CN108349867B - 用于抑制asc的表达、nlrp3的表达和/或nlrp3炎性复合体的形成的双醋瑞因或其类似物 - Google Patents

用于抑制asc的表达、nlrp3的表达和/或nlrp3炎性复合体的形成的双醋瑞因或其类似物 Download PDF

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CN108349867B
CN108349867B CN201680048207.3A CN201680048207A CN108349867B CN 108349867 B CN108349867 B CN 108349867B CN 201680048207 A CN201680048207 A CN 201680048207A CN 108349867 B CN108349867 B CN 108349867B
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nlrp3
expression
asc
diacerein
formation
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CN108349867A (zh
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卡尔·奥斯卡·布朗三世
陈志光
李静宜
卢威书
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TWi Biotechnology Inc
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CN201680048207.3A 2015-08-17 2016-08-17 用于抑制asc的表达、nlrp3的表达和/或nlrp3炎性复合体的形成的双醋瑞因或其类似物 Active CN108349867B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562206102P 2015-08-17 2015-08-17
US62/206,102 2015-08-17
PCT/US2016/047272 WO2017031161A1 (en) 2015-08-17 2016-08-17 Diacerein or its analogs for inhibiting expression of asc, nlrp3, and/or formation of nlrp3 inflammasome complex

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CN108349867A CN108349867A (zh) 2018-07-31
CN108349867B true CN108349867B (zh) 2021-03-09

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US (1) US10195170B2 (https=)
EP (2) EP3337782A4 (https=)
JP (3) JP6887987B2 (https=)
KR (1) KR20180037261A (https=)
CN (1) CN108349867B (https=)
AU (2) AU2016308121A1 (https=)
BR (1) BR112018003212A2 (https=)
CA (1) CA2994987C (https=)
IL (1) IL257379A (https=)
MX (1) MX2018002049A (https=)
RU (1) RU2729066C2 (https=)
TW (1) TWI743047B (https=)
WO (1) WO2017031161A1 (https=)

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CN110177547B (zh) 2017-01-18 2022-09-27 台睿生物科技股份有限公司 用于治疗炎症性肠病和肠结肠炎的组合物
WO2018225018A1 (en) 2017-06-09 2018-12-13 Cadila Healthcare Limited Novel substituted sulfoximine compounds
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WO2019043610A1 (en) 2017-08-31 2019-03-07 Cadila Healthcare Limited NEW SUBSTITUTED SULFONYLUREA DERIVATIVES
WO2020010273A1 (en) 2018-07-03 2020-01-09 University Of Miami Compositions and methods for treating inflammasome related diseases or conditions
KR102075724B1 (ko) * 2018-09-14 2020-02-10 한국원자력의학원 디아세레인을 유효성분으로 포함하는 항체의 종양 침투력 증진용 조성물 및 이의 용도
IL283127B1 (en) 2018-11-14 2026-02-01 Smilebiotek Zhuhai Ltd Animal-based models, scanning methods, and methods of treating intraocular diseases or disorders
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EA202191968A1 (ru) 2019-01-14 2021-11-16 Кадила Хелзкэр Лимитед Новые замещенные производные сульфонилмочевины
CN109833292A (zh) * 2019-02-23 2019-06-04 河南省人民医院 一种双醋瑞因滴眼液及其用途
US20220220480A1 (en) 2019-04-17 2022-07-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
CN110179865A (zh) * 2019-06-26 2019-08-30 广州中医药大学(广州中医药研究院) 一种大黄蒽醌类成分的制备方法及其应用
CN110787157A (zh) * 2019-11-27 2020-02-14 中南民族大学 双醋瑞因在用于舒张预收缩的气管平滑肌及治疗哮喘中的应用
JP7072260B2 (ja) * 2019-12-27 2022-05-20 国立大学法人愛媛大学 マックル・ウェルズ症候群の治療用医薬組成物
JP7459298B2 (ja) * 2020-01-06 2024-04-01 シーサン・セラピューティクス 細胞透過性核酸複合体を有効成分として含有する黄斑変性の予防又は治療用組成物
CN111358950A (zh) * 2020-03-20 2020-07-03 厦门大学 Caspase-1及ASC/Caspase-8作为靶点的应用
WO2021198511A1 (en) 2020-04-03 2021-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of sars-cov-2 infection
WO2022008597A1 (en) 2020-07-08 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of infectious diseases
WO2022084300A1 (en) 2020-10-20 2022-04-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosis and monitoring form of coronavirus infection
CN115616216B (zh) * 2021-07-15 2025-08-12 华南理工大学 抑制或阻断faah与nlrp3之间相互作用的制剂的用途
WO2024261302A1 (en) 2023-06-22 2024-12-26 Institut National de la Santé et de la Recherche Médicale Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders

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JP2018523687A (ja) 2018-08-23
JP2021121605A (ja) 2021-08-26
CN108349867A (zh) 2018-07-31
RU2729066C2 (ru) 2020-08-04
JP2023078360A (ja) 2023-06-06
AU2016308121A1 (en) 2018-03-01
RU2018109237A (ru) 2019-09-19
EP3337782A1 (en) 2018-06-27
CA2994987A1 (en) 2017-02-23
US10195170B2 (en) 2019-02-05
EP3337782A4 (en) 2019-04-03
IL257379A (en) 2018-04-30
RU2018109237A3 (https=) 2019-12-31
TWI743047B (zh) 2021-10-21
AU2021200117A1 (en) 2021-03-18
TW201717927A (zh) 2017-06-01
MX2018002049A (es) 2018-06-15
AU2021200117B2 (en) 2023-09-28
HK1254388A1 (zh) 2019-07-19
WO2017031161A1 (en) 2017-02-23
BR112018003212A2 (en) 2018-09-25
CA2994987C (en) 2023-09-26
JP6887987B2 (ja) 2021-06-16
KR20180037261A (ko) 2018-04-11
US20170049733A1 (en) 2017-02-23

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