HRP20201844T1 - Biodostupni poliamini - Google Patents
Biodostupni poliamini Download PDFInfo
- Publication number
- HRP20201844T1 HRP20201844T1 HRP20201844TT HRP20201844T HRP20201844T1 HR P20201844 T1 HRP20201844 T1 HR P20201844T1 HR P20201844T T HRP20201844T T HR P20201844TT HR P20201844 T HRP20201844 T HR P20201844T HR P20201844 T1 HRP20201844 T1 HR P20201844T1
- Authority
- HR
- Croatia
- Prior art keywords
- salt
- solid
- solid residue
- salt according
- dosage form
- Prior art date
Links
- 229920000768 polyamine Polymers 0.000 title claims 4
- 150000003839 salts Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical class CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000007909 solid dosage form Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008184 oral solid dosage form Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/126—Acids containing more than four carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (12)
1. Sol dvo-protoniranog oblika poliamina formule AMXT 1501 i deprotonirane kaprinske kiseline, pri čemu sol ima dva mola deprotonirane kaprinske kiseline za svaki mol protoniranog AMXT 1501
[image]
2. Sol prema zahtjevu 1, koja ima strukturu
[image]
3. Sol prema zahtjevu 1 u mješavini s najviše 5 mas.% bilo koje druge krute ili tekuće kemikalije.
4. Farmaceutski pripravak koji sadrži sol prema zahtjevu 1.
5. Farmaceutski pripravak prema zahtjevu 4 naznačen time što pripravak ima oralni oblik krutog doziranja.
6. Postupak koji obuhvaća:
kombiniranje poliaminskog farmaceutskog sredstva, hidrofobne karboksilne kiseline i otapala kako bi se dobila otopina; i
izoliranje krutog ostatka iz otopine,
pri čemu kruti ostatak sadrži sol prema zahtjevu 1.
7. Postupak prema zahtjevu 6, naznačen time što otapalo sadrži vodu, metanol ili njihovu kombinaciju.
8. Postupak prema zahtjevu 6, naznačen time što se 1.8-2.2 mola hidrofobne karboksilne kiseline kombinira sa svakih 1.0 mola poliaminskog farmaceutskog sredstva.
9. Postupak prema zahtjevu 6 naznačen time što kruti ostatak nastaje taloženjem iz otopine.
10. Postupak prema zahtjevu 6 nadalje obuhvaća formuliranje krutog ostatka ili njegovog dijela u lijek oblika krutog doziranja.
11. Sol prema zahtjevu 1 za uporabu u postupku liječenja raka, navedeni postupak sadrži davanje subjektu kojem je to potrebno terapeutski učinkovitu količinu soli.
12. Sol prema zahtjevu 11, naznačena time što se terapijski učinkovita količina soli daje subjektu kao oblik krutog doziranja.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662313657P | 2016-03-25 | 2016-03-25 | |
| EP17770923.5A EP3432914B1 (en) | 2016-03-25 | 2017-03-20 | Bioavailable polyamines |
| PCT/US2017/023250 WO2017165313A1 (en) | 2016-03-25 | 2017-03-20 | Bioavailable polyamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201844T1 true HRP20201844T1 (hr) | 2021-04-02 |
Family
ID=59899774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201844TT HRP20201844T1 (hr) | 2016-03-25 | 2020-11-20 | Biodostupni poliamini |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10632145B2 (hr) |
| EP (2) | EP3432914B1 (hr) |
| JP (1) | JP6949098B2 (hr) |
| KR (1) | KR102454783B1 (hr) |
| CN (1) | CN109069594B (hr) |
| AU (1) | AU2017236905B2 (hr) |
| CA (1) | CA3015849A1 (hr) |
| CY (1) | CY1123636T1 (hr) |
| DK (2) | DK3785706T3 (hr) |
| EA (1) | EA037149B1 (hr) |
| ES (2) | ES2955255T3 (hr) |
| HR (1) | HRP20201844T1 (hr) |
| HU (1) | HUE052620T2 (hr) |
| IL (1) | IL261512A (hr) |
| LT (1) | LT3432914T (hr) |
| MX (1) | MX2018010768A (hr) |
| PL (1) | PL3432914T3 (hr) |
| PT (1) | PT3432914T (hr) |
| SI (1) | SI3432914T1 (hr) |
| WO (1) | WO2017165313A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3785706T3 (da) | 2016-03-25 | 2023-09-11 | Aminex Therapeutics Inc | Biotilgængelige polyaminer |
| US11865095B2 (en) * | 2020-09-30 | 2024-01-09 | Aminex Therapeutics, Inc. | Combination drug substance of polyamine transport inhibitor and DFMO |
| US20230321012A1 (en) * | 2021-12-01 | 2023-10-12 | Aminex Therapeutics, Inc. | Methods To Treat Cancer With AMXT 1501 and DFMO |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3517M (fr) * | 1962-12-07 | 1965-09-06 | Hoffmann La Roche | Médicament a base de compositions vitaminées. |
| US4309442A (en) | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
| US4590288A (en) | 1983-06-29 | 1986-05-20 | Exxon Research And Engineering Co. | Bi- or polymetallic coordination complex |
| HU200093B (en) | 1983-12-20 | 1990-04-28 | Adam Kovacs | Process for production of medical compositions against tumour |
| DE3568063D1 (en) | 1985-01-10 | 1989-03-09 | Molecular Diagnostics Inc | Photochemical method of labelling nucleic acids for detection in hybridization assays |
| US4818770A (en) | 1986-10-22 | 1989-04-04 | Boyce Thompson Institute For Plant Research | Prevention of a plant disease by specific inhibition of fungal polyamine biosynthesis |
| US5342945A (en) | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
| WO1991000853A1 (en) | 1989-07-03 | 1991-01-24 | New York University | Use of polyamines as ionic-channel regulating agents |
| JP3072108B2 (ja) | 1988-12-09 | 2000-07-31 | ダイセル化学工業株式会社 | 新規なポリアミン化合物及びグルタミン酸レセプター遮断剤 |
| US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
| US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5561136A (en) | 1990-12-13 | 1996-10-01 | Merrell Pharmaceuticals Inc. | Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent |
| US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
| US5312928A (en) | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| US5187288A (en) | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
| US6743419B1 (en) | 1992-12-22 | 2004-06-01 | The Gillette Company | Method of reducing hair growth employing sulfhydryl active compounds |
| US5648394A (en) | 1993-05-27 | 1997-07-15 | Boxall; Brian Alfred | Topical composition for inhibiting hair growth |
| US5541230A (en) | 1993-11-05 | 1996-07-30 | Us Health | Therapeutic polyamines |
| RU2201224C2 (ru) | 1994-02-08 | 2003-03-27 | Эн-Пи-Эс Фармасьютикалз, Инк. | Соединения, активные в новом сайте на рецептор-регулируемых кальциевых каналах и используемые для лечения неврологических расстройств и заболеваний |
| AU690195B2 (en) | 1995-01-25 | 1998-04-23 | Sealed Air Corporation | Inflatable cushion and method of making same |
| US5583239A (en) | 1995-05-30 | 1996-12-10 | Lehigh University | Antimicrobial sterol conjugates |
| JPH09235271A (ja) | 1996-02-29 | 1997-09-09 | Suntory Ltd | ポリアミン誘導体 |
| CA2248876C (en) | 1996-03-14 | 2002-07-16 | Schering-Plough Healthcare Products, Inc. | Sunless tanning composition and method |
| US6646149B1 (en) | 1997-07-15 | 2003-11-11 | Nicolaas M. J. Vermeulin | Polyamine analogues as therapeutic and diagnostic agents |
| US7208528B1 (en) | 1997-07-15 | 2007-04-24 | Mediquest Therapeutics, Inc. | Polyamine analogues as therapeutic and diagnostic agents |
| WO1999003823A2 (en) | 1997-07-15 | 1999-01-28 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
| CA2304557C (en) | 1998-04-21 | 2008-12-30 | Universite Laval | Polyamine transport inhibitors |
| WO2000034226A1 (en) | 1998-12-10 | 2000-06-15 | Universite Laval | Polyamine transport inhibitors |
| AU778343B2 (en) | 1999-02-05 | 2004-12-02 | Mediquest Therapeutics, Inc. | Antizyme modulators and their use |
| CA2318004A1 (en) | 1999-09-15 | 2001-03-15 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
| US6235737B1 (en) | 2000-01-25 | 2001-05-22 | Peter Styczynski | Reduction of hair growth |
| JP2004500406A (ja) | 2000-03-24 | 2004-01-08 | メディクエスト セラピューティックス インク | 細胞毒性剤としてのポリアミン類似体 |
| JP4253503B2 (ja) | 2001-01-08 | 2009-04-15 | メディクエスト セラピューティックス インク | 疎水性ポリアミン類似体及びそれらの使用方法 |
| USRE43327E1 (en) | 2001-01-08 | 2012-04-24 | Aminex Therapeutics, Inc. | Hydrophobic polyamine analogs and methods for their use |
| US7432302B2 (en) | 2001-01-08 | 2008-10-07 | Mediquest Therapeutics, Inc. | Composition containing polyamine transport inhibitor and use thereof |
| US7144920B2 (en) | 2002-09-23 | 2006-12-05 | Mediquest Therapeutics, Inc. | Polyamine analogs that activate antizyme frameshifting |
| US6914079B2 (en) | 2002-09-23 | 2005-07-05 | Mediquest Therapeutics, Inc. | Polyamine analogs that activate antizyme frameshifting |
| US6919483B2 (en) | 2003-05-23 | 2005-07-19 | Mediquest Therapeutics, Inc. | Immunomodulation with novel pharmaceutical compositions |
| AU2005333545A1 (en) | 2004-11-12 | 2007-01-04 | Mediquest Therapeutics, Inc. | Hydrophobic polyamine amides as potent lipopolysaccharide sequestrants |
| US7199267B1 (en) | 2005-10-21 | 2007-04-03 | Mediquest Therapeutics, Inc. | Recognition of oligiosaccaride molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases |
| US7411002B2 (en) | 2006-06-07 | 2008-08-12 | The University Of Kansas | Polycationic sulfonamides and use thereof |
| US20110027172A1 (en) * | 2007-12-10 | 2011-02-03 | Zhuang Wang | Drug delivery system for pharmaceuticals and radiation |
| US8366600B2 (en) * | 2008-06-19 | 2013-02-05 | Nupathe Inc. | Polyamine enhanced formulations for triptan compound iontophoresis |
| DE102009000505A1 (de) * | 2009-01-30 | 2010-08-05 | Evonik Goldschmidt Gmbh | Zusammensetzungen enthaltend Reaktionsprodukte aus Alkylamidoaminen, Alkylaminoimidazolinen und freiem Amin sowie deren Verwendung |
| DK2453886T3 (en) | 2009-07-16 | 2019-03-25 | Pathologica Llc | ORGANIC ADMINISTRATION COMPREHENSIVE MGBG AND DISEASE METHODS |
| US20110256161A1 (en) * | 2010-04-19 | 2011-10-20 | Aminex Therapeutics Inc. | Methods for enhancing immune response |
| CN104540813A (zh) * | 2012-06-27 | 2015-04-22 | 默沙东公司 | 磺酰胺衍生物以及使用它们用于改善药物的药物动力学的方法 |
| US9439433B2 (en) * | 2013-05-22 | 2016-09-13 | Curza Global, Llc | Compositions and methods comprising a biocidal polyamine |
| DK3785706T3 (da) | 2016-03-25 | 2023-09-11 | Aminex Therapeutics Inc | Biotilgængelige polyaminer |
-
2017
- 2017-03-20 DK DK20196042.4T patent/DK3785706T3/da active
- 2017-03-20 MX MX2018010768A patent/MX2018010768A/es unknown
- 2017-03-20 EP EP17770923.5A patent/EP3432914B1/en active Active
- 2017-03-20 CN CN201780023734.3A patent/CN109069594B/zh active Active
- 2017-03-20 PT PT177709235T patent/PT3432914T/pt unknown
- 2017-03-20 DK DK17770923.5T patent/DK3432914T3/da active
- 2017-03-20 LT LTEP17770923.5T patent/LT3432914T/lt unknown
- 2017-03-20 WO PCT/US2017/023250 patent/WO2017165313A1/en active Application Filing
- 2017-03-20 ES ES20196042T patent/ES2955255T3/es active Active
- 2017-03-20 AU AU2017236905A patent/AU2017236905B2/en active Active
- 2017-03-20 EP EP20196042.4A patent/EP3785706B1/en active Active
- 2017-03-20 KR KR1020187030395A patent/KR102454783B1/ko active IP Right Grant
- 2017-03-20 JP JP2019500737A patent/JP6949098B2/ja active Active
- 2017-03-20 PL PL17770923T patent/PL3432914T3/pl unknown
- 2017-03-20 ES ES17770923T patent/ES2836289T3/es active Active
- 2017-03-20 US US15/753,291 patent/US10632145B2/en active Active
- 2017-03-20 EA EA201892175A patent/EA037149B1/ru unknown
- 2017-03-20 HU HUE17770923A patent/HUE052620T2/hu unknown
- 2017-03-20 SI SI201730526T patent/SI3432914T1/sl unknown
- 2017-03-20 CA CA3015849A patent/CA3015849A1/en active Pending
-
2018
- 2018-09-02 IL IL261512A patent/IL261512A/en active IP Right Grant
-
2020
- 2020-03-18 US US16/823,150 patent/US11395834B2/en active Active
- 2020-11-20 HR HRP20201844TT patent/HRP20201844T1/hr unknown
- 2020-12-16 CY CY20201101192T patent/CY1123636T1/el unknown
-
2022
- 2022-06-22 US US17/808,174 patent/US20230088829A1/en active Pending
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