EA201892175A1 - Биодоступные полиамины - Google Patents

Биодоступные полиамины

Info

Publication number
EA201892175A1
EA201892175A1 EA201892175A EA201892175A EA201892175A1 EA 201892175 A1 EA201892175 A1 EA 201892175A1 EA 201892175 A EA201892175 A EA 201892175A EA 201892175 A EA201892175 A EA 201892175A EA 201892175 A1 EA201892175 A1 EA 201892175A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical
salts
pharmaceutical agent
protonated
bioavailable
Prior art date
Application number
EA201892175A
Other languages
English (en)
Other versions
EA037149B1 (ru
Inventor
Марк Р. Бернс
Original Assignee
Аминекс Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аминекс Терапьютикс, Инк. filed Critical Аминекс Терапьютикс, Инк.
Publication of EA201892175A1 publication Critical patent/EA201892175A1/ru
Publication of EA037149B1 publication Critical patent/EA037149B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

В настоящем документе описаны фармацевтические соли катионного протонированного полиаминового фармацевтического агента и анионного органического карбоксилата, который является гидрофобным в протонированной форме, особенно подходящие для перорального введения, где эти соли обладают хорошей биодоступностью в виде твердой лекарственной формы и могут быть использованы для лечения злокачественного новообразования и других фармацевтических состояний, для которых предназначен фармацевтический агент.
EA201892175A 2016-03-25 2017-03-20 Биодоступные полиамины EA037149B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662313657P 2016-03-25 2016-03-25
PCT/US2017/023250 WO2017165313A1 (en) 2016-03-25 2017-03-20 Bioavailable polyamines

Publications (2)

Publication Number Publication Date
EA201892175A1 true EA201892175A1 (ru) 2019-02-28
EA037149B1 EA037149B1 (ru) 2021-02-11

Family

ID=59899774

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892175A EA037149B1 (ru) 2016-03-25 2017-03-20 Биодоступные полиамины

Country Status (20)

Country Link
US (3) US10632145B2 (ru)
EP (2) EP3785706B1 (ru)
JP (1) JP6949098B2 (ru)
KR (1) KR102454783B1 (ru)
CN (1) CN109069594B (ru)
AU (1) AU2017236905B2 (ru)
CA (1) CA3015849A1 (ru)
CY (1) CY1123636T1 (ru)
DK (2) DK3432914T3 (ru)
EA (1) EA037149B1 (ru)
ES (2) ES2836289T3 (ru)
HR (1) HRP20201844T1 (ru)
HU (1) HUE052620T2 (ru)
IL (1) IL261512A (ru)
LT (1) LT3432914T (ru)
MX (1) MX2018010768A (ru)
PL (1) PL3432914T3 (ru)
PT (1) PT3432914T (ru)
SI (1) SI3432914T1 (ru)
WO (1) WO2017165313A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037149B1 (ru) 2016-03-25 2021-02-11 Аминекс Терапьютикс, Инк. Биодоступные полиамины
EP4221698A1 (en) * 2020-09-30 2023-08-09 Aminex Therapeutics, Inc. Combination drug substance of polyamine transport inhibitor and dfmo
WO2023102402A1 (en) * 2021-12-01 2023-06-08 Aminex Therapeutics, Inc. Methods to treat cancer with amxt 1501 and dfmo

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EA037149B1 (ru) 2016-03-25 2021-02-11 Аминекс Терапьютикс, Инк. Биодоступные полиамины

Also Published As

Publication number Publication date
EP3432914B1 (en) 2020-09-23
MX2018010768A (es) 2018-11-29
JP2019513153A (ja) 2019-05-23
LT3432914T (lt) 2020-12-10
WO2017165313A1 (en) 2017-09-28
EP3785706A1 (en) 2021-03-03
PL3432914T3 (pl) 2021-03-08
US11395834B2 (en) 2022-07-26
AU2017236905A1 (en) 2018-09-06
KR20180123133A (ko) 2018-11-14
CA3015849A1 (en) 2017-09-28
DK3432914T3 (da) 2020-11-30
EP3432914A4 (en) 2019-11-13
CN109069594B (zh) 2022-03-08
AU2017236905B2 (en) 2024-03-28
US20190008892A1 (en) 2019-01-10
JP6949098B2 (ja) 2021-10-13
US10632145B2 (en) 2020-04-28
ES2955255T3 (es) 2023-11-29
CN109069594A (zh) 2018-12-21
SI3432914T1 (sl) 2021-01-29
PT3432914T (pt) 2020-12-24
EA037149B1 (ru) 2021-02-11
CY1123636T1 (el) 2022-03-24
US20200352983A1 (en) 2020-11-12
HUE052620T2 (hu) 2021-05-28
EP3785706B1 (en) 2023-06-07
IL261512A (en) 2018-10-31
HRP20201844T1 (hr) 2021-04-02
ES2836289T3 (es) 2021-06-24
DK3785706T3 (da) 2023-09-11
US20230088829A1 (en) 2023-03-23
KR102454783B1 (ko) 2022-10-13
EP3432914A1 (en) 2019-01-30

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