JP2018525000A5 - - Google Patents
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- JP2018525000A5 JP2018525000A5 JP2018506178A JP2018506178A JP2018525000A5 JP 2018525000 A5 JP2018525000 A5 JP 2018525000A5 JP 2018506178 A JP2018506178 A JP 2018506178A JP 2018506178 A JP2018506178 A JP 2018506178A JP 2018525000 A5 JP2018525000 A5 JP 2018525000A5
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- Prior art keywords
- nucleotide
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- 239000002773 nucleotide Substances 0.000 claims 97
- 125000003729 nucleotide group Chemical group 0.000 claims 97
- 238000012217 deletion Methods 0.000 claims 50
- 230000037430 deletion Effects 0.000 claims 50
- 210000004027 cell Anatomy 0.000 claims 38
- 108010009992 CD163 antigen Proteins 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 33
- 241001465754 Metazoa Species 0.000 claims 30
- 238000003780 insertion Methods 0.000 claims 24
- 230000037431 insertion Effects 0.000 claims 24
- 108700028369 Alleles Proteins 0.000 claims 22
- 230000002759 chromosomal effect Effects 0.000 claims 13
- 241000282898 Sus scrofa Species 0.000 claims 10
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 claims 7
- 235000013601 eggs Nutrition 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 108010042407 Endonucleases Proteins 0.000 claims 3
- 102000004533 Endonucleases Human genes 0.000 claims 3
- 210000000349 chromosome Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 210000000287 oocyte Anatomy 0.000 claims 3
- 244000052769 pathogen Species 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 210000004102 animal cell Anatomy 0.000 claims 2
- 230000000366 juvenile effect Effects 0.000 claims 2
- 244000144972 livestock Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102100025222 CD63 antigen Human genes 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 102000018120 Recombinases Human genes 0.000 claims 1
- 108010091086 Recombinases Proteins 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 238000009395 breeding Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 230000004952 protein activity Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000014616 translation Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021184502A JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2024025140A JP2024059790A (ja) | 2015-08-06 | 2024-02-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562202145P | 2015-08-06 | 2015-08-06 | |
| US62/202,145 | 2015-08-06 | ||
| PCT/US2016/043467 WO2017023570A1 (en) | 2015-08-06 | 2016-07-22 | Pathogen-resistant animals having modified cd163 genes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021184502A Division JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018525000A JP2018525000A (ja) | 2018-09-06 |
| JP2018525000A5 true JP2018525000A5 (enExample) | 2019-08-29 |
Family
ID=57943474
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506178A Withdrawn JP2018525000A (ja) | 2015-08-06 | 2016-07-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2021184502A Withdrawn JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2024025140A Pending JP2024059790A (ja) | 2015-08-06 | 2024-02-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021184502A Withdrawn JP2022033771A (ja) | 2015-08-06 | 2021-11-12 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
| JP2024025140A Pending JP2024059790A (ja) | 2015-08-06 | 2024-02-22 | 改変ｃｄ１６３遺伝子を有する病原体抵抗性動物 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US10091975B2 (enExample) |
| EP (2) | EP4361279A3 (enExample) |
| JP (3) | JP2018525000A (enExample) |
| CN (1) | CN109475107A (enExample) |
| BR (1) | BR112018002417A2 (enExample) |
| DK (1) | DK3331355T3 (enExample) |
| ES (1) | ES2981381T3 (enExample) |
| FI (1) | FI3331355T3 (enExample) |
| HR (1) | HRP20240908T1 (enExample) |
| HU (1) | HUE066989T2 (enExample) |
| LT (1) | LT3331355T (enExample) |
| MX (1) | MX2018001529A (enExample) |
| PH (1) | PH12018500257A1 (enExample) |
| PL (1) | PL3331355T3 (enExample) |
| PT (1) | PT3331355T (enExample) |
| RS (1) | RS65691B1 (enExample) |
| RU (1) | RU2018107842A (enExample) |
| SI (1) | SI3331355T1 (enExample) |
| SM (1) | SMT202400272T1 (enExample) |
| WO (1) | WO2017023570A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2709445T (pt) | 2011-05-16 | 2018-11-27 | Univ Missouri | Animais resistentes ao vírus da síntese reprodutiva e respiratória porcino |
| BR112018002417A2 (pt) * | 2015-08-06 | 2018-09-18 | Univ Missouri | animal não humano ou descendente do mesmo ou uma célula de animal, animal suíno, descendente ou célula, célula, descendente, método de reprodução, população de animais, método para aumentar uma resistência de animal, molécula de ácido nucleico, ácido nucleico e ácido nucleico isolado |
| GB201617559D0 (en) * | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
| WO2018175872A1 (en) * | 2017-03-24 | 2018-09-27 | President And Fellows Of Harvard College | Methods of genome engineering by nuclease-transposase fusion proteins |
| CN107354170A (zh) * | 2017-08-24 | 2017-11-17 | 中国农业科学院北京畜牧兽医研究所 | 一种基因敲除载体以及制备cd163基因敲除猪成纤维细胞的方法 |
| US12060403B2 (en) | 2017-10-16 | 2024-08-13 | Kansas State University Research Foundation | Methods and compositions for treating and protecting against porcine reproductive and respiratory syndrome virus |
| CN107937345B (zh) * | 2017-11-16 | 2019-01-29 | 山东蓝思种业股份有限公司 | 一种制备同时敲除cd163基因和cd13基因的猪成纤维细胞的方法 |
| BR112020021066A2 (pt) * | 2018-04-17 | 2021-02-17 | The Curators Of The University Of Missouri | método para proteger um feto suíno da infecção com o vírus da síndrome respiratória e reprodutiva suína (prrsv) |
| US11160260B2 (en) | 2018-04-17 | 2021-11-02 | The Curators Of The University Of Missouri | Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV) |
| CN108753832A (zh) * | 2018-04-20 | 2018-11-06 | 中山大学 | 一种利用CRISPR/Cas9编辑大白猪CD163基因的方法 |
| KR102059503B1 (ko) | 2018-07-31 | 2019-12-26 | 충북대학교 산학협력단 | 돼지생식기호흡기증후군 바이러스 저항성 개체 판별을 위한 단일염기다형성 마커 조성물 |
| CN108998406B (zh) * | 2018-08-03 | 2022-05-10 | 福州大学 | 一种人类原代培养细胞基因组编辑、定点基因敲入方法 |
| WO2020198541A1 (en) * | 2019-03-27 | 2020-10-01 | Recombinetics, Inc. | Porcine reproductive and respiratory syndrome virus (prrsv) resistant swine |
| CN110438155A (zh) * | 2019-08-15 | 2019-11-12 | 中国农业科学院北京畜牧兽医研究所 | 修饰cd163基因第561位氨基酸的组合物、应用、细胞及基因编辑猪的制备方法 |
| CN110684723B (zh) * | 2019-11-21 | 2021-03-12 | 东北农业大学 | 一种猪卵母细胞体外成熟培养液及其制备方法与应用 |
| GB201919294D0 (en) * | 2019-12-24 | 2020-02-05 | Eco Animal Health Ltd | Antibodies or binding proteins |
| MX2022013704A (es) * | 2020-05-05 | 2022-12-07 | Genus Plc | Procedimientos para mejorar la salud de especies porcinas mediante la inactivacion dirigida de cd163. |
| CN113512534B (zh) * | 2020-09-23 | 2024-04-23 | 杭州启函生物科技有限公司 | 用于遗传修饰和靶向的组合物和方法 |
| WO2022081868A1 (en) * | 2020-10-15 | 2022-04-21 | Abs Global, Inc. | Porcine sexed semen and methods of use |
| CN112094866B (zh) * | 2020-11-10 | 2021-05-11 | 北京首农未来生物科技有限公司 | 一种利用SpRY-Cas9系统制备CD163基因编辑猪的方法 |
| US20250066816A1 (en) * | 2021-11-01 | 2025-02-27 | Sigma-Aldrich Co. Llc | Electroporation enhancers for crispr-cas systems |
| JP2023129028A (ja) | 2022-03-04 | 2023-09-14 | 三井化学株式会社 | 無電解めっき用プライマー組成物、積層体及びその製造方法 |
| CN114774468B (zh) * | 2022-04-20 | 2022-12-20 | 温氏食品集团股份有限公司 | 一种等位基因分子标记及抗蓝耳病猪群体组建方法 |
| US20240358007A1 (en) * | 2023-04-30 | 2024-10-31 | Vincenzo Michael Biella | High Efficiency Beef Cattle Having Modified ACTN3 Genes |
| CN116671491B (zh) * | 2023-07-04 | 2024-01-23 | 四川省畜牧科学研究院 | 一种南江黄羊的种羊选育方法 |
| CN119979720B (zh) * | 2025-02-26 | 2025-09-23 | 中国农业科学院北京畜牧兽医研究所 | 猪精液品质相关的分子标记鉴定及其应用 |
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| US20150275231A1 (en) | 2014-03-31 | 2015-10-01 | Mice With Horns, Llc | Method of Preventing or Reducing Virus Transmission in Animals |
| CN104593422A (zh) | 2015-01-08 | 2015-05-06 | 中国农业大学 | 一种抗蓝耳病克隆猪的制备方法 |
| KR20250016515A (ko) * | 2015-08-06 | 2025-02-03 | 더 큐레이터스 오브 더 유니버시티 오브 미주리 | 변형된 cd163 유전자를 갖는 병원균-내성 동물 |
| BR112018002417A2 (pt) * | 2015-08-06 | 2018-09-18 | Univ Missouri | animal não humano ou descendente do mesmo ou uma célula de animal, animal suíno, descendente ou célula, célula, descendente, método de reprodução, população de animais, método para aumentar uma resistência de animal, molécula de ácido nucleico, ácido nucleico e ácido nucleico isolado |
| US11160260B2 (en) * | 2018-04-17 | 2021-11-02 | The Curators Of The University Of Missouri | Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV) |
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2016
- 2016-07-22 BR BR112018002417A patent/BR112018002417A2/pt not_active Application Discontinuation
- 2016-07-22 DK DK16833514.9T patent/DK3331355T3/da active
- 2016-07-22 HR HRP20240908TT patent/HRP20240908T1/hr unknown
- 2016-07-22 EP EP24159749.1A patent/EP4361279A3/en active Pending
- 2016-07-22 HU HUE16833514A patent/HUE066989T2/hu unknown
- 2016-07-22 US US15/216,865 patent/US10091975B2/en active Active
- 2016-07-22 EP EP16833514.9A patent/EP3331355B1/en active Active
- 2016-07-22 RU RU2018107842A patent/RU2018107842A/ru not_active Application Discontinuation
- 2016-07-22 US US15/750,633 patent/US10827730B2/en active Active
- 2016-07-22 SM SM20240272T patent/SMT202400272T1/it unknown
- 2016-07-22 WO PCT/US2016/043467 patent/WO2017023570A1/en not_active Ceased
- 2016-07-22 RS RS20240750A patent/RS65691B1/sr unknown
- 2016-07-22 LT LTEPPCT/US2016/043467T patent/LT3331355T/lt unknown
- 2016-07-22 SI SI201631831T patent/SI3331355T1/sl unknown
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- 2016-07-22 PT PT168335149T patent/PT3331355T/pt unknown
- 2016-07-22 JP JP2018506178A patent/JP2018525000A/ja not_active Withdrawn
- 2016-07-22 FI FIEP16833514.9T patent/FI3331355T3/fi active
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- 2016-07-22 CN CN201680058107.9A patent/CN109475107A/zh active Pending
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- 2020-09-29 US US17/036,522 patent/US12219939B2/en active Active
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2021
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