JP2018525382A5 - - Google Patents
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- JP2018525382A5 JP2018525382A5 JP2018506281A JP2018506281A JP2018525382A5 JP 2018525382 A5 JP2018525382 A5 JP 2018525382A5 JP 2018506281 A JP2018506281 A JP 2018506281A JP 2018506281 A JP2018506281 A JP 2018506281A JP 2018525382 A5 JP2018525382 A5 JP 2018525382A5
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- polypeptide
- antibody
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- variant
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020205966A JP7591917B2 (ja) | 2015-08-07 | 2020-12-11 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562202772P | 2015-08-07 | 2015-08-07 | |
| US201562202775P | 2015-08-07 | 2015-08-07 | |
| US201562202779P | 2015-08-07 | 2015-08-07 | |
| US62/202,775 | 2015-08-07 | ||
| US62/202,779 | 2015-08-07 | ||
| US62/202,772 | 2015-08-07 | ||
| US201562265887P | 2015-12-10 | 2015-12-10 | |
| US62/265,887 | 2015-12-10 | ||
| US201662276801P | 2016-01-08 | 2016-01-08 | |
| US201662276796P | 2016-01-08 | 2016-01-08 | |
| US62/276,796 | 2016-01-08 | ||
| US62/276,801 | 2016-01-08 | ||
| US201662346414P | 2016-06-06 | 2016-06-06 | |
| US62/346,414 | 2016-06-06 | ||
| PCT/US2016/045914 WO2017027422A1 (en) | 2015-08-07 | 2016-08-05 | Constructs having a sirp-alpha domain or variant thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205966A Division JP7591917B2 (ja) | 2015-08-07 | 2020-12-11 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018525382A JP2018525382A (ja) | 2018-09-06 |
| JP2018525382A5 true JP2018525382A5 (OSRAM) | 2019-09-12 |
| JP6898303B2 JP6898303B2 (ja) | 2021-07-07 |
Family
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| JP2018506281A Active JP6898303B2 (ja) | 2015-08-07 | 2016-08-05 | Ｓｉｒｐ−アルファドメインまたはそのバリアントを有する構築物 |
| JP2020205966A Active JP7591917B2 (ja) | 2015-08-07 | 2020-12-11 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
| JP2023010460A Withdrawn JP2023061969A (ja) | 2015-08-07 | 2023-01-26 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
| JP2025003210A Pending JP2025069164A (ja) | 2015-08-07 | 2025-01-09 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
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| JP2020205966A Active JP7591917B2 (ja) | 2015-08-07 | 2020-12-11 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
| JP2023010460A Withdrawn JP2023061969A (ja) | 2015-08-07 | 2023-01-26 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
| JP2025003210A Pending JP2025069164A (ja) | 2015-08-07 | 2025-01-09 | Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物 |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US10259859B2 (OSRAM) |
| EP (2) | EP3331902B1 (OSRAM) |
| JP (4) | JP6898303B2 (OSRAM) |
| KR (2) | KR20250133806A (OSRAM) |
| CN (3) | CN117777267A (OSRAM) |
| AU (2) | AU2016304794B2 (OSRAM) |
| CA (1) | CA2993835A1 (OSRAM) |
| CL (3) | CL2018000340A1 (OSRAM) |
| CO (1) | CO2018002471A2 (OSRAM) |
| CY (1) | CY1124372T1 (OSRAM) |
| DK (1) | DK3331902T3 (OSRAM) |
| ES (1) | ES2881771T3 (OSRAM) |
| GE (2) | GEP20227447B (OSRAM) |
| HR (1) | HRP20211167T1 (OSRAM) |
| HU (1) | HUE055139T2 (OSRAM) |
| IL (3) | IL256989B (OSRAM) |
| LT (1) | LT3331902T (OSRAM) |
| MX (2) | MX395275B (OSRAM) |
| MY (1) | MY185014A (OSRAM) |
| NZ (1) | NZ738950A (OSRAM) |
| PE (1) | PE20180778A1 (OSRAM) |
| PH (1) | PH12018500269B1 (OSRAM) |
| PL (1) | PL3331902T3 (OSRAM) |
| PT (1) | PT3331902T (OSRAM) |
| RS (1) | RS62151B1 (OSRAM) |
| RU (2) | RU2020143675A (OSRAM) |
| SA (1) | SA518390881B1 (OSRAM) |
| SG (2) | SG10202101909RA (OSRAM) |
| SI (1) | SI3331902T1 (OSRAM) |
| SM (1) | SMT202100424T1 (OSRAM) |
| UA (2) | UA125638C2 (OSRAM) |
| WO (1) | WO2017027422A1 (OSRAM) |
| ZA (3) | ZA201800857B (OSRAM) |
Families Citing this family (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10053513B2 (en) * | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| HRP20211273T1 (hr) | 2014-11-26 | 2021-11-12 | Xencor, Inc. | Heterodimerna protutijela koja vežu cd3 i cd20 |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| US10259859B2 (en) | 2015-08-07 | 2019-04-16 | ALX Oncology Inc. | Constructs having a SIRP-α domain or variant thereof |
| SI3341015T2 (sl) | 2015-08-26 | 2024-03-29 | The Board Of Trustees Of The Leland Stanford, Junior University | Izboljšana deplecija ciljanih celic z blokado CD47 in imunostimulatornim agonistom |
| IL295423B2 (en) | 2015-10-01 | 2023-11-01 | Heat Biologics Inc | Compounds and methods for joining extracellular complexes of type 1 and 2 as heterologous chimeric proteins |
| ES2796378T3 (es) | 2016-01-11 | 2020-11-26 | Forty Seven Inc | Anticuerpos monoclonales anti-cd47 humanizados, de ratón o químicos |
| US11560433B2 (en) | 2016-05-27 | 2023-01-24 | Albert Einstein College Of Medicine | Methods of treatment by targeting VCAM1 and MAEA |
| ES3000558T3 (en) | 2016-08-10 | 2025-02-28 | Univ Ajou Ind Academic Coop Found | Heterodimeric fc-fused cytokine and pharmaceutical composition comprising the same |
| WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
| KR102597943B1 (ko) | 2017-01-05 | 2023-11-06 | 카 메디컬 리미티드 | Pd1-41bbl 융합 단백질 및 이의 이용 방법 |
| HUE057326T2 (hu) | 2017-01-05 | 2022-04-28 | Kahr Medical Ltd | SIRP1 Alfa-41 BBL fúziós fehérje és eljárások annak alkalmazására |
| US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
| EP3577133A1 (en) | 2017-02-06 | 2019-12-11 | Orionis Biosciences NV | Targeted chimeric proteins and uses thereof |
| US11267856B2 (en) | 2017-02-27 | 2022-03-08 | Shattuck Labs, Inc. | CSF1R-CD40L chimeric proteins |
| IL313003A (en) * | 2017-02-27 | 2024-07-01 | Shattuck Labs Inc | Tigit- and light-based chimeric proteins |
| CN110958888A (zh) * | 2017-03-28 | 2020-04-03 | 延龄草治疗公司 | Cd47阻断疗法 |
| AU2018264321B2 (en) | 2017-05-08 | 2025-03-06 | Shanghai Jmt-Bio Technology Co., Ltd. | Bispecific recombinant protein and use thereof |
| US11530247B2 (en) * | 2017-06-06 | 2022-12-20 | Relinia, Inc. | Single-chain TNF receptor 2 agonist fusion proteins |
| CN111051350B (zh) * | 2017-09-07 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | 包含信号调节蛋白α的免疫缀合物 |
| WO2019095358A1 (zh) | 2017-11-20 | 2019-05-23 | 泰州迈博太科药业有限公司 | 一种靶向cd47与pd-l1的双功能融合蛋白 |
| BR112020011295A2 (pt) | 2017-12-04 | 2020-11-24 | Beijing Hanmi Pharmaceutical Co., Ltd. | anticorpo biespecífico anti-pd-l1/anti-cd47 com estrutura semelhante ao anticorpo natural e em forma de heterodímero e preparação do mesmo |
| CN109971716B (zh) * | 2017-12-28 | 2023-08-01 | 上海细胞治疗研究院 | 自分泌cd47抗体的egfr特异性car-t细胞及其用途 |
| EP4129336B1 (en) | 2018-02-12 | 2025-05-07 | Forty Seven, LLC | Anti-cd47 agent-based treatment of cd20-positive cancer |
| EP3765090A4 (en) * | 2018-03-13 | 2022-03-16 | Trillium Therapeutics Inc. | COMBINATION OF CD47 BLOCKADE THERAPY AND A CD38 ANTIBODY |
| JP2021515779A (ja) * | 2018-03-13 | 2021-06-24 | トリリアム・セラピューティクス・インコーポレイテッドＴｒｉｌｌｉｕｍ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | Ｅｇｆｒ抗体によるｃｄ４７遮断療法における改善 |
| CN110386984B (zh) * | 2018-04-17 | 2022-04-22 | 杭州尚健生物技术有限公司 | 结合cd47蛋白的融合蛋白及其应用 |
| AU2019269641A1 (en) * | 2018-05-17 | 2020-12-03 | Immunome, Inc. | CH3 domain epitope tags |
| US20210221908A1 (en) * | 2018-06-03 | 2021-07-22 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
| CA3104778A1 (en) | 2018-07-11 | 2020-01-16 | Kahr Medical Ltd. | Pd1-4-1bbl variant fusion protein and methods of use thereof |
| CA3104780A1 (en) * | 2018-07-11 | 2020-01-16 | Kahr Medical Ltd. | Sirpalpha-4-1bbl variant fusion protein and methods of use thereof |
| WO2020033646A1 (en) | 2018-08-08 | 2020-02-13 | Orionis Biosciences, Inc. | SIRP1α TARGETED CHIMERIC PROTEINS AND USES THEREOF |
| US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
| WO2020047326A2 (en) | 2018-08-31 | 2020-03-05 | ALX Oncology Inc. | Decoy polypeptides |
| US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
| AU2019349651B2 (en) | 2018-09-27 | 2023-12-07 | Celgene Corporation | SIRP alpha binding proteins and methods of use thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109306017B (zh) * | 2018-10-12 | 2021-02-09 | 倍而达药业（苏州）有限公司 | 一种基于SIRP-αD1突变体制备的重组蛋白及应用 |
| PE20211279A1 (es) | 2018-10-23 | 2021-07-19 | Dragonfly Therapeutics Inc | Proteinas heterodimericas fusionadas con fc |
| EP3876977A1 (en) | 2018-11-06 | 2021-09-15 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
| CN111303293B (zh) | 2018-11-14 | 2022-08-30 | 杭州尚健生物技术有限公司 | 一种融合蛋白及其用途 |
| CN109517054B (zh) * | 2018-12-04 | 2022-04-08 | 江苏东抗生物医药科技有限公司 | SIRPα变体或其融合蛋白及其应用 |
| JP2022523543A (ja) * | 2019-03-06 | 2022-04-25 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | 二機能性融合タンパク質及びその医薬的使用 |
| CN113646622B (zh) * | 2019-03-29 | 2024-11-12 | 豪夫迈·罗氏有限公司 | 用于多价分子的功能分析的基于spr的结合测定 |
| CN111763261B (zh) * | 2019-04-02 | 2022-08-09 | 杭州尚健生物技术有限公司 | 一种融合蛋白及其用途 |
| US11013764B2 (en) | 2019-04-30 | 2021-05-25 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
| CN119700933A (zh) * | 2019-05-31 | 2025-03-28 | Alx肿瘤生物技术公司 | 用SIRPαFc融合体组合免疫检查点抑制剂治疗癌症的方法 |
| EP3980051A4 (en) * | 2019-06-05 | 2023-09-13 | Asher Biotherapeutics, Inc. | FUSIONS OF MUTANT INTERLEUKIN-2 POLYPEPTIDES WITH ANTIGEN-BINDING MOLECULES TO MODULATE THE FUNCTION OF IMMUNE CELLS |
| WO2020247820A1 (en) | 2019-06-07 | 2020-12-10 | ALX Oncology Inc. | Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays |
| CN112125975B (zh) * | 2019-06-25 | 2024-03-01 | 上海翰森生物医药科技有限公司 | Pd-l1和cd47双特异性融合蛋白及其医药用途 |
| KR102228271B1 (ko) * | 2019-07-16 | 2021-03-17 | 한국과학기술연구원 | 항암활성을 갖는 면역조절 단백질-siRNA 복합체 |
| JP7454645B2 (ja) | 2019-07-16 | 2024-03-22 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖワクチン並びにその作製方法及び使用方法 |
| EP4025686A4 (en) | 2019-09-03 | 2023-09-13 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| EP4045083B1 (en) | 2019-10-18 | 2024-01-10 | Forty Seven, Inc. | Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia |
| NZ786589A (en) | 2019-10-31 | 2025-03-28 | Forty Seven Llc | Anti-cd47 and anti-cd20 based treatment of blood cancer |
| AU2020394204A1 (en) * | 2019-11-27 | 2022-06-02 | ALX Oncology Inc. | Combination therapies for treating cancer |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| CN117736207A (zh) | 2019-12-24 | 2024-03-22 | 卡尔那生物科学株式会社 | 二酰基甘油激酶调节化合物 |
| WO2021146487A2 (en) | 2020-01-14 | 2021-07-22 | Synthekine, Inc. | Il2 orthologs and methods of use |
| TWI832035B (zh) | 2020-02-14 | 2024-02-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| CN111253482B (zh) * | 2020-02-18 | 2021-11-30 | 中国人民解放军军事科学院军事医学研究院 | SIRPa变体、融合蛋白、及其应用 |
| CA3172449A1 (en) | 2020-03-27 | 2021-09-30 | Erik Hans MANTING | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| AU2021283083A1 (en) | 2020-06-01 | 2022-12-01 | ALX Oncology Inc. | Combination therapies comprising a hypomethylation agent for treating cancer |
| CN116133679A (zh) | 2020-06-30 | 2023-05-16 | 门德斯有限公司 | 白血病衍生细胞在卵巢癌疫苗中的用途 |
| US20230235090A1 (en) * | 2020-06-30 | 2023-07-27 | Harbour Biomed US, Inc. | Bispecific antibody and use thereof |
| WO2022010806A1 (en) | 2020-07-06 | 2022-01-13 | ALX Oncology Inc. | Methods for reducing the interference of drugs that bind therapeutic targets expressed on blood cells in serological assays |
| CN113912736A (zh) * | 2020-07-09 | 2022-01-11 | 上海交通大学 | 靶向cd47与pd-l1双效融合蛋白及其应用 |
| CN111808183B (zh) * | 2020-07-25 | 2022-07-08 | 北京吉尔麦迪生物医药科技有限公司 | 一种靶向CD47的高亲和力SIRPα突变体及其融合蛋白 |
| CN114057888A (zh) * | 2020-07-30 | 2022-02-18 | 三生国健药业（上海）股份有限公司 | 一种SIRPα-Fc融合蛋白 |
| CN116390768B (zh) * | 2020-08-14 | 2024-07-09 | 韩国科学技术研究院 | 具有抗癌活性的免疫调节蛋白-siRNA复合物 |
| KR102557016B1 (ko) * | 2020-09-22 | 2023-07-20 | 비피진 주식회사 | 암 치료를 위한 cd47 바인더 및 리포좀 복합체 |
| KR102579284B1 (ko) * | 2020-09-22 | 2023-09-18 | 비피진 주식회사 | 신규의 cd47 바인더와 폴리뉴클레오티드를 포함하는 암 치료를 위한 리포좀 복합체 |
| IL302276A (en) | 2020-10-23 | 2023-06-01 | Asher Biotherapeutics Inc | Fusions with cd8 antigen binding molecules for modulating immune cell function |
| CA3197423A1 (en) | 2020-11-04 | 2022-05-12 | Daniel Getts | Engineered chimeric fusion protein compositions and methods of use thereof |
| JP2023552375A (ja) | 2020-12-06 | 2023-12-15 | エーエルエックス オンコロジー インコーポレイテッド | 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための多量体 |
| CN112979782B (zh) * | 2021-03-08 | 2023-07-18 | 深圳市乐土生物医药有限公司 | 一种多肽及其用途 |
| CN117157319A (zh) * | 2021-03-09 | 2023-12-01 | Xencor股份有限公司 | 结合cd3和cldn6的异二聚抗体 |
| WO2022190058A1 (en) | 2021-03-12 | 2022-09-15 | Dcprime B.V. | Methods of vaccination and use of cd47 blockade |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| JP2024518100A (ja) | 2021-05-11 | 2024-04-24 | マイエロイド・セラピューティクス，インコーポレーテッド | ゲノム組込みのための方法および組成物 |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
| AU2022275666A1 (en) | 2021-05-19 | 2023-12-07 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| CN117480155A (zh) | 2021-06-23 | 2024-01-30 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| WO2023003331A1 (en) * | 2021-07-19 | 2023-01-26 | Yuhan Corporation | Sirp-alpha variants and use thereof |
| CN113896802A (zh) * | 2021-10-09 | 2022-01-07 | 宜明昂科生物医药技术（上海）有限公司 | 靶向cd47和cd38的重组融合蛋白及其制备和用途 |
| WO2023076983A1 (en) | 2021-10-28 | 2023-05-04 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| JP7787991B2 (ja) | 2021-10-29 | 2025-12-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｄ７３化合物 |
| TWI859619B (zh) * | 2021-11-01 | 2024-10-21 | 大陸商山東先聲生物製藥有限公司 | SIRPa突變體及其應用 |
| TW202334191A (zh) * | 2021-11-19 | 2023-09-01 | 大陸商杭州尚健生物技術有限公司 | ＳＩＲＰα變體及其應用 |
| JP2024540448A (ja) | 2021-11-19 | 2024-10-31 | ケーアイエスティー（コリア インスティテュート オブ サイエンス アンド テクノロジー） | 標的細胞への医薬品有効成分の赤血球媒介送達のための治療化合物 |
| CN116178561B (zh) * | 2021-11-26 | 2025-07-18 | 杭州尚健生物技术有限公司 | 包含SIRPα突变体的融合蛋白 |
| IL313573A (en) * | 2021-12-21 | 2024-08-01 | Fbd Biologics Ltd | Transgenic sirpα variants and methods of using them |
| AU2022419982A1 (en) | 2021-12-22 | 2024-06-06 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| WO2023122615A1 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| KR102710779B1 (ko) * | 2022-01-04 | 2024-09-26 | 주식회사 보령바이오파마 | 5'-뉴클레오티다아제 변형 단백질을 암호화하는 암 치료를 위한 폴리뉴클레오티드 |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| US20250302953A1 (en) | 2022-02-14 | 2025-10-02 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
| TW202346277A (zh) | 2022-03-17 | 2023-12-01 | 美商基利科學股份有限公司 | Ｉｋａｒｏｓ鋅指家族降解劑及其用途 |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| JP2025510774A (ja) | 2022-03-24 | 2025-04-15 | ビタールート・バイオ・インコーポレイテッド | 修飾ｆｃドメインを有するｓｉｒｐ－ａｌｐｈａ融合ポリペプチド |
| AU2023240346A1 (en) | 2022-03-24 | 2024-09-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| US20250257113A1 (en) | 2022-03-24 | 2025-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Multivalent sirp-alpha fusion polypeptides |
| TWI876305B (zh) | 2022-04-05 | 2025-03-11 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| PE20250157A1 (es) | 2022-04-21 | 2025-01-22 | Gilead Sciences Inc | Compuestos de modulacion de kras g12d |
| JP2025517656A (ja) | 2022-05-11 | 2025-06-10 | 第一三共株式会社 | 腫瘍抗原に特異的である抗体と、ｃｄ４７阻害剤との組合せ |
| JP2025523369A (ja) | 2022-06-01 | 2025-07-23 | エーエルエックス オンコロジー インコーポレイテッド | 尿路上皮癌腫を治療するための併用療法 |
| CN119384415A (zh) | 2022-07-01 | 2025-01-28 | 吉利德科学公司 | Cd73化合物 |
| EP4554628A1 (en) | 2022-07-12 | 2025-05-21 | Gilead Sciences, Inc. | Hiv immunogenic polypeptides and vaccines and uses thereof |
| CN116041470B (zh) * | 2022-08-04 | 2024-10-22 | 四川大学华西医院 | 具有高亲和力结合肿瘤细胞cd47的细胞膜材料及其制备方法和应用 |
| KR102896511B1 (ko) * | 2022-09-07 | 2025-12-08 | 주식회사 시프트바이오 | SIRPα 변이체에 특이적으로 결합하는 항체 |
| WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
| US20240254118A1 (en) | 2022-12-22 | 2024-08-01 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| KR20250167002A (ko) | 2023-04-11 | 2025-11-28 | 길리애드 사이언시즈, 인코포레이티드 | Kras 조절 화합물 |
| CN121079300A (zh) | 2023-04-21 | 2025-12-05 | 吉利德科学公司 | Prmt5抑制剂及其用途 |
| EP4490201A1 (en) * | 2023-05-31 | 2025-01-15 | FBD Biologics Limited | Cd47/pd-l1-targeting protein complex and methods of use thereof |
| US20250042922A1 (en) | 2023-06-30 | 2025-02-06 | Gilead Sciences, Inc. | Kras modulating compounds |
| WO2025024811A1 (en) | 2023-07-26 | 2025-01-30 | Gilead Sciences, Inc. | Parp7 inhibitors |
| US20250066328A1 (en) | 2023-07-26 | 2025-02-27 | Gilead Sciences, Inc. | Parp7 inhibitors |
| US20250101042A1 (en) | 2023-09-08 | 2025-03-27 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| WO2025054530A1 (en) | 2023-09-08 | 2025-03-13 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
| WO2025072726A1 (en) | 2023-09-29 | 2025-04-03 | Trex Bio, Inc. | Tnf-alpha variant fusion molecules |
| WO2025096589A1 (en) | 2023-11-03 | 2025-05-08 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| FI101678B1 (fi) | 1990-12-31 | 1998-08-14 | Akzo Nv | Happolabiileja kytkentämolekyylejä |
| ES2109362T3 (es) | 1991-06-21 | 1998-01-16 | Univ Cincinnati | Unas proteinas administrables oralmente y metodo para hacerlas. |
| US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
| IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| EP0604580A1 (en) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES |
| US5505931A (en) | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| WO1997005266A1 (en) | 1995-07-25 | 1997-02-13 | Introgene B.V. | Methods and means for targeted gene delivery |
| ES2247621T3 (es) | 1996-02-15 | 2006-03-01 | Biosense Webster, Inc. | Sonda de excavacion. |
| EP0920339A2 (en) | 1996-07-09 | 1999-06-09 | The Johns Hopkins University | Gene delivery system |
| US6541615B1 (en) | 1996-11-15 | 2003-04-01 | Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. | SIRP proteins and uses thereof |
| CA2226962A1 (en) | 1998-02-16 | 1999-08-16 | Marie Sarfati | Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection |
| AU5591200A (en) | 1999-06-11 | 2001-01-02 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| US6613026B1 (en) | 1999-12-08 | 2003-09-02 | Scimed Life Systems, Inc. | Lateral needle-less injection apparatus and method |
| GB9930706D0 (en) | 1999-12-24 | 2000-02-16 | Medical Res Council | Composition for inhibiting macrophage activity |
| US7662367B2 (en) | 2000-03-02 | 2010-02-16 | Xencor, Inc. | Pharmaceutical compositions for the treatment of TNF-α related disorders |
| TWI327597B (en) | 2001-08-01 | 2010-07-21 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
| GB0124145D0 (en) | 2001-10-08 | 2001-11-28 | Bayer Ag | Genes and proteins for prevention,prediction,prognosis and therapy of cardiovascular disease |
| US20040018522A1 (en) | 2002-05-09 | 2004-01-29 | Brigham And Women's Hospital, Inc. | Identification of dysregulated genes in patients with multiple sclerosis |
| WO2004011618A2 (en) | 2002-07-29 | 2004-02-05 | Hmgene, Inc. | Methods of identifying adipocyte specific genes, the genes identified, and their uses |
| CA2498274A1 (en) | 2002-09-16 | 2004-03-25 | Genentech, Inc. | Compositions and methods for the diagnosis of immune related diseases using pro7 |
| JP2006519763A (ja) | 2002-11-08 | 2006-08-31 | アブリンクス エン．ヴェー． | 治療用ポリペプチドの投与法およびそのためのポリペプチド |
| US20100215640A1 (en) | 2003-04-24 | 2010-08-26 | The University Of North Carolina At Chapel Hill | Method for inhibiting cellular activation by insulin-like growth factor-1 |
| US8613922B2 (en) | 2003-04-24 | 2013-12-24 | The University Of North Carolina At Chapel Hill | Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP) |
| US20040213792A1 (en) | 2003-04-24 | 2004-10-28 | Clemmons David R. | Method for inhibiting cellular activation by insulin-like growth factor-1 |
| AU2003264100A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of a bilin-binding protein with affinity for a given target |
| MXPA06009805A (es) | 2004-02-27 | 2007-04-02 | Vaxconsulting | Peptidos de interleucina 1 beta y factor de necrosis tumoral alfa y metodo de tratamiento utilizando los mismos. |
| US8518869B2 (en) | 2004-03-29 | 2013-08-27 | Austria Wirtschaftsservice Gesellschaft M.B.H. | Pharmaceutical combined preparation containing a therapeutic protein |
| WO2005108415A2 (en) | 2004-04-30 | 2005-11-17 | Biogen Idec Ma Inc. | Membrane associated molecules |
| US7514229B2 (en) | 2005-09-29 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and evaluating treatment of blood disorders |
| AR060017A1 (es) | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
| US8377448B2 (en) | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| CA2682605A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
| AR066240A1 (es) * | 2007-04-23 | 2009-08-05 | Wyeth Corp | Metodos y composiciones para tratar y monitorear el tratamiento de trastornos asociados con il-13 |
| CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| JP2011500005A (ja) | 2007-10-11 | 2011-01-06 | ユニバーシティー ヘルス ネットワーク | ヒト造血幹細胞の生着を増加させるためのＳＩＲＰα−ＣＤ４７相互作用の調節およびそのための化合物 |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| ES2563027T3 (es) | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
| ES2735144T3 (es) | 2008-01-15 | 2019-12-16 | Univ Leland Stanford Junior | Métodos para manipular fagocitosis mediada por CD47 |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| EA201100947A1 (ru) | 2008-12-19 | 2012-02-28 | Новартис Аг | Растворимые полипептиды, предназначенные для применения при лечении аутоиммунных и воспалительных нарушений |
| CN102482347B (zh) | 2009-01-12 | 2017-04-26 | 希托马克斯医疗有限责任公司 | 修饰抗体组合物及其制备和使用方法 |
| RU2011138951A (ru) | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
| CA2761438C (en) | 2009-05-15 | 2017-12-12 | University Health Network | Compositions and methods for treating hematologic cancers targeting the sirp.alpha.-cd47 interaction |
| AU2010276453A1 (en) | 2009-07-20 | 2012-02-09 | Dcb-Usa Llc | Polypeptides selective for av beta3 integrin conjugated with a variant of human serum albumin (HSA) and pharmaceutical uses thereof |
| KR101632312B1 (ko) | 2009-11-03 | 2016-06-21 | 삼성전자주식회사 | 항체 불변 영역에 특이적으로 결합하는 융합 단백질, 그의 제조 방법 및 이를 이용한 항체 분리 방법 |
| SI2506871T1 (sl) * | 2009-11-30 | 2016-12-30 | Janssen Biotech, Inc. | Mutanti Fc protitelesa z odstranjenimi efektorskimi funkcijami |
| CA2785139A1 (en) | 2009-12-22 | 2011-06-30 | Novartis Ag | Tetravalent cd47-antibody constant region fusion protein for use in therapy |
| JP6166177B2 (ja) | 2010-05-14 | 2017-07-19 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｃｄ４７に対するヒト化及びキメラモノクローナル抗体 |
| AU2011312106B8 (en) | 2010-10-08 | 2017-09-14 | City Of Hope | A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use |
| US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
| US9566347B2 (en) | 2011-02-07 | 2017-02-14 | The Trustees Of The University Of Pennsylvania | Peptides and methods using same |
| HUE041335T2 (hu) | 2011-03-29 | 2019-05-28 | Roche Glycart Ag | Antitest FC-variánsok |
| SMT201700025T1 (it) * | 2011-04-13 | 2017-03-08 | Bristol Myers Squibb Co | Proteine di fusione ad fc comprendenti nuovi raccordi o arrangiamenti |
| KR20140059168A (ko) | 2011-04-21 | 2014-05-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 시신경 척수염 치료용 조성물 및 치료 방법 |
| US20140161800A1 (en) * | 2011-04-22 | 2014-06-12 | John W. Blankenship | Prostate-Specific Membrane Antigen Binding Proteins and Related Compositions and Methods |
| MX2013014789A (es) | 2011-06-16 | 2014-01-20 | Novartis Ag | Proteinas solubles para utilizarse como productos terapeuticos. |
| US20140242095A1 (en) | 2011-10-19 | 2014-08-28 | University Health Network | Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers |
| WO2013063076A1 (en) | 2011-10-25 | 2013-05-02 | Indiana University Research & Technology Corporation | Compositions for and methods of modulating complications, risks and issues with xenotransplantation |
| SMT202000689T1 (it) * | 2012-01-17 | 2021-01-05 | Univ Leland Stanford Junior | Reagenti per sirp-alfa ad alta affinita' |
| US9428553B2 (en) | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| EP2863948B1 (en) | 2012-06-22 | 2018-10-24 | Cytomx Therapeutics Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| US9856314B2 (en) | 2012-06-22 | 2018-01-02 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and methods of using the same |
| GB201216649D0 (en) | 2012-09-18 | 2012-10-31 | Univ Birmingham | Agents and methods |
| CA2894245C (en) | 2012-12-17 | 2022-03-22 | Trillium Therapeutics Inc. | Treatment of cd47+ disease cells with sirp alpha-fc fusions |
| US9873747B2 (en) | 2013-01-31 | 2018-01-23 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
| US9771428B2 (en) | 2013-02-05 | 2017-09-26 | The Board Of Trustees Of The Leland Stanford Junior University | CD47 targeted therapies for the treatment of infectious disease |
| CN105101997B (zh) | 2013-02-06 | 2018-11-09 | 印希彼有限合伙公司 | 不减少血小板和不减少血红细胞的cd47抗体及其使用方法 |
| WO2014160183A1 (en) | 2013-03-13 | 2014-10-02 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Methods for modulating chemotherapeutic cytotoxicity |
| ES2728066T3 (es) | 2013-03-15 | 2019-10-22 | Univ Leland Stanford Junior | Métodos para la obtención de dosis terapéuticamente eficaces de agentes anti-CD47 |
| JP6843611B2 (ja) | 2013-04-29 | 2021-03-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 免疫を強化する抗ｃｄ４７因子の使用 |
| US9945870B2 (en) | 2013-05-17 | 2018-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for determining responsiveness to an anti-CD47 agent |
| BR112016002219A2 (pt) * | 2013-07-31 | 2017-09-12 | Amgen Inc | estabilização de polipeptídeos contendo fc |
| ES2765483T3 (es) | 2013-09-18 | 2020-06-09 | Univ Leland Stanford Junior | Modulación de las vías de eferocitosis para el tratamiento de una enfermedad aterosclerótica |
| PT4269430T (pt) | 2013-09-23 | 2025-08-06 | Regeneron Pharma | Animais não-humanos com um gene humanizado de proteína reguladora de sinal |
| US20150087810A1 (en) | 2013-09-25 | 2015-03-26 | Cytomx Therapeutics, Inc. | Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof |
| AU2014337367B2 (en) * | 2013-10-15 | 2020-04-30 | The Scripps Research Institute | Peptidic chimeric antigen receptor T cell switches and uses thereof |
| BR112016017649B1 (pt) | 2014-01-31 | 2024-01-30 | Cytomx Therapeutics, Inc | Polipeptídeo isolado compreendendo substratos de matriptase e de ativador do plasminogênio u e outras porções cliváveis, composição farmacêutica compreendendo o dito polipeptídeo, bem como métodos para produzir e fabricar um polipeptídeo isolado compreendendo uma porção clivável e uso da composição farmacêutica e quantidade terapeuticamente eficaz da dita composição no tratamento de um distúrbio ou doença |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| CN114081946A (zh) | 2014-03-12 | 2022-02-25 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤 |
| TWI702228B (zh) | 2014-08-08 | 2020-08-21 | 美商Ａｌｘ腫瘤技術股份有限公司 | 信號調節蛋白α（ｓｉｇｎａｌ-ｒｅｇｕｌａｔｏｒｙ ｐｒｏｔｅｉｎ α， ＳＩＲＰ-α）變體構築物及其用途 |
| WO2016023001A1 (en) | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Multispecific high affinity pd-1 agents and methods of use |
| ES2819451T3 (es) | 2014-08-08 | 2021-04-16 | Univ Leland Stanford Junior | Agentes PD-1 de alta afinidad y procedimientos de uso |
| US10087257B2 (en) | 2014-08-08 | 2018-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | SIRP alpha-antibody fusion proteins |
| EP3643727A1 (en) | 2014-08-15 | 2020-04-29 | Merck Patent GmbH | Sirp-alpha immunoglobulin fusion proteins |
| HRP20210057T4 (hr) | 2014-08-26 | 2025-07-18 | The Board Of Trustees Of The Leland Stanford Junior University | Presađivanje stem stanica s kombinacijom sredstva koje cilja stem stanice i modulacija imunoregulatorne signalizacije |
| US10822411B2 (en) | 2014-09-15 | 2020-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting aneurysm disease by modulating phagocytosis pathways |
| US11053314B2 (en) | 2014-10-10 | 2021-07-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to eliminate cancer stem cells by targeting CD47 |
| EP3012271A1 (en) | 2014-10-24 | 2016-04-27 | Effimune | Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases |
| EP3209769B1 (en) | 2014-10-24 | 2020-08-05 | The Board of Trustees of the Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance |
| MX2017006485A (es) | 2014-11-18 | 2018-03-23 | Janssen Pharmaceutica Nv | Anticuerpos anti-cd47, metodos y usos. |
| ES2941387T3 (es) | 2015-02-27 | 2023-05-22 | Univ Leland Stanford Junior | Terapia de combinación para el tratamiento de la ateroesclerosis |
| CN106146670B (zh) | 2015-04-24 | 2019-01-15 | 宜明昂科生物医药技术（上海）有限公司 | 一种新的重组双功能融合蛋白及其制备和应用 |
| US10259859B2 (en) | 2015-08-07 | 2019-04-16 | ALX Oncology Inc. | Constructs having a SIRP-α domain or variant thereof |
| EP3443010B1 (en) | 2016-04-14 | 2024-08-07 | Ose Immunotherapeutics | New anti-sirpa antibodies and their therapeutic applications |
| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| CN119700933A (zh) | 2019-05-31 | 2025-03-28 | Alx肿瘤生物技术公司 | 用SIRPαFc融合体组合免疫检查点抑制剂治疗癌症的方法 |
| WO2020247820A1 (en) | 2019-06-07 | 2020-12-10 | ALX Oncology Inc. | Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays |
| AU2020394204A1 (en) | 2019-11-27 | 2022-06-02 | ALX Oncology Inc. | Combination therapies for treating cancer |
| AU2021283083A1 (en) | 2020-06-01 | 2022-12-01 | ALX Oncology Inc. | Combination therapies comprising a hypomethylation agent for treating cancer |
| WO2022010806A1 (en) | 2020-07-06 | 2022-01-13 | ALX Oncology Inc. | Methods for reducing the interference of drugs that bind therapeutic targets expressed on blood cells in serological assays |
| JP2023552375A (ja) | 2020-12-06 | 2023-12-15 | エーエルエックス オンコロジー インコーポレイテッド | 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための多量体 |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
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