|
US20030027216A1
(en)
|
2001-07-02 |
2003-02-06 |
Kiernan Urban A. |
Analysis of proteins from biological fluids using mass spectrometric immunoassay
|
|
US20030229037A1
(en)
|
2000-02-07 |
2003-12-11 |
Ulrich Massing |
Novel cationic amphiphiles
|
|
US20070026394A1
(en)
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
|
US20030072794A1
(en)
|
2000-06-09 |
2003-04-17 |
Teni Boulikas |
Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
|
|
EP1873259B1
(en)
|
2000-12-01 |
2012-01-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
RNA interference mediated by 21 and 22nt RNAs
|
|
WO2002059621A2
(en)
|
2001-01-24 |
2002-08-01 |
Bayer Corporation |
Regulation of transthyretin to treat obesity
|
|
US20030170891A1
(en)
|
2001-06-06 |
2003-09-11 |
Mcswiggen James A. |
RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
AU2002318396A1
(en)
|
2001-06-21 |
2003-01-08 |
The Cleveland Clinic Foundation |
Homocysteinylated transthyretin
|
|
US20030191056A1
(en)
|
2002-04-04 |
2003-10-09 |
Kenneth Walker |
Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
|
|
EP3222724B1
(en)
|
2002-08-05 |
2018-10-31 |
Silence Therapeutics GmbH |
Further novel forms of interfering rna molecules
|
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
CA2502413A1
(en)
|
2002-11-01 |
2004-05-21 |
The Regents Of The University Of Colorado, A Body Corporate |
Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
|
|
US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
EP2314691A3
(en)
|
2002-11-14 |
2012-01-18 |
Dharmacon, Inc. |
Fuctional and hyperfunctional siRNA
|
|
WO2004090108A2
(en)
|
2003-04-03 |
2004-10-21 |
Alnylam Pharmaceuticals |
Irna conjugates
|
|
ATE479752T1
(de)
|
2003-03-07 |
2010-09-15 |
Alnylam Pharmaceuticals Inc |
Therapeutische zusammensetzungen
|
|
JP4951338B2
(ja)
|
2003-07-16 |
2012-06-13 |
プロチバ バイオセラピューティクス インコーポレイティッド |
脂質に封入された干渉ｒｎａ
|
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
EP1766071A4
(en)
|
2004-06-03 |
2009-11-11 |
Isis Pharmaceuticals Inc |
DOUBLE-STRONG COMPOSITIONS WITH DIFFERENTLY MODIFIED STRANDS FOR USE IN GENE MODULATION
|
|
US7745651B2
(en)
|
2004-06-07 |
2010-06-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use
|
|
AU2005252273B2
(en)
|
2004-06-07 |
2011-04-28 |
Arbutus Biopharma Corporation |
Lipid encapsulated interfering RNA
|
|
US7838561B2
(en)
|
2004-06-14 |
2010-11-23 |
Wisconsin Alumni Research Foundation |
Method for preventing or treating cardiac hypertrophy
|
|
WO2006063128A2
(en)
|
2004-12-08 |
2006-06-15 |
Sirion Therapeutics, Inc. |
Methods, assays and compositions for treating retinol-related diseases
|
|
WO2007086881A2
(en)
|
2005-02-14 |
2007-08-02 |
Sirna Therapeutics, Inc. |
Cationic lipids and formulated molecular compositions containing them
|
|
ATE541928T1
(de)
|
2005-03-31 |
2012-02-15 |
Calando Pharmaceuticals Inc |
Inhibitoren der untereinheit 2 der ribonukleotidreduktase und ihre verwendungen
|
|
US7915230B2
(en)
|
2005-05-17 |
2011-03-29 |
Molecular Transfer, Inc. |
Reagents for transfection of eukaryotic cells
|
|
EP1937213B1
(en)
|
2005-07-27 |
2017-10-25 |
Protiva Biotherapeutics Inc. |
Systems and methods for manufacturing liposomes
|
|
EP1948674A4
(en)
|
2005-11-02 |
2009-02-04 |
Protiva Biotherapeutics Inc |
MODIFIED SIRNA MOLECULES AND APPLICATIONS THEREOF
|
|
KR20150038522A
(ko)
|
2006-03-31 |
2015-04-08 |
알닐람 파마슈티칼스 인코포레이티드 |
Ｅｇ5 유전자의 발현을 억제하는 이본쇄 리보핵산
|
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
|
CN105030654A
(zh)
|
2006-10-03 |
2015-11-11 |
阿尔尼拉姆医药品有限公司 |
含脂质的制品
|
|
GB0704764D0
(en)
|
2007-03-12 |
2007-04-18 |
Electrophoretics Ltd |
Isobarically labelled reagents and methods of their use
|
|
WO2009002944A1
(en)
|
2007-06-22 |
2008-12-31 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
|
AU2008342535B2
(en)
|
2007-12-27 |
2015-02-05 |
Arbutus Biopharma Corporation |
Silencing of polo-like kinase expression using interfering RNA
|
|
EP3100718B1
(en)
|
2008-01-02 |
2019-11-27 |
Arbutus Biopharma Corporation |
Improved compositions and methods for the delivery of nucleic acids
|
|
EP2245039A4
(en)
|
2008-01-31 |
2012-06-06 |
Alnylam Pharmaceuticals Inc |
OPTIMIZED METHODS FOR EXPORING DSRNA TO TARGET THE PCSK9 GEN
|
|
US20100323381A1
(en)
|
2008-02-08 |
2010-12-23 |
Bergen Iii Harold R |
Classifying amyloidosis
|
|
JP5475753B2
(ja)
|
2008-04-15 |
2014-04-16 |
プロチバ バイオセラピューティクス インコーポレイティッド |
核酸送達用の脂質製剤
|
|
TWI455944B
(zh)
|
2008-07-01 |
2014-10-11 |
Daiichi Sankyo Co Ltd |
雙股多核苷酸
|
|
EP2323667A4
(en)
|
2008-08-07 |
2012-07-25 |
Isis Pharmaceuticals Inc |
MODULATION OF TRANSTHYRETIN EXPRESSION BY TREATMENT OF CNS DISEASES
|
|
EP3225621A1
(en)
|
2008-10-09 |
2017-10-04 |
Arbutus Biopharma Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
JP5791505B2
(ja)
|
2008-10-20 |
2015-10-07 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
トランスチレチンの発現を阻害するための組成物および方法
|
|
CN104910025B
(zh)
|
2008-11-07 |
2019-07-16 |
麻省理工学院 |
氨基醇类脂质和其用途
|
|
MX338780B
(es)
|
2008-11-10 |
2016-05-02 |
Alnylam Pharmaceuticals Inc |
Lipidos y composiciones novedosas para el suministro de terapeuticos.
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
EP3243504A1
(en)
|
2009-01-29 |
2017-11-15 |
Arbutus Biopharma Corporation |
Improved lipid formulation
|
|
EP3097908A1
(en)
|
2009-05-05 |
2016-11-30 |
Arbutus Biopharma Corporation |
Lipid compositions
|
|
PL2440183T3
(pl)
|
2009-06-10 |
2019-01-31 |
Arbutus Biopharma Corporation |
Ulepszona formulacja lipidowa
|
|
NZ597504A
(en)
|
2009-06-15 |
2013-10-25 |
Alnylam Pharmaceuticals Inc |
Lipid formulated dsrna targeting the pcsk9 gene
|
|
US9051567B2
(en)
|
2009-06-15 |
2015-06-09 |
Tekmira Pharmaceuticals Corporation |
Methods for increasing efficacy of lipid formulated siRNA
|
|
US9101643B2
(en)
|
2009-11-03 |
2015-08-11 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of transthyretin (TTR)
|
|
EP2552456B1
(en)
|
2010-03-29 |
2017-08-23 |
Alnylam Pharmaceuticals, Inc. |
Sirna therapy for transthyretin (ttr) related ocular amyloidosis
|
|
US20230340473A1
(en)
|
2010-03-29 |
2023-10-26 |
Alnylam Pharmaceuticals, Inc. |
Sirna therapy for transthyretin (ttr) related ocular amyloidosis
|
|
WO2011139917A1
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modulation of transthyretin expression
|
|
US9290760B2
(en)
|
2010-09-15 |
2016-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
|
US9339513B2
(en)
|
2010-11-09 |
2016-05-17 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
|
|
EP2723865B1
(en)
|
2011-06-21 |
2019-03-27 |
Alnylam Pharmaceuticals, Inc. |
METHODS FOR DETERMINING ACTIVITY OF RNAi IN A SUBJECT
|
|
IL303831A
(en)
*
|
2011-11-18 |
2023-08-01 |
Alnylam Pharmaceuticals Inc |
Adapted RNAI factors
|
|
IL284530B
(en)
*
|
2011-11-18 |
2022-07-01 |
Alnylam Pharmaceuticals Inc |
rnai factors, preparations and methods of using them for the treatment of transthyretin-related diseases
|
|
WO2013166041A1
(en)
|
2012-05-01 |
2013-11-07 |
The Trustees Of Columbia University In The City Of New York |
Transthyretin ligands capable of inhibiting retinol-dependent rbp4-ttr interaction for treatment of age-related macular
|
|
AU2013296321B2
(en)
|
2012-08-03 |
2019-05-16 |
Alnylam Pharmaceuticals, Inc. |
Modified RNAi agents
|
|
WO2015042564A1
(en)
*
|
2013-09-23 |
2015-03-26 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing transthyretin (ttr) associated diseases
|
|
WO2015085158A1
(en)
|
2013-12-06 |
2015-06-11 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of transthyretin (ttr) by double-stranded rna
|
|
KR102736538B1
(ko)
*
|
2013-12-12 |
2024-12-03 |
알닐람 파마슈티칼스 인코포레이티드 |
보체 성분 ｉＲＮＡ 조성물 및 이의 이용 방법
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
CN107106874B
(zh)
|
2014-08-29 |
2021-08-31 |
阿尔尼拉姆医药品有限公司 |
治疗甲状腺素运载蛋白(ttr)介导的淀粉样变性的方法
|
|
WO2016080853A1
(en)
|
2014-11-21 |
2016-05-26 |
Bsim2 – Biomolecular Simulations Lda |
2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof
|
|
JP6896703B2
(ja)
|
2015-07-31 |
2021-06-30 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法
|
|
SG10201913552UA
(en)
|
2016-12-16 |
2020-03-30 |
Alnylam Pharmaceuticals Inc |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
|
EP3684931A1
(en)
|
2017-09-19 |
2020-07-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating transthyretin (ttr) mediated amyloidosis
|
|
AU2019350765A1
(en)
|
2018-09-28 |
2021-05-27 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated ocular diseases
|
|
EP4022062A1
(en)
|
2019-08-30 |
2022-07-06 |
Alnylam Pharmaceuticals, Inc. |
Neurofilament light chain (nfl) as a biomarker for transthyretin amyloidosis polyneuropathy
|
|
EP4055165A1
(en)
|
2019-11-06 |
2022-09-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
|
JP2023516748A
(ja)
|
2020-03-06 |
2023-04-20 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
トランスサイレチン（ｔｔｒ）の発現を阻害するための組成物および方法
|
|
JP2024518374A
(ja)
|
2021-05-03 |
2024-05-01 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
トランスサイレチン（ｔｔｒ）媒介性アミロイドーシスを治療するための組成物および方法
|
|
EP4351541A2
(en)
|
2021-06-08 |
2024-04-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders
|
|
KR20240042004A
(ko)
|
2021-08-03 |
2024-04-01 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴(TTR) iRNA 조성물 및 이의 사용 방법
|