JP2018513841A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018513841A5 JP2018513841A5 JP2017546667A JP2017546667A JP2018513841A5 JP 2018513841 A5 JP2018513841 A5 JP 2018513841A5 JP 2017546667 A JP2017546667 A JP 2017546667A JP 2017546667 A JP2017546667 A JP 2017546667A JP 2018513841 A5 JP2018513841 A5 JP 2018513841A5
- Authority
- JP
- Japan
- Prior art keywords
- administration
- pharmaceutical composition
- inhibitor
- recombinant vector
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003112 inhibitor Substances 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 206010022489 Insulin Resistance Diseases 0.000 claims 6
- 108020004459 Small interfering RNA Proteins 0.000 claims 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 229920002477 rna polymer Polymers 0.000 claims 5
- 230000002452 interceptive effect Effects 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 230000033228 biological regulation Effects 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101000640735 Homo sapiens TSC22 domain family protein 4 Proteins 0.000 claims 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 102100033848 TSC22 domain family protein 4 Human genes 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007914 intraventricular administration Methods 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15160259.6A EP3072969A1 (en) | 2015-03-23 | 2015-03-23 | Oligonucleotide sequences targeting transcription factor TSC22D4 for the treatment of insulin resistance |
| EP15160259.6 | 2015-03-23 | ||
| PCT/EP2016/053050 WO2016150618A1 (en) | 2015-03-23 | 2016-02-12 | Oligonucleotide sequences targeting transcription factor tsc22d4 for the treatment of insulin resistance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018513841A JP2018513841A (ja) | 2018-05-31 |
| JP2018513841A5 true JP2018513841A5 (enExample) | 2019-03-14 |
Family
ID=52784935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546667A Pending JP2018513841A (ja) | 2015-03-23 | 2016-02-12 | インスリン抵抗性の治療のための転写因子ｔｓｃ２２ｄ４を標的とするオリゴヌクレオチド配列 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10676739B2 (enExample) |
| EP (2) | EP3072969A1 (enExample) |
| JP (1) | JP2018513841A (enExample) |
| KR (1) | KR20170128348A (enExample) |
| CN (1) | CN107278229A (enExample) |
| BR (1) | BR112017016021A2 (enExample) |
| CA (1) | CA2979115A1 (enExample) |
| DK (1) | DK3274455T3 (enExample) |
| ES (1) | ES2837085T3 (enExample) |
| MX (1) | MX384193B (enExample) |
| RU (1) | RU2723091C2 (enExample) |
| WO (1) | WO2016150618A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7289510B2 (ja) * | 2019-05-08 | 2023-06-12 | 国立大学法人高知大学 | 認知症治療薬のスクリーニング方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1206234A4 (en) * | 1999-06-03 | 2005-06-01 | Jessie L S Au | METHODS AND COMPOSITIONS FOR MODULATING PROLIFERATION AND CELL DEATH |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| JP4869942B2 (ja) | 2003-12-11 | 2012-02-08 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | インスリン感受性／抵抗性、糖尿病および肥満におけるｒｂｐ４ |
| AU2005248147A1 (en) * | 2004-05-11 | 2005-12-08 | Alphagen Co., Ltd. | Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same |
| US7943306B2 (en) * | 2005-01-12 | 2011-05-17 | The Board Of Trustees Of The Leland Stanford Junior University | Gene expression signature for prediction of human cancer progression |
| US20140227289A1 (en) | 2011-05-13 | 2014-08-14 | Stephen Michael Cohen | Compounds and methods for treating insulin resistance syndrome |
| GB201120317D0 (en) | 2011-11-24 | 2012-01-04 | Queen Mary & Westfield College | Screening method |
| EP2816356A1 (en) | 2013-06-17 | 2014-12-24 | Ruprecht-Karls-Universität Heidelberg | Treatment of insulin resistance through inhibitors of transcription factor TSC22D4 |
| RU2573450C1 (ru) * | 2014-08-11 | 2016-01-20 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Способ выявления генов-мишеней для диагностики и терапии лейкозов человека |
-
2015
- 2015-03-23 EP EP15160259.6A patent/EP3072969A1/en not_active Withdrawn
-
2016
- 2016-02-12 CN CN201680012500.4A patent/CN107278229A/zh active Pending
- 2016-02-12 RU RU2017131900A patent/RU2723091C2/ru active
- 2016-02-12 CA CA2979115A patent/CA2979115A1/en active Pending
- 2016-02-12 EP EP16704222.5A patent/EP3274455B1/en active Active
- 2016-02-12 WO PCT/EP2016/053050 patent/WO2016150618A1/en not_active Ceased
- 2016-02-12 JP JP2017546667A patent/JP2018513841A/ja active Pending
- 2016-02-12 ES ES16704222T patent/ES2837085T3/es active Active
- 2016-02-12 US US15/545,104 patent/US10676739B2/en active Active
- 2016-02-12 BR BR112017016021-8A patent/BR112017016021A2/pt not_active IP Right Cessation
- 2016-02-12 KR KR1020177026584A patent/KR20170128348A/ko not_active Ceased
- 2016-02-12 DK DK16704222.5T patent/DK3274455T3/da active
- 2016-02-12 MX MX2017012231A patent/MX384193B/es unknown
-
2020
- 2020-04-30 US US16/862,930 patent/US11053499B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10961535B2 (en) | Compositions and agents against hepatitis B virus and uses thereof | |
| US11534452B2 (en) | Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection | |
| JP2018529732A5 (enExample) | ||
| JP2016513976A5 (enExample) | ||
| JP2016530882A5 (enExample) | ||
| JP2016502858A5 (enExample) | ||
| BR112020020220A2 (pt) | Uso de inibidores da fubp1 para o tratamento de infecção pelo vírus da hepatite b | |
| US11685921B2 (en) | Molecules and agents for treating hepatitis B virus | |
| WO2018209848A1 (zh) | 抑制HBV的siRNA分子及其应用 | |
| TW201406774A (zh) | 微ｒｎａ之ｍｉｒ－１５家族之抑制劑 | |
| JP2017528441A5 (enExample) | ||
| US20200407721A1 (en) | Compounds of chemically modified oligonucleotides and methods of use thereof | |
| JP2011515357A5 (enExample) | ||
| RU2014121304A (ru) | Ингибирование экспрессии вирусных генов | |
| JP2009533475A5 (enExample) | ||
| CN114901821A (zh) | Sept9抑制剂用于治疗乙型肝炎病毒感染的用途 | |
| JP2018513841A5 (enExample) | ||
| TW202342747A (zh) | 具有高穩定性和基因沉默活性的小干擾rna分子的修飾模式 | |
| JP2009533466A5 (enExample) | ||
| JP2007517498A5 (enExample) | ||
| CN114867856A (zh) | Saraf抑制剂用于治疗乙型肝炎病毒感染的用途 | |
| CN114829599A (zh) | Scamp3抑制剂用于治疗乙型肝炎病毒感染的用途 | |
| RU2017131900A (ru) | Олигонуклеотидные последовательности, нацеленные на транскрипционный фактор tsc22d4, для лечения резистентности к инсулину | |
| CN107709561B (zh) | 修饰的siRNA及含有该修饰的siRNA的药物组合物 | |
| KR101783444B1 (ko) | miR-33-5p 를 이용한 뇌신경세포 보호 물질 스크리닝 방법 |