JP2018526321A - 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ - Google Patents

適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ Download PDF

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JP2018526321A
JP2018526321A JP2017556248A JP2017556248A JP2018526321A JP 2018526321 A JP2018526321 A JP 2018526321A JP 2017556248 A JP2017556248 A JP 2017556248A JP 2017556248 A JP2017556248 A JP 2017556248A JP 2018526321 A JP2018526321 A JP 2018526321A
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alkyl
independently
carbon
antigen
lnp
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JP2018526321A5 (https=
Inventor
ワイズマン，ドリュー
パーディ，ノーバート
タム，イン
ホープ，マイケル・ジェイ
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Acuitas Therapeutics Inc
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Acuitas Therapeutics Inc
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Publication of JP2018526321A publication Critical patent/JP2018526321A/ja
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Priority to JP2021096084A priority Critical patent/JP7506030B2/ja
Priority to JP2024060190A priority patent/JP2024084804A/ja
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    • A—HUMAN NECESSITIES
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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    • C08G65/32—Polymers modified by chemical after-treatment
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017556248A 2015-04-27 2016-04-27 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ Pending JP2018526321A (ja)

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Application Number Priority Date Filing Date Title
JP2021096084A JP7506030B2 (ja) 2015-04-27 2021-06-08 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ
JP2024060190A JP2024084804A (ja) 2015-04-27 2024-04-03 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ

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US201562153143P 2015-04-27 2015-04-27
US62/153,143 2015-04-27
PCT/US2016/029572 WO2016176330A1 (en) 2015-04-27 2016-04-27 Nucleoside-modified rna for inducing an adaptive immune response

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JP2018526321A true JP2018526321A (ja) 2018-09-13
JP2018526321A5 JP2018526321A5 (https=) 2019-06-06

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JP2017556248A Pending JP2018526321A (ja) 2015-04-27 2016-04-27 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ
JP2021096084A Active JP7506030B2 (ja) 2015-04-27 2021-06-08 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ
JP2024060190A Pending JP2024084804A (ja) 2015-04-27 2024-04-03 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ

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JP2024060190A Pending JP2024084804A (ja) 2015-04-27 2024-04-03 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ

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US (4) US20180303925A1 (https=)
EP (1) EP3289083A4 (https=)
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JP2018521052A (ja) * 2015-06-29 2018-08-02 アクイタス セラピューティクス インコーポレイテッド 核酸の送達のための脂質および脂質ナノ粒子製剤
JP2019504002A (ja) * 2015-12-10 2019-02-14 モデルナティーエックス， インコーポレイテッド 治療薬の送達のための組成物及び方法
JP2019218403A (ja) * 2014-06-25 2019-12-26 アクイタス セラピューティクス インコーポレイテッド 核酸の送達のための新規脂質および脂質ナノ粒子製剤
JP2020504764A (ja) * 2016-10-26 2020-02-13 キュアバック アーゲー 脂質ナノ粒子ｍＲＮＡワクチン
JP2022517783A (ja) * 2019-01-11 2022-03-10 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
JP2023500921A (ja) * 2019-11-07 2023-01-11 サムヤン ホールディングス コーポレイション 免疫誘導用ポリマーナノ粒子組成物及びその製造方法
JP2023514951A (ja) * 2020-11-27 2023-04-12 グアンジョウ リボビオ カンパニー リミテッド 脂質化合物及びその組成物
JP2023537887A (ja) * 2020-08-20 2023-09-06 スージョウ・アボジェン・バイオサイエンシズ・カンパニー・リミテッド 脂質化合物及び脂質ナノ粒子組成物
JP2023550666A (ja) * 2020-03-31 2023-12-05 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ヌクレオシド修飾ｍＲＮＡを使用する汎用インフルエンザワクチン
JP2025503982A (ja) * 2022-01-27 2025-02-06 広州立得生物医薬科技有限公司 カチオン性脂質類似体、その組成物および使用
JP2025523019A (ja) * 2022-07-15 2025-07-17 シェンチェン シェンシン バイオテクノロジー カンパニー リミテッド アミノ脂質化合物、その調製方法、その組成物およびその使用

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HRP20230209T1 (hr) * 2015-10-28 2023-04-14 Acuitas Therapeutics Inc. Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
LT3394030T (lt) 2015-12-22 2022-04-11 Modernatx, Inc. Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu
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AU2017356699B2 (en) 2016-11-08 2021-11-11 Ramot At Tel-Aviv University Ltd. Cationic lipids for nucleic acid delivery and preparation thereof
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CA3049991A1 (en) 2017-01-11 2018-07-19 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an immune response against zika virus
BR112019015797A2 (pt) 2017-02-01 2020-03-17 Modernatx, Inc. Composições de mrna terapêuticas imunomoduladoras que codificam peptídeos de mutação de oncogene de ativação
TW202428301A (zh) 2017-02-28 2024-07-16 法商賽諾菲公司 治療性rna
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WO2018170270A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Varicella zoster virus (vzv) vaccine
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WO2018188730A1 (en) * 2017-04-11 2018-10-18 Biontech Rna Pharmaceuticals Gmbh Rna for treatment of autoimmune diseases
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