JP2013531655A5 - - Google Patents

Download PDF

Info

Publication number
JP2013531655A5
JP2013531655A5 JP2013514691A JP2013514691A JP2013531655A5 JP 2013531655 A5 JP2013531655 A5 JP 2013531655A5 JP 2013514691 A JP2013514691 A JP 2013514691A JP 2013514691 A JP2013514691 A JP 2013514691A JP 2013531655 A5 JP2013531655 A5 JP 2013531655A5
Authority
JP
Japan
Prior art keywords
antibody
fragment
hybridoma
seq
produced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013514691A
Other languages
English (en)
Japanese (ja)
Other versions
JP6081911B2 (ja
JP2013531655A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2011/059868 external-priority patent/WO2011157724A1/en
Publication of JP2013531655A publication Critical patent/JP2013531655A/ja
Publication of JP2013531655A5 publication Critical patent/JP2013531655A5/ja
Application granted granted Critical
Publication of JP6081911B2 publication Critical patent/JP6081911B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013514691A 2010-06-14 2011-06-14 Ｓ１００ａ４抗体およびその治療上の使用 Expired - Fee Related JP6081911B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10382170 2010-06-14
EP10382170.8 2010-06-14
PCT/EP2011/059868 WO2011157724A1 (en) 2010-06-14 2011-06-14 S100a4 antibodies and therapeutic uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017007296A Division JP6564408B2 (ja) 2010-06-14 2017-01-19 Ｓ１００ａ４抗体およびその治療上の使用

Publications (3)

Publication Number Publication Date
JP2013531655A JP2013531655A (ja) 2013-08-08
JP2013531655A5 true JP2013531655A5 (https=) 2014-07-31
JP6081911B2 JP6081911B2 (ja) 2017-02-15

Family

ID=43617041

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013514691A Expired - Fee Related JP6081911B2 (ja) 2010-06-14 2011-06-14 Ｓ１００ａ４抗体およびその治療上の使用
JP2017007296A Expired - Fee Related JP6564408B2 (ja) 2010-06-14 2017-01-19 Ｓ１００ａ４抗体およびその治療上の使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017007296A Expired - Fee Related JP6564408B2 (ja) 2010-06-14 2017-01-19 Ｓ１００ａ４抗体およびその治療上の使用

Country Status (22)

Country Link
US (2) US8916152B2 (https=)
EP (1) EP2580240B1 (https=)
JP (2) JP6081911B2 (https=)
KR (1) KR101869413B1 (https=)
CN (1) CN103201290B (https=)
AU (3) AU2011267089B2 (https=)
BR (1) BR112012032008B1 (https=)
CA (1) CA2802631C (https=)
CL (1) CL2012003538A1 (https=)
CY (1) CY1121742T1 (https=)
DK (1) DK2580240T3 (https=)
ES (1) ES2717908T3 (https=)
IL (1) IL223667B (https=)
LT (1) LT2580240T (https=)
MX (1) MX347734B (https=)
NZ (1) NZ604643A (https=)
PL (1) PL2580240T4 (https=)
PT (1) PT2580240T (https=)
RU (1) RU2615684C2 (https=)
SM (1) SMT201900219T1 (https=)
TR (1) TR201903026T4 (https=)
WO (1) WO2011157724A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2580240T (pt) * 2010-06-14 2019-03-29 Lykera Biomed S A Anticorpos as100a4 e utilizações terapêuticas dos mesmos
DK3252076T3 (da) 2011-01-14 2019-12-02 Univ California Diagnostisk anvendelse af antistoffer mod ror-1-protein
RU2484096C1 (ru) * 2012-02-08 2013-06-10 Общество с ограниченной ответственностью "Технофарма" ОДНОДОМЕННОЕ АНТИТЕЛО, СПЕЦИФИЧЕСКИ СВЯЗЫВАЮЩЕЕ БЕЛОК S100A4/Mts1, ПРИМЕНЕНИЕ ПОЛУЧЕННОГО АНТИТЕЛА ДЛЯ ДЕТЕКЦИИ ЭТОГО БЕЛКА
GB201219487D0 (en) 2012-10-30 2012-12-12 Cancer Rec Tech Ltd Anti-S100A4 antibody molecules and their uses
JP2014094919A (ja) * 2012-11-09 2014-05-22 Univ Of Fukui 腎炎の予防または治療剤
JP6183920B2 (ja) * 2012-11-09 2017-08-23 国立大学法人福井大学 腎炎の病変部位の検査方法およびそのための試薬
US9914768B2 (en) 2013-04-09 2018-03-13 Lykera Biomed, S.A. Anti-S100A7 antibodies for the treatment and diagnosis of cancer
CN107375923A (zh) * 2017-07-06 2017-11-24 北京多赢时代转化医学研究院 抗s100a4抗体在抗cd137抗体介导抗肿瘤免疫损伤中的应用
CN112083167B (zh) * 2019-06-14 2024-03-26 复旦大学附属华山医院 S100a4作为评估甲氨蝶呤干预银屑病的生物标记物及其用途
EP3999531A1 (en) * 2019-07-15 2022-05-25 University of Connecticut Metallothionein antibodies and their use
KR102151133B1 (ko) * 2019-12-27 2020-09-02 주식회사 인투앱 프로피오니박테리움 아크네스에 특이적으로 결합하는 신규한 항체 및 이의 용도
AU2021205893A1 (en) 2020-01-08 2022-06-23 Synthis Therapeutics, Inc. ALK5 inhibitor conjugates and uses thereof
JP2023531230A (ja) * 2020-06-30 2023-07-21 アークス セラピューティクス エーエス 全身性硬化症の治療のための抗ｓ１００ａ４抗体
IL304971A (en) 2021-02-09 2023-10-01 Arxx Therapeutics As Humanized anti-S100A4 antibody, uses and methods
CN113718029A (zh) * 2021-10-22 2021-11-30 中国人民解放军北部战区总医院 S100a4蛋白在动脉粥样硬化性肾动脉狭窄诊断中的应用
EP4433084A1 (en) 2021-11-19 2024-09-25 Lykera Biomed, S.A. Treatment and diagnosis of diseases associated to pathogenic fibrosis
CN117686722B (zh) * 2023-12-20 2024-08-09 内蒙古元牛繁育科技有限公司 一种s100a4纳米抗体及其应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
EP0052322B1 (de) 1980-11-10 1985-03-27 Gersonde, Klaus, Prof. Dr. Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
EP0143949B1 (en) 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6638504B1 (en) * 1990-07-09 2003-10-28 Research Corporation Technologies, Inc. Methods for treating cancer
US5798257A (en) * 1990-07-09 1998-08-25 Research Corporation Technologies, Inc. Nucleic acid encoding human MTS-1 protein
JP3398149B2 (ja) * 1990-07-09 2003-04-21 リサーチ コーポレーション テクノロジーズ インコーポレーテッド Ｍｔｓ―１遺伝子による転移性の癌の診断
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
AU665025B2 (en) 1991-09-23 1995-12-14 Cambridge Antibody Technology Limited Production of chimeric antibodies - a combinatorial approach
DE69232137T2 (de) 1991-11-25 2002-05-29 Enzon Inc Multivalente antigen-bindende proteine
AU6852594A (en) 1993-06-03 1995-01-03 Therapeutic Antibodies Inc. Production of antibody fragments
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US6113898A (en) 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
DE19915485A1 (de) 1999-04-07 2000-10-19 Hugo A Katus Therapie der Herzinsuffizienz
JP2002542297A (ja) * 1999-04-23 2002-12-10 リサーチ コーポレイション テクノロジーズ，インコーポレイテッド 血管形成を増強するための治療組成物および方法
DE10017249A1 (de) 2000-04-06 2001-10-11 Peter Solisch In-Vitro-Verfahren zur Feststellung bösartiger Tumore in der Human- und Veterinärmedizin
GB0120238D0 (en) 2001-08-20 2001-10-10 Univ College Of London Sodium channel regulators and modulators
AU2002347182A1 (en) 2001-12-18 2003-06-30 Mondobiotech Licensing Out Ag Pharmaceutical composition of interferon gamma or pirfenidone with molecular diagnostics for the improved treatment of interstitial lung diseases
JP2005532036A (ja) 2002-01-09 2005-10-27 理化学研究所 癌プロフィール
US20040157278A1 (en) 2002-12-13 2004-08-12 Bayer Corporation Detection methods using TIMP 1
US20050208518A1 (en) 2003-05-16 2005-09-22 Longueville Francoise D Method and apparatus for determination of RNAi cell transfection effects by multiple gene expression analysis on micro-arrays
US20040229225A1 (en) 2003-05-16 2004-11-18 Jose Remacle Determination of a general three-dimensional status of a cell by multiple gene expression analysis on micro-arrays
ATE419392T1 (de) 2003-07-04 2009-01-15 Johnson & Johnson Res Pty Ltd Verfahren zum nachweis von alkyliertem cytosin in dna
CA2534456A1 (en) 2003-08-01 2005-02-10 The University Of Western Australia Methods and kits for predicting the likelihood of successful treatment of cancer
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
JP2007537717A (ja) 2004-01-07 2007-12-27 ブリストル−マイヤーズ　スクイブ　カンパニー 上皮増殖因子受容体モデュレーターに対する感受性を決定するためのバイオマーカーおよび方法
WO2006052795A2 (en) 2004-11-05 2006-05-18 University Of Rochester Methods of inhibiting the activity of hsp90 and/or aryl hydrocarbon receptor
KR100664589B1 (ko) 2004-12-28 2007-01-04 김현기 인간 암 억제 유전자, 이에 의해 코딩되는 단백질, 및이를 포함하는 발현 벡터
US20080307537A1 (en) 2005-03-31 2008-12-11 Dana-Farber Cancer Institute, Inc. Compositions and Methods for the Identification, Assessment, Prevention, and Therapy of Neurological Diseases, Disorders and Conditions
US20060269948A1 (en) 2005-05-16 2006-11-30 Halloran Philip F Tissue rejection
US7666596B2 (en) 2005-05-23 2010-02-23 University Of Alberta Tissue rejection
CN101365806B (zh) 2005-12-01 2016-11-16 医学预后研究所 用于鉴定治疗反应的生物标记的方法和装置及其预测疗效的用途
US20100040623A1 (en) * 2005-12-20 2010-02-18 Elisabeth Bock Neuritogenic and neuronal survival promoting peptides derived from the family of s-100 proteins
TW200745556A (en) 2006-01-24 2007-12-16 Ind Tech Res Inst Biomarkers for liver fibrotic injury
JP2007263896A (ja) 2006-03-29 2007-10-11 Univ Nagoya 肺癌患者の術後予後予測のための生物マーカー及びその方法
WO2007126391A1 (en) 2006-04-28 2007-11-08 Singapore Health Services Pte Ltd Investigation of mucosa dryness conditions
WO2008030278A2 (en) 2006-06-05 2008-03-13 Fred Hutchinson Cancer Research Center Assays for radiation exposure
US7811778B2 (en) 2006-09-06 2010-10-12 Vanderbilt University Methods of screening for gastrointestinal cancer
WO2008037432A2 (en) 2006-09-27 2008-04-03 Charité - Universitätsmedizin Berlin METHODS FOR DIAGNOSING METASTASIS BY ANALYZING MUTATIONS IN β-CATENIN
US20100248225A1 (en) 2006-11-06 2010-09-30 Bankaitis-Davis Danute M Gene expression profiling for identification, monitoring and treatment of melanoma
WO2008063413A2 (en) 2006-11-13 2008-05-29 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of lung cancer
US20100196889A1 (en) 2006-11-13 2010-08-05 Bankaitis-Davis Danute M Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer
DE102006056784A1 (de) 2006-12-01 2008-06-05 Meyer, Helmut E., Prof.Dr. Biomarker für die Diagnose von Pankreaskrebs
WO2008073290A1 (en) 2006-12-08 2008-06-19 The Board Of Trustees Of The University Of Arkansas Tp53 gene expression and uses thereof
WO2008079406A2 (en) 2006-12-19 2008-07-03 Genentech, Inc. Gene expression markers for inflammatory bowel disease
WO2008079269A2 (en) 2006-12-19 2008-07-03 Genego, Inc. Novel methods for functional analysis of high-throughput experimental data and gene groups identified therfrom
US20080161203A1 (en) 2006-12-27 2008-07-03 Su Chun-Lin Markers identified for liver fibrosis and cirrhosis and the microarray panel thereof
US20100120788A1 (en) 2007-01-09 2010-05-13 Bristol-Myers Squibb Company Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in prostate cells
EP2155897A2 (en) 2007-03-30 2010-02-24 Source Precision Medicine, Inc. d/b/a Source MDX. Gene expression profiling for identification, monitoring, and treatment of prostate cancer
CA2682827A1 (en) 2007-04-05 2008-10-16 Source Precision Medicine, Inc., D/B/A Source Mdx Gene expression profiling for identification, monitoring and treatment of ovarian cancer
AU2007353824A1 (en) 2007-04-06 2008-11-27 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of cervical cancer
WO2008137552A2 (en) 2007-05-02 2008-11-13 Medimmune, Llc Anti-rage antibodies and methods of use thereof
US20090093005A1 (en) 2007-10-05 2009-04-09 University Of Virginia Patent Foundation Protein-based biomarkers for abdominal aortic aneurysm
PT2580240T (pt) * 2010-06-14 2019-03-29 Lykera Biomed S A Anticorpos as100a4 e utilizações terapêuticas dos mesmos

Similar Documents

Publication Publication Date Title
JP2013531655A5 (https=)
RU2013101529A (ru) Специфическое антитело к s100a4 или его фрагмент, способ их получения, фармацевтическая композиция их содержащая, гибридомная клеточная линия, конъюгат, композиция, способ предупреждения и/или лечения рака, метастазирования, ангиогенеза и воспалительных заболеваний, способ и набор для диагностики рака или заболевания, ассоциированного с воспалением, способ детекции s100a4, способ создания индивидуальной терапии
DK2493503T3 (en) DOSAGE SCHEDULE FOR THE ADMINISTRATION OF A CD19xCD3 bispecific antibody
JP2012526530A5 (https=)
JP2012012402A5 (https=)
JP2017532005A5 (https=)
RU2017107773A (ru) Антитела, специфичные к ммр9
US12222356B2 (en) Cytokine profiling analysis
JP2013518903A5 (https=)
JP2011518773A5 (https=)
JP2014523401A5 (https=)
WO2015038538A1 (en) Compositions and methods for treating sepsis
RU2016144178A (ru) Антитело против muc1 или его антигенсвязывающий фрагмент и его применение
WO2022082073A2 (en) Compositions and methods for muc18 targeting
TWI710575B (zh) 人類抗-fgfr4抗體
HUE030578T2 (en) Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation
JP2016509585A5 (https=)
JP2009529497A5 (https=)
US20150361504A1 (en) Biomarker for predicting response of cll to treatment with a btk inhibitor
RU2014120577A (ru) Моноклональное антитело cd44 для лечения b-клеточной хронической лимфоцитарной лейкемии и других гематологических злокачественных заболеваний
JP2017538439A5 (https=)
EP2523687A1 (en) Methods for diagnosis and treatment of cutaneous t cell lymphomas
WO2015107171A1 (en) Methods of identifying patients suffering from liver cancer who will most likely benefit from a treatment with an antagonist anti-fgfr4 antibody
JP2018532699A5 (https=)
CN116997566A (zh) 用PDGFRα抑制剂治疗癌症的方法