HRP20151327T1 - Farmaceutska kombinacija za lijeäśenje boli - Google Patents
Farmaceutska kombinacija za lijeäśenje boli Download PDFInfo
- Publication number
- HRP20151327T1 HRP20151327T1 HRP20151327TT HRP20151327T HRP20151327T1 HR P20151327 T1 HRP20151327 T1 HR P20151327T1 HR P20151327T T HRP20151327T T HR P20151327TT HR P20151327 T HRP20151327 T HR P20151327T HR P20151327 T1 HRP20151327 T1 HR P20151327T1
- Authority
- HR
- Croatia
- Prior art keywords
- pain
- addition salt
- dimethylamino
- phenol
- propyl
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title claims 13
- 150000003839 salts Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 206010065390 Inflammatory pain Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 claims 3
- KWTWDQCKEHXFFR-RISCZKNCSA-N 3-[(2s,3s)-1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)C[C@@H](C)[C@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-RISCZKNCSA-N 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000009935 visceral pain Diseases 0.000 claims 2
- YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 claims 1
- KWTWDQCKEHXFFR-FZMZJTMJSA-N 3-[(2r,3s)-1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)C[C@H](C)[C@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-FZMZJTMJSA-N 0.000 claims 1
- KWTWDQCKEHXFFR-BXUZGUMPSA-N 3-[(2s,3r)-1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)C[C@@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-BXUZGUMPSA-N 0.000 claims 1
- KWTWDQCKEHXFFR-UHFFFAOYSA-N 3-[1-(dimethylamino)-2-methylpentan-3-yl]phenol Chemical compound CN(C)CC(C)C(CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-UHFFFAOYSA-N 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229960003299 ketamine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (15)
1. Kombinacija naznačena time da kao komponentu(e) sadrži:
(a) barem jedan 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol s formulom (I),
[image]
proizvoljno u obliku jednog od njegovih stereoizomera, posebno u obliku enantiomera ili diastereomera, racemata ili u obliku smjese njegovih stereoizomera, naročito enantiomera i/ili diastereomera u bilo kojem omjeru miješanja, ili bilo koja njihova odgovarajuća adicijska sol, te
(b) barem jedan antagonist NMDA odabran iz skupine koju čine (R,S)-ketamin ili njihova kisela adicijska sol, kao što je hidrokloridna adicijska sol , (S)-ketamin ili njihova kisela adicijska sol, kao što je hidrokloridna adicijska sol, te memantin ili njegova kisela adicijska sol, kao što je njegova hidrokloridna adicijska sol.
2. Kombinacija prema zahtjevu 1, naznačena time da je spoj s formulom (I) odabran od
(1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenola,
(1S,2S)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenola,
(1R,2S)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenola,
(1S,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol, te bilo koje njihove smjese.
3. Kombinacija prema zahtjevu 2, naznačena time da je spoj s formulom (I) odabran od
(1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenola,
(1S,2S)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenola, te bilo koje njihove smjese.
4. Kombinacija prema zahtjevu 2 ili 3, naznačena time da je spoj s formulom (I) (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol prema formuli (I'),
[image]
ili njegova kisela adicijska sol, pri čemu je poželjna hidrokloridna kisela adicijska sol.
5. Farmaceutski pripravak naznačen time da sadrži kombinaciju prema bilo kojem od zahtjeva 1-4 i proizvoljno jedno ili više pomoćnih sredstava.
6. Oblik doziranja naznačen time da sadrži kombinaciju prema bilo kojem od zahtjeva 1-4 i proizvoljno jedno ili više pomoćnih sredstava.
7. Oblik doziranja prema zahtjevu 6, naznačen time da je prikladan za oralno, intravenozno, intraarterijalno, intraperitonealno, intradermalno, transdermalno, intramuskularno, intratekalno, intranazalno, transmukozno, potkožno, ili rektalno davanje.
8. Oblik doziranja prema zahtjevu 6 ili 7, naznačen time da jedna ili obje komponente (a) i (b) je/su prisutne u obliku s kontroliranim otpuštanjem.
9. Kombinacija prema bilo kojem od zahtjeva 1-4 naznačena time da je za uporabu za liječenje boli.
10. Kombinacija prema zahtjevu 9, naznačena time da je bol odabrana od upalne boli, neuropatske boli, akutne boli, kronične boli, visceralne boli, boli zbog migrene, te boli zbog karcinoma.
11. Kombinacija prema zahtjevu 9, naznačena time da bol je upalna bol.
12. Uporaba kombinacije prema bilo kojem od zahtjeva 9 do 11 naznačena time da je za proizvodnju lijeka za liječenje boli kod sisavca, koje se sastoji od davanja sisavcu učinkovite količine kombinacije prema bilo kojem od zahtjeva 1 do 4.
13. Uporaba prema zahtjevu 12, naznačena time da se komponenta (a) i komponenta (b) iz kombinacije primjenjuju na sisavca istovremeno ili uzastopno pri čemu se spoj (a) može davati prije ili poslije spoja (b) i pri čemu se spojevi (a) i (b) daju sisavcu bilo istim ili različitim putem primjene.
14. Uporaba prema zahtjevima 12 ili 13, naznačena time da bol je odabrana od upalne boli, neuropatske boli, akutne boli, kronične boli, visceralne boli, boli zbog migrene, te boli zbog karcinoma.
15. Uporaba prema bilo kojem od zahtjeva 12 do 14 , naznačena time da bol je upalna bol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10006202 | 2010-06-15 | ||
| PCT/EP2011/002905 WO2011157391A1 (en) | 2010-06-15 | 2011-06-14 | Pharmaceutical combination for the treatment of pain |
| EP11730199.4A EP2582366B1 (en) | 2010-06-15 | 2011-06-14 | Pharmaceutical combination for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151327T1 true HRP20151327T1 (hr) | 2016-01-01 |
Family
ID=42395008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151327TT HRP20151327T1 (hr) | 2010-06-15 | 2015-12-04 | Farmaceutska kombinacija za lijeäśenje boli |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8846765B2 (hr) |
| EP (2) | EP2992877A1 (hr) |
| JP (3) | JP6133772B2 (hr) |
| KR (1) | KR101831616B1 (hr) |
| CN (1) | CN103108631B (hr) |
| AR (1) | AR081931A1 (hr) |
| AU (2) | AU2011267474B2 (hr) |
| BR (1) | BR112012031836A2 (hr) |
| CA (1) | CA2796774C (hr) |
| CL (1) | CL2012002551A1 (hr) |
| CO (1) | CO6602157A2 (hr) |
| CY (1) | CY1117118T1 (hr) |
| DK (1) | DK2582366T3 (hr) |
| EC (2) | ECSP12012217A (hr) |
| ES (1) | ES2560676T3 (hr) |
| HK (2) | HK1184370A1 (hr) |
| HR (1) | HRP20151327T1 (hr) |
| HU (1) | HUE026619T2 (hr) |
| IL (1) | IL221926A (hr) |
| MX (1) | MX2012014482A (hr) |
| NZ (1) | NZ602625A (hr) |
| PE (2) | PE20160531A1 (hr) |
| PL (1) | PL2582366T3 (hr) |
| PT (1) | PT2582366E (hr) |
| RS (1) | RS54439B1 (hr) |
| RU (2) | RU2589692C2 (hr) |
| SI (1) | SI2582366T1 (hr) |
| WO (1) | WO2011157391A1 (hr) |
| ZA (1) | ZA201208646B (hr) |
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| KR101831616B1 (ko) | 2010-06-15 | 2018-04-04 | 그뤼넨탈 게엠베하 | 통증 치료용 약제학적 병용물 |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| WO2013138322A1 (en) * | 2012-03-12 | 2013-09-19 | Janssen Pharmaceutica Nv | Esketamine for the treatment of treatment-refractory or treatment-resistant depression |
| BR112015017535A2 (pt) | 2013-01-22 | 2020-02-04 | Vistagen Therapeutics Inc | formas de dosagem e utilizações terapêuticas de l-4-cloroquinurenina |
| WO2014152196A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| CN103655523A (zh) * | 2013-12-24 | 2014-03-26 | 南京艾德凯腾生物医药有限责任公司 | 他喷他多组合物 |
| CN106659762A (zh) * | 2014-05-06 | 2017-05-10 | 西北大学 | Nmdar调节化合物的组合 |
| US10098854B2 (en) | 2014-08-13 | 2018-10-16 | Janssen Pharmaceutica Nv | Method for the treatment of depression |
| CN107208133A (zh) | 2014-09-15 | 2017-09-26 | 詹森药业有限公司 | 用于治疗抑郁症的Val66Met (SNPrs6265)基因型特异性给药方案和方法 |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| JP6845162B2 (ja) | 2015-06-27 | 2021-03-17 | シェノックス・ファーマシューティカルズ・エルエルシー | ケタミン経皮送達システム |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| SG11202005896WA (en) | 2017-12-22 | 2020-07-29 | Janssen Pharmaceuticals Inc | Esketamine for the treatment of depression |
| CN112105349A (zh) * | 2018-04-12 | 2020-12-18 | 阿纳韦克斯生命科学公司 | A2-73结晶多晶型物质组合物及其使用方法 |
| MX2021010683A (es) | 2019-03-05 | 2021-12-10 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
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| US20100190752A1 (en) | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
| KR101831616B1 (ko) * | 2010-06-15 | 2018-04-04 | 그뤼넨탈 게엠베하 | 통증 치료용 약제학적 병용물 |
| PL2619212T3 (pl) | 2010-09-21 | 2016-09-30 | Analogi buprenorfiny działające agonistycznie i/lub antagonistycznie na receptory opioidowe | |
| PE20181177A1 (es) | 2010-12-22 | 2018-07-20 | Purdue Pharma Lp | Formas de dosis de liberacion controlada encerradas resistentes a manipulaciones indebidas |
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