JP2018523687A5 - - Google Patents
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- JP2018523687A5 JP2018523687A5 JP2018508748A JP2018508748A JP2018523687A5 JP 2018523687 A5 JP2018523687 A5 JP 2018523687A5 JP 2018508748 A JP2018508748 A JP 2018508748A JP 2018508748 A JP2018508748 A JP 2018508748A JP 2018523687 A5 JP2018523687 A5 JP 2018523687A5
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- JP
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- Prior art keywords
- disease
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- pharmaceutical composition
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- familial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 208000022993 cryopyrin-associated periodic syndrome Diseases 0.000 claims 18
- 208000020832 chronic kidney disease Diseases 0.000 claims 16
- 208000035690 Familial cold urticaria Diseases 0.000 claims 14
- 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims 8
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 8
- 206010016654 Fibrosis Diseases 0.000 claims 8
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 8
- 206010072219 Mevalonic aciduria Diseases 0.000 claims 8
- 201000010848 Schnitzler Syndrome Diseases 0.000 claims 8
- 206010042953 Systemic sclerosis Diseases 0.000 claims 8
- 201000008937 atopic dermatitis Diseases 0.000 claims 8
- 230000001684 chronic effect Effects 0.000 claims 8
- 201000000523 end stage renal failure Diseases 0.000 claims 8
- 230000004761 fibrosis Effects 0.000 claims 8
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 8
- 206010072221 mevalonate kinase deficiency Diseases 0.000 claims 8
- 201000006417 multiple sclerosis Diseases 0.000 claims 8
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 8
- 208000011580 syndromic disease Diseases 0.000 claims 8
- 102100029647 Apoptosis-associated speck-like protein containing a CARD Human genes 0.000 claims 6
- 201000003883 Cystic fibrosis Diseases 0.000 claims 6
- 201000009040 Epidermolytic Hyperkeratosis Diseases 0.000 claims 6
- 208000019693 Lung disease Diseases 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 208000008589 Obesity Diseases 0.000 claims 6
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 claims 6
- 206010003246 arthritis Diseases 0.000 claims 6
- 208000006673 asthma Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 201000002491 encephalomyelitis Diseases 0.000 claims 6
- 208000033286 epidermolytic ichthyosis Diseases 0.000 claims 6
- 206010064570 familial cold autoinflammatory syndrome Diseases 0.000 claims 6
- 235000020824 obesity Nutrition 0.000 claims 6
- TYNLGDBUJLVSMA-UHFFFAOYSA-N 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid Chemical compound O=C1C2=CC(C(O)=O)=CC(OC(C)=O)=C2C(=O)C2=C1C=CC=C2OC(=O)C TYNLGDBUJLVSMA-UHFFFAOYSA-N 0.000 claims 5
- 229960004590 diacerein Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 208000002874 Acne Vulgaris Diseases 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 208000033116 Asbestos intoxication Diseases 0.000 claims 4
- 201000001320 Atherosclerosis Diseases 0.000 claims 4
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 208000009137 Behcet syndrome Diseases 0.000 claims 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 206010010741 Conjunctivitis Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 208000001490 Dengue Diseases 0.000 claims 4
- 206010012310 Dengue fever Diseases 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 206010012434 Dermatitis allergic Diseases 0.000 claims 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims 4
- 206010053776 Eosinophilic cellulitis Diseases 0.000 claims 4
- 208000007530 Essential hypertension Diseases 0.000 claims 4
- 201000005569 Gout Diseases 0.000 claims 4
- 208000033892 Hyperhomocysteinemia Diseases 0.000 claims 4
- 206010058490 Hyperoxia Diseases 0.000 claims 4
- 206010020751 Hypersensitivity Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 4
- 206010028594 Myocardial fibrosis Diseases 0.000 claims 4
- 101710126825 NACHT, LRR and PYD domains-containing protein 3 Proteins 0.000 claims 4
- 108091008099 NLRP3 inflammasome Proteins 0.000 claims 4
- 208000000592 Nasal Polyps Diseases 0.000 claims 4
- 201000004681 Psoriasis Diseases 0.000 claims 4
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 4
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 4
- 206010037660 Pyrexia Diseases 0.000 claims 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims 4
- 201000010001 Silicosis Diseases 0.000 claims 4
- 206010042496 Sunburn Diseases 0.000 claims 4
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 4
- 206010046851 Uveitis Diseases 0.000 claims 4
- 206010047642 Vitiligo Diseases 0.000 claims 4
- 208000008526 Wells syndrome Diseases 0.000 claims 4
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 4
- 206010000496 acne Diseases 0.000 claims 4
- 206010000891 acute myocardial infarction Diseases 0.000 claims 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims 4
- 201000009961 allergic asthma Diseases 0.000 claims 4
- 208000026935 allergic disease Diseases 0.000 claims 4
- 201000010105 allergic rhinitis Diseases 0.000 claims 4
- 206010003441 asbestosis Diseases 0.000 claims 4
- 208000010668 atopic eczema Diseases 0.000 claims 4
- 230000001363 autoimmune Effects 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims 4
- 208000010247 contact dermatitis Diseases 0.000 claims 4
- 208000025729 dengue disease Diseases 0.000 claims 4
- 230000002500 effect on skin Effects 0.000 claims 4
- 208000028208 end stage renal disease Diseases 0.000 claims 4
- 230000003176 fibrotic effect Effects 0.000 claims 4
- 206010061989 glomerulosclerosis Diseases 0.000 claims 4
- 230000003225 hyperhomocysteinemia Effects 0.000 claims 4
- 230000000222 hyperoxic effect Effects 0.000 claims 4
- 230000009610 hypersensitivity Effects 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 206010023332 keratitis Diseases 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- 201000004792 malaria Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 208000010125 myocardial infarction Diseases 0.000 claims 4
- 208000016366 nasal cavity polyp Diseases 0.000 claims 4
- 230000000737 periodic effect Effects 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 208000009954 pyoderma gangrenosum Diseases 0.000 claims 4
- 201000002793 renal fibrosis Diseases 0.000 claims 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 4
- 230000037380 skin damage Effects 0.000 claims 4
- 230000009885 systemic effect Effects 0.000 claims 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 208000022715 Autoinflammatory syndrome Diseases 0.000 claims 2
- 206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 208000003926 Myelitis Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 208000034189 Sclerosis Diseases 0.000 claims 2
- 210000001367 artery Anatomy 0.000 claims 2
- 230000003143 atherosclerotic effect Effects 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 208000002849 chondrocalcinosis Diseases 0.000 claims 2
- 206010021198 ichthyosis Diseases 0.000 claims 2
- 230000000366 juvenile effect Effects 0.000 claims 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 201000009240 nasopharyngitis Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021083646A JP2021121605A (ja) | 2015-08-17 | 2021-05-18 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
| JP2023045240A JP2023078360A (ja) | 2015-08-17 | 2023-03-22 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562206102P | 2015-08-17 | 2015-08-17 | |
| US62/206,102 | 2015-08-17 | ||
| PCT/US2016/047272 WO2017031161A1 (en) | 2015-08-17 | 2016-08-17 | Diacerein or its analogs for inhibiting expression of asc, nlrp3, and/or formation of nlrp3 inflammasome complex |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083646A Division JP2021121605A (ja) | 2015-08-17 | 2021-05-18 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523687A JP2018523687A (ja) | 2018-08-23 |
| JP2018523687A5 true JP2018523687A5 (https=) | 2019-09-19 |
| JP6887987B2 JP6887987B2 (ja) | 2021-06-16 |
Family
ID=58051269
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018508748A Active JP6887987B2 (ja) | 2015-08-17 | 2016-08-17 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
| JP2021083646A Pending JP2021121605A (ja) | 2015-08-17 | 2021-05-18 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
| JP2023045240A Pending JP2023078360A (ja) | 2015-08-17 | 2023-03-22 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083646A Pending JP2021121605A (ja) | 2015-08-17 | 2021-05-18 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
| JP2023045240A Pending JP2023078360A (ja) | 2015-08-17 | 2023-03-22 | Ａｓｃの発現、ｎｌｒｐ３の発現、及び／又はｎｌｒｐ３インフラマソーム複合体の形成を阻害するためのジアセレイン又はそのアナログ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10195170B2 (https=) |
| EP (2) | EP4147694A1 (https=) |
| JP (3) | JP6887987B2 (https=) |
| KR (1) | KR20180037261A (https=) |
| CN (1) | CN108349867B (https=) |
| AU (2) | AU2016308121A1 (https=) |
| BR (1) | BR112018003212A2 (https=) |
| CA (1) | CA2994987C (https=) |
| IL (1) | IL257379A (https=) |
| MX (1) | MX2018002049A (https=) |
| RU (1) | RU2729066C2 (https=) |
| TW (1) | TWI743047B (https=) |
| WO (1) | WO2017031161A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
| RU2019123160A (ru) | 2016-12-29 | 2021-01-29 | Юниверсити Оф Майами | Способ модуляции активности инфламмасом и воспаления в легком |
| CN110177547B (zh) | 2017-01-18 | 2022-09-27 | 台睿生物科技股份有限公司 | 用于治疗炎症性肠病和肠结肠炎的组合物 |
| EP3634951B8 (en) | 2017-06-09 | 2024-08-21 | Zydus Lifesciences Limited | Novel substituted sulfoximine compounds |
| WO2019032672A1 (en) * | 2017-08-11 | 2019-02-14 | Olatec Therapeutics Llc | METHOD OF TREATING SCHNITZLER SYNDROME |
| WO2019043610A1 (en) | 2017-08-31 | 2019-03-07 | Cadila Healthcare Limited | NEW SUBSTITUTED SULFONYLUREA DERIVATIVES |
| SG11202013176VA (en) | 2018-07-03 | 2021-01-28 | Univ Miami | Compositions and methods for treating inflammasome related diseases or conditions |
| KR102075724B1 (ko) * | 2018-09-14 | 2020-02-10 | 한국원자력의학원 | 디아세레인을 유효성분으로 포함하는 항체의 종양 침투력 증진용 조성물 및 이의 용도 |
| IL283127B1 (en) * | 2018-11-14 | 2026-02-01 | Smilebiotek Zhuhai Ltd | Animal-based models, scanning methods, and methods of treating intraocular diseases or disorders |
| CN113226309B (zh) * | 2018-12-03 | 2024-10-29 | 珠海岐微生物科技有限公司 | 一种治疗年龄相关性黄斑变性的方法 |
| CN120208846A (zh) | 2019-01-14 | 2025-06-27 | 载度思生命科学有限公司 | 经取代的磺酰脲类衍生物 |
| CN109833292A (zh) * | 2019-02-23 | 2019-06-04 | 河南省人民医院 | 一种双醋瑞因滴眼液及其用途 |
| EP3956446A1 (en) | 2019-04-17 | 2022-02-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders |
| CN110179865A (zh) * | 2019-06-26 | 2019-08-30 | 广州中医药大学(广州中医药研究院) | 一种大黄蒽醌类成分的制备方法及其应用 |
| CN110787157A (zh) * | 2019-11-27 | 2020-02-14 | 中南民族大学 | 双醋瑞因在用于舒张预收缩的气管平滑肌及治疗哮喘中的应用 |
| JP7072260B2 (ja) * | 2019-12-27 | 2022-05-20 | 国立大学法人愛媛大学 | マックル・ウェルズ症候群の治療用医薬組成物 |
| US20230070129A1 (en) * | 2020-01-06 | 2023-03-09 | Seasun Therapeutics | Composition for preventing or treating macular degeneration, containing cell permeable nucleic acid complex as active ingredient |
| CN111358950A (zh) * | 2020-03-20 | 2020-07-03 | 厦门大学 | Caspase-1及ASC/Caspase-8作为靶点的应用 |
| WO2021198511A1 (en) | 2020-04-03 | 2021-10-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of sars-cov-2 infection |
| WO2022008597A1 (en) | 2020-07-08 | 2022-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of infectious diseases |
| WO2022084300A1 (en) | 2020-10-20 | 2022-04-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosis and monitoring form of coronavirus infection |
| CN115616216B (zh) * | 2021-07-15 | 2025-08-12 | 华南理工大学 | 抑制或阻断faah与nlrp3之间相互作用的制剂的用途 |
| WO2024261302A1 (en) | 2023-06-22 | 2024-12-26 | Institut National de la Santé et de la Recherche Médicale | Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020128317A1 (en) * | 2001-01-23 | 2002-09-12 | Laboratories Negma | Treatment of pathological conditions characterized by an increased IL-1 level |
| FR2842738B1 (fr) * | 2002-07-23 | 2006-02-10 | Negma Lerads | Utilisation d'une rheine pour la preparation d'un medicament pour le traitement de l'inflammation chronique, la prevention et le traitement du rejet des transplantations d'organes et de tissus |
| GB0404953D0 (en) * | 2004-03-04 | 2004-04-07 | Arakis Ltd | Pro-drugs |
| WO2010003092A1 (en) | 2008-07-03 | 2010-01-07 | University Of Massachusetts | Methods and compositions for reducing inflammation and treating inflammatory disorders |
| TWI473610B (zh) * | 2008-10-28 | 2015-02-21 | Twi Biotechnology Inc | 包含雙醋瑞因（ｄｉａｃｅｒｅｉｎ）之醫藥組合物 |
| CN102060809B (zh) * | 2009-05-01 | 2015-05-20 | 常州高新技术产业开发区三维工业技术研究所有限公司 | 一种大黄酸衍生物及其制备和用途 |
| KR101567925B1 (ko) | 2010-04-08 | 2015-11-10 | 티더블유아이 바이오테크놀로지 인코포레이티드 | 당뇨병 보조치료요법으로서 디아세레인을 사용하는 방법 |
| EP2598536A1 (en) * | 2010-07-29 | 2013-06-05 | Université de Genève | Process for the esterification of hyaluronic acid with hydrophobic organic compounds |
| CN103429236B (zh) * | 2011-03-11 | 2016-09-21 | 安成生物科技股份有限公司 | 治疗高尿酸血症和与高尿酸血症相关的代谢性病症的方法和组合物 |
| US9707272B2 (en) | 2011-07-12 | 2017-07-18 | Universitat Zurich | Method for the treatment of acne by administering IL-1β antibody |
| US8652540B2 (en) * | 2012-06-04 | 2014-02-18 | Hong Kong Baptist University | Method of using rhein for treating fibrotic conditions and tumors |
| CN103110617A (zh) * | 2013-03-22 | 2013-05-22 | 中国人民解放军肾脏病研究所 | 一种双醋瑞因在制备治疗糖尿病肾病药物中的用途 |
| KR101486147B1 (ko) * | 2013-07-09 | 2015-01-23 | 주식회사 엘지생활건강 | Tslp 분비 저해능 및 이에 의한 알러지성 질환의 개선능을 가지는 조성물 |
| MX373702B (es) * | 2015-07-01 | 2020-05-07 | Twi Biotechnology Inc | Formulaciones topicas de diacereina o rheina y sus usos. |
-
2016
- 2016-08-17 US US15/238,950 patent/US10195170B2/en active Active
- 2016-08-17 BR BR112018003212-3A patent/BR112018003212A2/en not_active Application Discontinuation
- 2016-08-17 AU AU2016308121A patent/AU2016308121A1/en not_active Abandoned
- 2016-08-17 MX MX2018002049A patent/MX2018002049A/es unknown
- 2016-08-17 CA CA2994987A patent/CA2994987C/en active Active
- 2016-08-17 JP JP2018508748A patent/JP6887987B2/ja active Active
- 2016-08-17 EP EP22204951.2A patent/EP4147694A1/en not_active Withdrawn
- 2016-08-17 TW TW105126278A patent/TWI743047B/zh active
- 2016-08-17 EP EP16837725.7A patent/EP3337782A4/en not_active Withdrawn
- 2016-08-17 KR KR1020187006526A patent/KR20180037261A/ko not_active Ceased
- 2016-08-17 CN CN201680048207.3A patent/CN108349867B/zh active Active
- 2016-08-17 WO PCT/US2016/047272 patent/WO2017031161A1/en not_active Ceased
- 2016-08-17 RU RU2018109237A patent/RU2729066C2/ru active
-
2018
- 2018-02-06 IL IL257379A patent/IL257379A/en unknown
-
2021
- 2021-01-11 AU AU2021200117A patent/AU2021200117B2/en not_active Ceased
- 2021-05-18 JP JP2021083646A patent/JP2021121605A/ja active Pending
-
2023
- 2023-03-22 JP JP2023045240A patent/JP2023078360A/ja active Pending
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