JP2018514204A5 - - Google Patents
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- JP2018514204A5 JP2018514204A5 JP2017554350A JP2017554350A JP2018514204A5 JP 2018514204 A5 JP2018514204 A5 JP 2018514204A5 JP 2017554350 A JP2017554350 A JP 2017554350A JP 2017554350 A JP2017554350 A JP 2017554350A JP 2018514204 A5 JP2018514204 A5 JP 2018514204A5
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- JP
- Japan
- Prior art keywords
- domain
- cell
- car
- signaling domain
- intracellular signaling
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1507368.7A GB201507368D0 (en) | 2015-04-30 | 2015-04-30 | Cell |
| GB1507368.7 | 2015-04-30 | ||
| PCT/GB2016/051235 WO2016174461A1 (en) | 2015-04-30 | 2016-04-29 | T cell which expresses a gamma-delta t cell receptor (tcr) and a chimeric antigen receptor (car) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514204A JP2018514204A (ja) | 2018-06-07 |
| JP2018514204A5 true JP2018514204A5 (cg-RX-API-DMAC7.html) | 2019-06-06 |
| JP6986449B2 JP6986449B2 (ja) | 2021-12-22 |
Family
ID=53488907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554350A Expired - Fee Related JP6986449B2 (ja) | 2015-04-30 | 2016-04-29 | ガンマデルタｔ細胞受容体（ｔｃｒ）とキメラ抗原受容体（ｃａｒ）とを発現するｔ細胞 |
Country Status (16)
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CA3057838A1 (en) * | 2017-03-24 | 2018-09-27 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-cd33 immunotherapy |
| RU2019128544A (ru) | 2017-03-27 | 2021-04-28 | Нэшнл Юниверсити Оф Сингапур | Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров |
| CN117384929A (zh) | 2017-03-27 | 2024-01-12 | 新加坡国立大学 | 一种编码由细胞表达的嵌合受体的多核苷酸 |
| CA3071495A1 (en) * | 2017-08-02 | 2019-02-07 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed |
| AU2018341227B2 (en) * | 2017-09-27 | 2024-10-03 | Ohio State Innovation Foundation | Tissue factor-targeting CAR-NK and CAR-T cell therapy |
| GB201715918D0 (en) * | 2017-09-29 | 2017-11-15 | Tc Biopharm Ltd | Modified CAR-T |
| GB201720949D0 (en) | 2017-12-15 | 2018-01-31 | Autolus Ltd | Cell |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| GB201804701D0 (en) * | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| CN110343710B (zh) * | 2018-04-04 | 2024-01-12 | 达仁生物科技有限公司 | 嵌合抗原受体和其治疗肝癌的方法 |
| WO2019202323A1 (en) * | 2018-04-18 | 2019-10-24 | Ucl Business Plc | Method for enhancing the suppressive properties of treg cells |
| CN108588023B (zh) * | 2018-05-09 | 2020-02-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| CN110577932A (zh) * | 2018-06-07 | 2019-12-17 | 亘喜生物科技（上海）有限公司 | 一种脐带血来源的嵌合抗原受体t细胞 |
| US20220265709A1 (en) * | 2018-06-19 | 2022-08-25 | Nanjing Legend Biotech Co., Ltd. | Engineered cells and uses thereof |
| WO2020027094A1 (ja) | 2018-07-31 | 2020-02-06 | サイアス株式会社 | ｉＰＳ細胞を介して再生Ｔ細胞集団を製造する方法 |
| WO2020033464A1 (en) * | 2018-08-07 | 2020-02-13 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Car t-cells for the treatment of bone metastatic cancer |
| CN112567025B (zh) * | 2018-08-10 | 2025-01-17 | 国立大学法人京都大学 | Cd3阳性细胞的制造方法 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| CN113260629A (zh) * | 2018-09-19 | 2021-08-13 | 拉法医疗有限公司 | 用于治疗恶性血液病的新双特异性抗体 |
| CN109234236A (zh) * | 2018-09-29 | 2019-01-18 | 吉林大学第医院 | 一种嵌合抗原受体γδT细胞的制备方法 |
| BR112021006254A2 (pt) * | 2018-10-01 | 2021-07-27 | Adicet Bio, Inc. | composições e métodos relativos a células t¿d engenheiradas e não engenheiradas para tratamento de tumores sólidos |
| AU2019354391A1 (en) * | 2018-10-01 | 2021-05-06 | Adicet Therapeutics, Inc. | Compositions and methods regarding engineered and non- engineered γδ-Τ cells for treatment of hematological tumors |
| EP3919515A4 (en) * | 2019-01-29 | 2022-11-23 | Shanghai Jiao Tong University | CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF |
| US20220088074A1 (en) * | 2019-02-21 | 2022-03-24 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY |
| WO2020210247A1 (en) * | 2019-04-12 | 2020-10-15 | Phanes Therapeutics, Inc. | Humanized anti-folate receptor 1 chimeric antigen receptors and uses thereof |
| SG11202111679XA (en) * | 2019-04-22 | 2021-11-29 | Nanjing Legend Biotech Co Ltd | Engineered cells and uses thereof |
| US20220233665A1 (en) | 2019-06-14 | 2022-07-28 | Thyas Co. Ltd. | Medicinal composition |
| EP3986442A4 (en) * | 2019-06-21 | 2023-10-25 | Shattuck Labs, Inc. | Chimeric protein expressing t-cells |
| GB201909283D0 (en) * | 2019-06-27 | 2019-08-14 | Cancer Research Tech Ltd | Fusion proteins with enzyme activity |
| CN110981972B (zh) * | 2019-12-25 | 2022-09-30 | 华夏源（上海）细胞基因工程股份有限公司 | 一种分泌双特异性抗体的嵌合抗原受体及其表达载体和应用 |
| AU2021232141A1 (en) * | 2020-03-03 | 2022-09-22 | Janssen Biotech, Inc. | ꝩδ T cells and uses thereof |
| IL298346A (en) | 2020-05-22 | 2023-01-01 | Chongqing Prec Biotech Co Ltd | A fusion protein for reversal of the tumor microenvironment and its use |
| IL299886A (en) | 2020-07-17 | 2023-03-01 | Instil Bio Uk Ltd | Receptors that provide targeted costimulation for host cell therapy |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| WO2022266192A1 (en) | 2021-06-16 | 2022-12-22 | Instil Bio, Inc. | Receptors providing targeted costimulation for adoptive cell therapy |
| EP4370213A4 (en) | 2021-07-16 | 2025-06-04 | Instil Bio (Uk) Limited | Chimeric molecules for targeted costimulation for adoptive cell therapy |
| CN113528455A (zh) * | 2021-07-19 | 2021-10-22 | 广州百暨基因科技有限公司 | 表达嵌合抗原受体的γδT细胞 |
| CA3233987A1 (en) * | 2021-10-06 | 2023-04-13 | Carl NOVINA | Engineered cytokine receptors for tunable adoptive cell therapy |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002535002A (ja) | 1999-01-28 | 2002-10-22 | パルメット ヘルス アライアンス，デー／ビー／エー パルメット リッチランド メモリアル ホスピタル | インビトロ活性化ガンマデルタリンパ球 |
| EP1268746B1 (en) | 2000-04-03 | 2009-11-18 | Therapure Biopharma Inc. | PRODUCTION OF TcR GAMMA DELTA T CELLS |
| DE60132937T2 (de) | 2000-09-11 | 2009-02-12 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zur Herstellung von Benzimidazol-2-yl -Chinolinonderivaten |
| WO2006006720A1 (ja) | 2004-07-13 | 2006-01-19 | Medinet., Co.Ltd | γδＴ細胞の培養方法、γδＴ細胞及び治療・予防剤 |
| JP5016489B2 (ja) | 2004-08-19 | 2012-09-05 | ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド | 抗原提示ヒトγδＴ細胞の調製及び免疫療法における使用 |
| WO2008152822A1 (ja) | 2007-06-15 | 2008-12-18 | Medinet Co., Ltd. | 医薬 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2013033626A2 (en) * | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| JP6850528B2 (ja) * | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| CN113005091A (zh) | 2013-02-06 | 2021-06-22 | 细胞基因公司 | 具有改进特异性的修饰的t淋巴细胞 |
| ES2760023T3 (es) * | 2013-02-20 | 2020-05-12 | Univ Pennsylvania | Tratamiento del cáncer utilizando receptor de antígeno quimérico anti-EGFRvIII humanizado |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| WO2014186469A2 (en) * | 2013-05-14 | 2014-11-20 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| ES2910004T3 (es) * | 2013-07-29 | 2022-05-11 | 2Seventy Bio Inc | Proteínas de señalización de múltiples partes y sus usos |
| KR20160068960A (ko) | 2013-10-25 | 2016-06-15 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 면역요법을 위한 다클론성 감마 델타 t 세포 |
| WO2015066262A1 (en) * | 2013-11-04 | 2015-05-07 | Trustees Of Dartmouth College | Methods for preventing toxicity of adoptive cell therapy |
| MX377283B (es) * | 2013-11-21 | 2025-03-07 | Ucl Business Ltd | Célula t o nk que coexpresa un receptor antigénico quimérico (car). |
| RU2753965C2 (ru) * | 2014-02-14 | 2021-08-24 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Химерные антигенные рецепторы и способы их получения |
| GB201403972D0 (en) * | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| WO2015164594A1 (en) * | 2014-04-23 | 2015-10-29 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| EA201790010A1 (ru) | 2014-07-09 | 2017-05-31 | ТиСи БАЙОФАРМ ЛТД. | Гамма-дельта t-клетки и их применение |
| AU2015350103A1 (en) | 2014-11-17 | 2017-06-29 | Adicet Bio, Inc. | Engineered gamma delta T-cells |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CN105158466B (zh) | 2015-05-05 | 2017-12-22 | 中国科学院广州生物医药与健康研究院 | 一种检测抗cd19的嵌合抗原受体t细胞对白血病细胞抑制作用的方法 |
-
2015
- 2015-04-30 GB GBGB1507368.7A patent/GB201507368D0/en not_active Ceased
-
2016
- 2016-04-29 HK HK18111473.3A patent/HK1252235A1/zh unknown
- 2016-04-29 KR KR1020177034648A patent/KR20180020140A/ko not_active Ceased
- 2016-04-29 JP JP2017554350A patent/JP6986449B2/ja not_active Expired - Fee Related
- 2016-04-29 US US15/567,165 patent/US20180125890A1/en not_active Abandoned
- 2016-04-29 CN CN201680024237.0A patent/CN107771215A/zh active Pending
- 2016-04-29 WO PCT/GB2016/051235 patent/WO2016174461A1/en not_active Ceased
- 2016-04-29 ES ES16720532T patent/ES3018558T3/es active Active
- 2016-04-29 EA EA201792042A patent/EA201792042A1/ru unknown
- 2016-04-29 CA CA2982532A patent/CA2982532C/en active Active
- 2016-04-29 BR BR112017023409A patent/BR112017023409A2/pt not_active Application Discontinuation
- 2016-04-29 EP EP16720532.7A patent/EP3288567B1/en active Active
- 2016-04-29 AU AU2016255611A patent/AU2016255611B2/en active Active
- 2016-04-29 SG SG11201708402UA patent/SG11201708402UA/en unknown
-
2017
- 2017-10-12 ZA ZA2017/06923A patent/ZA201706923B/en unknown
- 2017-10-22 IL IL255186A patent/IL255186B/en unknown
-
2021
- 2021-11-17 US US17/528,836 patent/US12331316B2/en active Active
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