 (en) * | 2016-06-03 | 2019-04-11 | 国立大学法人京都大学 | Production and use of pluripotent stem cell-derived motor neurons |
JP6376196B2 (en) * | 2016-09-29 | 2018-08-22 | 株式会社ニコン | Cell evaluation apparatus, cell evaluation method and program |
US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
CN108048399B (en) * | 2017-11-13 | 2021-03-23 | 昆明医科大学 | Method for inducing tree shrew dopamine neuron primary cell autophagy by METH |
JP2019106895A (en) * | 2017-12-15 | 2019-07-04 | インダストリー‐ユニバーシティー コーぺレーション ファンデーション ハンヤン ユニバーシティ | Method of differentiating neural stem cells or neural precursor cells into dopamine neurons |
EP3775161A4 (en) * | 2018-04-06 | 2022-04-06 | Cedars-Sinai Medical Center | Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip |
US11981918B2 (en) | 2018-04-06 | 2024-05-14 | Cedars-Sinai Medical Center | Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
WO2019236082A1 (en) * | 2018-06-06 | 2019-12-12 | The Regents Of The University Of California | Neural stem cell compositions and methods to treat neurodegenerative disorders |
JP6798533B2 (en) * | 2018-07-26 | 2020-12-09 | 株式会社ニコン | Cell evaluation device, incubator and program |
WO2021045217A1 (en) * | 2019-09-06 | 2021-03-11 | 学校法人慶應義塾 | Method for producing cell aggregate including glial progenitor cells |
JP7235027B2 (en) * | 2020-11-16 | 2023-03-08 | 株式会社ニコン | Cell evaluation instruments, incubators and programs |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001083715A2 (en) * | 2000-05-01 | 2001-11-08 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary, | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
WO2001088104A2 (en) * | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
US20030068819A1 (en) * | 2001-10-03 | 2003-04-10 | Su-Chun Zhang | Method of in vitro differentiation of transplantatable neural precursor cells from primate embryonic stem cells |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7144997B2 (en) * | 1997-07-24 | 2006-12-05 | Curis, Inc. | Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto |
CA2298506A1 (en) * | 1997-08-04 | 1999-02-11 | The Regents Of The University Of California | Methods for treating neurological deficits |
CN100422315C (en) * | 2000-11-30 | 2008-10-01 | 斯坦姆荣公司 | Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same |
US20030211605A1 (en) * | 2001-05-01 | 2003-11-13 | Lee Sang-Hun | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
-
2004
- 2004-08-27 KR KR1020067004226A patent/KR20060115351A/en not_active Application Discontinuation
- 2004-08-27 AU AU2004269361A patent/AU2004269361B2/en active Active
- 2004-08-27 WO PCT/US2004/027841 patent/WO2005021720A2/en active Application Filing
- 2004-08-27 CA CA2536588A patent/CA2536588C/en active Active
- 2004-08-27 GB GB0605851A patent/GB2421029B/en active Active
- 2004-08-27 EP EP04782339A patent/EP1670901A4/en not_active Withdrawn
- 2004-08-27 KR KR1020087028900A patent/KR20080109943A/en not_active Application Discontinuation
- 2004-08-27 JP JP2006524872A patent/JP2007503811A/en not_active Withdrawn
-
2006
- 2006-02-20 IL IL173832A patent/IL173832A/en active IP Right Grant
-
2009
- 2009-04-28 IL IL198450A patent/IL198450A/en active IP Right Grant
-
2010
- 2010-01-28 JP JP2010017013A patent/JP5529561B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001083715A2 (en) * | 2000-05-01 | 2001-11-08 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary, | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
WO2001088104A2 (en) * | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
US20030068819A1 (en) * | 2001-10-03 | 2003-04-10 | Su-Chun Zhang | Method of in vitro differentiation of transplantatable neural precursor cells from primate embryonic stem cells |
Non-Patent Citations (6)
Title |
---|
BAIN G ET AL: "Embryonic stem cells express neuronal properties in vitro", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 168, no. 2, 1995, pages 342 - 357, XP002317725, ISSN: 0012-1606 * |
LI X ET AL: "Differentiation of human embryonic stem cells into motoneurons.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, 2003, 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages ABSTRACT NO. 347.7, XP009087528, Retrieved from the Internet <URL:http://sfn.scholarone.com> [retrieved on 30070730] * |
LI XUE-JUN ET AL: "Specification of motoneurons from human embryonic stem cells", NATURE BIOTECHNOLOGY, vol. 23, no. 2, February 2005 (2005-02-01), pages 215 - 221, XP009087451, ISSN: 1087-0156 * |
MUJTABA T ET AL: "Lineage-restricted neural precursors can be isolated from both the mouse neural tube and cultured ES cells", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 214, no. 1, 1 October 1999 (1999-10-01), pages 113 - 127, XP002216609, ISSN: 0012-1606 * |
See also references of WO2005021720A2 * |
YAN YIPING ET AL: "Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells", STEM CELLS (MIAMISBURG), vol. 23, no. 6, June 2005 (2005-06-01), pages 781 - 790, XP009087442, ISSN: 1066-5099 * |
Also Published As
Publication number | Publication date |
---|---|
GB2421029B (en) | 2008-04-09 |
GB2421029A (en) | 2006-06-14 |
WO2005021720A3 (en) | 2005-05-19 |
JP2010162024A (en) | 2010-07-29 |
GB0605851D0 (en) | 2006-05-03 |
JP5529561B2 (en) | 2014-06-25 |
CA2536588A1 (en) | 2005-03-10 |
WO2005021720A2 (en) | 2005-03-10 |
EP1670901A2 (en) | 2006-06-21 |
IL173832A0 (en) | 2006-07-05 |
KR20080109943A (en) | 2008-12-17 |
JP2007503811A (en) | 2007-03-01 |
CA2536588C (en) | 2018-04-24 |
IL198450A (en) | 2011-01-31 |
AU2004269361A1 (en) | 2005-03-10 |
IL173832A (en) | 2011-02-28 |
KR20060115351A (en) | 2006-11-08 |
AU2004269361B2 (en) | 2010-05-20 |
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Legal Events
Date | Code | Title | Description |
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