JP6867045B2 - 血漿ｄｎａの単分子配列決定 - Google Patents

血漿ｄｎａの単分子配列決定 Download PDF

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JP6867045B2
JP6867045B2 JP2018506601A JP2018506601A JP6867045B2 JP 6867045 B2 JP6867045 B2 JP 6867045B2 JP 2018506601 A JP2018506601 A JP 2018506601A JP 2018506601 A JP2018506601 A JP 2018506601A JP 6867045 B2 JP6867045 B2 JP 6867045B2
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cell
free dna
dna fragments
concatemer
sequence
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JP2018531583A (ja
JP2018531583A5 (enExample
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ユク−ミン デニス ロ
ユク−ミン デニス ロ
ロッサ ウェイ クン チウ
ロッサ ウェイ クン チウ
スク ハン チョン
スク ハン チョン
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Chinese University of Hong Kong CUHK
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
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    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/151—Modifications characterised by repeat or repeated sequences, e.g. VNTR, microsatellite, concatemer
    • C—CHEMISTRY; METALLURGY
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/191—Modifications characterised by incorporating an adaptor
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/197—Modifications characterised by incorporating a spacer/coupling moiety
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/631—Detection means characterised by use of a special device being a biochannel or pore

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  • Bioinformatics & Computational Biology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Hematology (AREA)
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  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nanotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
JP2018506601A 2015-08-12 2016-08-12 血漿ｄｎａの単分子配列決定 Active JP6867045B2 (ja)

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JP2021060027A JP7506408B2 (ja) 2015-08-12 2021-03-31 血漿ｄｎａの単分子配列決定
JP2024092950A JP2024113130A (ja) 2015-08-12 2024-06-07 血漿ｄｎａの単分子配列決定

Applications Claiming Priority (3)

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US201562204396P 2015-08-12 2015-08-12
US62/204,396 2015-08-12
PCT/CN2016/094802 WO2017025059A1 (en) 2015-08-12 2016-08-12 Single-molecule sequencing of plasma dna

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JP2024092950A Pending JP2024113130A (ja) 2015-08-12 2024-06-07 血漿ｄｎａの単分子配列決定

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US (2) US11319586B2 (enExample)
EP (1) EP3334843A4 (enExample)
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CN (2) CN107849607B (enExample)
AU (3) AU2016305103C1 (enExample)
CA (1) CA2995422A1 (enExample)
HK (1) HK1248286A1 (enExample)
IL (3) IL285795B (enExample)
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SA (1) SA518390907B1 (enExample)
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AU2016305103B2 (en) 2020-01-02
TW201718874A (zh) 2017-06-01
US11319586B2 (en) 2022-05-03
TWI728994B (zh) 2021-06-01
JP2018531583A (ja) 2018-11-01
AU2023202572A1 (en) 2023-05-18
US20220205038A1 (en) 2022-06-30
AU2023202572B2 (en) 2025-04-10
CN115433769A (zh) 2022-12-06
CN107849607B (zh) 2022-10-11
IL294192A (en) 2022-08-01
AU2020202153A1 (en) 2020-04-16
JP2021118691A (ja) 2021-08-12
IL285795B (en) 2022-07-01
TWI793586B (zh) 2023-02-21
HK1248286A1 (zh) 2018-10-12
CN107849607A (zh) 2018-03-27
AU2016305103A1 (en) 2018-03-22
JP7506408B2 (ja) 2024-06-26
CA2995422A1 (en) 2017-02-16
IL294192B2 (en) 2023-08-01
AU2020202153B2 (en) 2023-02-02
IL285795A (en) 2021-09-30
AU2016305103C1 (en) 2020-06-04
TW202130815A (zh) 2021-08-16
IL257074B (en) 2021-09-30
US20170044606A1 (en) 2017-02-16
JP2024113130A (ja) 2024-08-21
EP3334843A1 (en) 2018-06-20
EP3334843A4 (en) 2019-01-02
IL294192B1 (en) 2023-04-01
IL257074A (en) 2018-03-29
WO2017025059A1 (en) 2017-02-16
SA518390907B1 (ar) 2021-09-08
MY188348A (en) 2021-12-02
HK1245850A1 (zh) 2018-08-31

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