JP2018532699A5 - - Google Patents

Download PDF

Info

Publication number
JP2018532699A5
JP2018532699A5 JP2018510734A JP2018510734A JP2018532699A5 JP 2018532699 A5 JP2018532699 A5 JP 2018532699A5 JP 2018510734 A JP2018510734 A JP 2018510734A JP 2018510734 A JP2018510734 A JP 2018510734A JP 2018532699 A5 JP2018532699 A5 JP 2018532699A5
Authority
JP
Japan
Prior art keywords
antibody
antigen
binding fragment
seq
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018510734A
Other languages
English (en)
Japanese (ja)
Other versions
JP6890581B2 (ja
JP2018532699A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/048887 external-priority patent/WO2017040247A1/en
Publication of JP2018532699A publication Critical patent/JP2018532699A/ja
Publication of JP2018532699A5 publication Critical patent/JP2018532699A5/ja
Application granted granted Critical
Publication of JP6890581B2 publication Critical patent/JP6890581B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018510734A 2015-08-28 2016-08-26 Cd37の検出のための抗体およびアッセイ Active JP6890581B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562211455P 2015-08-28 2015-08-28
US62/211,455 2015-08-28
US201562212183P 2015-08-31 2015-08-31
US62/212,183 2015-08-31
PCT/US2016/048887 WO2017040247A1 (en) 2015-08-28 2016-08-26 Antibodies and assays for detection of cd37

Publications (3)

Publication Number Publication Date
JP2018532699A JP2018532699A (ja) 2018-11-08
JP2018532699A5 true JP2018532699A5 (https=) 2019-10-10
JP6890581B2 JP6890581B2 (ja) 2021-06-18

Family

ID=58188089

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018510734A Active JP6890581B2 (ja) 2015-08-28 2016-08-26 Cd37の検出のための抗体およびアッセイ

Country Status (16)

Country Link
US (1) US11104740B2 (https=)
EP (1) EP3341414A4 (https=)
JP (1) JP6890581B2 (https=)
KR (1) KR102766022B1 (https=)
CN (1) CN108699144B (https=)
AU (1) AU2016316758B2 (https=)
CA (1) CA2995243A1 (https=)
EA (1) EA201890347A1 (https=)
HK (1) HK1257199A1 (https=)
IL (1) IL257354B2 (https=)
MA (1) MA42706A (https=)
MX (1) MX2018002467A (https=)
SA (1) SA518391028B1 (https=)
UA (1) UA129489C2 (https=)
WO (1) WO2017040247A1 (https=)
ZA (1) ZA201800830B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG183542A1 (en) 2010-03-12 2012-10-30 Immunogen Inc Cd37-binding molecules and immunoconjugates thereof
EP2694105A4 (en) 2011-04-01 2015-04-29 Immunogen Inc CD37 BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF
SG10202108116SA (en) 2015-06-08 2021-08-30 Debiopharm International S A Anti-cd37 immunoconjugate and anti-cd20 antibody combinations
US11104740B2 (en) 2015-08-28 2021-08-31 Debiopharm International, S.A. Antibodies and assays for detection of CD37
US11278629B2 (en) 2016-11-02 2022-03-22 Debiopharm International, S.A. Methods for improving anti-CD37 immunoconjugate therapy
US12144818B2 (en) 2018-05-30 2024-11-19 Debiopharm International, S.A. Method for treating cancer in a human patient by administering an anti-CD37 immunoconjugate using various dosing regimens
WO2020210643A1 (en) * 2019-04-11 2020-10-15 Ian Basil Shine Cell membrane permeability restoring therapy

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL106992A (en) 1988-02-11 1994-06-24 Bristol Myers Squibb Co Acylhydrazone derivatives of anthracycline and methods for their preparation
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5977316A (en) 1995-01-17 1999-11-02 The Board Of Trustees Of The University Of Kentucky Monoclonal antibody 1A7 and related polypeptides
US7303749B1 (en) 1999-10-01 2007-12-04 Immunogen Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
SG136804A1 (en) 2000-07-12 2007-11-29 Idec Pharma Corp Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US20030103971A1 (en) 2001-11-09 2003-06-05 Kandasamy Hariharan Immunoregulatory antibodies and uses thereof
JP4463475B2 (ja) 2001-01-31 2010-05-19 バイオジェン アイデック インコーポレイテッド 腫瘍疾患の治療における免疫調節性抗体の使用
EP1370292A1 (en) 2001-01-31 2003-12-17 Idec Pharmaceuticals Corporation Use of cd23 antagonists for the treatment of neoplastic disorders
AU2002329540A1 (en) 2001-06-20 2003-01-02 Morphosys Ag Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
CN100339395C (zh) 2001-11-08 2007-09-26 养生堂有限公司 戊型肝炎病毒单克隆抗体及其用途
EP2022799A2 (en) 2001-11-16 2009-02-11 Biogen Idec Inc. Polycistronic expression of antibodies
JP2006514627A (ja) 2002-11-15 2006-05-11 イミューノメディクス、インコーポレイテッド 治療薬の標的化送達のための多重特異的非共有結合複合体の使用
EP1572242B1 (en) 2002-12-13 2014-04-16 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US7534427B2 (en) 2002-12-31 2009-05-19 Immunomedics, Inc. Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
CA2525251C (en) 2003-05-09 2015-10-27 Duke University Cd20-specific antibodies and methods employing same
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
US7241598B2 (en) * 2004-06-29 2007-07-10 The Chinese University Of Hong Kong Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering
CA2572289A1 (en) 2004-06-30 2006-08-17 Centocor, Inc. Anti-mcp-1 antibodies, compositions, methods and uses
ES2408704T3 (es) 2005-01-05 2013-06-21 Biogen Idec Ma Inc. Moléculas de unión a Cripto
WO2006086586A2 (en) 2005-02-10 2006-08-17 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
US20060280738A1 (en) 2005-06-08 2006-12-14 Tedder Thomas F Anti-CD19 antibody therapy for transplantation
US8318906B2 (en) 2005-04-15 2012-11-27 The Regents Of The University Of California EMP2 antibodies and their therapeutic uses
WO2006117910A1 (ja) * 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
ATE460672T1 (de) 2005-05-20 2010-03-15 Genentech Inc Vorbehandlung einer biologischen probe aus einem individuum mit autoimmunkrankheit
US20080279850A1 (en) 2005-07-25 2008-11-13 Trubion Pharmaceuticals, Inc. B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
HRP20140338T1 (hr) * 2005-07-25 2014-06-20 Emergent Product Development Seattle, Llc Smanjenje broja b-stanica upotrebom molekula koje se specifiäśno vežu na cd37 i cd20
EP1806365A1 (en) 2006-01-05 2007-07-11 Boehringer Ingelheim International GmbH Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
ES2567402T3 (es) 2006-05-30 2016-04-22 Genentech, Inc. Anticuerpos anti CD22, sus inmunoconjugados y usos de los mismos
WO2007146968A2 (en) 2006-06-12 2007-12-21 Trubion Pharmaceuticals, Inc. Single-chain multivalent binding proteins with effector function
MX2009001110A (es) 2006-08-03 2009-05-11 Vaccinex Inc Anticuerpos monoclonales anti-il-6 y usos de los mismos.
US7846434B2 (en) 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
CA2663536A1 (en) 2006-10-24 2008-05-02 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
RS53008B2 (sr) 2007-04-03 2022-12-30 Amgen Res Munich Gmbh Interspecijski specifičan cd3-epsilon vezujući domen
JP2010532764A (ja) 2007-07-06 2010-10-14 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド C末端に配置された特異的結合性ドメインを有する結合性ペプチド
PE20140196A1 (es) 2007-08-09 2014-03-19 Boehringer Ingelheim Int Anticuerpos anti-cd37
GB2454915B (en) 2007-11-23 2012-02-15 Schlumberger Holdings Spooling apparatus for well intervention system
WO2009085575A2 (en) 2007-12-28 2009-07-09 Spring Bioscience Corporation Calibrator quality control cell device for immunohistochemistry assay and methods of use thereof
EP2365003A1 (en) 2008-04-11 2011-09-14 Emergent Product Development Seattle, LLC CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
US7740844B2 (en) 2008-04-29 2010-06-22 Taiwan Liposome Co. Ltd Anti-VEGF monoclonal antibody
KR20200058590A (ko) 2008-04-30 2020-05-27 이뮤노젠 아이엔씨 가교제 및 그 용도
WO2010008726A1 (en) 2008-06-16 2010-01-21 Immunogen Inc. Novel synergistic effects
CN102159248B (zh) 2008-07-15 2013-09-11 健泰科生物技术公司 蒽环类衍生物缀合物、它们的制备方法以及它们作为抗肿瘤化合物的用途
RU2526156C2 (ru) 2008-11-13 2014-08-20 ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ, ЭлЭлСи Cd37-иммунотерапевтическая комбинированная терапия и ее применения
EP2486023A4 (en) 2009-10-06 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
CN102958942A (zh) 2009-12-29 2013-03-06 新兴产品开发西雅图有限公司 异二聚体结合蛋白及其应用
TW201129383A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
TW201129384A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
SG183542A1 (en) 2010-03-12 2012-10-30 Immunogen Inc Cd37-binding molecules and immunoconjugates thereof
KR20130108069A (ko) 2010-04-15 2013-10-02 알퍼 바이오테크, 엘엘씨 Her2 항원에 대한 모노클로날 항체 및 그를 위한 용도
RS58367B1 (sr) 2011-03-29 2019-03-29 Immunogen Inc Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
EP2694105A4 (en) 2011-04-01 2015-04-29 Immunogen Inc CD37 BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
BR112014014258A2 (pt) 2011-12-13 2020-10-27 Nordic Nanovector As. molécula de anticorpo que se liga a cd37 humano; anticorpo; molécula de dna; vetor de expressão; célula hospedeira; método para produzir um anticorpo; composição farmacêutica; método de esgotamento de células b que expressam cd37 dentre uma população de células; radioimunoconjugado que se liga a cd37 humano; método de tratamento de uma malignidade de célula b; kit para a produção do radioimunoconjugado; e preparação injetável de anticorpo hh1 quimérico ou humanizado para uso no pré-tratamento de uma malignidade de célula b
HK1202156A1 (en) 2012-03-30 2015-09-18 Immunogen, Inc. Methods for increasing efficacy of cd37-based therapy
EP2849783A1 (en) 2012-05-16 2015-03-25 Boehringer Ingelheim International GmbH Combination of cd37 antibodies with further agents
US20140120083A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
SI2900277T1 (sl) 2012-12-13 2022-05-31 Immunomedics, Inc. Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost
WO2014143807A2 (en) 2013-03-15 2014-09-18 Stromatt Scott Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders
BR112015030457A2 (pt) 2013-06-07 2017-08-22 Nordic Nanovector As Método para regular positivamente a expressão de antígeno
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
CN113995843A (zh) 2013-11-07 2022-02-01 豪夫迈·罗氏有限公司 抗cd20抗体与btk抑制剂的组合疗法
WO2015116729A2 (en) * 2014-01-28 2015-08-06 Emergent Product Development Seattle, Llc Anti-cd37 antibody and anti-cd20 antibody combination therapy for treatment of b-cell malignancies and disorders
WO2015175533A2 (en) 2014-05-13 2015-11-19 Immunogen, Inc. Anti-cd37 immunoconjugate dosing regimens
SG10202108116SA (en) 2015-06-08 2021-08-30 Debiopharm International S A Anti-cd37 immunoconjugate and anti-cd20 antibody combinations
US11104740B2 (en) 2015-08-28 2021-08-31 Debiopharm International, S.A. Antibodies and assays for detection of CD37
US11278629B2 (en) 2016-11-02 2022-03-22 Debiopharm International, S.A. Methods for improving anti-CD37 immunoconjugate therapy
US12144818B2 (en) 2018-05-30 2024-11-19 Debiopharm International, S.A. Method for treating cancer in a human patient by administering an anti-CD37 immunoconjugate using various dosing regimens

Similar Documents

Publication Publication Date Title
JP2018532699A5 (https=)
US11579142B2 (en) Dosage regimen for administering a CD19xCD3 bispecific antibody to patients at risk for potential adverse effects
JP6666905B2 (ja) Pd−l1抗体及びその使用
CN113330036B (zh) 结合pd-l1和ox40的双特异性抗体
JP2015533788A5 (https=)
KR102416144B1 (ko) 환자에서 항-cd19 치료법의 치료 이익의 예측 방법
TW201207396A (en) Novel antibody for the diagnosis and/or prognosis of cancer
AU2015207665A1 (en) Cell surface prostate cancer antigen for diagnosis
US20190154701A1 (en) Cytokine profiling analysis
CN116997566A (zh) 用PDGFRα抑制剂治疗癌症的方法
CN107430125B (zh) 通过抑制tmcc3以抑制癌症的方法
JP2020510608A (ja) 抗cd37イムノコンジュゲート療法を改善するための方法
JP2018059865A (ja) 微小胞マーカーによる抗cd20抗体医薬品に対する薬物感受性の予測方法
JP6977105B2 (ja) Igf−1r抗体および癌の診断のためのその使用
IL323614A (en) Detection of autoantibodies against nr1
TWI716400B (zh) 新穎的igf-1r抗體及其用於癌症診斷之用途(二)
JP7447255B2 (ja) ヒト化抗ca ix抗体、およびその使用方法
CN115516111A (zh) 治疗癌症的方法
WO2026073156A1 (en) Detection of autoantibodies against nr1
KR102172541B1 (ko) Bag2 항체를 이용한 암 진단용 조성물 및 이를 이용한 방법
CN116940844A (zh) 新颖生物标志物及其用途
Zorniak Membrane proteomics of human glioblastoma stem-like cells
HK40013319A (en) Anti-cd47 antibody and use thereof
CN110023762A (zh) 用于预测利用抗vegf药物对渗出性年龄相关性黄斑变性进行的处置的有效性的方法
HK1243434B (zh) Igf-1r抗体及其诊断癌症的用途