JP2018519831A5 - - Google Patents
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- JP2018519831A5 JP2018519831A5 JP2017568143A JP2017568143A JP2018519831A5 JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5 JP 2017568143 A JP2017568143 A JP 2017568143A JP 2017568143 A JP2017568143 A JP 2017568143A JP 2018519831 A5 JP2018519831 A5 JP 2018519831A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077341A JP7459168B2 (ja) | 2015-07-02 | 2022-05-10 | ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにそれらの使用法 |
Applications Claiming Priority (5)
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| AR103428A1 (es) * | 2015-01-16 | 2017-05-10 | Hope City | Anticuerpos de penetración celular |
| CN114525279A (zh) * | 2015-04-22 | 2022-05-24 | 米纳治疗有限公司 | C/EBP α SARNA组合物和使用方法 |
| CA2991052A1 (en) * | 2015-07-02 | 2017-01-05 | City Of Hope | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof |
| EP3576752A4 (en) | 2017-02-06 | 2020-12-16 | Mpeg La, LLC | MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| WO2019006371A1 (en) * | 2017-06-30 | 2019-01-03 | City Of Hope | COMPOSITIONS AND METHODS FOR MODULATING MACROPHAGE ACTIVITY |
| CA3075205A1 (en) * | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | Stabilized hnf4a sarna compositions and methods of use |
| CN110678549B (zh) * | 2018-04-10 | 2021-06-22 | 中美瑞康核酸技术(南通)研究院有限公司 | 一种激活p21基因表达的方法 |
| WO2019241766A1 (en) * | 2018-06-15 | 2019-12-19 | City Of Hope | Oligonucleotide-based proteolysis targeting chimera |
| CN109762042B (zh) * | 2018-09-21 | 2022-04-08 | 河北艾克美冀生物科技有限公司 | 一种治疗癌症的药物、其合成方法和应用 |
| EP3935168A4 (en) * | 2019-03-04 | 2024-04-10 | Mpeg La, LLC | MULTIMERIC OLIGONUCLEOTIDES WITH IMPROVED BIOACTIVITY |
| EP4003423A4 (en) * | 2019-07-26 | 2024-03-06 | MiNA Therapeutics Limited | Compositions and methods of using c/ebp alpha sarna |
| KR102433981B1 (ko) * | 2020-12-15 | 2022-08-19 | 대구가톨릭대학교산학협력단 | HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물 |
| KR20230154026A (ko) * | 2021-02-08 | 2023-11-07 | 락티젠 세러퓨틱스 | 다가 올리고뉴클레오티드 작용제 및 이의 사용 방법 |
| US20250376689A1 (en) * | 2021-08-31 | 2025-12-11 | City Of Hope | Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof |
| CN114908094B (zh) * | 2022-05-31 | 2024-03-12 | 中山大学 | 一类反义寡核苷酸分子及其在制备治疗恶性肿瘤药物中的应用 |
| WO2024077228A2 (en) * | 2022-10-07 | 2024-04-11 | City Of Hope | Double-stranded oligonucleotides and methods of use |
| CN120390802A (zh) * | 2022-11-29 | 2025-07-29 | 隆萨销售股份有限公司 | 使用靶向stat6的细胞外囊泡-aso的方法 |
| CN118480552B (zh) * | 2024-01-18 | 2024-10-01 | 成都先衍生物技术有限公司 | 一种靶向CEBPA基因表达的saRNA及其用途 |
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| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| DK0495421T3 (da) | 1991-01-15 | 1996-12-09 | Alcon Lab Inc | Anvendelse af carragenaner i topiske ophthalmiske sammensætninger |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6867289B1 (en) * | 1998-10-26 | 2005-03-15 | Board Of Regents, The University Of Texas Systems | Thio-modified aptamer synthetic methods and compositions |
| US6159694A (en) * | 1999-04-08 | 2000-12-12 | Isis Pharmaceuticals Inc. | Antisense modulation of stat3 expression |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
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| CA2572795A1 (en) * | 2004-05-27 | 2005-12-08 | The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services | Differential expression of molecules associated with acute stroke |
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| US8748405B2 (en) * | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2008094254A2 (en) | 2007-01-26 | 2008-08-07 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| US20110250138A1 (en) * | 2007-08-01 | 2011-10-13 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand |
| KR101866152B1 (ko) | 2008-12-04 | 2018-06-08 | 큐알엔에이, 인크. | 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료 |
| WO2012128785A1 (en) | 2011-03-22 | 2012-09-27 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| RS58489B1 (sr) * | 2011-04-01 | 2019-04-30 | Ionis Pharmaceuticals Inc | Modulacija eksprimiranja transduktora signala i aktivatora transkripcije 3 (stat3) |
| WO2014047649A1 (en) * | 2012-09-24 | 2014-03-27 | The Regents Of The University Of California | Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy |
| WO2014070868A1 (en) * | 2012-10-31 | 2014-05-08 | Isis Pharmaceuticals Inc | Cancer treatment |
| BR112015023383A2 (pt) | 2013-03-14 | 2017-07-18 | Hope City | compostocomposição farmacêutica; e método de modulação |
| WO2015077657A2 (en) * | 2013-11-22 | 2015-05-28 | City Of Hope | Stat3 inhibitors and uses thereof |
| CA3236835A1 (en) * | 2013-11-22 | 2015-05-28 | Mina Therapeutics Limited | C/ebp alpha short activating rna compositions and methods of use |
| CA2991052A1 (en) * | 2015-07-02 | 2017-01-05 | City Of Hope | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof |
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2016
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- 2016-06-30 CN CN202111383325.9A patent/CN114224907A/zh active Pending
- 2016-06-30 WO PCT/US2016/040361 patent/WO2017004357A1/en not_active Ceased
- 2016-06-30 CN CN201680047408.1A patent/CN107980001B/zh active Active
- 2016-06-30 US US15/740,914 patent/US10758624B2/en active Active
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2020
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2022
- 2022-05-10 JP JP2022077341A patent/JP7459168B2/ja active Active
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