JP2018527354A5 - - Google Patents
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- Publication number
- JP2018527354A5 JP2018527354A5 JP2018511436A JP2018511436A JP2018527354A5 JP 2018527354 A5 JP2018527354 A5 JP 2018527354A5 JP 2018511436 A JP2018511436 A JP 2018511436A JP 2018511436 A JP2018511436 A JP 2018511436A JP 2018527354 A5 JP2018527354 A5 JP 2018527354A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C1(C2CCOCC2)SC1 Chemical compound C*C1(C2CCOCC2)SC1 0.000 description 5
- MZSJUHDTQFOCAI-UHFFFAOYSA-N O=C(CCC1)N1I Chemical compound O=C(CCC1)N1I MZSJUHDTQFOCAI-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021096263A JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562213203P | 2015-09-02 | 2015-09-02 | |
| US62/213,203 | 2015-09-02 | ||
| PCT/US2016/049526 WO2017040545A1 (en) | 2015-09-02 | 2016-08-30 | 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096263A Division JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527354A JP2018527354A (ja) | 2018-09-20 |
| JP2018527354A5 true JP2018527354A5 (enExample) | 2019-10-10 |
| JP6898310B2 JP6898310B2 (ja) | 2021-07-07 |
Family
ID=58188367
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511436A Active JP6898310B2 (ja) | 2015-09-02 | 2016-08-30 | ６員アザヘテロ環を含有するデルタ−オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
| JP2021096263A Active JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021096263A Active JP7463318B2 (ja) | 2015-09-02 | 2021-06-09 | ６員アザヘテロ環を含有するデルタ－オピオイド受容体調節化合物、同化合物を使用する方法、および同化合物を作る方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10246436B2 (enExample) |
| EP (2) | EP3344248B1 (enExample) |
| JP (2) | JP6898310B2 (enExample) |
| KR (1) | KR102787317B1 (enExample) |
| CN (2) | CN108025002B (enExample) |
| AU (2) | AU2016315720B2 (enExample) |
| CA (1) | CA3015702A1 (enExample) |
| CY (1) | CY1125225T1 (enExample) |
| DK (1) | DK3344248T3 (enExample) |
| ES (1) | ES2920130T3 (enExample) |
| HR (1) | HRP20220735T1 (enExample) |
| HU (1) | HUE058819T2 (enExample) |
| IL (1) | IL257503B (enExample) |
| LT (1) | LT3344248T (enExample) |
| MA (1) | MA43313B1 (enExample) |
| MD (1) | MD3344248T2 (enExample) |
| PL (1) | PL3344248T3 (enExample) |
| PT (1) | PT3344248T (enExample) |
| RS (1) | RS63319B1 (enExample) |
| SI (1) | SI3344248T1 (enExample) |
| SM (1) | SMT202200377T1 (enExample) |
| WO (1) | WO2017040545A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3052480A1 (en) * | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN110446495B (zh) * | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN111533682B (zh) * | 2020-05-29 | 2022-03-01 | 清华大学 | 帕罗西汀及其类似物的制备方法 |
| CN113880815B (zh) * | 2020-07-03 | 2024-03-29 | 中国药科大学 | 一类吲哚衍生物及其制备方法和用途 |
| JP2023546729A (ja) * | 2020-10-27 | 2023-11-07 | トレベナ・インコーポレイテッド | デルタオピオイドモジュレーターの結晶形及び非晶形 |
| JP2022135015A (ja) * | 2021-03-04 | 2022-09-15 | 国立大学法人東京工業大学 | オピオイド受容体作動剤 |
| WO2023070605A1 (en) * | 2021-10-29 | 2023-05-04 | Trevena, Inc. | Methods of preparing 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds |
Family Cites Families (45)
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| SE352811B (enExample) | 1971-06-04 | 1973-01-15 | Pharmacia Ab | |
| US3960150A (en) | 1971-09-09 | 1976-06-01 | Alza Corporation | Bioerodible ocular device |
| US3867519A (en) | 1972-04-27 | 1975-02-18 | Alza Corp | Bioerodible drug delivery device |
| SE375007B (enExample) | 1972-11-30 | 1975-04-07 | Pharmacia Ab | |
| US3963025A (en) | 1974-09-16 | 1976-06-15 | Alza Corporation | Ocular drug delivery device |
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| US4186184A (en) | 1977-12-27 | 1980-01-29 | Alza Corporation | Selective administration of drug with ocular therapeutic system |
| US4303637A (en) | 1980-04-04 | 1981-12-01 | Alza Corporation | Medication indicated for ocular hypertension |
| DK231088D0 (da) * | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
| US5086063A (en) | 1988-03-28 | 1992-02-04 | Du Pont Merck Pharmaceutical Company | 4-aryl-4-piperidine (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| ES2246058T3 (es) | 1996-03-29 | 2006-02-01 | Pfizer Inc. | Derivados bencil(iden)-lactama, su preparacion y su uso como (ant)agonistas selectivos de receptores 5-ht1a y/o 5-ht1d. |
| JP2000513375A (ja) | 1996-06-28 | 2000-10-10 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプター拮抗薬プロドラッグ |
| AU756983B2 (en) * | 1998-03-10 | 2003-01-30 | Research Triangle Institute | Novel opiate compounds, methods of making and methods of use |
| AU1018801A (en) * | 1999-10-29 | 2001-05-14 | Novo Nordisk A/S | Use of 3,4-substituted piperidines |
| WO2002000651A2 (en) | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Factor xa inhibitors |
| US6995144B2 (en) | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| CN100372850C (zh) * | 2003-02-12 | 2008-03-05 | 神经研究公司 | 新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| EP1670476A4 (en) | 2003-09-30 | 2009-05-27 | Merck & Co Inc | Phenylpyrrolidine-ETHER-tachykinin receptor Antagonist |
| US7488745B2 (en) | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| EP1778676B1 (en) | 2004-07-16 | 2010-08-25 | Schering Corporation | Hydantoin derivatives for the treatment of inflammatory disorders |
| US7504424B2 (en) | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| US7098203B2 (en) | 2004-07-20 | 2006-08-29 | Bristol-Myers Squibb Company | Homopiperidine derivatives as NK-1 antagonists |
| US7872023B2 (en) | 2005-02-17 | 2011-01-18 | Research Triangle Institute | Kappa opioid receptor ligands |
| TW200804307A (en) | 2005-10-27 | 2008-01-16 | Synta Pharmaceuticals Corp | Process for preparing mesylate salts of IL-12 inhibitory compounds |
| ATE434605T1 (de) | 2005-12-01 | 2009-07-15 | Hoffmann La Roche | Inhibitoren des serotonintransporters (sert) |
| US20070142389A1 (en) * | 2005-12-20 | 2007-06-21 | Pfizer Inc. | Piperidine derivatives |
| JP2009530281A (ja) | 2006-03-14 | 2009-08-27 | アムジエン・インコーポレーテツド | 代謝障害の治療に有用である二環式カルボン酸誘導体 |
| US8470361B2 (en) | 2006-12-04 | 2013-06-25 | Orexo Ab | Non-abusable pharmaceutical composition comprising opioids |
| AU2008257559B2 (en) * | 2007-05-25 | 2013-10-10 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (MGLU2 receptor) |
| MX2010001080A (es) | 2007-08-07 | 2010-03-01 | Hoffmann La Roche | Pirrolidin-aril-eteres como antagonistas de receptor de nk3. |
| JP2011503120A (ja) | 2007-11-16 | 2011-01-27 | ニューラクソン，インコーポレーテッド | 内臓痛を治療するためのインドール化合物および方法 |
| US8664214B2 (en) | 2010-03-30 | 2014-03-04 | AbbVie Deutschland GmbH & Co. KG | Small molecule potentiators of metabotropic glutamate receptors I |
| US8507535B2 (en) | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| JP6133790B2 (ja) * | 2011-02-18 | 2017-05-24 | ザ スクリプス リサーチ インスティテュート | ミエリン形成細胞運命へのオリゴデンドロサイト前駆細胞の定方向分化 |
| US9464065B2 (en) | 2011-03-24 | 2016-10-11 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| US9630929B2 (en) * | 2011-10-31 | 2017-04-25 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| TW201334783A (zh) * | 2012-01-31 | 2013-09-01 | Eisai R&D Man Co Ltd | 帕羅西汀（Ｐａｒｏｘｅｔｉｎｅ）衍生物 |
| WO2013182612A1 (en) | 2012-06-07 | 2013-12-12 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| TW201441199A (zh) * | 2012-12-28 | 2014-11-01 | Purdue Pharma Lp | 經取代之嗎啡喃類及其用途 |
| US9765027B2 (en) | 2014-08-22 | 2017-09-19 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation |
| EP3313396B1 (en) * | 2015-06-26 | 2021-12-15 | The Regents of The University of Michigan | G protein-coupled receptor kinase inhibitors and methods for use of the same |
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2016
- 2016-08-30 EP EP16842832.4A patent/EP3344248B1/en active Active
- 2016-08-30 KR KR1020187008816A patent/KR102787317B1/ko active Active
- 2016-08-30 LT LTEPPCT/US2016/049526T patent/LT3344248T/lt unknown
- 2016-08-30 AU AU2016315720A patent/AU2016315720B2/en active Active
- 2016-08-30 PT PT168428324T patent/PT3344248T/pt unknown
- 2016-08-30 HR HRP20220735TT patent/HRP20220735T1/hr unknown
- 2016-08-30 MA MA43313A patent/MA43313B1/fr unknown
- 2016-08-30 WO PCT/US2016/049526 patent/WO2017040545A1/en not_active Ceased
- 2016-08-30 PL PL16842832.4T patent/PL3344248T3/pl unknown
- 2016-08-30 HU HUE16842832A patent/HUE058819T2/hu unknown
- 2016-08-30 ES ES16842832T patent/ES2920130T3/es active Active
- 2016-08-30 RS RS20220588A patent/RS63319B1/sr unknown
- 2016-08-30 JP JP2018511436A patent/JP6898310B2/ja active Active
- 2016-08-30 DK DK16842832.4T patent/DK3344248T3/da active
- 2016-08-30 SM SM20220377T patent/SMT202200377T1/it unknown
- 2016-08-30 CN CN201680055385.9A patent/CN108025002B/zh active Active
- 2016-08-30 CN CN202210425041.XA patent/CN114773318A/zh active Pending
- 2016-08-30 MD MDE20180679T patent/MD3344248T2/ro unknown
- 2016-08-30 SI SI201631546T patent/SI3344248T1/sl unknown
- 2016-08-30 CA CA3015702A patent/CA3015702A1/en active Pending
- 2016-08-30 US US15/252,112 patent/US10246436B2/en active Active
- 2016-08-30 EP EP22161847.3A patent/EP4086249A3/en not_active Withdrawn
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2018
- 2018-02-13 IL IL257503A patent/IL257503B/en unknown
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2019
- 2019-02-27 US US16/286,700 patent/US11465980B2/en active Active
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2021
- 2021-05-24 AU AU2021203337A patent/AU2021203337A1/en not_active Abandoned
- 2021-06-09 JP JP2021096263A patent/JP7463318B2/ja active Active
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2022
- 2022-06-22 CY CY20221100431T patent/CY1125225T1/el unknown
- 2022-08-03 US US17/879,923 patent/US20230203002A1/en active Pending