JP2018527354A5 - - Google Patents
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- Publication number
- JP2018527354A5 JP2018527354A5 JP2018511436A JP2018511436A JP2018527354A5 JP 2018527354 A5 JP2018527354 A5 JP 2018527354A5 JP 2018511436 A JP2018511436 A JP 2018511436A JP 2018511436 A JP2018511436 A JP 2018511436A JP 2018527354 A5 JP2018527354 A5 JP 2018527354A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C1(C2CCOCC2)SC1 Chemical compound C*C1(C2CCOCC2)SC1 0.000 description 5
- MZSJUHDTQFOCAI-UHFFFAOYSA-N O=C(CCC1)N1I Chemical compound O=C(CCC1)N1I MZSJUHDTQFOCAI-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021096263A JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562213203P | 2015-09-02 | 2015-09-02 | |
| US62/213,203 | 2015-09-02 | ||
| PCT/US2016/049526 WO2017040545A1 (en) | 2015-09-02 | 2016-08-30 | 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096263A Division JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527354A JP2018527354A (ja) | 2018-09-20 |
| JP2018527354A5 true JP2018527354A5 (enExample) | 2019-10-10 |
| JP6898310B2 JP6898310B2 (ja) | 2021-07-07 |
Family
ID=58188367
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511436A Active JP6898310B2 (ja) | 2015-09-02 | 2016-08-30 | ６員アザヘテロ環を含有するデルタ−オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
| JP2021096263A Active JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096263A Active JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10246436B2 (enExample) |
| EP (2) | EP4086249A3 (enExample) |
| JP (2) | JP6898310B2 (enExample) |
| KR (1) | KR102787317B1 (enExample) |
| CN (2) | CN114773318A (enExample) |
| AU (2) | AU2016315720B2 (enExample) |
| CA (1) | CA3015702A1 (enExample) |
| CY (1) | CY1125225T1 (enExample) |
| DK (1) | DK3344248T3 (enExample) |
| ES (1) | ES2920130T3 (enExample) |
| HR (1) | HRP20220735T1 (enExample) |
| HU (1) | HUE058819T2 (enExample) |
| IL (1) | IL257503B (enExample) |
| LT (1) | LT3344248T (enExample) |
| MA (1) | MA43313B1 (enExample) |
| MD (1) | MD3344248T2 (enExample) |
| PL (1) | PL3344248T3 (enExample) |
| PT (1) | PT3344248T (enExample) |
| RS (1) | RS63319B1 (enExample) |
| SI (1) | SI3344248T1 (enExample) |
| SM (1) | SMT202200377T1 (enExample) |
| WO (1) | WO2017040545A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110520129A (zh) * | 2017-02-17 | 2019-11-29 | 特维娜有限公司 | 含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN110446495B (zh) * | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN111533682B (zh) * | 2020-05-29 | 2022-03-01 | 清华大学 | 帕罗西汀及其类似物的制备方法 |
| CN113880815B (zh) * | 2020-07-03 | 2024-03-29 | 中国药科大学 | 一类吲哚衍生物及其制备方法和用途 |
| CN116406268A (zh) * | 2020-10-27 | 2023-07-07 | 特维娜有限公司 | δ-阿片样物质调节剂的结晶和无定形形式 |
| JP2022135015A (ja) * | 2021-03-04 | 2022-09-15 | 国立大学法人東京工業大学 | オピオイド受容体作動剤 |
| WO2023070605A1 (en) * | 2021-10-29 | 2023-05-04 | Trevena, Inc. | Methods of preparing 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE352811B (enExample) | 1971-06-04 | 1973-01-15 | Pharmacia Ab | |
| US3960150A (en) | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
| US3867519A (en) | 1972-04-27 | 1975-02-18 | Alza Corp | Bioerodible drug delivery device |
| SE375007B (enExample) | 1972-11-30 | 1975-04-07 | Pharmacia Ab | |
| US3963025A (en) | 1974-09-16 | 1976-06-15 | Alza Corporation | Ocular drug delivery device |
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4186184A (en) | 1977-12-27 | 1980-01-29 | Alza Corporation | Selective administration of drug with ocular therapeutic system |
| US4303637A (en) | 1980-04-04 | 1981-12-01 | Alza Corporation | Medication indicated for ocular hypertension |
| DK231088D0 (da) * | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
| US5086063A (en) | 1988-03-28 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| HUP9902160A3 (en) * | 1996-03-29 | 2001-02-28 | Pfizer | Benzyl(idene)-lactam derivatives, their use as selective (ant)agonists of 5-ht1a-and/or 5-ht1d receptors, pharmaceutical compositions containing these compounds |
| JP2000513375A (ja) | 1996-06-28 | 2000-10-10 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプター拮抗薬プロドラッグ |
| JP4498602B2 (ja) * | 1998-03-10 | 2010-07-07 | リサーチ・トライアングル・インスティチュート | 新規なオピエート化合物、その調製法及び使用法 |
| AU1018801A (en) * | 1999-10-29 | 2001-05-14 | Novo Nordisk A/S | Use of 3,4-substituted piperidines |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| US6995144B2 (en) | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| CN100372850C (zh) * | 2003-02-12 | 2008-03-05 | 神经研究公司 | 新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| JP2007507504A (ja) | 2003-09-30 | 2007-03-29 | メルク エンド カムパニー インコーポレーテッド | フェニルピロリジンエーテル系タキキニン受容体拮抗薬 |
| DE602005023172D1 (de) | 2004-07-16 | 2010-10-07 | Schering Corp | Hydantoinderivate zur behandlung von entzündlichen erkrankungen |
| US7488745B2 (en) | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7504424B2 (en) | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7098203B2 (en) | 2004-07-20 | 2006-08-29 | Bristol-Myers Squibb Company | Homopiperidine derivatives as NK-1 antagonists |
| US7872023B2 (en) | 2005-02-17 | 2011-01-18 | Research Triangle Institute | Kappa opioid receptor ligands |
| TW200804307A (en) | 2005-10-27 | 2008-01-16 | Synta Pharmaceuticals Corp | Process for preparing mesylate salts of IL-12 inhibitory compounds |
| CA2631221C (en) | 2005-12-01 | 2014-06-03 | F. Hoffmann-La Roche Ag | Serotonin transporter (sert) inhibitors |
| US20070142389A1 (en) * | 2005-12-20 | 2007-06-21 | Pfizer Inc. | Piperidine derivatives |
| AU2007225208A1 (en) | 2006-03-14 | 2007-09-20 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| US8470361B2 (en) | 2006-12-04 | 2013-06-25 | Orexo Ab | Non-abusable pharmaceutical composition comprising opioids |
| KR20100017372A (ko) * | 2007-05-25 | 2010-02-16 | 애보트 게엠베하 운트 콤파니 카게 | 향대사성 글루타메이트 수용체 2（ｍｇｌｕ2 수용체）의 포지티브 조절자로서의 헤테로사이클릭 화합물 |
| JP2010535733A (ja) | 2007-08-07 | 2010-11-25 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎｋ３受容体アンタゴニストとしてのピロリジンアリールエーテル |
| EA201000808A1 (ru) * | 2007-11-16 | 2011-04-29 | Ньюраксон, Инк. | Индольные соединения и способы лечения висцеральной боли |
| US8664214B2 (en) * | 2010-03-30 | 2014-03-04 | AbbVie Deutschland GmbH & Co. KG | Small molecule potentiators of metabotropic glutamate receptors I |
| US8507535B2 (en) | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| ES2716865T3 (es) * | 2011-02-18 | 2019-06-17 | Scripps Research Inst | Diferenciación dirigida de células precursoras de oligodendrocitos a un destino celular mielinizante |
| WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| ES2586213T3 (es) * | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
| EP2810942B1 (en) * | 2012-01-31 | 2016-03-30 | Eisai R&D Management Co., Ltd. | Paroxetine derivative |
| WO2013182612A1 (en) | 2012-06-07 | 2013-12-12 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| CA2896202A1 (en) * | 2012-12-28 | 2014-07-03 | Purdue Pharma L.P. | Substituted morphinans and the use thereof |
| WO2016029218A1 (en) | 2014-08-22 | 2016-02-25 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation |
| WO2016210403A1 (en) * | 2015-06-26 | 2016-12-29 | The Regents Of The University Of Michigan | G protein-coupled receptor kinase inhibitors and methods for use of the same |
-
2016
- 2016-08-30 MA MA43313A patent/MA43313B1/fr unknown
- 2016-08-30 JP JP2018511436A patent/JP6898310B2/ja active Active
- 2016-08-30 KR KR1020187008816A patent/KR102787317B1/ko active Active
- 2016-08-30 PT PT168428324T patent/PT3344248T/pt unknown
- 2016-08-30 SI SI201631546T patent/SI3344248T1/sl unknown
- 2016-08-30 MD MDE20180679T patent/MD3344248T2/ro not_active IP Right Cessation
- 2016-08-30 AU AU2016315720A patent/AU2016315720B2/en not_active Ceased
- 2016-08-30 LT LTEPPCT/US2016/049526T patent/LT3344248T/lt unknown
- 2016-08-30 HU HUE16842832A patent/HUE058819T2/hu unknown
- 2016-08-30 ES ES16842832T patent/ES2920130T3/es active Active
- 2016-08-30 CN CN202210425041.XA patent/CN114773318A/zh active Pending
- 2016-08-30 HR HRP20220735TT patent/HRP20220735T1/hr unknown
- 2016-08-30 RS RS20220588A patent/RS63319B1/sr unknown
- 2016-08-30 WO PCT/US2016/049526 patent/WO2017040545A1/en not_active Ceased
- 2016-08-30 DK DK16842832.4T patent/DK3344248T3/da active
- 2016-08-30 PL PL16842832.4T patent/PL3344248T3/pl unknown
- 2016-08-30 SM SM20220377T patent/SMT202200377T1/it unknown
- 2016-08-30 EP EP22161847.3A patent/EP4086249A3/en not_active Withdrawn
- 2016-08-30 CN CN201680055385.9A patent/CN108025002B/zh active Active
- 2016-08-30 EP EP16842832.4A patent/EP3344248B1/en active Active
- 2016-08-30 CA CA3015702A patent/CA3015702A1/en active Pending
- 2016-08-30 US US15/252,112 patent/US10246436B2/en active Active
-
2018
- 2018-02-13 IL IL257503A patent/IL257503B/en unknown
-
2019
- 2019-02-27 US US16/286,700 patent/US11465980B2/en active Active
-
2021
- 2021-05-24 AU AU2021203337A patent/AU2021203337A1/en not_active Abandoned
- 2021-06-09 JP JP2021096263A patent/JP7463318B2/ja active Active
-
2022
- 2022-06-22 CY CY20221100431T patent/CY1125225T1/el unknown
- 2022-08-03 US US17/879,923 patent/US20230203002A1/en active Pending
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