JP2018527000A5 - - Google Patents
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- Publication number
- JP2018527000A5 JP2018527000A5 JP2018513591A JP2018513591A JP2018527000A5 JP 2018527000 A5 JP2018527000 A5 JP 2018527000A5 JP 2018513591 A JP2018513591 A JP 2018513591A JP 2018513591 A JP2018513591 A JP 2018513591A JP 2018527000 A5 JP2018527000 A5 JP 2018527000A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- seq
- antibody
- myopathy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 59
- 102000036639 antigens Human genes 0.000 claims 59
- 108091007433 antigens Proteins 0.000 claims 59
- 239000012634 fragment Substances 0.000 claims 59
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 22
- 208000021642 Muscular disease Diseases 0.000 claims 22
- 201000009623 Myopathy Diseases 0.000 claims 22
- 108010056852 Myostatin Proteins 0.000 claims 22
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 7
- 206010006895 Cachexia Diseases 0.000 claims 6
- 201000002481 Myositis Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000017854 proteolysis Effects 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 206010068836 Metabolic myopathy Diseases 0.000 claims 4
- 208000010316 Myotonia congenita Diseases 0.000 claims 4
- 201000011474 congenital myopathy Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 208000030507 AIDS Diseases 0.000 claims 2
- 206010002261 Androgen deficiency Diseases 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010020100 Hip fracture Diseases 0.000 claims 2
- 208000010428 Muscle Weakness Diseases 0.000 claims 2
- 206010028289 Muscle atrophy Diseases 0.000 claims 2
- 206010028372 Muscular weakness Diseases 0.000 claims 2
- 206010028629 Myoglobinuria Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 201000010769 Prader-Willi syndrome Diseases 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 206010039020 Rhabdomyolysis Diseases 0.000 claims 2
- 208000032978 Structural Congenital Myopathies Diseases 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 208000022531 anorexia Diseases 0.000 claims 2
- 230000037444 atrophy Effects 0.000 claims 2
- 208000013908 autosomal dominant centronuclear myopathy Diseases 0.000 claims 2
- 208000013906 autosomal recessive centronuclear myopathy Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 230000002638 denervation Effects 0.000 claims 2
- 201000001981 dermatomyositis Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000007345 glycogen storage disease Diseases 0.000 claims 2
- 201000008319 inclusion body myositis Diseases 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 230000013190 lipid storage Effects 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 230000020763 muscle atrophy Effects 0.000 claims 2
- 201000000585 muscular atrophy Diseases 0.000 claims 2
- 201000006938 muscular dystrophy Diseases 0.000 claims 2
- 210000001087 myotubule Anatomy 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 208000005987 polymyositis Diseases 0.000 claims 2
- 208000020431 spinal cord injury Diseases 0.000 claims 2
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 210000005239 tubule Anatomy 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 1
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims 1
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022111605A JP7418508B2 (ja) | 2015-09-15 | 2022-07-12 | 抗プロ／潜在型ミオスタチン抗体およびその使用 |
| JP2024000878A JP7785107B2 (ja) | 2015-09-15 | 2024-01-05 | 抗プロ／潜在型ミオスタチン抗体およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562219094P | 2015-09-15 | 2015-09-15 | |
| US62/219,094 | 2015-09-15 | ||
| PCT/US2016/052014 WO2017049011A1 (en) | 2015-09-15 | 2016-09-15 | Anti-pro/latent-myostatin antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022111605A Division JP7418508B2 (ja) | 2015-09-15 | 2022-07-12 | 抗プロ／潜在型ミオスタチン抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527000A JP2018527000A (ja) | 2018-09-20 |
| JP2018527000A5 true JP2018527000A5 (enExample) | 2019-10-17 |
| JP7107836B2 JP7107836B2 (ja) | 2022-07-27 |
Family
ID=57043000
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513591A Active JP7107836B2 (ja) | 2015-09-15 | 2016-09-15 | 抗プロ／潜在型ミオスタチン抗体およびその使用 |
| JP2022111605A Active JP7418508B2 (ja) | 2015-09-15 | 2022-07-12 | 抗プロ／潜在型ミオスタチン抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022111605A Active JP7418508B2 (ja) | 2015-09-15 | 2022-07-12 | 抗プロ／潜在型ミオスタチン抗体およびその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10751413B2 (enExample) |
| EP (3) | EP3922645B1 (enExample) |
| JP (2) | JP7107836B2 (enExample) |
| KR (3) | KR20250033313A (enExample) |
| CN (4) | CN113896789A (enExample) |
| AU (2) | AU2016323447B2 (enExample) |
| BR (1) | BR112018004981A2 (enExample) |
| CA (1) | CA3036652A1 (enExample) |
| CO (1) | CO2018002703A2 (enExample) |
| CY (1) | CY1124619T1 (enExample) |
| DK (2) | DK3922645T3 (enExample) |
| EA (1) | EA038146B1 (enExample) |
| ES (2) | ES2881642T3 (enExample) |
| FI (1) | FI3922645T3 (enExample) |
| HR (2) | HRP20211081T1 (enExample) |
| HU (2) | HUE055331T2 (enExample) |
| IL (2) | IL305148A (enExample) |
| LT (2) | LT3922645T (enExample) |
| MX (5) | MX2018003196A (enExample) |
| PL (2) | PL3350220T3 (enExample) |
| PT (2) | PT3350220T (enExample) |
| RS (2) | RS62330B1 (enExample) |
| SI (2) | SI3922645T1 (enExample) |
| SM (2) | SMT202100432T1 (enExample) |
| WO (1) | WO2017049011A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
| JP6706617B2 (ja) | 2014-11-06 | 2020-06-10 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | 抗プロ／潜在型−ミオスタチン抗体およびその使用 |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| SG11201706014PA (en) | 2015-02-05 | 2017-08-30 | Chugai Pharmaceutical Co Ltd | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| RS62330B1 (sr) | 2015-09-15 | 2021-10-29 | Scholar Rock Inc | Antitela pro/latentnog miostatina i njihova upotreba |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
| US10287345B2 (en) | 2016-01-08 | 2019-05-14 | Scholar Rock, Inc. | Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies |
| KR20210082548A (ko) | 2016-06-13 | 2021-07-05 | 스칼러 락, 인크. | 미오스타틴 억제제의 용도 및 조합 요법 |
| KR102538749B1 (ko) | 2016-08-05 | 2023-06-01 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
| PT3565592T (pt) * | 2017-01-06 | 2023-05-31 | Scholar Rock Inc | Tratamento de doenças metabólicas através da inibição da ativação da miostatina |
| SI3565592T1 (sl) * | 2017-01-06 | 2023-05-31 | Scholar Rock, Inc. | Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina |
| PT3677278T (pt) | 2018-07-11 | 2022-02-03 | Scholar Rock Inc | Inibidores seletivos da isoforma tgfbeta1 e sua utilização |
| JP7540994B2 (ja) | 2018-07-11 | 2024-08-27 | スカラー ロック インコーポレイテッド | 高親和性のアイソフォーム選択的ＴＧＦβ１阻害剤、およびその使用 |
| EA202192130A1 (ru) * | 2019-01-30 | 2021-12-28 | Сколар Рок, Инк. | Специфичные к ltbp-комплексу ингибиторы tgf и их применение |
| CN110429214B (zh) | 2019-08-07 | 2021-12-07 | 宁德时代新能源科技股份有限公司 | 二次电池的盖组件及二次电池 |
| SG11202009970VA (en) * | 2019-08-28 | 2021-04-29 | Chugai Pharmaceutical Co Ltd | Cross-Species Anti-Latent TGF-Beta 1 Antibodies And Methods Of Use |
| JP2023511255A (ja) | 2020-01-11 | 2023-03-17 | スカラー ロック インコーポレイテッド | ＴＧＦ－β阻害剤及びその使用 |
| RU2750267C1 (ru) * | 2020-02-07 | 2021-06-25 | Общество с ограниченной ответственностью «НАУЧНО-ПРОИЗВОДСТВЕННОЕ ОБЪЕДИНЕНИЕ ИН-ВЕТ» | Рекомбинантный ростовой дифференцировочный фактор роста 11 (GDF11), способ его получения, инъекционный препарат для повышения мышечной массы млекопитающих животных и птицы, а также способ использования препарата |
| EP4232151B1 (en) | 2020-10-26 | 2025-10-22 | Scholar Rock, Inc. | Use of anti-pro/latent myostatin antibody for treating spinal muscular atrophy |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| WO2022271867A1 (en) | 2021-06-23 | 2022-12-29 | Scholar Rock, Inc. | A myostatin pathway inhibitor in combination with a glp-1 pathway activator for use in treating metabolic disorders |
| KR102840816B1 (ko) * | 2021-11-25 | 2025-07-31 | (주)네오크레마 | 근아세포의 증식과 근육세포로의 분화를 촉진하는 신규 펩티드 및 이의 용도 |
| KR102836354B1 (ko) * | 2021-11-25 | 2025-07-22 | (주)네오크레마 | 근아세포의 증식과 근육세포로의 분화를 촉진하는 신규 펩티드 및 이의 용도 |
| CA3251441A1 (en) | 2022-05-04 | 2023-11-09 | Scholar Rock Inc | USE OF A MYOSTATIN INHIBITOR FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY |
| IL319859A (en) | 2022-10-14 | 2025-05-01 | Genentech Inc | Methods for treating spinal muscular atrophy |
| KR20250122524A (ko) | 2022-12-22 | 2025-08-13 | 스칼러 락, 인크. | 미오스타틴 활성화의 선택적이고 강력한 억제 항체 |
| WO2024187051A1 (en) | 2023-03-07 | 2024-09-12 | Scholar Rock, Inc. | Tgf-beta inhibitors for use for treating resistant or unresponsive cancer in patients |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
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