JP2018519831A5 - - Google Patents
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- JP2018519831A5 JP2018519831A5 JP2017568143A JP2017568143A JP2018519831A5 JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5 JP 2017568143 A JP2017568143 A JP 2017568143A JP 2017568143 A JP2017568143 A JP 2017568143A JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077341A JP7459168B2 (ja) | 2015-07-02 | 2022-05-10 | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
Applications Claiming Priority (5)
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| AU2016206475B2 (en) * | 2015-01-16 | 2021-11-04 | City Of Hope | Cell penetrating antibodies |
| US10912790B2 (en) | 2015-04-22 | 2021-02-09 | Mina Therapeutics Limited | C/EBP alpha saRNA compositions and methods of use |
| JP7073109B2 (ja) | 2015-07-02 | 2022-05-23 | シティ・オブ・ホープ | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
| EP3576752A4 (en) | 2017-02-06 | 2020-12-16 | Mpeg La, LLC | MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| WO2019006371A1 (en) * | 2017-06-30 | 2019-01-03 | City Of Hope | COMPOSITIONS AND METHODS FOR MODULATING MACROPHAGE ACTIVITY |
| CA3075205A1 (en) | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | Stabilized hnf4a sarna compositions and methods of use |
| EP3778893A4 (en) * | 2018-04-10 | 2022-04-20 | Ractigen Therapeutics | P21 GENE EXPRESSION ACTIVATION METHOD |
| WO2019241766A1 (en) * | 2018-06-15 | 2019-12-19 | City Of Hope | Oligonucleotide-based proteolysis targeting chimera |
| CN109762042B (zh) * | 2018-09-21 | 2022-04-08 | 河北艾克美冀生物科技有限公司 | 一种治疗癌症的药物、其合成方法和应用 |
| CA3132505A1 (en) * | 2019-03-04 | 2020-09-10 | Mpeg La, L.L.C. | Multimeric oligonucleotides with enhanced bioactivity |
| US20220267770A1 (en) * | 2019-07-26 | 2022-08-25 | Mina Therapeutics Limited | Compositions and methods of using c/ebp alpha sarna |
| KR102433981B1 (ko) * | 2020-12-15 | 2022-08-19 | 대구가톨릭대학교산학협력단 | HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물 |
| US20240318174A1 (en) * | 2021-02-08 | 2024-09-26 | Ractigen Therapeutics | Multi-Valent Oligonucleotide Agent and Methods of Use Thereof |
| US20250376689A1 (en) * | 2021-08-31 | 2025-12-11 | City Of Hope | Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof |
| CN114908094B (zh) * | 2022-05-31 | 2024-03-12 | 中山大学 | 一类反义寡核苷酸分子及其在制备治疗恶性肿瘤药物中的应用 |
| JP2025535719A (ja) * | 2022-10-07 | 2025-10-28 | シティ・オブ・ホープ | 二本鎖オリゴヌクレオチド及び使用方法 |
| WO2024118592A2 (en) * | 2022-11-29 | 2024-06-06 | Lonza Sales Ag | Methods of using extracellular vesicle-aso targeting stat6 |
| CN118480552B (zh) * | 2024-01-18 | 2024-10-01 | 成都先衍生物技术有限公司 | 一种靶向CEBPA基因表达的saRNA及其用途 |
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| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6867289B1 (en) * | 1998-10-26 | 2005-03-15 | Board Of Regents, The University Of Texas Systems | Thio-modified aptamer synthetic methods and compositions |
| US6159694A (en) * | 1999-04-08 | 2000-12-12 | Isis Pharmaceuticals Inc. | Antisense modulation of stat3 expression |
| ITRM20030149A1 (it) * | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
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| WO2005116268A2 (en) * | 2004-05-27 | 2005-12-08 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health | Differential expression of molecules associated with acute stroke |
| CA2604532C (en) * | 2005-04-15 | 2017-03-07 | The Regents Of The University Of California | Small activating rna molecules and methods of use |
| US8748405B2 (en) * | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
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| CN102361985B (zh) | 2008-12-04 | 2017-06-20 | 库尔纳公司 | 通过抑制肿瘤抑制基因的天然反义转录物治疗肿瘤抑制基因相关性疾病 |
| WO2012128785A1 (en) | 2011-03-22 | 2012-09-27 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| JP5943993B2 (ja) * | 2011-04-01 | 2016-07-05 | アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 転写のシグナル伝達及び活性化因子３（ｓｔａｔ３）発現の調節 |
| WO2014047649A1 (en) * | 2012-09-24 | 2014-03-27 | The Regents Of The University Of California | Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy |
| JP6542669B2 (ja) * | 2012-10-31 | 2019-07-10 | アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 癌の治療 |
| CA2902914A1 (en) | 2013-03-14 | 2014-09-25 | City Of Hope | 5-bromo-indirubins |
| WO2015077657A2 (en) | 2013-11-22 | 2015-05-28 | City Of Hope | Stat3 inhibitors and uses thereof |
| CA3236835A1 (en) * | 2013-11-22 | 2015-05-28 | Mina Therapeutics Limited | C/ebp alpha short activating rna compositions and methods of use |
| JP7073109B2 (ja) | 2015-07-02 | 2022-05-23 | シティ・オブ・ホープ | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
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- 2016-06-30 WO PCT/US2016/040361 patent/WO2017004357A1/en not_active Ceased
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- 2016-06-30 CN CN201680047408.1A patent/CN107980001B/zh active Active
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