JP2018519831A5 - - Google Patents
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- JP2018519831A5 JP2018519831A5 JP2017568143A JP2017568143A JP2018519831A5 JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5 JP 2017568143 A JP2017568143 A JP 2017568143A JP 2017568143 A JP2017568143 A JP 2017568143A JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077341A JP7459168B2 (ja) | 2015-07-02 | 2022-05-10 | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
Applications Claiming Priority (5)
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| UY36519A (es) | 2015-01-16 | 2016-08-31 | Hope City | Anticuerpos de penetración celular |
| KR102599712B1 (ko) | 2015-04-22 | 2023-11-09 | 미나 테라퓨틱스 리미티드 | C/EBP 알파 saRNA 조성물 및 사용 방법 |
| US10758624B2 (en) | 2015-07-02 | 2020-09-01 | City Of Hope | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof |
| SG11201906728TA (en) | 2017-02-06 | 2019-08-27 | Mpeg La Llc | Multimeric oligonucleotides having decreased kidney clearance |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| US11554178B2 (en) | 2017-06-30 | 2023-01-17 | City Of Hope | Compositions and methods of modulating macrophage activity |
| WO2019048632A1 (en) * | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | STABILIZED COMPOSITIONS OF SMALL ACTIVATORY RNA (PARNA) OF HNF4A AND METHODS OF USE |
| WO2019196883A1 (zh) * | 2018-04-10 | 2019-10-17 | 中美瑞康核酸技术(南通)研究院有限公司 | 一种激活p21基因表达的方法 |
| US12404509B2 (en) | 2018-06-15 | 2025-09-02 | City Of Hope | Oligonucleotide-based proteolysis targeting chimera |
| CN109762042B (zh) * | 2018-09-21 | 2022-04-08 | 河北艾克美冀生物科技有限公司 | 一种治疗癌症的药物、其合成方法和应用 |
| EP3935168A4 (en) * | 2019-03-04 | 2024-04-10 | Mpeg La, LLC | MULTIMERIC OLIGONUCLEOTIDES WITH IMPROVED BIOACTIVITY |
| JP2022542167A (ja) * | 2019-07-26 | 2022-09-29 | ミナ セラピューティクス リミテッド | Ｃ／ＥＢＰアルファｓａＲＮＡを使用する組成物および方法 |
| KR102433981B1 (ko) * | 2020-12-15 | 2022-08-19 | 대구가톨릭대학교산학협력단 | HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물 |
| JP2024506042A (ja) * | 2021-02-08 | 2024-02-08 | ラクティゲン セラピューティクス | 多価オリゴヌクレオチド薬剤およびその使用方法 |
| WO2023034853A2 (en) * | 2021-08-31 | 2023-03-09 | City Of Hope | Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof |
| CN114908094B (zh) * | 2022-05-31 | 2024-03-12 | 中山大学 | 一类反义寡核苷酸分子及其在制备治疗恶性肿瘤药物中的应用 |
| EP4599065A2 (en) * | 2022-10-07 | 2025-08-13 | City of Hope | Double-stranded oligonucleotides and methods of use |
| EP4627086A2 (en) * | 2022-11-29 | 2025-10-08 | Lonza Sales AG | Methods of using extracellular vesicle-aso targeting stat6 |
| CN118480552B (zh) * | 2024-01-18 | 2024-10-01 | 成都先衍生物技术有限公司 | 一种靶向CEBPA基因表达的saRNA及其用途 |
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| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
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| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6423493B1 (en) * | 1998-10-26 | 2002-07-23 | Board Of Regents The University Of Texas System | Combinatorial selection of oligonucleotide aptamers |
| US6159694A (en) | 1999-04-08 | 2000-12-12 | Isis Pharmaceuticals Inc. | Antisense modulation of stat3 expression |
| ITRM20030149A1 (it) * | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
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| AU2005248410B2 (en) * | 2004-05-27 | 2010-04-22 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Differential expression of molecules associated with acute stroke |
| EP1871426B1 (en) * | 2005-04-15 | 2017-06-07 | The Regents of The University of California | Small activating rna molecules and their use |
| US8748405B2 (en) * | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| US20080214436A1 (en) * | 2007-01-26 | 2008-09-04 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2009018332A1 (en) * | 2007-08-01 | 2009-02-05 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand |
| US20110294870A1 (en) | 2008-12-04 | 2011-12-01 | Opko Curna, Llc | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
| WO2012128785A1 (en) | 2011-03-22 | 2012-09-27 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| CN103562215B (zh) | 2011-04-01 | 2017-04-26 | 埃西斯药品公司 | 信号转导及转录激活蛋白3(stat3)表达的调节 |
| WO2014047649A1 (en) * | 2012-09-24 | 2014-03-27 | The Regents Of The University Of California | Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy |
| HRP20190303T1 (hr) * | 2012-10-31 | 2019-05-17 | Ionis Pharmaceuticals, Inc. | Liječenje raka |
| CA2902914A1 (en) * | 2013-03-14 | 2014-09-25 | City Of Hope | 5-bromo-indirubins |
| SI3071696T1 (sl) * | 2013-11-22 | 2019-11-29 | Mina Therapeutics Ltd | C/EBP alfa kratko delujoči RNA sestavki in postopki uporabe |
| WO2015077657A2 (en) * | 2013-11-22 | 2015-05-28 | City Of Hope | Stat3 inhibitors and uses thereof |
| US10758624B2 (en) | 2015-07-02 | 2020-09-01 | City Of Hope | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof |
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2016
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- 2016-06-30 CN CN201680047408.1A patent/CN107980001B/zh active Active
- 2016-06-30 CN CN202111383325.9A patent/CN114224907A/zh active Pending
- 2016-06-30 JP JP2017568143A patent/JP7073109B2/ja active Active
- 2016-06-30 EP EP16818778.9A patent/EP3316894A4/en active Pending
- 2016-06-30 WO PCT/US2016/040361 patent/WO2017004357A1/en not_active Ceased
- 2016-06-30 CA CA2991052A patent/CA2991052A1/en active Pending
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2020
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