CN109475107A - 具有修饰的cd163基因的抗病原体动物 - Google Patents

具有修饰的cd163基因的抗病原体动物 Download PDF

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Publication number
CN109475107A
CN109475107A CN201680058107.9A CN201680058107A CN109475107A CN 109475107 A CN109475107 A CN 109475107A CN 201680058107 A CN201680058107 A CN 201680058107A CN 109475107 A CN109475107 A CN 109475107A
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nucleotide
base pair
cell
animal
compared
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R·S·普莱特尔
K·D·韦尔斯
K·M·惠特沃思
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University of Missouri Columbia
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
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CN201680058107.9A 2015-08-06 2016-07-22 具有修饰的cd163基因的抗病原体动物 Pending CN109475107A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562202145P 2015-08-06 2015-08-06
US62/202,145 2015-08-06
PCT/US2016/043467 WO2017023570A1 (en) 2015-08-06 2016-07-22 Pathogen-resistant animals having modified cd163 genes

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US (5) US10827730B2 (enExample)
EP (2) EP4361279A3 (enExample)
JP (3) JP2018525000A (enExample)
CN (1) CN109475107A (enExample)
BR (1) BR112018002417A2 (enExample)
DK (1) DK3331355T3 (enExample)
ES (1) ES2981381T3 (enExample)
FI (1) FI3331355T3 (enExample)
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PL (1) PL3331355T3 (enExample)
PT (1) PT3331355T (enExample)
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108753832A (zh) * 2018-04-20 2018-11-06 中山大学 一种利用CRISPR/Cas9编辑大白猪CD163基因的方法
CN110438155A (zh) * 2019-08-15 2019-11-12 中国农业科学院北京畜牧兽医研究所 修饰cd163基因第561位氨基酸的组合物、应用、细胞及基因编辑猪的制备方法
CN110684723A (zh) * 2019-11-21 2020-01-14 东北农业大学 一种猪卵母细胞体外成熟培养液及其制备方法与应用
CN112094866A (zh) * 2020-11-10 2020-12-18 北京首农未来生物科技有限公司 一种利用SpRY-Cas9系统制备CD163基因编辑猪的方法
CN113151291A (zh) * 2020-05-05 2021-07-23 吉纳斯公司 通过对cd163靶向灭活来改善猪类健康的方法
CN115151569A (zh) * 2019-12-24 2022-10-04 埃科动物健康有限公司 Cd163抗体或结合蛋白
CN119979720A (zh) * 2025-02-26 2025-05-13 中国农业科学院北京畜牧兽医研究所 猪精液品质相关的分子标记鉴定及其应用

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CA3184311A1 (en) 2011-05-16 2012-11-22 The Curators Of The University Of Missouri Porcine reproductive and respiratory syndrome virus resistant animals
SI3331355T1 (sl) 2015-08-06 2024-10-30 The Curators Of The University Of Missouri Prašič, odporen na virus prašičjegaa reproduktivnega in respiratornega sindroma (PRRSV) in celice s spremenjenimi geni CD163
GB201617559D0 (en) * 2016-10-17 2016-11-30 University Court Of The University Of Edinburgh The Swine comprising modified cd163 and associated methods
WO2018175872A1 (en) * 2017-03-24 2018-09-27 President And Fellows Of Harvard College Methods of genome engineering by nuclease-transposase fusion proteins
CN107354170A (zh) * 2017-08-24 2017-11-17 中国农业科学院北京畜牧兽医研究所 一种基因敲除载体以及制备cd163基因敲除猪成纤维细胞的方法
US12060403B2 (en) 2017-10-16 2024-08-13 Kansas State University Research Foundation Methods and compositions for treating and protecting against porcine reproductive and respiratory syndrome virus
CN107937345B (zh) * 2017-11-16 2019-01-29 山东蓝思种业股份有限公司 一种制备同时敲除cd163基因和cd13基因的猪成纤维细胞的方法
BR112020021066A2 (pt) * 2018-04-17 2021-02-17 The Curators Of The University Of Missouri método para proteger um feto suíno da infecção com o vírus da síndrome respiratória e reprodutiva suína (prrsv)
US11160260B2 (en) * 2018-04-17 2021-11-02 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
KR102059503B1 (ko) 2018-07-31 2019-12-26 충북대학교 산학협력단 돼지생식기호흡기증후군 바이러스 저항성 개체 판별을 위한 단일염기다형성 마커 조성물
CN108998406B (zh) * 2018-08-03 2022-05-10 福州大学 一种人类原代培养细胞基因组编辑、定点基因敲入方法
WO2020198541A1 (en) * 2019-03-27 2020-10-01 Recombinetics, Inc. Porcine reproductive and respiratory syndrome virus (prrsv) resistant swine
CN113512534B (zh) * 2020-09-23 2024-04-23 杭州启函生物科技有限公司 用于遗传修饰和靶向的组合物和方法
WO2022081868A1 (en) * 2020-10-15 2022-04-21 Abs Global, Inc. Porcine sexed semen and methods of use
WO2023077149A1 (en) * 2021-11-01 2023-05-04 Sigma-Aldrich Co. Llc Electroporation enhancers for crispr-cas systems
JP2023129028A (ja) 2022-03-04 2023-09-14 三井化学株式会社 無電解めっき用プライマー組成物、積層体及びその製造方法
CN114774468B (zh) * 2022-04-20 2022-12-20 温氏食品集团股份有限公司 一种等位基因分子标记及抗蓝耳病猪群体组建方法
US20240358007A1 (en) * 2023-04-30 2024-10-31 Vincenzo Michael Biella High Efficiency Beef Cattle Having Modified ACTN3 Genes
CN116671491B (zh) * 2023-07-04 2024-01-23 四川省畜牧科学研究院 一种南江黄羊的种羊选育方法

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CN102715132A (zh) * 2012-05-04 2012-10-10 吉林大学 猪繁殖与呼吸综合症病毒受体cd163敲除猪及培育方法
CN103687482A (zh) * 2011-05-16 2014-03-26 密苏里大学管理者 抗猪生殖与呼吸综合征病毒的动物
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CN104593422A (zh) * 2015-01-08 2015-05-06 中国农业大学 一种抗蓝耳病克隆猪的制备方法

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