JP2018528773A5 - - Google Patents
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- JP2018528773A5 JP2018528773A5 JP2018512167A JP2018512167A JP2018528773A5 JP 2018528773 A5 JP2018528773 A5 JP 2018528773A5 JP 2018512167 A JP2018512167 A JP 2018512167A JP 2018512167 A JP2018512167 A JP 2018512167A JP 2018528773 A5 JP2018528773 A5 JP 2018528773A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 75
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 102000008166 Member 25 Tumor Necrosis Factor Receptors Human genes 0.000 claims 3
- 108010060408 Member 25 Tumor Necrosis Factor Receptors Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000003651 pulmonary sarcoidosis Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022005039A JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220442P | 2015-09-18 | 2015-09-18 | |
| US62/220,442 | 2015-09-18 | ||
| PCT/US2016/052040 WO2017049024A1 (en) | 2015-09-18 | 2016-09-16 | Antibodies that specifically bind to tl1a |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022005039A Division JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528773A JP2018528773A (ja) | 2018-10-04 |
| JP2018528773A5 true JP2018528773A5 (https=) | 2019-10-24 |
| JP7013366B2 JP7013366B2 (ja) | 2022-02-15 |
Family
ID=57043002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512167A Active JP7013366B2 (ja) | 2015-09-18 | 2016-09-16 | Ｔｌ１ａに特異的に結合する抗体 |
| JP2022005039A Active JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022005039A Active JP7341259B2 (ja) | 2015-09-18 | 2022-01-17 | Ｔｌ１ａに特異的に結合する抗体 |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US10138296B2 (https=) |
| EP (2) | EP3350223B1 (https=) |
| JP (2) | JP7013366B2 (https=) |
| KR (1) | KR101998535B1 (https=) |
| CN (1) | CN108137693B (https=) |
| AR (1) | AR106055A1 (https=) |
| AU (2) | AU2016323460B2 (https=) |
| BR (1) | BR122021002400A8 (https=) |
| CA (1) | CA2997015A1 (https=) |
| CL (1) | CL2018000711A1 (https=) |
| CO (1) | CO2018003736A2 (https=) |
| CY (1) | CY1123499T1 (https=) |
| DK (1) | DK3350223T3 (https=) |
| EA (1) | EA201890756A1 (https=) |
| ES (1) | ES2810751T3 (https=) |
| HR (1) | HRP20201323T1 (https=) |
| HU (1) | HUE051496T2 (https=) |
| IL (1) | IL257761B2 (https=) |
| LT (1) | LT3350223T (https=) |
| MA (2) | MA52643A (https=) |
| MD (1) | MD3350223T2 (https=) |
| MX (1) | MX2018003185A (https=) |
| PE (1) | PE20181080A1 (https=) |
| PH (1) | PH12018500580B1 (https=) |
| PL (1) | PL3350223T3 (https=) |
| PT (1) | PT3350223T (https=) |
| RS (1) | RS60703B1 (https=) |
| SI (1) | SI3350223T1 (https=) |
| SM (1) | SMT202000500T1 (https=) |
| TW (1) | TWI703158B (https=) |
| UA (1) | UA125284C2 (https=) |
| WO (1) | WO2017049024A1 (https=) |
| ZA (1) | ZA201801427B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
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| KR102343212B1 (ko) | 2013-03-27 | 2021-12-23 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| TWI703158B (zh) * | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| EP3383271B1 (en) * | 2015-12-04 | 2022-08-24 | University Of Iowa Research Foundation | System for screening delirium patients for the presence of encephalopathy |
| CR20180365A (es) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS |
| US11186872B2 (en) | 2016-03-17 | 2021-11-30 | Cedars-Sinai Medical Center | Methods of diagnosing inflammatory bowel disease through RNASET2 |
| MY191324A (en) | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
| EP3617235B1 (en) * | 2017-04-28 | 2026-02-18 | Ajinomoto Co., Inc. | Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof |
| JP7332627B2 (ja) | 2018-04-25 | 2023-08-23 | プロメテウス バイオサイエンシーズ，インク． | 最適化された抗ｔｌ１ａ抗体 |
| JP2022533956A (ja) | 2019-05-14 | 2022-07-27 | プロメテウス バイオサイエンシーズ，インク． | Ｔｌ１ａ患者を選択する方法、システム、およびデバイス |
| KR20220103721A (ko) | 2019-10-24 | 2022-07-22 | 프로메테우스 바이오사이언시즈, 인크. | Tnf 유사 리간드 1a(tl1a)에 대한 인간화 항체 및 그의 용도 |
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| CA3207818A1 (en) * | 2021-02-18 | 2022-08-25 | Allison LUO | Anti-tl1a antibody compositions and methods of treatment in the lung |
| EP4562038A1 (en) | 2022-07-27 | 2025-06-04 | Cephalon LLC | Anti-tl1a antibody formulations |
| CA3262839A1 (en) | 2022-07-27 | 2024-02-01 | Cephalon Llc | ANTI-TL1A ANTIBODIES FOR THE TREATMENT OF ULCERATIVE COLITIS AND CROHN'S DISEASE |
| KR20260013470A (ko) | 2023-05-17 | 2026-01-28 | 제넨테크, 인크. | 항-tl1a 항체 치료 방법 |
| CN121794295A (zh) * | 2023-06-21 | 2026-04-03 | 派拉冈医疗公司 | Tl1a抗体组合物及使用方法 |
| EP4731662A2 (en) * | 2023-06-22 | 2026-04-29 | Paragon Therapeutics, Inc. | Il-17 antibody compositions and methods of use |
| TW202511288A (zh) * | 2023-06-22 | 2025-03-16 | 美商派拉岡醫療公司 | Il-23抗體組合物及使用方法 |
| CN121843714A (zh) | 2023-08-11 | 2026-04-10 | 派拉冈医疗公司 | Tl1a结合抗体及使用方法 |
| US12473370B2 (en) | 2023-10-03 | 2025-11-18 | Absci Corporation | TL1A associated antibody compositions and methods of use |
| CN120058933B (zh) * | 2023-11-30 | 2026-02-10 | 北京智仁美博生物科技有限公司 | 抗肿瘤坏死因子样配体1a的抗体及其用途 |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
| CN120424214A (zh) * | 2024-02-05 | 2025-08-05 | 三生国健药业（上海）股份有限公司 | 一种抗tl1a抗体及其制备方法和用途 |
| WO2025170982A2 (en) | 2024-02-06 | 2025-08-14 | Paragon Therapeutics, Inc. | Il-23 antibody compositions and methods of use |
| CN120590530A (zh) * | 2024-03-05 | 2025-09-05 | 帆礼生物技术(武汉)有限公司 | 靶向tl1a的抗体及其应用 |
| US20250376530A1 (en) | 2024-05-17 | 2025-12-11 | Genentech, Inc. | Methods for treatment of inflammatory bowel disease with an anti-tl1a antibody |
| WO2026072983A1 (en) | 2024-09-27 | 2026-04-02 | Genentech, Inc. | Methods for treatment of atopic dermatitis with an anti-tl1a antibody |
| WO2026072993A1 (en) | 2024-09-27 | 2026-04-02 | Genentech, Inc. | Methods for treatment of metabolic dysfunction-associated steatohepatitis with an anti-tl1a antibody |
| CN119552252B (zh) * | 2025-01-16 | 2025-11-25 | 华润生物医药有限公司 | 抗tl1a抗体及其制备方法和应用 |
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| CN118829653A (zh) | 2022-01-07 | 2024-10-22 | 普罗米修斯生物科学公司 | 用tl1a抑制剂和il23抑制剂的组合治疗炎性疾病的方法 |
| US20240059799A1 (en) | 2022-05-11 | 2024-02-22 | Pfizer Inc. | Anti-tl1a antibodies and methods of use thereof |
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