JP2018531583A5 - - Google Patents
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- Publication number
- JP2018531583A5 JP2018531583A5 JP2018506601A JP2018506601A JP2018531583A5 JP 2018531583 A5 JP2018531583 A5 JP 2018531583A5 JP 2018506601 A JP2018506601 A JP 2018506601A JP 2018506601 A JP2018506601 A JP 2018506601A JP 2018531583 A5 JP2018531583 A5 JP 2018531583A5
- Authority
- JP
- Japan
- Prior art keywords
- free dna
- dna fragments
- cell
- sequence
- subsequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 78
- 108020004414 DNA Proteins 0.000 claims 74
- 238000000034 method Methods 0.000 claims 40
- 210000004027 cell Anatomy 0.000 claims 23
- 108091028732 Concatemer Proteins 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 9
- 238000012163 sequencing technique Methods 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021060027A JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
| JP2024092950A JP2024113130A (ja) | 2015-08-12 | 2024-06-07 | 血漿ｄｎａの単分子配列決定 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204396P | 2015-08-12 | 2015-08-12 | |
| US62/204,396 | 2015-08-12 | ||
| PCT/CN2016/094802 WO2017025059A1 (en) | 2015-08-12 | 2016-08-12 | Single-molecule sequencing of plasma dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021060027A Division JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531583A JP2018531583A (ja) | 2018-11-01 |
| JP2018531583A5 true JP2018531583A5 (enExample) | 2019-09-05 |
| JP6867045B2 JP6867045B2 (ja) | 2021-04-28 |
Family
ID=57983895
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506601A Active JP6867045B2 (ja) | 2015-08-12 | 2016-08-12 | 血漿ｄｎａの単分子配列決定 |
| JP2021060027A Active JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
| JP2024092950A Pending JP2024113130A (ja) | 2015-08-12 | 2024-06-07 | 血漿ｄｎａの単分子配列決定 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021060027A Active JP7506408B2 (ja) | 2015-08-12 | 2021-03-31 | 血漿ｄｎａの単分子配列決定 |
| JP2024092950A Pending JP2024113130A (ja) | 2015-08-12 | 2024-06-07 | 血漿ｄｎａの単分子配列決定 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11319586B2 (enExample) |
| EP (1) | EP3334843A4 (enExample) |
| JP (3) | JP6867045B2 (enExample) |
| CN (2) | CN107849607B (enExample) |
| AU (3) | AU2016305103C1 (enExample) |
| CA (1) | CA2995422A1 (enExample) |
| HK (1) | HK1248286A1 (enExample) |
| IL (3) | IL285795B (enExample) |
| MY (1) | MY188348A (enExample) |
| SA (1) | SA518390907B1 (enExample) |
| TW (2) | TWI793586B (enExample) |
| WO (1) | WO2017025059A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7084470B2 (ja) | 2017-08-23 | 2022-06-14 | エフ．ホフマン－ラ ロシュ アーゲー | 酵素のスクリーニング法 |
| JP2020532999A (ja) * | 2017-09-07 | 2020-11-19 | クーパーゲノミクス， インコーポレイテッド | 非侵襲性の移植前遺伝子診断のためのシステムおよび方法 |
| EP3700856A4 (en) | 2017-10-26 | 2021-12-15 | Ultima Genomics, Inc. | METHODS AND SYSTEMS FOR SEQUENCE CALL |
| CA3044782A1 (en) | 2017-12-29 | 2019-06-29 | Clear Labs, Inc. | Automated priming and library loading device |
| WO2019204720A1 (en) * | 2018-04-20 | 2019-10-24 | The Regents Of The University Of California | Nucleic acid sequencing methods and computer-readable media for practicing same |
| WO2020185790A1 (en) | 2019-03-10 | 2020-09-17 | Ultima Genomics, Inc. | Methods and systems for sequence calling |
| KR20220062263A (ko) | 2019-06-21 | 2022-05-16 | 쿠퍼서지컬, 인코퍼레이션. | 배아에서 유전 패턴을 결정하기 위한 시스템 및 방법(systems and methods for determining pattern of inheritance in embryos) |
| US20220411863A1 (en) * | 2019-11-25 | 2022-12-29 | William Marsh Rice University | Linear dna assembly for nanopore sequencing |
| US20230249178A1 (en) | 2020-07-08 | 2023-08-10 | Roche Sequencing Solutions, Inc. | Split-pool synthesis apparatus and methods of performing split-pool synthesis |
| EP4228793A1 (en) | 2020-10-15 | 2023-08-23 | Kapa Biosystems, Inc. | Electrophoretic devices and methods for next-generation sequencing library preparation |
| CN114507708A (zh) * | 2020-11-16 | 2022-05-17 | 唐纳德·李 | 一种制备长分子测序dna的方法 |
| WO2022194764A1 (en) | 2021-03-15 | 2022-09-22 | F. Hoffmann-La Roche Ag | Targeted next-generation sequencing via anchored primer extension |
| US20250146055A1 (en) | 2021-03-26 | 2025-05-08 | Roche Sequencing Solutions, Inc. | Hybridization buffer formulations |
| WO2022207682A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Immune cell counting of sars-cov-2 patients based on immune repertoire sequencing |
| JP2024516365A (ja) * | 2021-04-12 | 2024-04-15 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 電気信号を使用する塩基修飾分析 |
| WO2023023561A1 (en) * | 2021-08-17 | 2023-02-23 | Quantapore, Inc. | Multiplex binding assays with optical nanopore readout |
| IL312140A (en) * | 2021-10-18 | 2024-06-01 | Belgian Volition Srl | Use of nanopore sequencing for determining the origin of circulating dna |
| JP2025521678A (ja) | 2022-06-30 | 2025-07-10 | カパ バイオシステムズ，インコーポレイティド | 古細菌ヒストン様タンパク質を使用したタグメンテーション配列決定ライブラリーインサートサイズの制御 |
| CN114898802B (zh) * | 2022-07-14 | 2022-09-30 | 臻和(北京)生物科技有限公司 | 基于血浆游离dna甲基化测序数据的末端序列频率分布特征确定方法、评价方法及装置 |
| EP4581153A1 (en) | 2022-09-02 | 2025-07-09 | F. Hoffmann-La Roche AG | Improvements to next-generation target enrichment performance |
| WO2024215528A1 (en) | 2023-04-13 | 2024-10-17 | Ventana Medical Systems, Inc. | Proliferation assay for fixed solid tumors |
| WO2024256358A2 (en) | 2023-06-14 | 2024-12-19 | F. Hoffmann-La Roche Ag | Accelerated marking of 5-formyl cytosine and use in nucleic acid methylation sequencing |
| WO2025193604A1 (en) | 2024-03-11 | 2025-09-18 | Ventana Medical Systems, Inc. | Non-enzymatic dissociation of ffpe tissue and generation of single cells with intact cell surface markers |
| WO2025210056A1 (en) | 2024-04-03 | 2025-10-09 | Roche Sequencing Solutions, Inc. | In vitro amplification of dna methylation patterns |
| WO2025247632A1 (en) | 2024-05-27 | 2025-12-04 | European Molecular Biology Laboratory | Preparation of cell-free fragmented nucleic acids for genetic analysis sequencing |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020197618A1 (en) * | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
| GB0504774D0 (en) | 2005-03-08 | 2005-04-13 | Lingvitae As | Method |
| JP2008161056A (ja) | 2005-04-08 | 2008-07-17 | Hiroaki Mita | Ｄｎａ配列解析装置、ｄｎａ配列解析方法およびプログラム |
| KR102458210B1 (ko) | 2007-07-23 | 2022-10-24 | 더 차이니즈 유니버시티 오브 홍콩 | 핵산 서열 불균형의 결정 |
| DE102008061772A1 (de) * | 2008-12-11 | 2010-06-17 | Febit Holding Gmbh | Verfahren zur Untersuchung von Nukleinsäure-Populationen |
| AU2009325069B2 (en) | 2008-12-11 | 2015-03-19 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
| LT3783110T (lt) | 2009-11-05 | 2023-01-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US8620593B2 (en) | 2009-11-06 | 2013-12-31 | The Chinese University Of Hong Kong | Size-based genomic analysis |
| US9121823B2 (en) | 2010-02-19 | 2015-09-01 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| KR20120045922A (ko) * | 2010-11-01 | 2012-05-09 | 엘지전자 주식회사 | 나노 포어를 포함하는 염기 서열 결정 장치 |
| EA038374B1 (ru) | 2010-11-30 | 2021-08-17 | Те Чайниз Юниверсити Ов Гонконг | Способ анализа биологического образца организма для выявления хромосомных делеций или амплификаций, ассоциированных с раком |
| JP6298404B2 (ja) * | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| GB2485635B (en) * | 2011-07-26 | 2012-11-28 | Verinata Health Inc | Method for determining the presence or absence of different aneuploidies in a sample |
| US20130040827A1 (en) * | 2011-08-14 | 2013-02-14 | Stephen C. Macevicz | Method and compositions for detecting and sequencing nucleic acids |
| EP3415901A1 (en) * | 2012-01-20 | 2018-12-19 | Genia Technologies, Inc. | Nanopore based molecular detection and sequencing |
| GB2559073A (en) | 2012-06-08 | 2018-07-25 | Pacific Biosciences California Inc | Modified base detection with nanopore sequencing |
| GB2510719A (en) * | 2012-06-15 | 2014-08-13 | Genia Technologies Inc | Chip set-up and high-accuracy nucleic acid sequencing |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| GB201215449D0 (en) | 2012-08-30 | 2012-10-17 | Zoragen Biotechnologies Llp | Method of detecting chromosonal abnormalities |
| BR112015006183B1 (pt) | 2012-09-20 | 2022-04-26 | The Chinese University Of Hong Kong | Métodos para analisar uma amostra biológica de um organismo, para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, para detecção de uma anormalidade cromossômica de uma amostra biológica de um organismo e para estimar um nível de metilação do dna em uma amostra biológica de um organismo, produto de computador, e, kit para análise de dna fetal |
| US10767222B2 (en) * | 2013-12-11 | 2020-09-08 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| CN107002130B (zh) * | 2014-11-11 | 2022-02-01 | 深圳华大基因研究院 | 多程测序 |
| AU2016406443A1 (en) | 2016-05-10 | 2018-11-15 | Nec Corporation | Demand and supply adjustment system, control apparatus, control method, and program |
-
2016
- 2016-08-12 CA CA2995422A patent/CA2995422A1/en active Pending
- 2016-08-12 TW TW110115619A patent/TWI793586B/zh active
- 2016-08-12 US US15/235,630 patent/US11319586B2/en active Active
- 2016-08-12 MY MYPI2018000139A patent/MY188348A/en unknown
- 2016-08-12 EP EP16834683.1A patent/EP3334843A4/en active Pending
- 2016-08-12 WO PCT/CN2016/094802 patent/WO2017025059A1/en not_active Ceased
- 2016-08-12 JP JP2018506601A patent/JP6867045B2/ja active Active
- 2016-08-12 CN CN201680046621.0A patent/CN107849607B/zh active Active
- 2016-08-12 AU AU2016305103A patent/AU2016305103C1/en active Active
- 2016-08-12 TW TW105125873A patent/TWI728994B/zh active
- 2016-08-12 CN CN202211147693.8A patent/CN115433769A/zh active Pending
- 2016-08-12 HK HK18108082.2A patent/HK1248286A1/zh unknown
- 2016-08-12 IL IL285795A patent/IL285795B/en unknown
-
2018
- 2018-01-22 IL IL257074A patent/IL257074B/en unknown
- 2018-02-12 SA SA518390907A patent/SA518390907B1/ar unknown
-
2020
- 2020-03-26 AU AU2020202153A patent/AU2020202153B2/en active Active
-
2021
- 2021-03-31 JP JP2021060027A patent/JP7506408B2/ja active Active
-
2022
- 2022-03-18 US US17/698,574 patent/US20220205038A1/en active Pending
- 2022-06-22 IL IL294192A patent/IL294192B2/en unknown
-
2023
- 2023-04-27 AU AU2023202572A patent/AU2023202572B2/en active Active
-
2024
- 2024-06-07 JP JP2024092950A patent/JP2024113130A/ja active Pending
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