RU2017119539A - Новая терапия транстиретин-ассоциированного амилоидоза - Google Patents
Новая терапия транстиретин-ассоциированного амилоидоза Download PDFInfo
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- RU2017119539A RU2017119539A RU2017119539A RU2017119539A RU2017119539A RU 2017119539 A RU2017119539 A RU 2017119539A RU 2017119539 A RU2017119539 A RU 2017119539A RU 2017119539 A RU2017119539 A RU 2017119539A RU 2017119539 A RU2017119539 A RU 2017119539A
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- RU
- Russia
- Prior art keywords
- transthyretin
- administered
- comt inhibitor
- amyloidosis
- associated amyloidosis
- Prior art date
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- 206010002022 amyloidosis Diseases 0.000 title claims 7
- 108010071690 Prealbumin Proteins 0.000 title claims 6
- 102000009190 Transthyretin Human genes 0.000 title claims 6
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000003543 catechol methyltransferase inhibitor Substances 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 4
- TXEIIPDJKFWEEC-UHFFFAOYSA-N tafamidis Chemical group O1C2=CC(C(=O)O)=CC=C2N=C1C1=CC(Cl)=CC(Cl)=C1 TXEIIPDJKFWEEC-UHFFFAOYSA-N 0.000 claims 4
- 229960001353 tafamidis Drugs 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 229960004603 tolcapone Drugs 0.000 claims 4
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical group C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 claims 4
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims 3
- 239000006186 oral dosage form Substances 0.000 claims 3
- 102000006378 Catechol O-methyltransferase Human genes 0.000 claims 2
- 108020002739 Catechol O-methyltransferase Proteins 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000008298 dragée Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims 1
- 229930014124 (-)-epigallocatechin gallate Natural products 0.000 claims 1
- 125000000355 1,3-benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- SSYOLLIRAAWGDJ-UHFFFAOYSA-N 5-(2,4-difluorophenyl)-2-hydroxy-3-iodobenzoic acid Chemical compound IC1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 SSYOLLIRAAWGDJ-UHFFFAOYSA-N 0.000 claims 1
- 206010007509 Cardiac amyloidosis Diseases 0.000 claims 1
- 208000034846 Familial Amyloid Neuropathies Diseases 0.000 claims 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims 1
- 206010019889 Hereditary neuropathic amyloidosis Diseases 0.000 claims 1
- UPMRZALMHVUCIN-UHFFFAOYSA-N Nitecapone Chemical compound CC(=O)C(C(C)=O)=CC1=CC(O)=C(O)C([N+]([O-])=O)=C1 UPMRZALMHVUCIN-UHFFFAOYSA-N 0.000 claims 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 1
- BHTRKEVKTKCXOH-UHFFFAOYSA-N Taurochenodesoxycholsaeure Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)CC2 BHTRKEVKTKCXOH-UHFFFAOYSA-N 0.000 claims 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 1
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 claims 1
- 229960000616 diflunisal Drugs 0.000 claims 1
- 229960003722 doxycycline Drugs 0.000 claims 1
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 claims 1
- 229960003337 entacapone Drugs 0.000 claims 1
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229950008980 nitecapone Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 229940016667 resveratrol Drugs 0.000 claims 1
- 235000021283 resveratrol Nutrition 0.000 claims 1
- -1 sachets Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- BHTRKEVKTKCXOH-LBSADWJPSA-N tauroursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-LBSADWJPSA-N 0.000 claims 1
- 201000007905 transthyretin amyloidosis Diseases 0.000 claims 1
- 208000027121 wild type ATTR amyloidosis Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (19)
1. Способ лечения транстиретин-ассоциированного амилоидоза, включающий введение субъекту, нуждающемуся в этом, терапевтически эффективного количества по меньшей мере одного ингибитора катехол-O-метилтрансферазы (COMT).
2. Способ по п. 1, где ингибитор COMT вводят в пероральной лекарственной форме.
3. Способ по п. 2, где пероральная лекарственная форма выбрана из группы, состоящей из таблетки, драже, порошка, капсулы, пакетика, жидкого сиропа, суспензии и эликсира.
4. Способ по п. 3, где пероральная лекарственная форма выбрана из группы, состоящей из таблетки, драже и капсулы.
5. Способ по п. 1, где вводят от приблизительно 1 мг/день до приблизительно 2000 мг/день по меньшей мере одного ингибитора COMT.
6. Способ по п. 1, где транстиретин-ассоциированный амилоидоз представляет собой семейную амилоидную полинейропатию.
7. Способ по п. 1, где транстиретин-ассоциированный амилоидоз представляет собой сенильный системный амилоидоз.
8. Способ по п. 1, где транстиретин-ассоциированный амилоидоз представляет собой лептоменингеальный амилоидоз.
9. Способ по п. 1, где транстиретин-ассоциированный амилоидоз представляет собой семейную амилоидную кардиомиопатию.
10. Способ по п. 1, дополнительно включающий введение дополнительного лечебного средства, выбранного из группы, состоящей из производного бензоксазола, йододифлунизала, дифлунизала, ресвератрола, тауроурсодезоксихолевой кислоты, доксициклина и эпигаллокатехин-3-галлата.
11. Способ по п. 10, где по меньшей мере один ингибитор COMT и дополнительное лечебное средство вводят одновременно или последовательно.
12. Способ по п. 11, где по меньшей мере один ингибитор COMT и дополнительное лечебное средство вводят в двух различных композициях.
13. Способ по п. 1, где ингибитор COMT выбран из группы, состоящей из толкапона, энтакапона, нитекапона и их фармацевтически приемлемых солей.
14. Способ по п. 13, где ингибитор COMT представляет собой толкапон.
15. Способ по п. 10, где производное бензоксазола представляет собой тафамидис.
16. Способ по п. 10, где ингибитор COMT представляет собой толкапон и дополнительное лечебное средство представляет собой производное бензоксазола.
17. Способ по п. 16, где производное бензоксазола представляет собой тафамидис.
18. Способ по п. 17, где толкапон и тафамидис вводят в двух различных композициях.
19. Способ по п. 18, где толкапон и тафамидис вводят одновременно или последовательно.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES11382326.4 | 2011-10-24 | ||
| EP11382326 | 2011-10-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014114930A Division RU2623062C2 (ru) | 2011-10-24 | 2012-10-23 | Новая терапия транстиретин-ассоциированного амилоидоза |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017119539A true RU2017119539A (ru) | 2018-11-09 |
| RU2017119539A3 RU2017119539A3 (ru) | 2020-06-29 |
| RU2747536C2 RU2747536C2 (ru) | 2021-05-06 |
Family
ID=47076222
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014114930A RU2623062C2 (ru) | 2011-10-24 | 2012-10-23 | Новая терапия транстиретин-ассоциированного амилоидоза |
| RU2017119539A RU2747536C2 (ru) | 2011-10-24 | 2012-10-23 | Новая терапия транстиретин-ассоциированного амилоидоза |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014114930A RU2623062C2 (ru) | 2011-10-24 | 2012-10-23 | Новая терапия транстиретин-ассоциированного амилоидоза |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9610270B2 (ru) |
| EP (1) | EP2770988B1 (ru) |
| JP (1) | JP6068484B2 (ru) |
| KR (1) | KR102017354B1 (ru) |
| CN (1) | CN103889407B (ru) |
| AU (2) | AU2012327275B2 (ru) |
| BR (1) | BR112014009322B1 (ru) |
| CA (1) | CA2852808C (ru) |
| CL (1) | CL2014000893A1 (ru) |
| CY (1) | CY1118151T1 (ru) |
| ES (1) | ES2593038T3 (ru) |
| HK (1) | HK1198432A1 (ru) |
| IL (1) | IL231907B (ru) |
| MX (1) | MX347784B (ru) |
| PL (1) | PL2770988T3 (ru) |
| PT (1) | PT2770988T (ru) |
| RU (2) | RU2623062C2 (ru) |
| SG (2) | SG10201609933WA (ru) |
| WO (1) | WO2013060668A1 (ru) |
| ZA (1) | ZA201402546B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102017354B1 (ko) * | 2011-10-24 | 2019-09-02 | 솜 이노베이션 바이오테크, 에스.엘. | 트랜스타이레틴―관련 아밀로이드증에 대한 신규 치료법 |
| KR102631505B1 (ko) * | 2014-08-29 | 2024-02-01 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스타이레틴(ttr) 매개 아밀로이드증의 치료 방법 |
| EP3275433A1 (en) * | 2016-07-29 | 2018-01-31 | Som Innovation Biotech S.L. | Sustained release composition comprising micronized tolcapone |
| MX2020009548A (es) * | 2018-03-12 | 2021-01-08 | Corino Therapeutics Inc | Terapia combinada para la amiloidosis ttr. |
| MX2021014682A (es) * | 2019-05-31 | 2022-04-06 | Plex Pharmaceuticals Inc | Agentes farmacológicos para tratar enfermedades de agregación de proteínas de los ojos. |
| CN114324693B (zh) * | 2022-01-14 | 2023-01-13 | 大连博源医学科技有限公司 | 一种血液中转甲状腺素蛋白(ttr)四聚体浓度测定的预处理方法和检测方法 |
| WO2024081554A2 (en) * | 2022-10-10 | 2024-04-18 | Corino Therapeutics, Inc. | Modified release tolcapone formulations |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744368A (en) | 1993-11-04 | 1998-04-28 | Research Foundation Of State University Of New York | Methods for the detection of soluble amyloid β-protein (βAP) or soluble transthyretin (TTR) |
| WO1998027972A2 (en) | 1996-12-23 | 1998-07-02 | Texas A & M University | Anti-amyloidogenic agents |
| FI20002044A0 (fi) * | 2000-09-15 | 2000-09-15 | Orion Yhtymae Oyj | Comt-entsyymiä estäviä naftaleenijohdannaisia |
| WO2003013442A2 (en) | 2001-03-15 | 2003-02-20 | Proteotech. Inc. | Catechins for the treatment of fibrillogenesis in alzheimer's disease, parkinson's disease, systemic aa amyloidosis, and other amyloid disorders |
| EP1565172A2 (en) | 2002-01-29 | 2005-08-24 | Protemix Corporation Limited | Suppression of cytotoxic protein conformers |
| US20040175382A1 (en) | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
| CN1921856A (zh) * | 2004-02-20 | 2007-02-28 | 诺瓦提斯公司 | 用于治疗神经变性疾病和认知障碍的dpp－iv抑制剂 |
| AU2005215136A1 (en) | 2004-02-20 | 2005-09-01 | Novartis Ag | DPP-IV inhibitors for treating neurodegeneration and cognitive disorders |
| US7868033B2 (en) * | 2004-05-20 | 2011-01-11 | Foldrx Pharmaceuticals, Inc. | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| US8173627B2 (en) | 2004-08-30 | 2012-05-08 | Seo Hong Yoo | Neuroprotective effect of solubilized UDCA in focal ischemic model |
| GB2429645A (en) | 2006-03-10 | 2007-03-07 | Sekhsaria Chemicals Ltd | Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent |
| US20120016037A1 (en) | 2006-07-24 | 2012-01-19 | Frank Toppo | Method for prevention and treatment of Alzheimers |
| GB0718718D0 (en) | 2007-09-25 | 2007-11-07 | Pentraxin Therapeutics Ltd | Compound and use thereof |
| DE102010010572A1 (de) | 2010-03-08 | 2011-09-08 | Mahle International Gmbh | Trockenseparator |
| KR102017354B1 (ko) * | 2011-10-24 | 2019-09-02 | 솜 이노베이션 바이오테크, 에스.엘. | 트랜스타이레틴―관련 아밀로이드증에 대한 신규 치료법 |
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2012
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