JP2018513841A - インスリン抵抗性の治療のための転写因子ｔｓｃ２２ｄ４を標的とするオリゴヌクレオチド配列 - Google Patents

インスリン抵抗性の治療のための転写因子ｔｓｃ２２ｄ４を標的とするオリゴヌクレオチド配列 Download PDF

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JP2018513841A
JP2018513841A JP2017546667A JP2017546667A JP2018513841A JP 2018513841 A JP2018513841 A JP 2018513841A JP 2017546667 A JP2017546667 A JP 2017546667A JP 2017546667 A JP2017546667 A JP 2017546667A JP 2018513841 A JP2018513841 A JP 2018513841A
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administration
tsc22d4
insulin resistance
pharmaceutical composition
seq
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JP2018513841A5 (enExample
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ヘルツィヒ，シュテファン
ディアス，マウリシオ ベリエル
ディアス，マウリシオ ベリエル
シャフマイヤー，トビアス
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German Cancer Research Center
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German Cancer Research Center
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017546667A 2015-03-23 2016-02-12 インスリン抵抗性の治療のための転写因子ｔｓｃ２２ｄ４を標的とするオリゴヌクレオチド配列 Pending JP2018513841A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15160259.6A EP3072969A1 (en) 2015-03-23 2015-03-23 Oligonucleotide sequences targeting transcription factor TSC22D4 for the treatment of insulin resistance
EP15160259.6 2015-03-23
PCT/EP2016/053050 WO2016150618A1 (en) 2015-03-23 2016-02-12 Oligonucleotide sequences targeting transcription factor tsc22d4 for the treatment of insulin resistance

Publications (2)

Publication Number Publication Date
JP2018513841A true JP2018513841A (ja) 2018-05-31
JP2018513841A5 JP2018513841A5 (enExample) 2019-03-14

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JP2017546667A Pending JP2018513841A (ja) 2015-03-23 2016-02-12 インスリン抵抗性の治療のための転写因子ｔｓｃ２２ｄ４を標的とするオリゴヌクレオチド配列

Country Status (11)

Country Link
US (2) US10676739B2 (enExample)
EP (2) EP3072969A1 (enExample)
JP (1) JP2018513841A (enExample)
KR (1) KR20170128348A (enExample)
CN (1) CN107278229A (enExample)
BR (1) BR112017016021A2 (enExample)
DK (1) DK3274455T3 (enExample)
ES (1) ES2837085T3 (enExample)
MX (1) MX384193B (enExample)
RU (1) RU2723091C2 (enExample)
WO (1) WO2016150618A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020183905A (ja) * 2019-05-08 2020-11-12 国立大学法人高知大学 認知症治療薬のスクリーニング方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014202602A1 (en) * 2013-06-17 2014-12-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Treatment of insulin resistance through inhibitors of transcription factor tsc22d4

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377385A1 (en) * 1999-06-03 2000-12-14 Jessie L.S. Au Methods and compositions for modulating cell proliferation and cell death
EP2305813A3 (en) * 2002-11-14 2012-03-28 Dharmacon, Inc. Fuctional and hyperfunctional sirna
EP1692521A1 (en) 2003-12-11 2006-08-23 Beth Israel Deaconess Medical Center, Inc. Rbp4 in insulin sensitivity/resistance, diabetes, and obesity
CA2566286A1 (en) * 2004-05-11 2005-12-08 Rnai Co., Ltd. Polynucleotide causing rna interfere and method of regulating gene expression with the use of the same
US7943306B2 (en) * 2005-01-12 2011-05-17 The Board Of Trustees Of The Leland Stanford Junior University Gene expression signature for prediction of human cancer progression
US20140227289A1 (en) 2011-05-13 2014-08-14 Stephen Michael Cohen Compounds and methods for treating insulin resistance syndrome
GB201120317D0 (en) 2011-11-24 2012-01-04 Queen Mary & Westfield College Screening method
RU2573450C1 (ru) * 2014-08-11 2016-01-20 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Способ выявления генов-мишеней для диагностики и терапии лейкозов человека

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014202602A1 (en) * 2013-06-17 2014-12-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Treatment of insulin resistance through inhibitors of transcription factor tsc22d4

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HOMO SAPIENCE TSC22 DOMAIN FAMILY MEMBER 4, MRNA COMPLETE CDS, JPN6019047208, 2006, ISSN: 0004166925 *
METHODS MOL BIOL, vol. 1269, JPN7019003904, 2015, pages 393 - 412, ISSN: 0004166924 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020183905A (ja) * 2019-05-08 2020-11-12 国立大学法人高知大学 認知症治療薬のスクリーニング方法
JP7289510B2 (ja) 2019-05-08 2023-06-12 国立大学法人高知大学 認知症治療薬のスクリーニング方法

Also Published As

Publication number Publication date
MX384193B (es) 2025-03-12
EP3274455A1 (en) 2018-01-31
US20180023078A1 (en) 2018-01-25
US20200255834A1 (en) 2020-08-13
RU2017131900A3 (enExample) 2019-06-10
EP3072969A1 (en) 2016-09-28
BR112017016021A2 (pt) 2018-03-20
RU2017131900A (ru) 2019-04-23
DK3274455T3 (da) 2020-12-14
EP3274455B1 (en) 2020-10-14
RU2723091C2 (ru) 2020-06-08
US10676739B2 (en) 2020-06-09
WO2016150618A1 (en) 2016-09-29
CA2979115A1 (en) 2016-09-29
US11053499B2 (en) 2021-07-06
MX2017012231A (es) 2018-01-30
KR20170128348A (ko) 2017-11-22
ES2837085T3 (es) 2021-06-29
CN107278229A (zh) 2017-10-20

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