JP2018530587A - ｍＲＮＡキャップ類似体およびｍＲＮＡキャッピングの方法 - Google Patents

ｍＲＮＡキャップ類似体およびｍＲＮＡキャッピングの方法 Download PDF

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JP2018530587A
JP2018530587A JP2018519312A JP2018519312A JP2018530587A JP 2018530587 A JP2018530587 A JP 2018530587A JP 2018519312 A JP2018519312 A JP 2018519312A JP 2018519312 A JP2018519312 A JP 2018519312A JP 2018530587 A JP2018530587 A JP 2018530587A
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alkyl
halo
compound according
optionally substituted
methyl
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JP2018530587A5 (cg-RX-API-DMAC7.html
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ブトラ、ガボール
スタントン、マシュー
スティール、トーマス
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ModernaTx Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018519312A 2015-10-16 2016-10-17 ｍＲＮＡキャップ類似体およびｍＲＮＡキャッピングの方法 Pending JP2018530587A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562242881P 2015-10-16 2015-10-16
US62/242,881 2015-10-16
PCT/US2016/057405 WO2017066793A1 (en) 2015-10-16 2016-10-17 Mrna cap analogs and methods of mrna capping

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JP2018530587A true JP2018530587A (ja) 2018-10-18
JP2018530587A5 JP2018530587A5 (cg-RX-API-DMAC7.html) 2019-11-28

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JP2018519312A Pending JP2018530587A (ja) 2015-10-16 2016-10-17 ｍＲＮＡキャップ類似体およびｍＲＮＡキャッピングの方法

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US (1) US20190225644A1 (cg-RX-API-DMAC7.html)
EP (1) EP3362460A1 (cg-RX-API-DMAC7.html)
JP (1) JP2018530587A (cg-RX-API-DMAC7.html)
AU (1) AU2016340183A1 (cg-RX-API-DMAC7.html)
CA (1) CA3001014A1 (cg-RX-API-DMAC7.html)
WO (1) WO2017066793A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023540562A (ja) * 2020-09-04 2023-09-25 ヴァーヴ・セラピューティクス，インコーポレーテッド Ｒｎａをキャッピングするための組成物および方法

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