JP2018523665A - 抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体 - Google Patents
抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体 Download PDFInfo
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- JP2018523665A JP2018523665A JP2018506115A JP2018506115A JP2018523665A JP 2018523665 A JP2018523665 A JP 2018523665A JP 2018506115 A JP2018506115 A JP 2018506115A JP 2018506115 A JP2018506115 A JP 2018506115A JP 2018523665 A JP2018523665 A JP 2018523665A
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Classifications
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
Landscapes
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- Oncology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| ES2792899T3 (es) * | 2015-02-24 | 2020-11-12 | Pfizer | Derivados de nucleósidos sustituidos útiles como agentes anticancerosos |
| US10472364B2 (en) * | 2016-09-09 | 2019-11-12 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| JP7016170B2 (ja) * | 2016-12-16 | 2022-02-04 | 国立大学法人東海国立大学機構 | ヌクレオシド誘導体及びその利用 |
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| ES3011607T3 (en) | 2017-09-21 | 2025-04-07 | Chimerix Inc | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof |
| CA3080896A1 (en) | 2017-10-31 | 2019-05-09 | Yamasa Corporation | Nucleoside derivative and use thereof |
| SG11202004403QA (en) | 2017-12-07 | 2020-06-29 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
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| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| EP4106876B1 (en) | 2020-02-18 | 2025-09-17 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| JP2023517579A (ja) * | 2020-03-09 | 2023-04-26 | オルガンズ ティシューズ リジェネレーション リパレーション レムプレースメント - オーティーアール3 | 呼吸器系の病変の治療のための組成物 |
| WO2021211759A1 (en) * | 2020-04-14 | 2021-10-21 | Oyagen, Inc. | Method for treating poxviridae infections |
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| EP4323362B1 (en) | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| JP7719954B2 (ja) | 2021-08-18 | 2025-08-06 | ギリアード サイエンシーズ, インコーポレイテッド | リン脂質化合物並びにその製造方法及び使用方法 |
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| US3037980A (en) * | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
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| US4892865A (en) | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
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| CA2108041A1 (en) | 1991-03-29 | 1992-09-30 | Nicholas S. Bodor | Targeted drug delivery via mixed phosphate derivatives |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023538442A (ja) * | 2020-08-24 | 2023-09-07 | ギリアード サイエンシーズ, インコーポレイテッド | リン脂質化合物及びその使用 |
| JP7559223B2 (ja) | 2020-08-24 | 2024-10-01 | ギリアード サイエンシーズ, インコーポレイテッド | リン脂質化合物及びその使用 |
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| PH12018500263A1 (en) | 2018-08-13 |
| CN108026136A (zh) | 2018-05-11 |
| EP3331895B1 (en) | 2020-07-29 |
| WO2017024310A1 (en) | 2017-02-09 |
| US20250084119A1 (en) | 2025-03-13 |
| MX2018001073A (es) | 2018-06-12 |
| CA2992278A1 (en) | 2017-02-09 |
| US10407457B2 (en) | 2019-09-10 |
| US9708359B2 (en) | 2017-07-18 |
| US20200199167A1 (en) | 2020-06-25 |
| US9701706B2 (en) | 2017-07-11 |
| EP3331895A1 (en) | 2018-06-13 |
| EA201890454A1 (ru) | 2018-07-31 |
| US20170137454A1 (en) | 2017-05-18 |
| AU2016301188A1 (en) | 2018-02-15 |
| KR102630013B1 (ko) | 2024-01-25 |
| US11981700B2 (en) | 2024-05-14 |
| KR20180039666A (ko) | 2018-04-18 |
| US20220002335A1 (en) | 2022-01-06 |
| US10941175B2 (en) | 2021-03-09 |
| BR112018002399A2 (pt) | 2018-09-25 |
| US20170044202A1 (en) | 2017-02-16 |
| US20170253628A1 (en) | 2017-09-07 |
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