|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4657760A
(en)
|
1979-03-20 |
1987-04-14 |
Ortho Pharmaceutical Corporation |
Methods and compositions using monoclonal antibody to human T cells
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US5206344A
(en)
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
ATE108068T1
(de)
|
1987-09-23 |
1994-07-15 |
Bristol Myers Squibb Co |
Antikörper-heterokonjugate zur töting von hiv- infizierten zellen.
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5750373A
(en)
|
1990-12-03 |
1998-05-12 |
Genentech, Inc. |
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
|
|
ATE102631T1
(de)
|
1988-11-11 |
1994-03-15 |
Medical Res Council |
Klonierung von immunglobulin sequenzen aus den variabelen domaenen.
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
AU641673B2
(en)
|
1989-06-29 |
1993-09-30 |
Medarex, Inc. |
Bispecific reagents for aids therapy
|
|
US5225212A
(en)
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
ATE139258T1
(de)
|
1990-01-12 |
1996-06-15 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
DE69132709T2
(de)
|
1990-06-29 |
2002-06-20 |
Large Scale Biology Corp., Vacaville |
Melaninproduktion durch transformierte mikroorganismen
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
JPH06507398A
(ja)
|
1991-05-14 |
1994-08-25 |
リプリジェン コーポレーション |
Hiv感染治療のための異種複合抗体
|
|
DK0590058T3
(da)
|
1991-06-14 |
2004-03-29 |
Genentech Inc |
Humaniseret heregulin-antistof
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
WO1993006217A1
(en)
|
1991-09-19 |
1993-04-01 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
FI941572A7
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
AU3178993A
(en)
|
1991-11-25 |
1993-06-28 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
CA2103887C
(en)
|
1991-12-13 |
2005-08-30 |
Gary M. Studnicka |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5869619A
(en)
|
1991-12-13 |
1999-02-09 |
Xoma Corporation |
Modified antibody variable domains
|
|
ATE295420T1
(de)
|
1992-02-06 |
2005-05-15 |
Chiron Corp |
Marker für krebs und biosynthetisches bindeprotein dafür
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
WO1994004690A1
(en)
|
1992-08-17 |
1994-03-03 |
Genentech, Inc. |
Bispecific immunoadhesins
|
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
AU5632296A
(en)
|
1995-04-27 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
WO1997011971A1
(en)
|
1995-09-28 |
1997-04-03 |
Alexion Pharmaceuticals, Inc. |
Porcine cell interaction proteins
|
|
DE19544393A1
(de)
|
1995-11-15 |
1997-05-22 |
Hoechst Schering Agrevo Gmbh |
Synergistische herbizide Mischungen
|
|
EP2305027B1
(en)
|
1996-12-03 |
2014-07-02 |
Amgen Fremont Inc. |
Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
|
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
|
AU760562B2
(en)
|
1997-12-05 |
2003-05-15 |
Scripps Research Institute, The |
Humanization of murine antibody
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
|
MXPA02003456A
(es)
|
1999-10-04 |
2002-10-23 |
Medicago Inc |
Metodo para regular la transcripcion de genes foraneos.
|
|
EP1272647B1
(en)
|
2000-04-11 |
2014-11-12 |
Genentech, Inc. |
Multivalent antibodies and uses therefor
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
MXPA03004793A
(es)
|
2000-11-30 |
2004-12-03 |
Medarex Inc |
Roedores transgenicos transcromosomales para elaborar anticuerpos humnanos.
|
|
JP2005532253A
(ja)
|
2001-10-25 |
2005-10-27 |
ジェネンテック・インコーポレーテッド |
糖タンパク質組成物
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
ATE503829T1
(de)
|
2002-04-09 |
2011-04-15 |
Kyowa Hakko Kirin Co Ltd |
Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins
|
|
EP1498490A4
(en)
|
2002-04-09 |
2006-11-29 |
Kyowa Hakko Kogyo Kk |
PROCESS FOR PRODUCING ANTIBODY COMPOSITION
|
|
KR20050000380A
(ko)
|
2002-04-09 |
2005-01-03 |
교와 핫꼬 고교 가부시끼가이샤 |
게놈이 개변된 세포
|
|
JPWO2003084569A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物含有医薬
|
|
US20040119010A1
(en)
|
2002-11-01 |
2004-06-24 |
The Regents Of The University Of Colorado |
Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
|
|
ES2380055T3
(es)
|
2002-12-20 |
2012-05-08 |
H. Lundbeck A/S |
Modulación de la actividad de neurotrofinas; método de escrutinio
|
|
WO2005044293A2
(en)
|
2003-11-07 |
2005-05-19 |
Lay Line Genomics S.P.A. |
Compositions able to prevent neurodegenerative processes and methods of assaying the same
|
|
WO2005097832A2
(en)
|
2004-03-31 |
2005-10-20 |
Genentech, Inc. |
Humanized anti-tgf-beta antibodies
|
|
MX2007008017A
(es)
|
2004-12-31 |
2007-09-12 |
Genentech Inc |
Polipeptidos que se ligan a br3 y usos de los mismos.
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
US8877714B2
(en)
|
2005-06-14 |
2014-11-04 |
Raptor Pharmaceutical Inc. |
Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof
|
|
KR101888321B1
(ko)
*
|
2005-07-01 |
2018-08-13 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
JP2009508494A
(ja)
|
2005-09-16 |
2009-03-05 |
ラプトール ファーマシューティカル インコーポレイテッド |
Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用
|
|
FR2896881B1
(fr)
|
2006-01-31 |
2008-04-18 |
Biomerieux Sa |
Procede de dosage du prongf pour le diagnostic in vitro du cancer du sein et utilisation du prongf en therapie
|
|
AU2007225044C1
(en)
|
2006-03-15 |
2018-03-29 |
Alexion Pharmaceuticals, Inc. |
Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
|
|
TW200812616A
(en)
|
2006-05-09 |
2008-03-16 |
Genentech Inc |
Binding polypeptides with optimized scaffolds
|
|
EP2059533B1
(en)
|
2006-08-30 |
2012-11-14 |
Genentech, Inc. |
Multispecific antibodies
|
|
CN101594878A
(zh)
|
2006-09-18 |
2009-12-02 |
雷普特药品公司 |
通过给予受体相关蛋白(rap)-缀合物对肝病症的治疗
|
|
WO2008052016A2
(en)
|
2006-10-23 |
2008-05-02 |
Columbia University |
The sortilin-related receptor sorl1 is functionally and genetically associated with alzheimer's disease
|
|
US20100028333A1
(en)
*
|
2006-12-15 |
2010-02-04 |
Getty Krista L |
Receptor for amyloid beta and uses thereof
|
|
UY30776A1
(es)
|
2006-12-21 |
2008-07-03 |
Medarex Inc |
Anticuerpos cd44
|
|
HRP20170530T1
(hr)
|
2006-12-21 |
2017-06-02 |
H. Lundbeck A/S |
Modulacija aktivnosti proneutrofina
|
|
WO2008086452A2
(en)
|
2007-01-10 |
2008-07-17 |
Columbia University |
Treatment and prevention of alzheimer's disease
|
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
EP2193146B1
(en)
|
2007-09-14 |
2016-05-25 |
Adimab, LLC |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
DK2235064T3
(en)
|
2008-01-07 |
2016-01-11 |
Amgen Inc |
A process for the preparation of heterodimeric Fc molecules using electrostatic control effects
|
|
CN102131826B
(zh)
*
|
2008-04-27 |
2014-07-02 |
H.隆德贝克有限公司 |
人类分拣蛋白的晶体结构及其用于鉴定分拣蛋白的配体的用途
|
|
US20160359907A1
(en)
|
2015-06-02 |
2016-12-08 |
Vmware, Inc. |
Automatically auditing virtual machines for security hardening compliance
|
|
ES2533787T3
(es)
|
2008-05-22 |
2015-04-14 |
H. Lundbeck A/S |
Modulación de los receptores con dominio Vps10p
|
|
DK2307042T3
(da)
|
2008-06-25 |
2014-05-12 |
Lundbeck & Co As H |
Modulering af trpv: vps10p-domænereceptorsystem til behandlingen af smerte
|
|
PE20141432A1
(es)
*
|
2008-07-16 |
2014-10-18 |
Inst Research In Biomedicine |
Anticuerpos neutralizantes de citomegalovirus humano
|
|
WO2010022175A1
(en)
*
|
2008-08-19 |
2010-02-25 |
Yale University |
Identification of sortilin as a neuronal receptor for the frontotemporal dementia protein, progranulin
|
|
WO2010028333A2
(en)
|
2008-09-08 |
2010-03-11 |
Mayo Foundation For Medical Education And Research |
Methods and devices for ligating tubular structures
|
|
CN105641694B
(zh)
|
2008-12-19 |
2020-08-14 |
H.隆德贝克有限公司 |
用于治疗精神和行为障碍的对Vps10p-结构域受体家族的调节
|
|
FR2945538B1
(fr)
|
2009-05-12 |
2014-12-26 |
Sanofi Aventis |
Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide.
|
|
EP2483406A2
(en)
|
2009-09-30 |
2012-08-08 |
President and Fellows of Harvard College |
Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products
|
|
US20130115222A1
(en)
|
2010-06-15 |
2013-05-09 |
Cornell University |
Methods of limiting microvascular damage following acute myocardial ischemia
|
|
AU2011279073B2
(en)
|
2010-07-16 |
2016-06-09 |
Adimab, Llc |
Antibody libraries
|
|
US20130336988A1
(en)
|
2010-11-17 |
2013-12-19 |
New York University |
Methods for treating early stage or mild neurological disorders
|
|
JP6187777B2
(ja)
*
|
2011-06-13 |
2017-08-30 |
シーエスエル、リミテッド |
G−csfrに対する抗体およびその使用
|
|
JP6239635B2
(ja)
|
2012-11-02 |
2017-11-29 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. |
血管石灰化の誘導因子であるソルチリン1
|
|
US10156574B2
(en)
|
2013-04-29 |
2018-12-18 |
Adimab, Llc |
Polyspecificity reagents, methods for their preparation and use
|
|
SG10201710758PA
(en)
*
|
2013-07-09 |
2018-02-27 |
Annexon Inc |
Anti-complement factor c1q antibodies and uses thereof
|
|
US10357542B2
(en)
|
2014-02-04 |
2019-07-23 |
New York University |
Progranulin (PGRN) and its derivatives for diagnosis and treatment of lysosomal storage diseases
|
|
HK1232289A1
(zh)
|
2014-02-12 |
2018-01-05 |
H. Lundbeck A/S |
分拣蛋白作为针对情感/心境障碍的生物标记的用途
|
|
US20170096486A1
(en)
|
2014-03-26 |
2017-04-06 |
Goran Landberg |
Agents inhibiting granulin for treatment of cancer
|
|
MA40460A
(fr)
|
2014-08-11 |
2016-02-18 |
Shire Human Genetic Therapies |
Ciblage lysosomial et utilisation correspondante
|
|
PT3280441T
(pt)
|
2015-04-07 |
2021-11-30 |
Alector Llc |
Anticorpos anti-sortilina e métodos para a sua utilização
|
|
WO2016164608A1
(en)
|
2015-04-07 |
2016-10-13 |
Alector Llc |
Methods of screening for sortilin binding antagonists
|
|
US20160331746A1
(en)
|
2015-05-12 |
2016-11-17 |
University Of South Florida |
Sortilin-Binding Small Molecules for Increasing Glucose Uptake
|
|
GB201512215D0
(en)
|
2015-07-13 |
2015-08-19 |
Lundbeck & Co As H |
Agents,uses and methods
|
|
WO2017024137A1
(en)
|
2015-08-04 |
2017-02-09 |
New York University |
Progranulin (pgrn) fragments and derivatives for treatment or alleviation of lysosomal storage diseases
|
|
US10085969B1
(en)
|
2016-02-12 |
2018-10-02 |
University Of South Florida |
Sortilin binding compounds, formulations, and uses thereof
|
|
US10894833B2
(en)
|
2017-07-20 |
2021-01-19 |
H. Lundbeck A/S |
Agents, uses and methods for treatment
|
|
JP7438119B2
(ja)
|
2017-10-23 |
2024-02-26 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド |
細胞外小胞関連疾患のための材料および方法
|
|
TWI874321B
(zh)
|
2018-06-18 |
2025-03-01 |
美商戴納立製藥公司 |
包含顆粒蛋白前體之融合蛋白
|
|
PL3618928T3
(pl)
|
2018-07-13 |
2023-05-02 |
Alector Llc |
Przeciwciała antysortylinowe i sposoby ich stosowania
|
|
CA3110414A1
(en)
|
2018-08-24 |
2020-02-27 |
Transfert Plus, S.E.C. |
Methods and compounds for targeting sortilin receptors and inhibiting vasculogenic mimicry
|
|
WO2020051624A1
(en)
|
2018-09-11 |
2020-03-19 |
Grophin Pty Ltd |
Methods and compositions for improving recovery from a brain injury
|
|
EP3666281A1
(en)
|
2018-12-14 |
2020-06-17 |
Insusense ApS |
Compositions comprising sortilin-1
|
|
US20220154182A1
(en)
|
2019-03-20 |
2022-05-19 |
President And Fellows Of Harvard College |
Antisense oligonucleotide-based progranulin augmentation therapy in neurodegenerative diseases
|
|
AU2020291527A1
(en)
|
2019-06-11 |
2022-01-20 |
Alector Llc |
Anti-Sortilin antibodies for use in therapy
|