JP2018531580A5 - - Google Patents
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- JP2018531580A5 JP2018531580A5 JP2018501228A JP2018501228A JP2018531580A5 JP 2018531580 A5 JP2018531580 A5 JP 2018531580A5 JP 2018501228 A JP2018501228 A JP 2018501228A JP 2018501228 A JP2018501228 A JP 2018501228A JP 2018531580 A5 JP2018531580 A5 JP 2018531580A5
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- 239000012634 fragment Substances 0.000 claims description 70
- 102000013498 tau Proteins Human genes 0.000 claims description 52
- 108010026424 tau Proteins Proteins 0.000 claims description 52
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- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims description 8
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- 206010018338 Glioma Diseases 0.000 claims description 2
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- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
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- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 2
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- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims description 2
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- 208000031124 Dementia Alzheimer type Diseases 0.000 description 1
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- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1512211.2A GB201512211D0 (en) | 2015-07-13 | 2015-07-13 | Agents, uses and methods |
| GB1512211.2 | 2015-07-13 | ||
| GB1518375.9 | 2015-10-16 | ||
| GBGB1518375.9A GB201518375D0 (en) | 2015-10-16 | 2015-10-16 | Agents,uses and methods |
| PCT/EP2016/066470 WO2017009308A2 (en) | 2015-07-13 | 2016-07-12 | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531580A JP2018531580A (ja) | 2018-11-01 |
| JP2018531580A5 true JP2018531580A5 (OSRAM) | 2019-08-15 |
| JP6878395B2 JP6878395B2 (ja) | 2021-05-26 |
Family
ID=56557664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501228A Active JP6878395B2 (ja) | 2015-07-13 | 2016-07-12 | 過リン酸化タウに特異的な抗体およびその使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US10196439B2 (OSRAM) |
| EP (1) | EP3322442A2 (OSRAM) |
| JP (1) | JP6878395B2 (OSRAM) |
| KR (1) | KR20180030047A (OSRAM) |
| CN (1) | CN107847595B (OSRAM) |
| AU (1) | AU2016292892B2 (OSRAM) |
| BR (1) | BR112018000769A2 (OSRAM) |
| CL (1) | CL2018000096A1 (OSRAM) |
| CO (1) | CO2017013318A2 (OSRAM) |
| CR (1) | CR20180026A (OSRAM) |
| DO (1) | DOP2018000012A (OSRAM) |
| EA (1) | EA038703B1 (OSRAM) |
| EC (1) | ECSP18002644A (OSRAM) |
| GE (1) | GEP20227369B (OSRAM) |
| HK (1) | HK1254357A1 (OSRAM) |
| IL (1) | IL256791B (OSRAM) |
| JO (1) | JO3711B1 (OSRAM) |
| MA (1) | MA42446A (OSRAM) |
| MX (1) | MX392396B (OSRAM) |
| NI (1) | NI201800005A (OSRAM) |
| NZ (1) | NZ738595A (OSRAM) |
| PE (1) | PE20180607A1 (OSRAM) |
| PH (1) | PH12018500062A1 (OSRAM) |
| RU (1) | RU2727911C2 (OSRAM) |
| SG (1) | SG10202101343RA (OSRAM) |
| SV (1) | SV2018005611A (OSRAM) |
| TN (1) | TN2017000541A1 (OSRAM) |
| TW (1) | TWI741987B (OSRAM) |
| UA (1) | UA123862C2 (OSRAM) |
| WO (1) | WO2017009308A2 (OSRAM) |
| ZA (1) | ZA201800070B (OSRAM) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2970453B1 (en) | 2013-03-13 | 2019-12-04 | Prothena Biosciences Limited | Tau immunotherapy |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| JP6793134B2 (ja) | 2015-06-05 | 2020-12-02 | ジェネンテック， インコーポレイテッド | 抗ｔａｕ抗体及び使用方法 |
| US10344081B2 (en) | 2015-07-06 | 2019-07-09 | Ucb Biopharma Sprl | Tau-binding antibodies |
| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| PT3452507T (pt) | 2016-05-02 | 2022-12-20 | Prothena Biosciences Ltd | Imunoterapia anti-tau |
| SG11201808434WA (en) | 2016-05-02 | 2018-10-30 | Prothena Biosciences Ltd | Antibodies recognizing tau |
| US10034861B2 (en) | 2016-07-04 | 2018-07-31 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
| GEP20217222B (en) * | 2016-07-12 | 2021-02-10 | Lundbeck A/S H | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
| US11590304B2 (en) | 2016-08-15 | 2023-02-28 | The Board Of Regents Of The University Of Texas System | Volume control device for manually operated resuscitator and ventilation apparatus and method of use |
| PT3532064T (pt) | 2016-10-28 | 2020-09-03 | H Lundbeck As | Tratamentos de combinação compreendendo imidazopirazinonas para o tratamento de distúrbios psiquiátricos e/ou cognitivos |
| MA46621A (fr) | 2016-10-28 | 2021-06-02 | H Lundbeck As | Traitements combinés comprenant l'administration d'imidazopyrazinones |
| MY198942A (en) | 2016-12-07 | 2023-10-03 | Genentech Inc | Anti-tau antibodies and methods of use |
| CN110248959B (zh) | 2016-12-07 | 2023-06-30 | 基因泰克公司 | 抗tau抗体和使用方法 |
| WO2018127519A1 (en) * | 2017-01-04 | 2018-07-12 | H. Lundbeck A/S | Antibodies specific for hyperphosphorylated tau for the treatment of ocular diseases |
| MA47499A (fr) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
| JOP20180014A1 (ar) | 2017-02-27 | 2019-01-30 | Teijin Pharma Ltd | جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه |
| EA039569B1 (ru) * | 2017-03-14 | 2022-02-11 | Х. Лундбекк А/С | Антитела, специфичные к гиперфосфорилированному тау-белку, и способы их применения |
| CN110881274B (zh) | 2017-05-02 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| WO2019077500A1 (en) | 2017-10-16 | 2019-04-25 | Eisai R&D Management Co., Ltd. | ANTI-WATER ANTIBODIES AND USES THEREOF |
| AR113926A1 (es) | 2017-12-14 | 2020-07-01 | H Lundbeck As | Derivados de 1h-pirazolo[4,3-b]piridinas |
| HUE057202T2 (hu) | 2017-12-14 | 2022-04-28 | H Lundbeck As | Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával |
| WO2019121840A1 (en) | 2017-12-20 | 2019-06-27 | H. Lundbeck A/S | Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors |
| WO2019149798A1 (en) * | 2018-02-01 | 2019-08-08 | Janssen Vaccines & Prevention B.V. | Binding molecules that specifically bind to tau |
| CN116063505B (zh) | 2019-01-30 | 2024-05-03 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CA3131531A1 (en) | 2019-03-03 | 2020-09-10 | Prothena Biosciences Limited | Antibodies recognizing tau |
| US12264197B2 (en) | 2019-03-11 | 2025-04-01 | Janssen Biotech, Inc. | Anti-Vβ17/anti-CD123 bispecific antibodies |
| CN113748343A (zh) | 2019-03-28 | 2021-12-03 | H.隆德贝克有限公司 | pS396测定用于诊断TAU蛋白病的用途 |
| GB201909393D0 (en) * | 2019-06-28 | 2019-08-14 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| SG10201908922UA (en) * | 2019-09-25 | 2021-04-29 | Sengenics Corp Pte Ltd | Identification of health status in the elderly using immunological biomarkers |
| CN116249712A (zh) | 2020-04-15 | 2023-06-09 | 沃雅戈治疗公司 | Tau结合化合物 |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| BR112022026575A2 (pt) | 2020-06-25 | 2023-01-17 | Merck Sharp & Dohme Llc | Anticorpos de alta afinidade que alvejam tau fosforilado em serina 413 |
| BR112023002488A2 (pt) | 2020-08-10 | 2023-05-02 | Janssen Biotech Inc | Materiais e métodos para produzir linfócitos biomodificados contra vírus específicos |
| WO2022056197A1 (en) | 2020-09-11 | 2022-03-17 | Janssen Biotech, Inc. | Immune targeting molecules and uses thereof |
| US11965024B2 (en) | 2020-09-11 | 2024-04-23 | Janssen Biotech, Inc. | Methods and compositions for modulating beta chain mediated immunity |
| US20220089737A1 (en) * | 2020-09-11 | 2022-03-24 | Janssen Biotech, Inc. | Multi-specific immune targeting molecules and uses thereof |
| US20250298039A1 (en) * | 2020-11-12 | 2025-09-25 | Children`S Medical Center Corporation | Methods and compositions for tauopathy diagnosis and treatment |
| TW202239765A (zh) | 2020-12-16 | 2022-10-16 | 美商航海家醫療公司 | Tau結合化合物 |
| CL2021001380A1 (es) | 2021-05-26 | 2022-01-14 | Corporacion Centro Int De Biomedicina Icc | Generación de un nuevo anticuerpo monoclonal sitio específico para la proteína tau y su uso como herramienta en biomarcadores específicos para la detección temprana de enfermedades neurodegenerativas y patologías involucradas con la proteína tau como alzheimer y otras demencias. |
| CN113702647B (zh) * | 2021-08-31 | 2024-03-15 | 普十生物科技(北京)有限公司 | 人生长分化因子15即时检测试剂盒、其制备方法及其应用 |
| US20250034559A1 (en) | 2021-11-17 | 2025-01-30 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| EP4543473A1 (en) | 2022-06-22 | 2025-04-30 | Voyager Therapeutics, Inc. | Tau binding compounds |
| AU2023342086A1 (en) | 2022-09-15 | 2025-03-13 | Voyager Therapeutics, Inc. | Tau binding compounds |
| EP4595977A1 (en) * | 2022-09-26 | 2025-08-06 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Ultra-long-acting platform comprising fc-advanced fatty acid chain |
| CN116794328A (zh) * | 2023-06-20 | 2023-09-22 | 南京鼓楼医院 | 一种基于多位点的高灵敏磷酸化Tau蛋白检测方法 |
| CN116754776A (zh) * | 2023-06-20 | 2023-09-15 | 南京鼓楼医院 | 一种基于S396与S404位点的高灵敏磷酸化Tau蛋白检测方法 |
| WO2025122634A1 (en) | 2023-12-05 | 2025-06-12 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
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